Analysis Of Gamma Hydroxybutyric Acid Ghb In Spiked Water And Beverage Samples Using Solid Phase Microextraction Spme On Fiber Derivatization Gas Chromatography Mass Spectrometry Gc Ms

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Analysis of Gamma-Hydroxybutyric Acid (GHB) in Spiked Water and Beverage Samples Using Solid Phase Microextraction (SPME) on Fiber Derivatization/Gas Chromatography-Mass Spectrometry (GC/MS)

Author : JE. Meyers
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Analysis of Gamma-Hydroxybutyric Acid (GHB) in Spiked Water and Beverage Samples Using Solid Phase Microextraction (SPME) on Fiber Derivatization/Gas Chromatography-Mass Spectrometry (GC/MS) by : JE. Meyers

Download or read book Analysis of Gamma-Hydroxybutyric Acid (GHB) in Spiked Water and Beverage Samples Using Solid Phase Microextraction (SPME) on Fiber Derivatization/Gas Chromatography-Mass Spectrometry (GC/MS) written by JE. Meyers and published by . This book was released on 2005 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gamma-Hydroxybutyric acid (GHB) is a CNS depressant that has been abused recreationally for its purported euphoric and relaxation effects and for the purposes of drug facilitated sexual assault due to its sedative and amnesic effects at higher doses. The dramatic increase in the abuse of GHB and association in criminal investigations over the past decade has created the need for forensic laboratories to develop analytical methods to detect GHB in a variety of matrices. The method developed in this work used solid-phase microextraction (SPME) to extract GHB from aqueous samples followed by on-fiber derivatization and analysis by gas chromatography/mass spectrometry (GC/MS) This method detected GHB in aqueous matrices with good sensitivity, high precision, excellent linearity from 0.01 mg/mL to 0.25 mg/mL, and without the need for sample manipulation that could cause interconversion between GHB and its lactone, GBL. The method was successfully applied for detection of GHB in spiked water and beverage samples.

Adelson's The Pathology of Homicide: A Guide for Forensic Pathologists and Homicide Investigators (2nd Edition)

Author : James R. Gill
Publisher : Charles C Thomas Publisher
ISBN 13 : 0398093911
Total Pages : 795 pages
Book Rating : 4.3/5 (98 download)

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Book Synopsis Adelson's The Pathology of Homicide: A Guide for Forensic Pathologists and Homicide Investigators (2nd Edition) by : James R. Gill

Download or read book Adelson's The Pathology of Homicide: A Guide for Forensic Pathologists and Homicide Investigators (2nd Edition) written by James R. Gill and published by Charles C Thomas Publisher. This book was released on 2022-10-05 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Lester Adelson's original The Pathology of Homicide has been described as a "superb textbook" and "without doubt…the best written book of its type in the English language" by Dr. Charles Hirsch. This new, revised edition preserves Dr. Adelson's eloquent and articulate voice, while bringing the subject matter up to date. Since the first edition was published in 1974, Dr. Adelson’s book was a treasured text among many forensic pathologists. The “aging” of the book, however, made it less appealing to the new generation of forensic pathologists, and Dr. Adelson’s important contribution to forensic pathology was at risk of being lost. Although much has changed in forensic pathology in the ensuing nearly fifty years since it was first written, much also has stayed the same. In this new edition, the author, Dr. James Gill—Chief Medical Examiner of the State of Connecticut and past president of the National Association of Medical Examiners—preserves the voice, vision, and wisdom of Dr. Adelson while updating the forensic pathology material. The author has included nearly 700 all new color images. In addition, the references have been updated with over 4,400 citations. Six new chapters and sections have been added, including death certification, elder abuse, pediatric head injury, drugs of misuse, histopathology, and bereavement. Other updates are included on DNA technology, CT scans, and novel drugs. Although primarily concerned with homicides, there is the need to be able to recognize natural, accidental, and suicidal deaths; therefore, these topics are interspersed in the text to give the appropriate context. This book will help the reader understand the details of injuries and how a person was injured, why they died, and how these injuries, perhaps at first blush seemingly insignificant, can shed new light on a death investigation. It is the author’s hope to get this book to the next generation of forensic pathologists.

Interpol's Forensic Science Review

Author : Niamh Nic Daeid
Publisher : CRC Press
ISBN 13 : 1439826595
Total Pages : 798 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Interpol's Forensic Science Review by : Niamh Nic Daeid

Download or read book Interpol's Forensic Science Review written by Niamh Nic Daeid and published by CRC Press. This book was released on 2017-08-09 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every three years, worldwide forensics experts gather at the Interpol Forensic Science Symposium to exchange ideas and discuss scientific advances in the field of forensic science and criminal justice. Drawn from contributions made at the latest gathering in Lyon, France, Interpol's Forensic Science Review is a one-source reference providing a comp

Determination of Gamma-hydroxybutyrate in Water and Human Urine by Solid Phase Microextraction-Gas Chromatography/Quadrupole Ion Trap Spectrometry

Download Determination of Gamma-hydroxybutyrate in Water and Human Urine by Solid Phase Microextraction-Gas Chromatography/Quadrupole Ion Trap Spectrometry PDF Online Free

Author : S. Blair
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Determination of Gamma-hydroxybutyrate in Water and Human Urine by Solid Phase Microextraction-Gas Chromatography/Quadrupole Ion Trap Spectrometry by : S. Blair

Download or read book Determination of Gamma-hydroxybutyrate in Water and Human Urine by Solid Phase Microextraction-Gas Chromatography/Quadrupole Ion Trap Spectrometry written by S. Blair and published by . This book was released on 2001 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: A simple method of detection was developed for gamma-hydroxybutyrate (GHB) The method involves the derivatization of GHB using a hexyl-chloroformate procedure in aqueous media (such as water or urine), extraction of the derivatization product directly from the sample using solid-phase microextraction, and subsequent separation and detection with gas chromatography quadrupole ion trap mass spectrometry. The deuterated form of GHB (GHB-D6) is used as an internal standard for quantitation. The method was linear for GHB-spiked pure water samples from 2 to 150 μg/mL GHB with a detection limit of 0.2 μg/mL. Spiked urine samples showed linearity from 5 to 500 μg/mL GHB with a detection limit of 2 μg/mL. The SPME-GC/MS method is applied to actual case samples, and the results are compared to those values obtained using a conventional GC/MS method. Sensitivity and linearity are comparable to those seen using traditional methods of separation, yet the SPME method is superior due to the simplicity, speed of analysis, reduction in solvent waste, and ability to differentiate between GHB and gamma-butyrolactone (GBL).

Environmental Chemistry for a Sustainable World

Author : Eric Lichtfouse
Publisher : Springer Science & Business Media
ISBN 13 : 940072439X
Total Pages : 559 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Environmental Chemistry for a Sustainable World by : Eric Lichtfouse

Download or read book Environmental Chemistry for a Sustainable World written by Eric Lichtfouse and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental chemistry is a fast developing science aimed at deciphering fundamental mechanisms ruling the behaviour of pollutants in ecosystems. Applying this knowledge to current environmental issues leads to the remediation of environmental media, and to new, low energy, low emission, sustainable processes. Chapters review analysis and remediation of pollutants such as greenhouse gases, chiral pharmaceuticals, dyes, chlorinated organics, arsenic, toxic metals and pathogen in air, water, plant and soil. Several highlights include the overlooked impact of air pollutants from buildings for health risk, innovative remediation techniques such as bioreactors for gas treatment, electrochemical cleaning of pharmaceuticals, sequestration on Fe-Mn nodules, phytoremediation and photocatalytical inactivation of microbial pathogens. This book will be a valuable source of information for engineers and students developing novel applied techniques to monitor and clean pollutants in air, wastewater, soils and sediments.

The Extraction and Infrared Identification of Gamma-Hydroxybutyric Acid (GHB) from Aqueous Solutions

Author : JS. Chappell
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis The Extraction and Infrared Identification of Gamma-Hydroxybutyric Acid (GHB) from Aqueous Solutions by : JS. Chappell

Download or read book The Extraction and Infrared Identification of Gamma-Hydroxybutyric Acid (GHB) from Aqueous Solutions written by JS. Chappell and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical analysis of gamma-hydroxybutyric acid (GHB) in most forensic laboratories is complicated by the highly polar nature of the GHB molecule, which makes it unsuitable for direct analysis by gas chromatography (GC) Consequently, a popular analytical approach is to convert GHB into the corresponding lactone or a derivative compound that is then identified by mass spectrometry employed in conjunction with GC (GC/MS) An alternative approach is presented here where GHB may be isolated as a free acid specie from complex aqueous solutions employing a liquid-liquid extraction technique. This approach can yield a relatively pure residue of GHB that presents an infrared transmission spectrum that is sufficiently distinct for identification purposes. Infrared spectroscopy (IR) is a very popular technique that is available to most crime laboratories. The liquid-liquid extraction behavior of GHB is examined in detail and the uniqueness of the infrared spectrum is discussed.

Sample Preparation/concentration for Trace Analysis in GC/MS

Author : Yuwen Wang
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Sample Preparation/concentration for Trace Analysis in GC/MS by : Yuwen Wang

Download or read book Sample Preparation/concentration for Trace Analysis in GC/MS written by Yuwen Wang and published by . This book was released on 1997 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gas Chromatography - Derivatization, Sample Preparation, Application

Author : Peter Kusch
Publisher :
ISBN 13 : 9781838818678
Total Pages : 142 pages
Book Rating : 4.8/5 (186 download)

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Book Synopsis Gas Chromatography - Derivatization, Sample Preparation, Application by : Peter Kusch

Download or read book Gas Chromatography - Derivatization, Sample Preparation, Application written by Peter Kusch and published by . This book was released on 2019 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas chromatography (GC) is one of the most important types of chromatography used in analytical chemistry for separating and analyzing chemical organic compounds. Today, gas chromatography is one of the most widespread investigation methods of instrumental analysis. This technique is used in the laboratories of chemical, petrochemical, and pharmaceutical industries, in research institutes, and also in clinical, environmental, and food and beverage analysis. This book is the outcome of contributions by experts in the field of gas chromatography and includes a short history of gas chromatography, an overview of derivatization methods and sample preparation techniques, a comprehensive study on pyrazole mass spectrometric fragmentation, and a GC/MS/MS method for the determination and quantification of pesticide residues in grape samples.

Handbook of Solid Phase Microextraction

Author : Janusz Pawliszyn
Publisher : Elsevier
ISBN 13 : 0123914493
Total Pages : 497 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Handbook of Solid Phase Microextraction by : Janusz Pawliszyn

Download or read book Handbook of Solid Phase Microextraction written by Janusz Pawliszyn and published by Elsevier. This book was released on 2011-12-01 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed. This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method. Practical application of Solid Phase Microextraction methods including detailed steps Provides history of extraction methods to better understand the process Suitable for all levels, from beginning student to experienced practitioner

GC/MS Assays for Abused Drugs in Body Fluids

Author : Rodger L. Foltz
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis GC/MS Assays for Abused Drugs in Body Fluids by : Rodger L. Foltz

Download or read book GC/MS Assays for Abused Drugs in Body Fluids written by Rodger L. Foltz and published by . This book was released on 1980 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Identification and Quantitation of Gamma-Hydroxybutyrate (NaGHB) by Nuclear Magnetic Resonance Spectroscopy

Author : SL. Chew
Publisher :
ISBN 13 :
Total Pages : 7 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Identification and Quantitation of Gamma-Hydroxybutyrate (NaGHB) by Nuclear Magnetic Resonance Spectroscopy by : SL. Chew

Download or read book Identification and Quantitation of Gamma-Hydroxybutyrate (NaGHB) by Nuclear Magnetic Resonance Spectroscopy written by SL. Chew and published by . This book was released on 2003 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most common means of identification of gamma-hydroxybutyrate (NaGHB) involves using Fourier transform infrared spectroscopy (FTIR) or gas chromatography-mass spectrometry (GC-MS) of a suitable derivative. However, these methods may be complicated by possible shifts in chemical equilibrium between gamma-hydroxybutyric acid (GHB), GHB salts and the precursor lactone, gamma-butyrolactone (GBL) This paper addresses the technique of proton and carbon nuclear magnetic resonance spectroscopy (1H and 13C NMR) for the direct and accurate identification of GHB and GBL. The application of 1H NMR for GHB quantitation is also discussed.

Gas Chromatography

Author : Bekir Salih
Publisher : BoD – Books on Demand
ISBN 13 : 9535102958
Total Pages : 252 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Gas Chromatography by : Bekir Salih

Download or read book Gas Chromatography written by Bekir Salih and published by BoD – Books on Demand. This book was released on 2012-03-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas Chromatography involves the study of various vaporizable molecules in chemistry and the other related research fields. This analytical method has a number of features and advantages that make it an extremely valuable tool for the identification, quantification and structural elucidation of organic molecules. This book provides detailed gas chromatography information to applications of biochemicals, narcotics and essential oils. The details of the applications were briefly handled by the authors to increase their comprehensibility and feasibility. This guide should be certainly valuable to the novice, as well as to the experienced gas chromatography user who may not have the enough experience about the specific applications covered in this book. We believe this book will prove useful in most laboratories where modern gas chromatography is practiced.

Automated Derivatization and Identification of Controlled Substances Via Total Vaporization Solid Phase Microextraction (TV-SPME) and Gas Chromatography/mass Spectrometry (GS/MS)

Download Automated Derivatization and Identification of Controlled Substances Via Total Vaporization Solid Phase Microextraction (TV-SPME) and Gas Chromatography/mass Spectrometry (GS/MS) PDF Online Free

Author : John Vincent Goodpaster
Publisher :
ISBN 13 :
Total Pages : 13 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Automated Derivatization and Identification of Controlled Substances Via Total Vaporization Solid Phase Microextraction (TV-SPME) and Gas Chromatography/mass Spectrometry (GS/MS) by : John Vincent Goodpaster

Download or read book Automated Derivatization and Identification of Controlled Substances Via Total Vaporization Solid Phase Microextraction (TV-SPME) and Gas Chromatography/mass Spectrometry (GS/MS) written by John Vincent Goodpaster and published by . This book was released on 2018 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Comparison of Static Headspace and Solid Phase Microextraction Headspace Gas Chromatographic Sampling Techniques for Some Relevant Volatile Components of Beer

Download A Comparison of Static Headspace and Solid Phase Microextraction Headspace Gas Chromatographic Sampling Techniques for Some Relevant Volatile Components of Beer PDF Online Free

Author : Greg Bryan Fry
Publisher :
ISBN 13 :
Total Pages : 292 pages
Book Rating : 4.:/5 (56 download)

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Book Synopsis A Comparison of Static Headspace and Solid Phase Microextraction Headspace Gas Chromatographic Sampling Techniques for Some Relevant Volatile Components of Beer by : Greg Bryan Fry

Download or read book A Comparison of Static Headspace and Solid Phase Microextraction Headspace Gas Chromatographic Sampling Techniques for Some Relevant Volatile Components of Beer written by Greg Bryan Fry and published by . This book was released on 1997 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Headspace/Solid-Phase Microextraction/Gas Chromatography-Mass Spectrometry

Author : DJ. Tranthim-Fryer
Publisher :
ISBN 13 :
Total Pages : 13 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Headspace/Solid-Phase Microextraction/Gas Chromatography-Mass Spectrometry by : DJ. Tranthim-Fryer

Download or read book Headspace/Solid-Phase Microextraction/Gas Chromatography-Mass Spectrometry written by DJ. Tranthim-Fryer and published by . This book was released on 2001 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper describes the application of Headspace/Solid-Phase Microextraction/Gas Chromatography-Mass Spectrometry (HS/SPME/GC-MS) to the recovery and identification of volatile organic compounds in blood and viscera samples from decreased persons. The technique is used as a screening procedure to rapidly obtain information relating to toxicological investigations. The technique is suitable for the detection of volatiles (of wide boiling range) including butane, halothane, toluene, xylenes, and petrol residues in blood and viscera (lung, brain, and body fat).

Derivatization of Small Acids to Enhance Sensitivity in Gas Chromatography Mass Spectrometry and Gas Chromatography Vacuum Ultraviolet Spectroscopy

Download Derivatization of Small Acids to Enhance Sensitivity in Gas Chromatography Mass Spectrometry and Gas Chromatography Vacuum Ultraviolet Spectroscopy PDF Online Free

Author : Chih-Hao Wang
Publisher :
ISBN 13 :
Total Pages : 47 pages
Book Rating : 4.:/5 (973 download)

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Book Synopsis Derivatization of Small Acids to Enhance Sensitivity in Gas Chromatography Mass Spectrometry and Gas Chromatography Vacuum Ultraviolet Spectroscopy by : Chih-Hao Wang

Download or read book Derivatization of Small Acids to Enhance Sensitivity in Gas Chromatography Mass Spectrometry and Gas Chromatography Vacuum Ultraviolet Spectroscopy written by Chih-Hao Wang and published by . This book was released on 2016 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disinfection by-products (DBPs) are a significant concern in drinking water quality. Haloacetic acids, which are generated from disinfection processes, are one of the major groups in disinfection by-products. Because they induce potential harmful effects for human health, the US government has already established regulations to control the levels of haloacetic acids in drinking water. In order to control the presence of haloacetic acids in drinking water and monitor other potential harmful compounds, an appropriate analytical method is needed. In this study, a gas chromatography (GC) method was developed for detecting haloacetic acids in water. Three different derivatization reagents were compared for sensitivity enhancement in conjunction with mass spectrometry (MS) and vacuum ultraviolet (VUV) detection. A model study was first performed using acetic acid and then the study was extended to haloacetic acids. The sensitivity of GC-MS and GCVUV had been increased after the derivatization. However, it also had many shortcomings and challenges that needed to be overcome: (1) the efficiency of derivatization was low; (2) the benzyl alcohol derivatization caused many side reactions in complex samples and generated high intensities of interference noises. Further study will need to modify the GC-MS and GCVUV methods, especially for the detection of brominated trihaloacetic acids.

Improved Gas Chromatography/Mass Spectrometry Analysis of Barbiturates in Urine Using Centrifuge-Based Solid-Phase Extraction, Methylation, with D5-Pentobarbital as Internal Standard

Download Improved Gas Chromatography/Mass Spectrometry Analysis of Barbiturates in Urine Using Centrifuge-Based Solid-Phase Extraction, Methylation, with D5-Pentobarbital as Internal Standard PDF Online Free

Author : WD. Bensley
Publisher :
ISBN 13 :
Total Pages : 11 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Improved Gas Chromatography/Mass Spectrometry Analysis of Barbiturates in Urine Using Centrifuge-Based Solid-Phase Extraction, Methylation, with D5-Pentobarbital as Internal Standard by : WD. Bensley

Download or read book Improved Gas Chromatography/Mass Spectrometry Analysis of Barbiturates in Urine Using Centrifuge-Based Solid-Phase Extraction, Methylation, with D5-Pentobarbital as Internal Standard written by WD. Bensley and published by . This book was released on 1994 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effective solid-phase extraction, derivatization, and GC/MS procedures are developed for the simultaneous determinations of butalbital, amobarbital, pentobarbital, and secobarbital, using a deuterated pentobarbital (d5-pentobarbital) as the internal standard. Buffered (pH 7) urine samples were extracted with Bond Elute Certify IITM cartridge. Iodomethane/ tetramethylammonium hydroxide in dimethylsulfoxide was used for methylation, while a HP 5970 MSD equipped with a 13 m J & W DB-5 column (5% phenyl polysiloxane phase) and the Thru-Put Target® software package were used for GC/MS analysis and data processing. This protocol was found to be superior, in both chromatographic performance characteristics and quantitation results, over a liquid-liquid extraction procedure without derivatization using hexobarbital as the internal standard. Extraction recoveries observed from control samples containing four barbiturates range from 80% to 90%. Good one-point calibration data are obtained for all four barbiturates in the 50 to 3200 ng/mL range. Interestingly, the one-point calibration data for pentobarbital are inferior to the other three barbiturates--due to interference from the internal standard (d5-pentobarbital) The calibration data of pentobarbital are best described by a hyperbolic curve regression model. Precision data (% CV) for GC/MS analysis, over-all procedure, and day-to-day performance are approximately 2.0%, 6.0%, and 8.0%, respectively. With the use of a 2 mL sample size, the attainable detection limit is approximately 20 ng/mL.