An Invitro Model For Synaptic Loss In Neurodegenerative Diseases Suggests A Neuroprotective Role For Valproic Acid Via Inhibition Of Cpla2 Dependent Signalling

Download An Invitro Model For Synaptic Loss In Neurodegenerative Diseases Suggests A Neuroprotective Role For Valproic Acid Via Inhibition Of Cpla2 Dependent Signalling full books in PDF, epub, and Kindle. Read online An Invitro Model For Synaptic Loss In Neurodegenerative Diseases Suggests A Neuroprotective Role For Valproic Acid Via Inhibition Of Cpla2 Dependent Signalling ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Deciphering Drug Targets for Alzheimer’s Disease

Author : Dileep Kumar
Publisher : Springer Nature
ISBN 13 : 9819926572
Total Pages : 388 pages
Book Rating : 4.8/5 (199 download)

DOWNLOAD NOW!

Book Synopsis Deciphering Drug Targets for Alzheimer’s Disease by : Dileep Kumar

Download or read book Deciphering Drug Targets for Alzheimer’s Disease written by Dileep Kumar and published by Springer Nature. This book was released on 2023-10-02 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.

Epigenetics of Aging and Longevity

Author : Alexey Moskalev
Publisher : Academic Press
ISBN 13 : 012811083X
Total Pages : 546 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics of Aging and Longevity by : Alexey Moskalev

Download or read book Epigenetics of Aging and Longevity written by Alexey Moskalev and published by Academic Press. This book was released on 2017-11-17 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. - Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease - Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory - Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Herbal Medicine in Depression

Author : Clara Grosso
Publisher : Springer
ISBN 13 : 3319140213
Total Pages : 589 pages
Book Rating : 4.3/5 (191 download)

DOWNLOAD NOW!

Book Synopsis Herbal Medicine in Depression by : Clara Grosso

Download or read book Herbal Medicine in Depression written by Clara Grosso and published by Springer. This book was released on 2016-05-30 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written for researchers, undergraduate students and postgraduate students, physicians and traditional medicine practitioners who develop research in the field of neurosciences, phytochemistry and ethnopharmacology or can be useful for their practice. Topics discussed include the description of depression, its biochemical causes, the targets of antidepressant drugs, animal and cell models commonly used in the research of this pathology, medicinal plants and bioactive compounds with antidepressant activity used in traditional medicine, advances in nanotechnology for drug delivery to the brain and finally the future challenges for researchers studying this pathology.

Bee Products - Chemical and Biological Properties

Author : José M Alvarez-Suarez
Publisher : Springer
ISBN 13 : 3319596896
Total Pages : 301 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Bee Products - Chemical and Biological Properties by : José M Alvarez-Suarez

Download or read book Bee Products - Chemical and Biological Properties written by José M Alvarez-Suarez and published by Springer. This book was released on 2017-09-05 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an updated discussion of the chemical composition and biological properties of the main bee products. Specific attention is focused on the beneficial biological activities of bee products in human health. Honey, royal jelly, propolis, bee pollen and bee venom are used as nutriment and in traditional medicine. Their composition is rather variable and depends on the floral source and external factors, such as seasonal, environmental conditions and processing. Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed.

Astrocytes in Psychiatric Disorders

Author : Baoman Li
Publisher : Springer Nature
ISBN 13 : 3030773752
Total Pages : 368 pages
Book Rating : 4.0/5 (37 download)

DOWNLOAD NOW!

Book Synopsis Astrocytes in Psychiatric Disorders by : Baoman Li

Download or read book Astrocytes in Psychiatric Disorders written by Baoman Li and published by Springer Nature. This book was released on 2021-12-09 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.

Protein Homeostasis

Author : Richard I. Morimoto
Publisher :
ISBN 13 : 9781936113064
Total Pages : 0 pages
Book Rating : 4.1/5 (13 download)

DOWNLOAD NOW!

Book Synopsis Protein Homeostasis by : Richard I. Morimoto

Download or read book Protein Homeostasis written by Richard I. Morimoto and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proper folding of proteins is crucial for cell function. Chaperones and enzymes that post-translationally modify newly synthesized proteins help ensure that proteins fold correctly, and the unfolded protein response functions as a homeostatic mechanism that removes misfolded proteins when cells are stressed. This book covers the entire spectrum of proteostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry.

Ketogenic Diet and Metabolic Therapies

Author : Susan Masino
Publisher : Oxford University Press
ISBN 13 : 0190497998
Total Pages : 425 pages
Book Rating : 4.1/5 (94 download)

DOWNLOAD NOW!

Book Synopsis Ketogenic Diet and Metabolic Therapies by : Susan Masino

Download or read book Ketogenic Diet and Metabolic Therapies written by Susan Masino and published by Oxford University Press. This book was released on 2016-11-17 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer's disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.

Contemporary Issues in Modeling Psychopathology

Author : Michael S. Myslobodsky
Publisher : Springer Science & Business Media
ISBN 13 : 1475748604
Total Pages : 350 pages
Book Rating : 4.4/5 (757 download)

DOWNLOAD NOW!

Book Synopsis Contemporary Issues in Modeling Psychopathology by : Michael S. Myslobodsky

Download or read book Contemporary Issues in Modeling Psychopathology written by Michael S. Myslobodsky and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite considerable progress in clinical and basic neurosciences, the cure of psychiatric disorders is still remote, little is known about their prevention, and the etiology and molecular mechanisms of mental disorders are still obscure. Diagnoses are still guided by patients' stories. The mission of animal models is to bridge the gap between `the story and the synapse.' Contemporary Issues in Modeling of Psychopathology attempts to do this by examining such questions as `What good might come from such a model? Are we wasting our time? How far can we carry results from model animals, such as rats and mice, without causing a highly distorted view of the field and its goals?' This book serves as the opening volume for a new series, Neurobiological Foundation of Aberrant Behaviors.

Clinical Autonomic and Mitochondrial Disorders

Author : Nicholas L. DePace
Publisher : Springer
ISBN 13 : 9783030170158
Total Pages : 0 pages
Book Rating : 4.1/5 (71 download)

DOWNLOAD NOW!

Book Synopsis Clinical Autonomic and Mitochondrial Disorders by : Nicholas L. DePace

Download or read book Clinical Autonomic and Mitochondrial Disorders written by Nicholas L. DePace and published by Springer. This book was released on 2019-08-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings. It includes lifestyle and supplement recommendations for beginning and maintaining autonomic nervous system and mitochondrial health and wellness. The book is organized around a six-pronged mind-body wellness program and contains a series of clinical applications and frequently asked questions. The physiologic need and clinical benefit and synergism of all six aspects working together are detailed, including the underlying biochemistry, with exhaustive references to statistically significant and clinically relevant studies. The book covers a range of clinical disorders, including anxiety, arrhythmia, atherosclerosis, bipolar disease, dementia, depression, fatigue, fibromyalgia, heart diseases, hypertension, mast cell disorder, migraine, and PTSD. Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, primary care, neurology, endocrinology, psychiatry, and integrative and functional medicine. It provides therapy options to the indications and diagnoses published in the authors' book Clinical Autonomic Dysfunction (Springer, 2014).

Neurodegenerative Diseases

Author : M. Flint Beal
Publisher : Cambridge University Press
ISBN 13 : 1139443453
Total Pages : 1009 pages
Book Rating : 4.1/5 (394 download)

DOWNLOAD NOW!

Book Synopsis Neurodegenerative Diseases by : M. Flint Beal

Download or read book Neurodegenerative Diseases written by M. Flint Beal and published by Cambridge University Press. This book was released on 2005-06-02 with total page 1009 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Aspirin and Related Drugs

Author : Kim D. Rainsford
Publisher : CRC Press
ISBN 13 : 0203646967
Total Pages : 801 pages
Book Rating : 4.2/5 (36 download)

DOWNLOAD NOW!

Book Synopsis Aspirin and Related Drugs by : Kim D. Rainsford

Download or read book Aspirin and Related Drugs written by Kim D. Rainsford and published by CRC Press. This book was released on 2004-10-28 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of

Essential Fatty Acids and Eicosanoids

Author : Andrew Sinclair
Publisher : The American Oil Chemists Society
ISBN 13 : 9780935315431
Total Pages : 504 pages
Book Rating : 4.3/5 (154 download)

DOWNLOAD NOW!

Book Synopsis Essential Fatty Acids and Eicosanoids by : Andrew Sinclair

Download or read book Essential Fatty Acids and Eicosanoids written by Andrew Sinclair and published by The American Oil Chemists Society. This book was released on 1992 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers from the March 1992 conference explore the importance of EFA and eicosanoids on living organisms. Organization is around five interrelated themes: examination of the biological function of docosahexaenoic acid at the fundamental level of molecular and cellular research; biosynthesis of PUFA in mammals; types of biological markers that can provide information about the adequacy of EFA intake; role that EFA and eicosanoids play in the development of disease states; and in the nutrition of the fetus and newly born infants, especially those born prematurely. Member price, $100. Annotation copyright by Book News, Inc., Portland, OR

Metallotherapeutic Drugs and Metal-Based Diagnostic Agents

Author : Marcel Gielen
Publisher : John Wiley & Sons
ISBN 13 : 0470864044
Total Pages : 638 pages
Book Rating : 4.4/5 (78 download)

DOWNLOAD NOW!

Book Synopsis Metallotherapeutic Drugs and Metal-Based Diagnostic Agents by : Marcel Gielen

Download or read book Metallotherapeutic Drugs and Metal-Based Diagnostic Agents written by Marcel Gielen and published by John Wiley & Sons. This book was released on 2005-09-01 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

Glial ⇔ Neuronal Signaling

Author : Glenn I. Hatton
Publisher : Springer Science & Business Media
ISBN 13 : 9781402079368
Total Pages : 460 pages
Book Rating : 4.0/5 (793 download)

DOWNLOAD NOW!

Book Synopsis Glial ⇔ Neuronal Signaling by : Glenn I. Hatton

Download or read book Glial ⇔ Neuronal Signaling written by Glenn I. Hatton and published by Springer Science & Business Media. This book was released on 2004-05-31 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glial Neuronal Signaling fills a need for a monograph/textbook to be used in advanced courses or graduate seminars aimed at exploring glial-neuronal interactions. Even experts in the field will find useful the authoritative summaries of evidence on ion channels and transporters in glia, genes involved in signaling during development, metabolic cross talk and cooperation between astrocytes and neurons, to mention but a few of the timely summaries of a wide range of glial-neuronal interactions. The chapters are written by the top researchers in the field of glial-neuronal signaling, and cover the most current advances in this field. The book will also be of value to the workers in the field of cell biology in general. When we think about the brain we usually think about neurons. Although there are 100 billion neurons in mammalian brain, these cells do not constitute a majority. Quite the contrary, glial cells and other non-neuronal cells are 10-50 times more numerous than neurons. This book is meant to integrate the emerging body of information that has been accumulating, revealing the interactive nature of the brain's two major neural cell types, neurons and glia, in brain function.

New Antiepileptic Drugs

Author : Francesco Pisani
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis New Antiepileptic Drugs by : Francesco Pisani

Download or read book New Antiepileptic Drugs written by Francesco Pisani and published by Elsevier Publishing Company. This book was released on 1991 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.

Brain-Gut Interactions

Author : Yvette Tache
Publisher : CRC Press
ISBN 13 : 9780849353680
Total Pages : 400 pages
Book Rating : 4.3/5 (536 download)

DOWNLOAD NOW!

Book Synopsis Brain-Gut Interactions by : Yvette Tache

Download or read book Brain-Gut Interactions written by Yvette Tache and published by CRC Press. This book was released on 1991-02-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain-Gut Interactions serves as a reference source and stimulus for expanded research efforts aimed at unravelling the pathophysiology of brain-gut interactions. Within the general framework of brain-gut interactions, it covers the various areas in which this growing interdisciplinary field has evolved. Topics discussed in this volume include the topography and morphology of afferent and efferent connections between the gut and the medulla and hypothalamic nuclei, the role of afferent and efferent pathways in the regulation of gastrointestinal function, the brain's regulation of gastrointestinal secretory and motor function, and the function of peripheral and central cholecystokinin in the mechanisms of satiety. The final section of this book focuses on topics such as stress, emesis, visceral pain, and brain-related disorders of the intestine based on experimental and clinical data. Students and investigators working with brain-gut interactions, gastroenterologists, psychologists, and psychiatrists will find this book to be an essential reference resource.