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Ambient Ionization Mass Spectrometry For The Forensic Screening Of Pharmaceuticals And The Determination Of Potential Drug Candidates
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Book Synopsis Ambient Ionization Mass Spectrometry for the Forensic Screening of Pharmaceuticals and the Determination of Potential Drug Candidates by : Leonard Nyadong
Download or read book Ambient Ionization Mass Spectrometry for the Forensic Screening of Pharmaceuticals and the Determination of Potential Drug Candidates written by Leonard Nyadong and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient mass spectrometry (MS) is a new and growing sub-field in MS which has opened new research avenues, particularly for applications relating to the analysis of solid samples. Results on the implementation and application of ambient MS techniques including: desorption electrospray ionization (DESI) and direct analysis in real time (DART) indicated that these techniques could serve as complementary tools for the rapid qualitative screening of pharmaceuticals, allowing up to two orders of magnitude improvement in throughput compared to traditional methods such as liquid chromatography MS. The selectivity of DESI could be enhanced by performing the experiment in the reactive mode. In this mode, complexation reactions between reagents added to the spray solvent and analytes on the sample surface resulted in analyte stabilization, inhibiting fragmentation. They also resulted in a concomitant enhancement in the analyte surface activity, facilitating their evaporation from secondary droplets culminating in an improvement in sensitivity. Also for drug tablets analysis, the analyte signal dependency on DESI geometrical set-up variables could be mitigated following the careful and controlled addition of an isotopically labeled internal standard (IS) to the sample or by spraying samples with a pair of reagents with different affinities for the analyte. Either of these approaches resulted in an analyte-to-IS signal ratio (in the former) or an analyte complex ratio (in the later), which was largely independent of DESI experimental variables allowing quantitative analysis using this technique. DESI MS was also observed to be a very powerful tool for determining the 2-D distribution of various pharmaceutically important compounds on tablet and tissue surfaces. The ability to map the distribution of molecules of interest by DESI MS has very great implications in drug tablet quality control and in determining the role of chemical signals presented on tissue surfaces. DESI was observed to be limited to ionizing molecules of medium to high polarities without much limitation in terms of mass range, whereas DART was better suited for the analysis of molecules within a broader range of polarities, but within a more limited mass range (up to 800 Da approximately). These limitations were circumvented by implementing a novel multimode ambient ion source, desorption electrospray/metastable-induced ionization (DEMI), which combines various aspects of DESI and DART. Initial experiments with the DEMI ion source demonstrated its ability to enable the simultaneous analysis of molecules within a broader range of polarities and masses than DESI and DART alone.
Book Synopsis Ambient Ionization Mass Spectrometry by : Marek Domin
Download or read book Ambient Ionization Mass Spectrometry written by Marek Domin and published by Royal Society of Chemistry. This book was released on 2014-11-14 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
Book Synopsis Mass Spectrometry in Drug Discovery by : David T. Rossi
Download or read book Mass Spectrometry in Drug Discovery written by David T. Rossi and published by CRC Press. This book was released on 2001-11-07 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.
Book Synopsis High-Throughput Mass Spectrometry in Drug Discovery by : Chang Liu
Download or read book High-Throughput Mass Spectrometry in Drug Discovery written by Chang Liu and published by John Wiley & Sons. This book was released on 2023-06-29 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-Throughput Mass Spectrometry in Drug Discovery Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry. High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development. High-Throughput Mass Spectrometry in Drug Discovery readers will also find: Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more An authorial team with extensive combined experience in research and industrial applications Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.
Book Synopsis Using Mass Spectrometry for Drug Metabolism Studies by : Walter A. Korfmacher
Download or read book Using Mass Spectrometry for Drug Metabolism Studies written by Walter A. Korfmacher and published by CRC Press. This book was released on 2004-12-17 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field. Using Mass Spectrometry
Book Synopsis Mass Spectrometry in Medicinal Chemistry by : Klaus Wanner
Download or read book Mass Spectrometry in Medicinal Chemistry written by Klaus Wanner and published by Wiley-VCH. This book was released on 2007-06-27 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Book Synopsis Clinical Applications of Mass Spectrometry in Drug Analysis by : Uttam Garg
Download or read book Clinical Applications of Mass Spectrometry in Drug Analysis written by Uttam Garg and published by Springer Nature. This book was released on 2023-11-30 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.
Book Synopsis Development of Ambient Ionization Mass Spectrometry Approaches for the Characterization and Quantification of Psychoactive Small-molecule Constituents in Complex Plant Matrices by : Megan Isabella Chambers
Download or read book Development of Ambient Ionization Mass Spectrometry Approaches for the Characterization and Quantification of Psychoactive Small-molecule Constituents in Complex Plant Matrices written by Megan Isabella Chambers and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug chemistry sections of forensic crime laboratories are tasked with analyzing a variety of unknown materials, a subset of which are derived from plants. In comparison to the analysis of small-molecule drugs, these plant matrices are incredibly complex and present unique challenges. When traditional chromatographic approaches are used to interrogate these materials in forensic investigations, large amounts of time, resources, and funds are directed towards the extensive sample preparation steps required. Exacerbating the issue is that the matrix characteristics often result in instrument downtime to accomplish the maintenance required to address ingredients adhering to columns or clogging syringes, which are common problems when testing Cannabis-derived samples. Furthermore, the increased legalization and decriminalization of marijuana in the U.S. has contributed to the rise in popularity of Cannabis products, which will require new testing methods to analyze the myriad of sample types available as the industry continues to evolve. Therefore, the unique capabilities of direct analysis in real time – high-resolution mass spectrometry (DART-HRMS) were investigated for the analysis of plant materials, including Cannabis, as an approach to circumventing many of the sample preparation and other difficulties often encountered. A DART-HRMS triage approach, which requires no sample pretreatment steps, has been developed for the detection of Cannabis-related molecules in a wide variety of sample types, including edibles, beverages, concentrates, topicals, vaporizers, marijuana/hemp flower, and pre-rolls. Additional applications of DART-HRMS for the analysis of Cannabis materials include the following: (1) differentiation of cannabinoids; (2) quantification of cannabinoids in edibles extracts; and (3) distinguishing between hemp and marijuana varieties of C. sativa through statistical analysis of mass spectral data. DART-HRMS was also proven effective for the analysis of plant-based legal-highs, specifically those identified as “plants of concern” by the United Nations Office on Drugs and Crime. Ambient ionization mass spectrometry (AIMS) approaches were developed for the rapid detection and validated quantification of psychoactive small-molecule constituents in complex plant matrices. The methods described would greatly improve forensic science and criminal justice practices in the U.S. for the analysis of complex plant materials, both Cannabis-derived and plant-based legal-highs.
Book Synopsis Ambient Ionization Mass Spectrometry in Life Sciences by : Kei Zaitsu
Download or read book Ambient Ionization Mass Spectrometry in Life Sciences written by Kei Zaitsu and published by Elsevier. This book was released on 2019-11-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient Ionization Mass Spectrometry in Life Sciences: Principles and Applications is a systematic introduction to this rapidly expanding area of study. Underlying principles of each technique are explained in detail, along with discussions on their applications across life science disciplines. Ambient ionization has recently emerged as one of the hottest and fastest growing topics in mass spectrometry, hence this book is not just for analysts and researchers who use and study mass spectrometry. This volume would be of interest to anyone who works in or studies analytical chemistry, omics sciences (including metabolomics), pharmacokinetics, forensic science or drug analysis. Covers the most up-to-date techniques, including DART, DCBI, DESI, PESI, PSI, REIMS and laser-based ambient ionization Includes easy-to-understand pros and cons of each ionization technique to aid in decision-making Provides plentiful examples of life science applications
Book Synopsis Ambient Mass Spectroscopy Techniques in Food and the Environment by : Leo M.L. Nollet
Download or read book Ambient Mass Spectroscopy Techniques in Food and the Environment written by Leo M.L. Nollet and published by CRC Press. This book was released on 2019-01-30 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient mass spectrometry—that is the use of mass spec but in the atmospheric environment—has been widely employed in food and environmental analysis. Ambient Mass Spectroscopy Techniques in Food and the Environment presents the theoretical underpinnings of mass spectrometry, and the benefits and pitfalls of ambient mass spectrometry, as well as the latest developments of the technique, in the analysis of food and environmental parameters. It describes methods that enable the detection of surface materials like waxes, alkaloids, flavors, or pesticides by plainly exposing the corresponding items to the ionization region of the interface, without harm to samples. Features: Explains the theoretical aspects of ambient mass spectrometry Describes how to use ambient MS techniques for food safety, authenticity, and traceability screening Lists the benefits of ambient MS in analysis of food and environmental parameters Covers recent developments of ambient MS in analysis of food and environmental parameters The specialized work provides insight to professionals practicing in food and the environment, including food scientists, food engineers, food biotechnologists, chemical engineers, and those working in research labs, universities, and government regulatory agencies.
Book Synopsis Mass Spectrometry in Drug Metabolism and Disposition by : Mike S. Lee
Download or read book Mass Spectrometry in Drug Metabolism and Disposition written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
Book Synopsis Modified Ambient Mass Spectrometric Methods for Field Screening and Confirmation of Forensic Evidence by : William Lee Fatigante
Download or read book Modified Ambient Mass Spectrometric Methods for Field Screening and Confirmation of Forensic Evidence written by William Lee Fatigante and published by . This book was released on 2019 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The utility of field-portable analytical instrumentation has the potential to revolutionize many fields of science, particularly for forensic science and law enforcement. While colorimetric testing can be employed for drug evidence screening, the influx of novel psychoactive substances has significantly decreased the effectiveness of this investigation strategy. One approach to meeting the needs of today's practitioner is coupling flexible, ambient ionization techniques with portable mass spectrometric (MS) instrumentation. Ambient ionization techniques have a rich history of being amendable to the sample at hand. Since their inception in 2005, numerous techniques saturate the field. The main drive for this development is to allow the analysis of wider sample classes with doing as minimal sample preparation required. Herein, the efforts to develop and perform a selection of simplified, rapidly-interchangeable, ambient ionization sources will be discussed, including paper spray ionization (PSI) and paper cone spray ionization (PCSI).First reported by Cha and Kim, PCSI has been shown adept at bulk analyte analysis. Here, a modified PCSI source that allows for real-time extraction and filtration of forensic samples known to hinder screening or compromise hygiene on MS systems is investigated. Also, studies will be included that evaluates an inter-source comparison of ionization methods that have already shown broad utility within the forensic community, PSI and direct analysis in real time (DART), in order to discern analytical performance and usability in forensic evidence processing.While portable MS systems have been shown capable of assisting investigative decision-making, this single technology does not fulfill the two-tiered identification guidelines suggested by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) for generating prosecutorial data. By integrating surface-enhanced Raman spectroscopy (SERS) with a portable MS system, a rapid, yet robust, method for drug evidence identification is discussed, while looking at the development and characterization of this instrumental strategy.
Book Synopsis Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis by :
Download or read book Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis written by and published by Elsevier. This book was released on 2016-06-02 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis deals with the use of high-resolution mass spectrometry (MS) in the analysis of small organic molecules. Over the past few years, time-of-flight (ToF) and Orbitrap MS have both experienced tremendous growth in a great number of analytical sectors and are now well established in many laboratories where high requirements are placed on analytical performance. This book gives a head-to-head comparison of these two technologies that compete directly with each other. As users with hands-on experience in both techniques, the authors provide a balanced description of the strengths and weaknesses of both techniques. In the vast majority of cases, ToF-MS and Orbitrap-MS have been used for qualitative purposes, mainly identification of discrete molecular entities such as drug metabolites or transformation products of environmental contaminants. This paradigm is now changing as quantitative capabilities are increasingly being explored, as are non-target approaches for unbiased broad-scope screening. In view of the continuous innovation of high-resolution MS instrument manufacturers in designing and developing more powerful machines, technological advances in both hardware and software are considerable, with many novel applications. This book summarizes and analyzes these trends. The compilation of selected examples from diverse analytical fields will allow the readers to discover not only the potential of high-resolution MS in their sector, but also shows advances in other fields that rely on hi-res MS. Provides comprehensive coverage of applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysis Explores a variety of specialized techniques, giving a balanced description of the strengths and weaknesses of each Presents a general overview of imaging techniques within analysis
Book Synopsis Molecular Characterization of Biological Samples by Ambient Ionization Mass Spectrometry to Advance Clinical Assessment of Human Disease by : Kyana Yvette Garza
Download or read book Molecular Characterization of Biological Samples by Ambient Ionization Mass Spectrometry to Advance Clinical Assessment of Human Disease written by Kyana Yvette Garza and published by . This book was released on 2021 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient ionization mass spectrometry (MS) approaches have revolutionized the way diagnostic molecular information can be obtained from biological and clinical samples, requiring minimal to no sample pretreatment, being operationally simple, and most importantly, providing near real time assessment of molecular information directly from biospecimens. Ambient ionization approaches have been widely applied to various clinical applications including screening of inborn errors of metabolism, therapeutic drug monitoring, and disease diagnosis and subtyping, with the goal of evaluating their use for addressing complex challenges in human health. Desorption electrospray ionization (DESI) MS is the most extensively used ambient ionization method for the investigation of molecular changes in tissue biospecimens, showing great potential for providing complimentary information to routine histopathology. Since its inception, a variety of other ambient ionization MS methods have been developed, with newer techniques, such as the MasSpec Pen, envisioned for the intraoperative analysis of in vivo and ex vivo tissue specimen during surgery. This dissertation describes the development and application of ambient ionization MS methods for the investigation of various human diseases. Chapter 2 provides discussion on the robustness of DESI-MS for breast cancer tissue section evaluation and receptor status determination in a multi-center study, providing evidence of its potential use to compliment routine histopathological assessment. Chapter 3 describes the optimization of DESI-MS to expand the molecular information obtained from a single tissue section, demonstrating for the first time the detection of proteins directly from tissue sections by DESI-MS. Chapters 4 and 5 discuss the clinical translation of the MasSpec Pen into an operating room for feasibility testing as well as the evaluation of the technology for improving intraoperative surgical margin evaluation during breast cancer surgeries. Lastly, Chapter 6 discusses the modification of the MasSpec Pen to better analyze clinical nasal swabs and its application toward screening of COVID-19 disease using lipid information
Book Synopsis Forensic Mass Spectrometry by : Jehuda Yinon
Download or read book Forensic Mass Spectrometry written by Jehuda Yinon and published by Springer. This book was released on 1987-08-31 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Forensic Applications of Mass Spectrometry by : Jehuda Yinon
Download or read book Forensic Applications of Mass Spectrometry written by Jehuda Yinon and published by CRC Press. This book was released on 2020-11-25 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic Applications of Mass Spectrometry combines the most current developments in applications of mass spectrometry techniques to forensic analyses. The techniques discussed include: capillary-GC/MS thermospray-LC/MS tandem mass spectrometry (MS/MS) pyrolysis-GC/MS isotope ratio mass spectrometry The applications include: analysis of body fluids and hair for drugs of abuse drug testing in sports analysis of accelerants in fire debris detection of hidden explosives in luggage and mail identification of explosives in post-explosion debris examination of evidential materials (paints, fibers, synthetic polymers) authentication of regulated products (flavoring substances, fruit juices) protection of industrial products by isotopic signature
Book Synopsis Identification of Drugs by Chemical Ionization Mass Spectroscopy--Part II by : R. Saferstein
Download or read book Identification of Drugs by Chemical Ionization Mass Spectroscopy--Part II written by R. Saferstein and published by . This book was released on 1974 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic scientists are currently actively evaluating new instrumental techniques to determine their potential application for solving some of the problems that are unique to their field. Liquid chromatography, flameless atomic absorption, electron scanning microscopy, and thermal analysis offer fertile areas for research and development. Mass spectroscopy is by no means a new instrumental technique; its application to analytical organic chemistry has been well documented since the early 1960's [1-4]. Unfortunately, its utilization in the forensic sciences has been minimal up to the present. A major limitation has been the cost and complexity of the instrument. However, with increased fundings becoming available to many laboratories and with the improved engineering and reliability of the latest generation of mass spectrometers, this technique is becoming feasible for many forensic laboratories. Its application to forensic drug identification has been demonstrated in previous publications [5-8].
