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Antibodies In Diagnosis And Therapy
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Book Synopsis Diagnostic and Therapeutic Antibodies by : Andrew J.T. George
Download or read book Diagnostic and Therapeutic Antibodies written by Andrew J.T. George and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the “magic bullet” that would allow the specific destruction of neoplastic cells. H- ever, many years’ effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display. The results of recent clinical trials have demonstrated unequivocally the benefit of antibody therapy in a number of settings, and, finally, more careful consideration has been taken of the types of disease best treated using this approach.
Book Synopsis Introduction to Antibody Engineering by : Florian Rüker
Download or read book Introduction to Antibody Engineering written by Florian Rüker and published by Springer Nature. This book was released on 2021-01-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.
Book Synopsis Antibodies in Diagnosis and Therapy by : Matzku
Download or read book Antibodies in Diagnosis and Therapy written by Matzku and published by Routledge. This book was released on 2019-06-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.
Book Synopsis Monoclonal Antibody Production by : National Research Council
Download or read book Monoclonal Antibody Production written by National Research Council and published by National Academies Press. This book was released on 1999-05-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.
Book Synopsis Radiolabeled Monoclonal Antibodies for Imaging and Therapy by : Suresh C. Srivastava
Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by Suresh C. Srivastava and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.
Book Synopsis Covalently Modified Antigens and Antibodies in Diagnosis and Therapy by : Gerard A. Quash
Download or read book Covalently Modified Antigens and Antibodies in Diagnosis and Therapy written by Gerard A. Quash and published by Marcel Dekker. This book was released on 1989 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a symposium in Lyon, France, in June 1989. Eleven papers survey the use of antibodies, vaccines, and anti-ideotypes in tumor therapy; discuss a variety of immunoconjugates for diagnosis and therapy in which the antibodies are coupled to a range of proteins, chemotherapeutic agents and isotypes; and explore a series of systems in which antibodies (and/or antigens) are used in, in vitro diagnostic or therapeutic procedures. Of interest to researchers in a wide range of medical and biological fields. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)
Book Synopsis Handbook of Therapeutic Antibodies by : Stefan Dübel
Download or read book Handbook of Therapeutic Antibodies written by Stefan Dübel and published by John Wiley & Sons. This book was released on 2014-12-03 with total page 2538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Nachschlagewerk zu therapeutischen Antikörpern sucht auch in der komplett überarbeiteten 2. Auflage seinesgleichen und bietet 30 % neue Inhalte zu Entwicklung, Herstellung und therapeutischen Anwendungen dieser Biomoleküle.
Book Synopsis Antibodies in Diagnosis and Therapy by : Mary Osborn
Download or read book Antibodies in Diagnosis and Therapy written by Mary Osborn and published by . This book was released on 1990 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy by : Menotti Ruvo
Download or read book Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy written by Menotti Ruvo and published by . This book was released on 2022-02-11 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Prevention and In Vivo Diagnosis of Human Disease (1989: Utrecht Symposium on Monoclonal Antibodies for Therapy (the Netherlands)) Publisher : ISBN 13 : Total Pages :246 pages Book Rating :4.:/5 (78 download)
Book Synopsis Symposium on Monoclonal Antibodies for Therapy, Prevention and in Vivo Diagnosis of Human Disease by : Prevention and In Vivo Diagnosis of Human Disease (1989: Utrecht Symposium on Monoclonal Antibodies for Therapy (the Netherlands))
Download or read book Symposium on Monoclonal Antibodies for Therapy, Prevention and in Vivo Diagnosis of Human Disease written by Prevention and In Vivo Diagnosis of Human Disease (1989: Utrecht Symposium on Monoclonal Antibodies for Therapy (the Netherlands)) and published by . This book was released on 1989 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy by :
Download or read book International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy written by and published by . This book was released on 1987 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Symposium on Monoclonal Antibodies for Therapy, Prevention, and in Vivo Diagnosis of Human Disease by :
Download or read book Symposium on Monoclonal Antibodies for Therapy, Prevention, and in Vivo Diagnosis of Human Disease written by and published by . This book was released on 1990 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers by : Veysel Kayser
Download or read book Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers written by Veysel Kayser and published by Mdpi AG. This book was released on 2022-01-25 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody-Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint inhibitors and other closely related topics. Each paper was written by leading active research groups in their fields both from academia and industry. The book should be of interest to those scientists and researchers who develop or use biologics, biotherapeutics, biosimilars and biobetters in cancer treatment.
Book Synopsis Antibodies in Human Diagnosis and Therapy by : Edgar Haber
Download or read book Antibodies in Human Diagnosis and Therapy written by Edgar Haber and published by . This book was released on 1977 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Use of Antibodies by : Richard P. Baum
Download or read book Clinical Use of Antibodies written by Richard P. Baum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was at Frankfurt/Mainin 1899 that Paul Ehrlich first expounded his famous "site-chain theory" -which described the basic immunological principal of antibody-antigen interactio- on the occasion of the opening of the Institute for Experimental Therapeutics (which was later named after him). Nearly 100 years have passed since, and in retrospect it can be said that the "Ehrlich Era" (first steps in immunology "Magic Bullet" concept) and the "Behring Era" (detection of antibodies and serum therapy) formed the essential basis in the development of immunology. Niels K. Jerne, the former director of the Paul Ehrlich Institute in Frankfurt/Main received, together with Georges Kohler and Cesar Milstein, the Nobel Prize in Medicine 1984. These late successors of Ehrlich and Behring first described the hybridoma technology (in 1975) which enabled one of the most important and revolutionary technological innovations in the field of immunology -the production of monoclonal antibodies. It happens that, the time of the publication of this book, just a decade has passed since the first use of radiolabelled monoclonal antibodies in man (by the Lausanne Group). Over these 10 years a tremendous progress has taken place in the field of immunoscintigraphy:A large panel of highly specific monoclonal antibodies against tumour-associated antigens as well as normal cell compounds have been developed. Enormous progress has been made in the field of radiolabelling -from iodine-131 to technetium-99mor even positron-emittingradionuclides, e. g. iodine-124.
Book Synopsis Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.0 by : Menotti Ruvo
Download or read book Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.0 written by Menotti Ruvo and published by Mdpi AG. This book was released on 2022-02-11 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal antibodies (mAbs) are among the most specialised molecules for the recognition and capture of specific analytes. Hundreds of thousands of mAbs have been generated for a large number of different antigens with increasing affinity and specificity and are available for the most diverse purposes. Many of them have been validated as irreplaceable agents for diagnosis and therapy or as unique reagents for research. Others have been developed using emerging technologies that avoid the need for animal immunisation. This short book strives to gather the perspective view of the various contributing authors and to survey the new strategic assets adopted to generate novel monoclonal antibodies or surrogates, such as Fab, Fab2, ScFv and nanobodies, which have an increasing impact in biomedicine as therapeutic or diagnostic assets in various diseases.
Book Synopsis The role of antibodies in cancer treatment and diagnosis by :
Download or read book The role of antibodies in cancer treatment and diagnosis written by and published by GRIN Verlag. This book was released on 2023-02-15 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bachelor Thesis from the year 2022 in the subject Medicine - Human Genetics, grade: 2,0, , language: English, abstract: Monoclonal antibodies in cancer therapy, future outlook, present situation. The topic is approached via a literature review article to give the reader a good overview. The report is based on online database research via PubMed, Cochrane Library, Google Scholar, and ScienceDirect. The purpose of this article is to evaluate the role of antibodies in immunology and their possibilities and limitations in cancer diagnosis and treatment. The references were chosen with regard to their relevance and actuality regarding the discussed topic. Mesh search was used, and further information regarding research tactics is provided in the methodology. In this article, we did shine a light on different aspects of monoclonal antibody usage and the general principles of this novel therapeutic approach. The general mechanism, as well as pharmaceutical preparations, are discussed. This approach lets this work present solid basics of the theoretical and practical considerations, pathways, as well as benefits and risks of monoclonal therapeutics. More research in the future could provide even more promising results and provide ways to lower mortality from cancer and, eventually, other diseases.
