An Introduction To Toxicogenomics

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An Introduction to Toxicogenomics

Author : Michael E. Burczynski
Publisher : CRC Press
ISBN 13 : 1135511853
Total Pages : 507 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis An Introduction to Toxicogenomics by : Michael E. Burczynski

Download or read book An Introduction to Toxicogenomics written by Michael E. Burczynski and published by CRC Press. This book was released on 2003-03-26 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Toxicogenomics

Author : Hisham K. Hamadeh
Publisher : John Wiley & Sons
ISBN 13 : 9780471434177
Total Pages : 386 pages
Book Rating : 4.4/5 (341 download)

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Book Synopsis Toxicogenomics by : Hisham K. Hamadeh

Download or read book Toxicogenomics written by Hisham K. Hamadeh and published by John Wiley & Sons. This book was released on 2004-09-06 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309112982
Total Pages : 300 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by : National Research Council

Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-12-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Author : Darrell R. Boverhof
Publisher : John Wiley & Sons
ISBN 13 : 1118008987
Total Pages : 470 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by : Darrell R. Boverhof

Download or read book Applications of Toxicogenomics in Safety Evaluation and Risk Assessment written by Darrell R. Boverhof and published by John Wiley & Sons. This book was released on 2011-10-11 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Handbook of Toxicogenomics

Author : Jürgen Borlak
Publisher : John Wiley & Sons
ISBN 13 : 3527604510
Total Pages : 705 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Handbook of Toxicogenomics by : Jürgen Borlak

Download or read book Handbook of Toxicogenomics written by Jürgen Borlak and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."

Toxicogenomics

Author : Saura C. Sahu
Publisher : John Wiley & Sons
ISBN 13 : 0470699647
Total Pages : 422 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Toxicogenomics by : Saura C. Sahu

Download or read book Toxicogenomics written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomics analysis and interpretation of toxicogenomic data principles of data mining in toxicogenomics design issues in toxicogenomics studies sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity toxicogenomics as a tool to assess immunotoxicity toxicogenomics and ecogenomics for studying endocrine disruption and basic biology use of toxicogenomics as an early predictive tool for hepatotoxicity nutrigenomics: the application of genomic signatures in nutrition-related research application of toxicogenomics in drug discovery potential uses of toxicogenomic biomarkers in occupational health and risk assessment usefulness of toxicogenomics in the regulatory environment perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.

Genomics in Drug Discovery and Development

Author : Dimitri Semizarov
Publisher : John Wiley & Sons
ISBN 13 : 0470409762
Total Pages : 496 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Genomics in Drug Discovery and Development by : Dimitri Semizarov

Download or read book Genomics in Drug Discovery and Development written by Dimitri Semizarov and published by John Wiley & Sons. This book was released on 2008-11-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.

Genomic Approaches for Cross-Species Extrapolation in Toxicology

Author : William H. Benson
Publisher : CRC Press
ISBN 13 : 1420043641
Total Pages : 218 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Genomic Approaches for Cross-Species Extrapolation in Toxicology by : William H. Benson

Download or read book Genomic Approaches for Cross-Species Extrapolation in Toxicology written by William H. Benson and published by CRC Press. This book was released on 2006-12-13 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

An Introduction to Aquatic Toxicology

Author : Mikko Nikinmaa
Publisher : Elsevier
ISBN 13 : 0124115810
Total Pages : 253 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis An Introduction to Aquatic Toxicology by : Mikko Nikinmaa

Download or read book An Introduction to Aquatic Toxicology written by Mikko Nikinmaa and published by Elsevier. This book was released on 2014-07-01 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Aquatic Toxicology is an introductory reference for all aspects of toxicology pertaining to aquatic environments. As water sources diminish, the need to understand the effects that contaminants may have on aquatic organisms and ecosystems increases in importance. This book will provide you with a solid understanding of aquatic toxicology, its past, its cutting-edge present and its likely future. An Introduction to Aquatic Toxicology will introduce you to the global issue of aquatic contamination, detailing the major sources of contamination, from where they originate, and their effects on aquatic organisms and their environment. State-of-the-art toxicological topics covered include nanotoxicology, toxicogenomics, bioinformatics, transcriptomics, metabolomics, as well as water management and the toxicological effects of major environmental issues such as algal blooms, climate change and ocean acidification. This book is intended for anyone who wants to know more about the impact of toxicants on aquatic organisms and ecosystems, or to keep up to date with recent and future developments in the field. Provides with the latest perspectives on the impacts of toxicants on aquatic environments, such as nanotoxicology, toxicogenomics, ocean acidification and eutrophication Offers a complete overview, beginning with the origins of aquatic toxicology and concluding with potential future challenges Includes guidance on testing methods and a glossary of aquatic toxicology terms

An Introduction to Toxicogenomics

Author : Michael E. Burczynski
Publisher : CRC Press
ISBN 13 : 020350481X
Total Pages : 357 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis An Introduction to Toxicogenomics by : Michael E. Burczynski

Download or read book An Introduction to Toxicogenomics written by Michael E. Burczynski and published by CRC Press. This book was released on 2003-03-26 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Toxicogenomics

Author : Hamadeh
Publisher :
ISBN 13 : 9780471669036
Total Pages : 368 pages
Book Rating : 4.6/5 (69 download)

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Book Synopsis Toxicogenomics by : Hamadeh

Download or read book Toxicogenomics written by Hamadeh and published by . This book was released on 2004 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies.; A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support t.

Application of Toxicogenomics to Cross-Species Extrapolation

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309181682
Total Pages : 58 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Application of Toxicogenomics to Cross-Species Extrapolation by : National Research Council

Download or read book Application of Toxicogenomics to Cross-Species Extrapolation written by National Research Council and published by National Academies Press. This book was released on 2006-04-24 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.

Advances in Computational Toxicology

Author : Huixiao Hong
Publisher : Springer
ISBN 13 : 3030164438
Total Pages : 412 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Advances in Computational Toxicology by : Huixiao Hong

Download or read book Advances in Computational Toxicology written by Huixiao Hong and published by Springer. This book was released on 2019-05-21 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

Author : Ali S. Faqi
Publisher : Elsevier
ISBN 13 : 0323984622
Total Pages : 1074 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Nonclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Elsevier. This book was released on 2024-02-11 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Genomic Biomarkers for Pharmaceutical Development

Author : Yuping Wang
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128063556
Total Pages : 208 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genomic Biomarkers for Pharmaceutical Development by : Yuping Wang

Download or read book Genomic Biomarkers for Pharmaceutical Development written by Yuping Wang and published by Elsevier Inc. Chapters. This book was released on 2013-07-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although we have seen increased spending on drug research and development, the submission of new drug applications to the US Food and Drug Administration (FDA) has steadily decreased over the past 15 years. Meanwhile, toxicology is celebrating the ten-year anniversary of the introduction of toxicogenomics, a field that was anticipated to change our way of conducting toxicology with enhanced safety assessment. Despite the excitement, and a decade of further technical advancement, the anticipated benefits have been slow to reach the clinical bedside. The failure to translate toxicogenomics to drug development faster, illustrates the need for further innovations in its methodology as well as in its technology. This review introduces the concept of toxicogenomics, summarizes the prominent applications of this relatively young discipline in drug development, and provides a future perspective of advancement in this field.

Toxicogenomics

Author : Mohamed A. Selmy
Publisher : Delve Publishing
ISBN 13 : 9781773610818
Total Pages : 0 pages
Book Rating : 4.6/5 (18 download)

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Book Synopsis Toxicogenomics by : Mohamed A. Selmy

Download or read book Toxicogenomics written by Mohamed A. Selmy and published by Delve Publishing. This book was released on 2017-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological research targets the identification of risk factors that trigger harmful effects as a result of exposure, which may leads to acute illnesses, chronic disease or even immediate death. It is clear that exposing people intentionally to chemicals is limited both scientifically and ethically. Therefore, the assessment of chemical safety is predominantly based on animal testing as a substitute to study toxic effects of environmental chemicals in humans. A broad range of animal models have been developed to test different types and levels of toxicity, comprising tests for immunotoxicty, carcinogenicity and reproduction toxicity. In this regard, regulations and policies have been adopted to enhance the protection of human health and the environment from the risks that may develop through chemical exposures. One of the consequences of this regulation is an enormous increase in the number of laboratory animals needed to perform such safety evaluations. With this increase, regulations have been developed with regard to the ethical acceptability of such tests, leading to a demand for a development of animal free alternatives.In relation, the completion of the human genome project and sequencing of the genomes of many other organisms have opened new tracks in the biological area. Analysis of gene expression and proteomics have made it mandatory to combine mathematics, biology and information technology in one bioinformatics framework, which has been a growing field in recent years.Applying this technology to toxicology, known as toxicogenomics, has provided new potentials to the field, including compound screening for hazards, dose-response assessment, prediction of sensitivity to toxic agent and assessment of cellular response to different agents. However, despite the potential capability of the combination of genomic technologies with toxicology to improve risk assessment and the predictive capabilities, still many challenge ahead of the growing field. This book sheds light on the tools, benefits and applications of this newly developed field. In addition, an emphasis will be put on toxicogenomic databases and how they have improved throughout the last decade. This book discusses: an introduction to toxicogenomics in Chapter 1 followed by an illustration of the technologies encompassed in toxicogenomics as described in Chapter 2. This is followed by a description of study design and data analysis in Chapter 3. Chapter 4 discusses the current databases of toxicogenomics in terms of organization, methods of analysis and pitfalls. Chapter 5 discusses the common applications of toxicogenomic technologies. Chapter 6 addresses ethical considerations in the implementation of toxicogenomics and finally chapter 7 discusses the future directions of toxicogenomics.

OMICS

Author : Debmalya Barh
Publisher : CRC Press
ISBN 13 : 1439850089
Total Pages : 625 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis OMICS by : Debmalya Barh

Download or read book OMICS written by Debmalya Barh and published by CRC Press. This book was released on 2011-11-21 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.