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An Investigation Into Ultrasonic Methods Of Imaging The Tissue Ablation Induced During Focused Ultrasound Surgery
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Book Synopsis An Investigation Into Ultrasonic Methods of Imaging the Tissue Ablation Induced During Focused Ultrasound Surgery by : Alison Louise Malcolm
Download or read book An Investigation Into Ultrasonic Methods of Imaging the Tissue Ablation Induced During Focused Ultrasound Surgery written by Alison Louise Malcolm and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MRI-Guided Focused Ultrasound Surgery by : Ferenc A. Jolesz
Download or read book MRI-Guided Focused Ultrasound Surgery written by Ferenc A. Jolesz and published by CRC Press. This book was released on 2007-09-26 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr
Book Synopsis Image-guided Focused Ultrasound Therapy by : Feng Wu
Download or read book Image-guided Focused Ultrasound Therapy written by Feng Wu and published by CRC Press. This book was released on 2024-07-31 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound has been widely used in diagnostic imaging for a long time. In the past 10 years, image-guided focused ultrasound therapy has seen rapid growth, in biomedical science and engineering, and in clinical medicine. The purpose of this book is to bring internationally renowned authorities and experts in this field together to provide up-to-date and comprehensive reviews of basic physics, biomedical engineering, and clinical applications of focused ultrasound therapy in a widely accessible fashion. Focusing on applications in cancer treatment, this book covers basic principles, practical aspects, and clinical applications of focused ultrasound therapy. It reviews the medical physics and bio-effects of focused ultrasound beams on living tissues, dosimetric methods and measurements, transducer engineering, image guidance and monitoring (including magnetic resonance imaging -- MRI -- and ultrasound), treatment delivery systems, and clinical applications. The book also gives practical guidelines on patient setup, target localisation, treatment planning and image-guided procedures for the treatment in various sites, including the prostate, liver, pancreas, breast, kidney, uterus, bone, and brain. The book discusses major challenges for the use of focused ultrasound energy on living tissues and explores the cellular and physiological responses that can be employed in the fight against cancer from biological, physics and engineering perspectives. It also highlights recent advances, including the treatment of solid tumours using image-guided drug delivery, and the exploitation of microbubbles, nanoparticles, and other cutting-edge techniques. Readers who are interested in learning more about the technique and the clinical applications described in each chapter can find more information in the comprehensive bibliographies provided. This book is suitable for anyone involved in, or looking to become involved in, the research and clinical applications of focused ultrasound therapy, including medical professionals, physicists, biomedical engineers, graduate students and others working in this multidisciplinary field. It offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and an outlook on the future of focused ultrasound therapy. It presents a thorough introduction for those new to the field while providing helpful, up-to-date information and guidelines for readers already using this therapy in clinical and pre-clinical settings. Key Features: Brings together a wide range of world-leading experts in this new field, presenting the latest clinical outcomes of using focused ultrasound for the treatment of benign and malignant diseases Covers the fundamental physics of focused ultrasound therapy and ultrasound-mediated drug delivery, including chapters on the mechanism of sonoporation, microbubble and ultrasound interaction, and their potential clinical applications Introduces clinical guidelines for focused ultrasound therapy, including indications and contraindications, treatment goals, the selection of patients, clinical observation during treatment procedure and follow-up, and characteristics of image changes after treatment
Book Synopsis Therapeutic Ultrasound by : Jean-Michel Escoffre
Download or read book Therapeutic Ultrasound written by Jean-Michel Escoffre and published by Springer. This book was released on 2015-10-20 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.
Book Synopsis Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2011 Edition by :
Download or read book Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about High-Intensity Focused Ultrasound Ablation in a compact format. The editors have built Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about High-Intensity Focused Ultrasound Ablation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2012 Edition by :
Download or read book Advances in High-Intensity Focused Ultrasound Ablation Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in High-Intensity Focused Ultrasound Ablation Research and Application / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about High-Intensity Focused Ultrasound Ablat in a compact format. The editors have built Advances in High-Intensity Focused Ultrasound Ablation Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about High-Intensity Focused Ultrasound Ablat in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in High-Intensity Focused Ultrasound Ablation Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Essentials of Ultrasound Imaging by : Thomas L. Szabo
Download or read book Essentials of Ultrasound Imaging written by Thomas L. Szabo and published by Elsevier. This book was released on 2023-11-28 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Ultrasound Imaging offers a fast track introduction to the science, physics and technology of ultrasound imaging systems. Uniquely, principles are revealed by examples from software simulation programs, thus allowing the reader to engage with the concepts having minimal mathematical background. The material is organized around a functional block diagram which is, in turn, related to physical processes and implementations of the functional concepts on commercial and research imaging systems. Examples from a Verasonics Vantage Research Ultrasound System provide unparalleled insight into each step of ultrasound image creation including signal processing, transducer operation, different types of beamforming, and image formation. The last chapter examines the potential and capabilities of ultrasound imaging and measurement for future applications. With a thorough grounding of the physics and methods of ultrasound imaging, this book is suitable for students learning about ultrasound and researchers involved, or starting out in, ultrasound research development who might not have the background to understand the latest developments. Gives an understanding of wave propagation, piezoelectric transducers, beam focusing, Doppler imaging of fluid flow, types of ultrasound systems, and real-time image formation and resolution Explains basic mathematical and scientific concepts underlying ultrasound imaging and physics Follows the passage of pulse-echo waveforms through the changes made by wave propagation, array beam formation, absorption, and system processing to image formation Describes the concepts written in MATLAB® that are illustrated by numerous examples from unique simulations of physics, processing, and imaging and from experiments and signals within an ultrasound research system Presents an accompanying simulator software package, in executable form, designed to demonstrate concepts with minimal mathematical background, together with a curriculum of hands-on experiments using an ultrasound research system, both available from Verasonics
Book Synopsis Emerging Therapeutic Ultrasound by : Junru Wu
Download or read book Emerging Therapeutic Ultrasound written by Junru Wu and published by World Scientific. This book was released on 2006 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by internationally re-knowned authorities and experts in the field of ultrasonic imaging, this book provides comprehensive reviews on basic physical principles and applications of emerging and rapidly developing therapeutic techniques.In specific, reviews of mechanisms for bioeffects of ultrasound relevant to therapeutic applications, high intensity focused ultrasound and its application in surgery, ultrasound assisted target drug and gene delivery, as well as transdermal drug delivery are discussed.The book will be a useful reference source for graduate students, academics and researchers.
Download or read book Ultrasound written by F.J. Fry and published by Elsevier. This book was released on 2013-10-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods and Phenomena, 3: Ultrasound: Its Applications in Medicine and Biology, Part II focuses on the applications of ultrasound in biology and medicine, including irradiation, acoustic attenuation, and impedance distribution. The selection first tackles selected non-thermal mechanisms of interaction of ultrasound and biological media, therapy with continuous wave ultrasound, and pulse echo visualization. Discussions focus on imaging properties, modes of operation, rationale for selecting ultrasound as a therapeutic agent, mechanical disarrangement of tissue structures, and wave distortion. The manuscript then examines a research approach to visualization of breast tumors by ultrasound methods, acoustic characterization of tissue at the microscopic level, and intense focused ultrasound. Concerns cover systems for irradiation with intense focused ultrasound, interaction of intense focused ultrasound and biological tissue, sonomicroscopic characterization of tissues, acoustic attenuation and impedance distribution, velocity of sound distribution, and methods of procedure. The book tackles cavitation and its effects on organized mammalian tissues and thermal mechanisms in ultrasound-tissue interactions. The selection is a valuable source of data for researchers interested in the applications of ultrasound in biology and medicine.
Book Synopsis Interventional Ultrasound, An Issue of Ultrasound Clinics by : David L. Waldman
Download or read book Interventional Ultrasound, An Issue of Ultrasound Clinics written by David L. Waldman and published by Elsevier Health Sciences. This book was released on 2013-04-28 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Ultrasound Clinics addresses interventional procedures in Ultrasound. Topics include: Breast-Ultrasound Surveillance and Intervention; Ultrasound-Guided Abscess Drainage: Technical and Clinical Aspects; The Use of Ultrasound in TIPS: Pre-Procedural Role in Evaluating the Need for Intervention; Dialysis Fistula Surveillance; Ultrasound-Guided Solid Organ Biopsy; Ultrasound-Guided Biopsies of Superficial Structures (Thyroids and Lymph Nodes); Ultrasound-Guided Biliary Intervention; Tumor Ablation: US vs CT; Ultrasound-Guided Vascular Access and Intervention; The Use of Ultrasound in Musculoskeletal Interventions; Ultrasound and GPS Technology; High-Intensity Focused Ultrasound; Varicose Vein Ablation; Diagnosis and Intervention in the Venous Portal System; and Ultrasound Evaluation of Hepatic Artery Stenosis.
Book Synopsis Quantitative Ultrasound Imaging During Ablation Procedures by : Kayvan Samimi
Download or read book Quantitative Ultrasound Imaging During Ablation Procedures written by Kayvan Samimi and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional ultrasound imaging (i.e. B-mode sonogram) is a qualitative mode of imaging based on visualizing the relative echogenicity of different tissue types within the body. This useful mode of imaging has aided clinicians for more than 50 years. However, B-mode imaging does not capture any of the frequency-dependent information that is contained within the ultrasound echo signal. Additionally, due to its qualitative nature, there is much inter-system and inter-observer variability with regard to generation and interpretation of B-mode images. Quantitative Ultrasound (QUS) methods have been developed to extract additional information by estimating acoustic properties of tissue from the frequency-domain representation of echo signals. These estimates can be converted to color-coded maps that are visualized along with conventional B-mode images to form enhanced ultrasound images. Such images can potentially provide valuable diagnostic and prognostic information to medical professionals. Some of the more important acoustic parameters of interest in QUS and tissue characterization are the ultrasonic attenuation coefficient and the backscatter coefficient. Attenuation has been studied as a potential classifier of normal and pathological liver tissue. In addition to providing pathological information for diagnosis, monitoring these QUS parameters during therapeutic procedures such as tumor ablation can lead to targeted and optimized treatment. The goals of this dissertation are to theoretically model and analyze current methods of acoustic attenuation estimation; improve attenuation estimation algorithms to enhance the quality of subsequent QUS images; and correlate changes in QUS parameter values with progression of thermally ablative procedures for ex-vivo and in-vivo liver ablations. Although QUS imaging may be used to assist clinicians in various stages of diagnosis and treatment of diseases in a multitude of bodily organs and tissue types, this dissertation focuses on thermal ablation of primary or metastatic liver tumors in order to showcase the possible benefits of the proposed estimation methods and to compare their performance with existing estimation techniques. Additionally, simulated and physical tissue-mimicking (TM) phantoms with known acoustic properties are used to statistically test and compare the accuracy and precision of these methods. Theoretical analysis and experimental results suggest that our proposed method for estimation of the ultrasonic attenuation coefficient based on measurement of frequency shifts in a normalized power-spectral representation of the ultrasonic echo signal is best suited to in-vivo QUS imaging in clinical settings and provides estimates with standard deviations that are at least three times smaller than was previously possible with other methods.
Book Synopsis Physical Principles of Medical Ultrasonics by : C. R. Hill
Download or read book Physical Principles of Medical Ultrasonics written by C. R. Hill and published by John Wiley & Sons. This book was released on 2005-08-05 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The physical properties of ultrasound, particularly its highly directional beam behaviour, and its complex interactions with human tissues, have led to its becoming a vitally important tool in both investigative and interventional medicine, and one that still has much exciting potential. This new edition of a well-received book treats the phenomenon of ultrasound in the context of medical and biological applications, systematically discussing fundamental physical principles and concepts. Rather than focusing on earlier treatments, based largely on the simplifications of geometrical acoustics, this book examines concepts of wave acoustics, introducing them in the very first chapter. Practical implications of these concepts are explored, first the generation and nature of acoustic fields, and then their formal descriptions and measurement. Real tissues attenuate and scatter ultrasound in ways that have interesting relationships to their physical chemistry, and the book includes coverage of these topics. Physical Principles of Medical Ultrasonics also includes critical accounts and discussions of the wide variety of diagnostic and investigative applications of ultrasound that are now becoming available in medicine and biology. The book also encompasses the biophysics of ultrasound, its practical applications to therapeutic and surgical objectives, and its implications in questions of hazards to both patient and operator.
Download or read book The Tumor written by John Grisham and published by Focused Ultrasound Foundation. This book was released on 2015-03 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: John Grisham says THE TUMOR is the most important book he has ever written. In this short book, he provides readers with a fictional account of how a real, new medical technology could revolutionize the future of medicine by curing with sound. THE TUMOR follows the present day experience of the fictional patient Paul, an otherwise healthy 35-year-old father who is diagnosed with a malignant brain tumor. Grisham takes readers through a detailed account of Paul’s treatment and his family’s experience that doesn’t end as we would hope. Grisham then explores an alternate future, where Paul is diagnosed with the same brain tumor at the same age, but in the year 2025, when a treatment called focused ultrasound is able to extend his life expectancy. Focused ultrasound has the potential to treat not just brain tumors, but many other disorders, including Parkinson’s, Alzheimer’s, hypertension, and prostate, breast and pancreatic cancer. For more information or to order a free hardcopy of the book, please visit The Focused Ultrasound Foundation’s website www.fusfoundation.org. Here you will find a video of Grisham on the TEDx stage with the Foundation’s chairman and a Parkinson’s patient who brings the audience to its feet sharing her incredible story of a focused ultrasound “miracle.” Readers will get a taste of the narrative they expect from Grisham, but this short book will also educate and inspire people to be hopeful about the future of medical innovation.
Book Synopsis Non-invasive Treatment of Cardiac Arrhythmias by High-intensity Focussed Ultrasound Guided by Magnetic Resonance Imaging by : Pierre Bour
Download or read book Non-invasive Treatment of Cardiac Arrhythmias by High-intensity Focussed Ultrasound Guided by Magnetic Resonance Imaging written by Pierre Bour and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: High intensity focused ultrasound has the ability to deposit ultrasonic energy locally and non-invasively into biological tissues. It is possible to exploit the mechanical and/or thermal effects according to the ultrasonic parameters used. Guided by a Magnetic Resonance Imaging (MRI) scanner, this technology is equipped with a planning modality and real-time monitoring of the procedure. As of now, applications of MRI-guided focused ultrasound are on fixed organs, including brain and bone or uterine fibroid. For the heart, the presence of cardiac and respiratory movements constitutes an important difficulty, both for the ultrasonic (ballistic) treatment and for the temperature monitoring under MRI (artefacts on images). In addition, the rib cage acts as a barrier for the propagation of ultrasounds. In this thesis work, a set of new technological development have been developed for ablation and non-invasive cardiac stimulation using focused MRI-guided ultrasound. A first study shows the technical feasibility of controlling heart rhythm by short ultrasound pulses targeted to the myocardium. The influence of the parameters of the pulses (duration, amplitude, emission time in the cardiac cycle) were studied quantitatively on isolated beating heart then in vivo on a preclinical model. For this, an original device was developed. A second study presents new rapid MRI methods for simultaneously mapping the temperature and local displacement induced by focused ultrasound. The method is validated on the liver on a preclinical model and demonstrates that it is possible to correlate the thermal dose obtained by MR-thermometry with a change in the mechanical properties of the treated tissues measured simultaneously. A third study consisted in developing a technique for measuring the position of the target in 3D real-time using some elements of the ultrasonic transmitter as receivers. This measure allows to dynamically correct the position of the ultrasonic focus to maximize energy deposition at the targeted point. In addition, we monitored in real-time the procedure using MR-thermometry at a rate of 10 images per second. Here again a preclinical validation is presented. This thesis work proposes important advances to remove the current locks of the technology allowing to envision noninvasive treatments of cardiac pathologies, all guided by MRI in real-time.
Download or read book Acoustical Imaging written by Sydney Lees and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contents of this volume are the proceedings of the 23'd International Symposium on Acoustical Imaging which took place 13-16 April, 1997, in Boston, Massachusetts. The first Symposium met 25 years ago. Originally the Symposium met in California, then elsewhere within the United States but beginning in 1988 the Symposia began to meet outside of the United States as welL It is now being held about every eighteen months, alternately in the United States and then outside. The present pattern is to hold one meeting in East Asia, then in the USA, then in Europe and again in the USA However, for scheduling reasons the next Symposium will be in Santa Barbara, California, followed by England and then East Asia. It is to be noted that the Symposium is a free standing institution, not associated with any other organization. Each meeting is the total responsibility of its chairman with the advice of past chairmen. Papers are submitted in response to the call for them and reviewed by an International Scientific Advisory Board . . The quality depends entirely on the response to the calL It is gratifYing to note that the Symposium has attained the status that attracts high quality contributions despite (or perhaps because ot) the loose structure. Two factors that have appeal are that there is only one session and that there is time during the meeting for extensive discussion.
Book Synopsis Application of Magnetic Resonance-guided Focused Ultrasound Thermal Ablation for Drug Delivery by : Andrew Wei Ping Wong
Download or read book Application of Magnetic Resonance-guided Focused Ultrasound Thermal Ablation for Drug Delivery written by Andrew Wei Ping Wong and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In Magnetic Resonance-guided Focused Ultrasound (MRgFUS), highly focused ultrasound noninvasively heats tissue under the guidance of magnetic resonance imaging and thermometry. To prevent recurrence, the treatment of cancer requires complete destruction, which is a challenge for noninvasive local therapy. We hypothesize that thermal ablation can enhance the accumulation of nanoparticle chemotherapeutics, and therefore combining chemotherapy and ultrasound is attractive. A combination of ultrasound and chemotherapeutic drugs may allow ultrasound thermal ablation to more effectively treat malignancy. MRgFUS can ablate tissue by raising temperatures to cytotoxic levels. Burn injuries release histamine, VEGF, and other factors which induce local edema and inflammation. Local inflammation prompts invasion by immune cells, while necrotic tumor cells release tumor specific antigen, events which may prompt the immune system to further respond to cancer. Histamine and VEGF also enhance the accumulation of nanoparticles, and preclinical trials using radiofrequency ablation have demonstrated greater accumulation of nanoparticle chemotherapy within tumors. Similar effects can be obtained with MRgFUS, with the added advantages of deeper penetration, a conformal region of interest and improved temperature control. Moreover, use of focused ultrasound provides the opportunity to explore ultrasonic mechanical effects. In this dissertation, we synthesize several types of labeled and chemotherapeutic liposomes, demonstrate the suitability of Positron Emission Tomography (PET) for the assessment of drug delivery, enhance delivery of liposomes with MRgFUS, examine the distribution of nanoparticles in a syngeneic murine model of mammary carcinoma, and examine the effect of this combination therapy on tumor growth and survival. As described in Chapter 3, an initial assessment of 64Cu-labeled long-circulating liposomes as PET contrast agents reveals excellent image contrast and quantitative mapping of tumor drug concentration. The tumor contrast ratio of 64Cu-labeled long-circulating liposomes was compared to 18F-FDG, the dominant clinical tracer. 18F-FDG demonstrated a contrast ratio of 0.88 ± 0.01 (mean ± standard error of the mean), while contrast ratio achieved with 64Cu-labeled long-circulating liposomes ranged from 0.78 ± 0.01 at 6 hours to 0.94 ± 0.01 at 48 hours, increasing over time as liposomes cleared from circulation. PET was then applied in Chapter 4 to evaluate the accumulation of nanoparticles within tumors following MRgFUS ablation. In mouse models, free doxorubicin has demonstrated tumor accumulation of 1-3 %ID/cc; nanoparticle formulations improve this by increasing circulation time and facilitating accumulation only in regions with leaky vasculature. Three strategies for MRgFUS application were compared: grid and circular protocols that mimic conformal ablation strategies and a single point ablation that enhances delivery but incompletely ablates the tumor. All strategies resulted in enhanced accumulation of 64Cu-LCL within tumors, with more than 80% of the accumulation occurring within 3 hours after ablation. At 20 hours after insonation, the spatial maximum accumulation was 33.8 ± 1.9, 39.7 ± 8.6, 27.4 ± 2.1, 8.6 ± 0.8 (%ID/cc, mean ± standard error of the mean), in grid protocol, circle protocol, single point, and untreated tumors, respectively. Autoradiography and fluorescence imaging confirmed the greatly enhanced accumulation in the remaining tumor. Locally-enhanced accumulation of LCL was preserved even after a multi-week protocol of doxorubicin-containing LCL (6 mg/kg) and MRgFUS. Following intraperitoneal injection, gadoteridol was also preferentially retained between 0 and 3 hours after ablation but was cleared after 3 hours and subsequent intravenous injections of contrast did not enhance imaging of the treated tumor. The combination of ultrasound and both long-circulating and thermally-sensitive copper-doxorubicin liposomes results in delayed tumor growth and enhanced survival, as described in Chapter 5. Four weeks of a single point ultrasound thermal ablation and biweekly copper-doxorubicin long-circulating liposomes (6 mg/kg) enhanced median survival from 43 ± 1 days (median ℗ł median absolute deviation) in untreated tumors to 114 ± 19 days. Substantial inhibition of tumor growth was also observed following four weeks of weekly copper-doxorubicin temperature sensitive liposomes (6 mg/kg) and weekly circle-patterned ultrasound. Taken as a whole, the work described here demonstrates the impact of combining chemotherapy with MRgFUS. This dissertation represents a small subset of potential ultrasound exposures, chemotherapeutic nanoparticles, and model systems. Future directions include modification of ultrasound frequency, intensity, and duty factor or inclusion of ultrasound contrast agents to induce mechanical disruption of tumor vasculature to further enhance local drug delivery.
Book Synopsis High Intensity Focused Ultrasound Therapy by : Vera A. Khokhlova
Download or read book High Intensity Focused Ultrasound Therapy written by Vera A. Khokhlova and published by . This book was released on 2016-05-22 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough introduction to the fundamental physics and current state-of-the art in therapeutic ultrasound. Expert chapters present theoretical and experimental methods and review characteristic parameters of transducers, tissue property, acoustic fields, induced bioeffects, and clinical applications. The book also reviews ultrasound and MR-based imaging methods used to monitor treatments; transducer designs, including a description of current devices and applications; and histological and biochemical methods to analyze the therapeutic effect of ultrasound. This key volume serves as a must-have reference for students, scientists, engineers, and clinicians.
