Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Analysis Of Endogenous Steroids In Hair Using Hplc Ms Ms full books in PDF, epub, and Kindle. Read online Analysis Of Endogenous Steroids In Hair Using Hplc Ms Ms ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Pascal Kintz
Publisher : Royal Society of Chemistry
ISBN 13 : 1839167262
Total Pages : 374 pages
Book Rating : 4.8/5 (391 download)
Download or read book Perspectives and Challenges of Hair Analysis written by Pascal Kintz and published by Royal Society of Chemistry. This book was released on 2023-12-18 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : V.K. Agarwal
Publisher : Springer Science & Business Media
ISBN 13 : 1461533562
Total Pages : 260 pages
Book Rating : 4.4/5 (615 download)
Download or read book Analysis of Antibiotic/Drug Residues in Food Products of Animal Origin written by V.K. Agarwal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last three decades. use of antibiotics/drugs in animal husbandry programs has grown tremendously. Antibiotics/drugs are used therapeutically to cure diseases. and subtherapeutically to control the outbreak of diseases, improve feed efficiency and promote growth. The presence of antibiotic/drug residues in food products of animal origin. i.e •• meat, poultry and milk, can be a potential health hazard to consumers. Significant research is being done to develop new methods or to improve on existing methods to confirm and quantitatively determine the antibiotic/drug residues in meat, poultry and milk. This book covers recent development and application of various analytical techniques for the determination of antibiotic/drug residues in food products of animal origin. I thank the authors for their time and efforts in preparing the manuscripts and "all the reviewers for reviewing the manuscripts. I also thank to the Division of Agricultural and Food Chemistry of the American Chemical Society for sponsoring the symposium and Hewlett Packard, Palo Alto, CA, Perkin Elmer Corp., Norwalk, CT, Millipore Corporation, Milford, MA, and Kraft General Foods, Glenview, IL, for their generous financial support for the symposium. Vipin K. Agarwal New Haven, CT v CONTENTS Importance of Laboratory Validations and Accurate Descriptions of Analytical Procedures for Drug Residues in Foods ................. .
Author : Wenkui Li
Publisher : John Wiley & Sons
ISBN 13 : 111867135X
Total Pages : 709 pages
Book Rating : 4.1/5 (186 download)
Download or read book Handbook of LC-MS Bioanalysis written by Wenkui Li and published by John Wiley & Sons. This book was released on 2013-09-03 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.
Author : Anthony C. Hackney
Publisher : Elsevier
ISBN 13 : 0128134437
Total Pages : 169 pages
Book Rating : 4.1/5 (281 download)
Download or read book Doping, Performance-Enhancing Drugs, and Hormones in Sport written by Anthony C. Hackney and published by Elsevier. This book was released on 2017-11-23 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doping, Performance-Enhancing Drugs, and Hormones in Sport: Mechanisms of Action and Methods of Detection examines the biochemistry and bioanalytical aspects of performance-enhancing drugs (PEDs) and other questionable procedures used by athletes to enhance performance. The book informs the specialist of emerging knowledge and techniques and allows the non-specialist to grasp the underlying science and current practice of the discipline. With clear and compelling language appropriate for a broad spectrum of readers, this book provides background on prevalence, types of agents, their actual or supposed benefits, and their negative effects on health. The technical aspects of detection are discussed, followed by a discussion of why detection is a problematic and still-evolving science. To facilitate comprehension, each chapter is organized in a uniform way with six sections: (1) standard medical uses, (2) why the drugs are used by athletes, (3) biological mechanism of action, (4) what research says about efficacy in improving performance, (5) major health side effects from use and abuse in sport, and 6) concluding key points. - Presents the scientific concepts of how performance enhancers work, how they are used, and how they are detected and masked from detection - Features language that is neither simplistic to scientists nor too sophisticated for a large, diverse global audience - Provides a short "close-up in each chapter to illustrate key topics that engage, entertain, and create a novel synthesis of thought
Author : Salvatore Fanali
Publisher : Elsevier
ISBN 13 : 0128093447
Total Pages : 840 pages
Book Rating : 4.1/5 (28 download)
Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-23 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. - Emphasizes the integration of chromatographic methods and sample preparation - Explains how liquid chromatography is used in different industrial sectors - Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) - Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making
Author : Jen-Chywan Wang
Publisher : Springer
ISBN 13 : 1493928953
Total Pages : 387 pages
Book Rating : 4.4/5 (939 download)
Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Author : Andrew E. Derocher
Publisher : JHU Press
ISBN 13 : 1421403056
Total Pages : 262 pages
Book Rating : 4.4/5 (214 download)
Download or read book Polar Bears written by Andrew E. Derocher and published by JHU Press. This book was released on 2012-03-08 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an introduction to the polar bear, discussing its evolution, physical characteristics, life cycle, predatory behavior, habitat, and the threats to its existence from global warming.
Author : Hugh L. J. Makin
Publisher : Springer Science & Business Media
ISBN 13 : 1402097751
Total Pages : 1240 pages
Book Rating : 4.4/5 (2 download)
Download or read book Steroid Analysis written by Hugh L. J. Makin and published by Springer Science & Business Media. This book was released on 2010-06-04 with total page 1240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this handbook concentrates on the analysis of steroids in biological fluids. It offers analysis of low levels of steroid analytes in biological fluids. This new edition also provides an extra chapter on pharmaceutical aspects of steroid analysis. Coverage details spectroscopic and other methods, including UV and IR absorption spectroscopy, NMR spectroscopy, mass spectrometry, X-ray diffraction, chromatography and immunoassay of steroids.
Author : Naidong Weng
Publisher : John Wiley & Sons
ISBN 13 : 1119103061
Total Pages : 397 pages
Book Rating : 4.1/5 (191 download)
Download or read book Targeted Biomarker Quantitation by LC-MS written by Naidong Weng and published by John Wiley & Sons. This book was released on 2017-07-31 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.
Author : Gary P. Moberg
Publisher : CABI
ISBN 13 : 9780851999302
Total Pages : 396 pages
Book Rating : 4.9/5 (993 download)
Download or read book The Biology of Animal Stress written by Gary P. Moberg and published by CABI. This book was released on 2000 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subjects of stress and animal welfare are currently attracting immense interest. This book brings together a range of perspectives from biomedical research (including human health and animal models of human stress) on stress and welfare, and assesses new approaches to conceptualising and alleviating stress.
Author : Janusz Pawliszyn
Publisher : Elsevier
ISBN 13 : 0123914493
Total Pages : 497 pages
Book Rating : 4.1/5 (239 download)
Download or read book Handbook of Solid Phase Microextraction written by Janusz Pawliszyn and published by Elsevier. This book was released on 2011-12-01 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed. This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method. - Practical application of Solid Phase Microextraction methods including detailed steps - Provides history of extraction methods to better understand the process - Suitable for all levels, from beginning student to experienced practitioner
Author : John William Honour
Publisher : Elsevier
ISBN 13 : 0128181257
Total Pages : 1014 pages
Book Rating : 4.1/5 (281 download)
Download or read book Steroids in the Laboratory and Clinical Practice written by John William Honour and published by Elsevier. This book was released on 2023-08-02 with total page 1014 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. - Addresses the normal production of steroids and concentrations found in biological fluids and tissues - Presents the changes in steroid concentrations at life events as reference points for clinical investigations - Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation
Author : Pascal Kintz
Publisher : CRC Press
ISBN 13 : 1040080421
Total Pages : 326 pages
Book Rating : 4.0/5 (4 download)
Download or read book Analytical and Practical Aspects of Drug Testing in Hair written by Pascal Kintz and published by CRC Press. This book was released on 2006-08-30 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by well-known, international authors, this comprehensive reference provides practical coverage of the best hair drug testing techniques and examines the drugs themselves. The authors review all new developments, the validation of analytical procedures, and the interpretation of data. Some of the applications discussed include doping, drug-facilitated crime investigating, workplace testing, and the granting of drivers' licenses. The authors describe specific drugs, such as opiates, cocaine, and cannabis, and discuss the different testing methods of them. The book also covers postmortem toxicology, pitfalls created by passive exposure, and testing for metals, including inductively coupled plasma spectrometry (ICP-MS), hair multielemen
Author : Victor R. Preedy
Publisher : Springer
ISBN 13 : 9086867286
Total Pages : 477 pages
Book Rating : 4.0/5 (868 download)
Download or read book Handbook of hair in health and disease written by Victor R. Preedy and published by Springer. This book was released on 2012-05-23 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hair is a major component of the body's tissue system that contributes to the individual's make up and confers a large degree of personal identity. Apart from its visible façade, hair also has a functional role. It has an unique structure and complex molecular development. The very nature of hair makes it a suitable marker for the prognosis of disease. Hair can also be used to screen for toxins and changes in the diet. However, there are currently no suitable publications available that describe hair in a rational scientific context. This handbook provides an academic approach to hair in health and disease. Divided into five sections the Handbook of Hair in Health and Disease provides an insight into hair growth and loss, molecular and cellular biology of hair, dietary toxicity and pathological history, diseases and treatments of hair, as well as shampoos and conditioners. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that will give a clear overview of the subjects treated in each chapter. The Handbook of Hair in Health and Disease will be essential to a variety of users, such as trichologists, doctors and nurses and all those interested or working within the area of hair health. This includes nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.
Download or read book Encyclopedia of Mass Spectrometry written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pascal Kintz
Publisher : Academic Press
ISBN 13 : 0128017104
Total Pages : 391 pages
Book Rating : 4.1/5 (28 download)
Download or read book Hair Analysis in Clinical and Forensic Toxicology written by Pascal Kintz and published by Academic Press. This book was released on 2015-06-25 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair. - Unites an international team of leading experts to provide an update on the cutting-edge advances in the toxicological analysis of hair - Demonstrates toxicological techniques relating to a variety of scenarios and exposure types - Ideal resource for the further study of the psychoactive substances, drug-facilitated crimes, ecotoxicology, analytical toxicology, occupational toxicology, toxicity testing, and forensic toxicology - Includes detailed instructions for the collection, preparation, and handling of hair, and how to best interpret results
Author : Andrzej T. Slominski
Publisher : Springer Science & Business Media
ISBN 13 : 3642196837
Total Pages : 128 pages
Book Rating : 4.6/5 (421 download)
Download or read book Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System written by Andrzej T. Slominski and published by Springer Science & Business Media. This book was released on 2012-06-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
