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Antagonist
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Download or read book The Antagonist written by Lynn Coady and published by Vintage. This book was released on 2013-01-22 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A piercing epistolary novel, The Antagonist explores, with wit and compassion, how the impressions of others shape, pervert, and flummox both our perceptions of ourselves and our very nature. Gordon Rankin Jr., aka “Rank,” thinks of himself as “King Midas in reverse”—and indeed misfortune seems to follow him at every turn. Against his will and his nature, he has long been considered—given his enormous size and strength—a goon and enforcer by his classmates, by his hockey coaches, and, not least, by his “tiny, angry” father. He gamely lives up to their expectations, until a vicious twist of fate forces him to flee underground. Now pushing forty, he discovers that an old, trusted friend from his college days has published a novel that borrows freely from the traumatic events of Rank’s own life. Outraged by this betrayal and feeling cruelly misrepresented, he bashes out his own version of his story in a barrage of e-mails to the novelist that range from funny to furious to heartbreaking. With The Antagonist, Lynn Coady demonstrates all of the gifts that have made her one of Canada’s most respected young writers. Here she gives us an astonishing story of sons and fathers and mothers, of the rewards and betrayals of male friendship, and a large-spirited, hilarious, and exhilarating portrait of a man tearing his life apart in order to put himself back together. This ebook edition includes a Reading Group Guide.
Book Synopsis The Antagonist Principle by : Lawrence Poston
Download or read book The Antagonist Principle written by Lawrence Poston and published by University of Virginia Press. This book was released on 2014-12-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Antagonist Principle is a critical examination of the works and sometimes controversial public career of John Henry Newman (1801–1890), first as an Anglican and then as Victorian England’s most famous convert to Roman Catholicism at a time when such a conversion was not only a minority choice but in some quarters a deeply offensive one. Lawrence Poston adopts the idea of personality as his theme, not only in the modern sense of warring elements in one’s own temperament and relationships with others but also in a theological sense as a central premise of orthodox Trinitarian Christian doctrine. The principle of "antagonism," in the sense of opposition, Poston argues, activated Newman's imagination while simultaneously setting limits to his achievement, both as a spiritual leader and as a writer. The author draws on a wide variety of biographical, historical, literary, and theological scholarship to provide an "ethical" reading of Newman’s texts that seeks to offer a humane and complex portrait. Neither a biography nor a revelation of a life, this textual study of Newman’s development as a theologian in his published works and private correspondence attempts to resituate him as one of the most combative of the Victorian seekers. Though his spiritual quest took place on the far right of the religious spectrum in Victorian England, it nonetheless allied him with a number of other prominent figures of his generation as distinct from each other as Thomas Carlyle, John Stuart Mill, and Walter Pater. Avoiding both hagiography and iconoclasm, Poston aims to "see Newman whole."
Book Synopsis We Were the Mulvaneys by : Joyce Carol Oates
Download or read book We Were the Mulvaneys written by Joyce Carol Oates and published by Penguin. This book was released on 2001-01-24 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Oprah Book Club® selection A New York Times Notable Book The Mulvaneys are blessed by all that makes life sweet. But something happens on Valentine’s Day, 1976—an incident that is hushed up in the town and never spoken of in the Mulvaney home—that rends the fabric of their family life...with tragic consequences. Years later, the youngest son attempts to piece together the fragments of the Mulvaneys’ former glory, seeking to uncover and understand the secret violation that brought about the family’s tragic downfall. Profoundly cathartic, this extraordinary novel unfolds as if Oates, in plumbing the darkness of the human spirit, has come upon a source of light at its core. Moving away from the dark tone of her more recent masterpieces, Joyce Carol Oates turns the tale of a family struggling to cope with its fall from grace into a deeply moving and unforgettable account of the vigor of hope and the power of love to prevail over suffering. “It’s the novel closest to my heart....I’m deeply moved that Oprah Winfrey has selected this novel for Oprah’s Book Club, a family novel presented to Oprah’s vast American family.”—Joyce Carol Oates
Book Synopsis The Handbook of Antagonism by : Joshua W. Miller
Download or read book The Handbook of Antagonism written by Joshua W. Miller and published by Academic Press. This book was released on 2019-02-15 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antagonism as a Personality Trait looks at the theoretical and empirical underpinnings of antagonism, highlighting the consequences of the trait, its role in a number of problem behaviors and psychiatric disorders, and how it exerts itself on externalizing behaviors. Covering the biological and evolutionary roots of antagonism, the book additionally provides clinical insight on assessment strategies while also outlining a number of treatment techniques, including motivational interviewing, cognitive behavioral therapy, interpersonal psychology, and psychodynamic treatment approaches. The book looks at the development of antagonism across childhood and adolescence, discussing the societal consequences of the trait, as well as its role in a number of problem behaviors, such as aggression, violence, crime, and substance use. Provides an overview on the development, assessment and treatment of antagonism Looks at antagonism's role in work, romantic relationships and other domains Outlines self-report and non-self-report assessment approaches Studies the links between antagonism, psychopathy, narcissism and antisocial personality Approaches antagonism from a dimensional trait model Analyzes the role antagonism plays in several prominent psychiatric disorders
Book Synopsis Last One at the Party by : Bethany Clift
Download or read book Last One at the Party written by Bethany Clift and published by Hodder & Stoughton. This book was released on 2021-02-04 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'A riotous, black-humoured tonic' Independent 'A masterpiece of modern fiction' Sophie Cousens December 2023. The human race has fought a deadly virus and lost. The only things left from the world before are burning cities and rotting corpses. But in London, one woman is still alive. Although she may be completely unprepared for her new existence, as someone who has spent her life trying to fit in, being alone is surprisingly liberating. Determined to discover if she really is the last survivor on earth, she sets off on an extraordinary adventure, with only an abandoned golden retriever named Lucky for company. Maybe she'll find a better life or maybe she'll die along the way. But whatever happens, the end of everything will be her new beginning. 'Fresh, frank, funny' Elizabeth Kay 'Brilliant. Creepy, witty, laugh-out-loud and shudder-inducing' Harriet Walker 'Harrowing, unflinching and uplifting' Jennifer Saint 'Original, brutal, funny and hugely addictive!' Emma Cooper
Book Synopsis Opiate Receptors and Antagonists by : Reginald Dean
Download or read book Opiate Receptors and Antagonists written by Reginald Dean and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 757 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
Book Synopsis Antagonists, Advocates and Allies by : Catrice Jackson
Download or read book Antagonists, Advocates and Allies written by Catrice Jackson and published by Catriceology Enterprises. This book was released on 2015-10-06 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Antagonists written by Ernest K Gann and published by . This book was released on 1970 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Godspeaker Trilogy by : Karen Miller
Download or read book The Godspeaker Trilogy written by Karen Miller and published by Orbit. This book was released on 2012-11-13 with total page 1375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sold into slavery, Hekat dreams of power. Fate leads her to the warlord Raklion, and she begins turning dreams into reality. For the nameless god of Mijak is with her, and it promises her the world. Far away, the King of Ethrea is dying. His daughter Princess Rhian is ready to rule, but if her enemies have their way the crown of Ethrea will never be worn by a woman. Dexterity Jones is a toymaker. To protect Rhian and his country, he must place his trust in an exile from Mijak. Yet, as Ethrea comes ever closer to civil war, a greater danger awaits. Hekat still desires the world . . . and power is no longer a dream. This omnibus edition of THe Godspeaker Trilogy includes Empress, The Riven Kingdom and The Hammer of God.
Download or read book The Antagonists written by James F. Simon and published by Touchstone Books. This book was released on 1990 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Narcotic Antagonists by : Robert E. Willette
Download or read book Narcotic Antagonists written by Robert E. Willette and published by . This book was released on 1976 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cholecystokinin Antagonists in Gastroenterology by : Guido Adler
Download or read book Cholecystokinin Antagonists in Gastroenterology written by Guido Adler and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new presentation of physiological regulatory mechanisms and therapeutic applications is given in this book. It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological applications of these compounds. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.
Book Synopsis Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists by : Michel Alexander Steiner
Download or read book Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists written by Michel Alexander Steiner and published by Frontiers E-books. This book was released on 2014-11-11 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecule OXR antagonists as novel treatments for sleep disorders. Proof of concept studies from Glaxo Smith Kline, Actelion Pharmaceuticals Ltd. and Merck have now consistently demonstrated the efficacy of dual OXR antagonists (DORAs) in promoting sleep in rodents, dogs, non-human primates and humans. Some of these antagonists have completed late stage clinical testing in primary insomnia. Orexin drug discovery programs have also been initiated by other large pharmaceutical companies including Hoffmann La Roche, Novartis, Eli Lilly and Johnson & Johnson. Orexins are increasingly recognized for orchestrating the activity of the organism’s arousal system with appetite, reward and stress processing pathways. Therefore, in addition to models of insomnia, pharmacological effects of DORAs have begun to be investigated in rodent models of addiction, depression and anxiety. The first clinical trials in diabetic neuropathy, migraine and depression have been initiated with Merck’s MK-6096 (www.clinicaltrials.gov). Whereas the pharmacology of DORAs is established for their effects on wakefulness, pharmacological effects of selective OXR-1 or OXR-2 antagonists (SORAs) have remained less clear. From an evolutionary point of view, the OXR-2 was expressed first in most vertebrate lineages, whereas the OXR-1 is believed to result from a gene duplication event, when mammals emerged. Yet, both receptors do not have redundant function. Their brain expression pattern, their intracellular signaling, as well as their affinity for orexin-A and orexin-B differs. During the past decade most preclinical research on selective OXR-1 antagonism was performed with SB-334867. Only in recent years, other selective OXR-1 and OXR-2 antagonists with optimized selectivity profiles and pharmacokinetic properties have been discovered, and phenotypes of OXR-1 and OXR-2 knockout mice were described. The present Research Topic (referred to in the Editorial as “special topics issue”) comprises submissions of original research manuscripts as well as reviews, directed towards the neuropharmacology of OXR antagonists. The submissions are preclinical papers dealing with dual and/or selective OXR antagonists that shed light on the differential contribution of endogenous orexin signaling through both OXRs for cellular, physiological and behavioral processes. Some manuscripts also report on convergence or divergence of DORA vs. SORA effects with phenotypes expressed by OXR-1 or OXR-2 knockout animals. Ultimately these findings may help further define the potential of DORAs and SORAs in particular therapeutic areas in insomnia and beyond insomnia.
Book Synopsis Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens by : Gene Barnett
Download or read book Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens written by Gene Barnett and published by . This book was released on 1978 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens by :
Download or read book QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens written by and published by . This book was released on 1978 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of PAF and PAF Antagonists by : lPierre Braquet
Download or read book Handbook of PAF and PAF Antagonists written by lPierre Braquet and published by CRC Press. This book was released on 2019-06-13 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in 1991: Since its characterization in the 1970s from antigen-stimulated rabbit basophils, platelet-activating factor (PAF) has been demonstrated to be produced by, and act upon, a variety of cell types. PAF antagonists, which have been obtained from both natural sources and chemical synthesis, now represent a new class of therapeutic agents and may provide new prospects for treating several major pathologies, particularly shock, ischemia and asthma. This book provides a unique overview of the chemistry, molecular modeling, pharmacology, and clinical potential of the major classes of natural and synthetic PAF antagonists. Compounds reviewed include the ginkgolides, diketopiperazines, neolignans, hetrazepines, cyclic and 1,3-dioxolan derived PAF analogs, pyrrolo[1,2-c]thiazoles, imidazo[2,1-a]isoquinolines and pyridoquinazoline carboxamides. Consisting of 12 chapters written by leading experts in PAF antagonist research, this book is essential reading for students, researchers, clinicians, and medical practitioners involved in this rapidly developing field of biomedical research.
Book Synopsis Cholecystokinin and Its Antagonists in Pain Management by : Gary McCleane
Download or read book Cholecystokinin and Its Antagonists in Pain Management written by Gary McCleane and published by CRC Press. This book was released on 2006-06-22 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examine the strong evidence of this unrealized pain management tool Cholecystokinin (CCK), the regulatory peptide hormone found primarily in the gastrointestinal tract that works as a neurotransmitter throughout the nervous system, has been researched for years. CCK antagonists in conjunction with opioids are beginning to be seen as having possible major therapeutic benefits in pain management. Cholecystokinin and Its Antagonists in Pain Management is an extensive examination that gathers the mounting compelling evidence into one comprehensive source. Here researchers, neuroscientists, physicians, and pharmacy professionals are given the research and findings they need to explore the possible applications of CCK antagonists for a variety of illnesses. Cholecystokinin and Its Antagonists in Pain Management extensively describes opioids in pain management, CCK and the body’s uses for the chemical, CCK receptor antagonists, and the evidence that points to its being a possible breakthrough application in pain management. Various animal studies are offered that present a convincing view of what may be the future of chronic pain management, with less side effects and a reduction in analgesic tolerance than when opioids are used alone. Potential uses of CCK antagonists are clearly discussed. The book is comprehensively referenced and provides several tables and graphs to fully illustrate the research findings. Topics in Cholecystokinin and Its Antagonists in Pain Management include: in vivo localization of CCK CCK as a gut and nervous system peptide factors that increase CCK anti-opioid effects CCK receptor antagonists pro-analgesic effect of CCK antagonists CCK antagonists reducing analgesic tolerance to opioids safety of combining opioids and CCK antagonists human clinical application of CCK antagonists Cholecystokinin and Its Antagonists in Pain Management is a crucial source of the latest information and research results on CCK that is certain to be important for neuroscientists, clinicians, and pharmaceutical industry professionals.
