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Author : Paul Racz
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.3/5 (91 download)
Download or read book Animal Models of HIV and Other Retroviral Infections written by Paul Racz and published by S. Karger AG (Switzerland). This book was released on 1993 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Huub Schellekens
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)
Download or read book Animal Models in AIDS written by Huub Schellekens and published by Elsevier Publishing Company. This book was released on 1990 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the recognized experts from Europe, U.S.A. and Japan have contributed to make this book the most comprehensive, up-to-date survey of animal models available for AIDS research. It concerns animals which can be infected by the Human Immune-deficiency Viruses, both HIV-1 and HIV-2, such as chimpanzees, rhesus monkeys, rabbits, SCID-mice reconstituted with human cells and mice transgenic for HIV. Information is also included on animals harbouring their own variants of HIV such as cats, non-human primates and bovines. Other retrovirus models, including lentivirus viruses like Equine Infectious Anemia Virus (EIAV), Visna-Maedi, Simian Retrovirus (SRV) and Feline Leukemia Virus (FeLV) are discussed. The book also deals with the biohazard aspects of working with these viruses, the comparative value of the models and their relation with AIDS in humans. Examples of the applications of these models in the development of antiretroviral agents and vacines are given.
Author : Herman Friedman
Publisher : Springer Science & Business Media
ISBN 13 : 0387257411
Total Pages : 445 pages
Book Rating : 4.3/5 (872 download)
Download or read book In vivo Models of HIV Disease and Control written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2007-04-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.
Author : Lois Ann Salzman
Publisher :
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)
Download or read book Animal Models of Retrovirus Infection and Their Relationship to AIDS written by Lois Ann Salzman and published by . This book was released on 1986 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
ISBN 13 : 1789231647
Total Pages : 410 pages
Book Rating : 4.7/5 (892 download)
Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.
Author : Larisa Y. Poluektova
Publisher : Springer
ISBN 13 : 1493916556
Total Pages : 536 pages
Book Rating : 4.4/5 (939 download)
Download or read book Humanized Mice for HIV Research written by Larisa Y. Poluektova and published by Springer. This book was released on 2015-02-18 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.
Author : Gianfranco Pancino
Publisher : Academic Press
ISBN 13 : 0123877156
Total Pages : 362 pages
Book Rating : 4.1/5 (238 download)
Download or read book Models of Protection Against HIV/SIV written by Gianfranco Pancino and published by Academic Press. This book was released on 2011-12-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Author : Robert C. Gallo
Publisher : Elsevier
ISBN 13 : 0080918328
Total Pages : 440 pages
Book Rating : 4.0/5 (89 download)
Download or read book The Human Retroviruses written by Robert C. Gallo and published by Elsevier. This book was released on 2012-12-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents twenty-four tightly focused reviews on the biology, molecular biology, pathology, and epidemiology of the human retroviruses, particularly HIV and HTLV (Types I and II), as well as animal model systems (simian retroviruses, STLV and SIV, and mouse models).Editor Robert C. Gallo is recognized as a co-discoverer of the AIDS virus.
Author : John M. Coffin
Publisher : CSHL Press
ISBN 13 : 9780879695712
Total Pages : 856 pages
Book Rating : 4.6/5 (957 download)
Download or read book Retroviruses written by John M. Coffin and published by CSHL Press. This book was released on 1997 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
Author : Jordan S. Orange
Publisher :
ISBN 13 : 9781416058564
Total Pages : 0 pages
Book Rating : 4.0/5 (585 download)
Download or read book Immunodeficiency Disorders written by Jordan S. Orange and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics include: "Genetic Diagnosis ofPrimary Immunodeficiencies","IPEX syndrome and Treg deficiency in primaryimmunodeficiency","DiGeorge syndrome and other thymic hypoplasias","Common VariableImmunodeficiency", "Hyper IgE syndromes","Hyper IgM syndromes","Hematophagocyticlymphohistiocytoses", "Defects of the Toll LikeReceptor System", "Congenital Neutropenias", "Advances in Severe Combined Immunodeficiency", "Genetic Defects of Apoptosis and PrimaryImmunodeficiency", "Principles of and Advances inimmunoglobuin replacement therapy for primary immunodeficiency", "Gene therapy for primary immunodeficiency"
Author : Uwe Gross
Publisher : Springer Science & Business Media
ISBN 13 : 3642510140
Total Pages : 268 pages
Book Rating : 4.6/5 (425 download)
Download or read book Toxoplasma gondii written by Uwe Gross and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.
Author : Kim A. Brogden
Publisher :
ISBN 13 :
Total Pages : 460 pages
Book Rating : 4.3/5 (91 download)
Download or read book Polymicrobial Diseases written by Kim A. Brogden and published by . This book was released on 2002 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.
Author : Tim Allen
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (3 download)
Download or read book Animal Models of Disease written by Tim Allen and published by . This book was released on 1995 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309175267
Total Pages : 134 pages
Book Rating : 4.3/5 (91 download)
Download or read book Xenotransplantation written by Institute of Medicine and published by National Academies Press. This book was released on 1996-07-12 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.
Author : Andre E. Baert
Publisher : IOS Press
ISBN 13 : 9789051991598
Total Pages : 396 pages
Book Rating : 4.9/5 (915 download)
Download or read book AIDS Research at EC Level written by Andre E. Baert and published by IOS Press. This book was released on 1995 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: At EC level the fight against AIDS, one of the major health problems and socioeconomic diseases today, is also part of the specific RTD programme in the field of biomedicine and health. About 600 research teams are collaborating within 30 concerted actions networks that are underpinned by centralised facilities. For example, the epidemiology research networks are monitored by the WHO/EC collaborating centre in St. Maurice, France. Common experiments on animal models, antiviral screening, genetic analysis of multiple virus strains and provision of reagents for vaccine development are also centralized facilities in AIDS research carried out under the principles of subsidiarity and Community added value. This publication presents an overview of their ongoing research activities in disease control and prevention, viro-immunological research, clinical research and vaccine development. Covered by Current Contents, Life Sciences (ISI), volume 38, no. 19, May 1995, p. 11-12 'Therefore, for anyone doing AIDS research, this is a must volume to have in order to understand what the European Community is doing in AIDS research. Highly recommended for all medical and academic libraries.' - H. Robert Malinowsky, The University of Illinois, Chicago, USA. AIDS Book Review Journal, no. 27, June 1996
Author : Anthony S. Fauci
Publisher : Springer Science & Business Media
ISBN 13 : 3642608671
Total Pages : 159 pages
Book Rating : 4.6/5 (426 download)
Download or read book Immunopathogenesis of HIV Infection written by Anthony S. Fauci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309084393
Total Pages : 201 pages
Book Rating : 4.3/5 (9 download)
Download or read book Animal Biotechnology written by National Research Council and published by National Academies Press. This book was released on 2002-12-29 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnologyâ€"key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effectsâ€"the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.
