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Author : Friederike Zunke
Publisher : Frontiers Media SA
ISBN 13 : 2889715728
Total Pages : 237 pages
Book Rating : 4.8/5 (897 download)
Download or read book Intracellular Mechanisms of α-Synuclein Processing written by Friederike Zunke and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jonas H. Ellenberg
Publisher : CRC Press
ISBN 13 : 9780824788230
Total Pages : 600 pages
Book Rating : 4.7/5 (882 download)
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Author : Fredric P. Manfredsson
Publisher : Frontiers Media SA
ISBN 13 : 2889636100
Total Pages : 151 pages
Book Rating : 4.8/5 (896 download)
Download or read book The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and its Role in Disease written by Fredric P. Manfredsson and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128159510
Total Pages : 764 pages
Book Rating : 4.1/5 (281 download)
Download or read book Genetics, Neurology, Behavior, and Diet in Parkinson's Disease written by Colin R Martin and published by Academic Press. This book was released on 2020-08-13 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease
Author : Sarika Singh
Publisher : Springer
ISBN 13 : 9811309442
Total Pages : 301 pages
Book Rating : 4.8/5 (113 download)
Download or read book Pathology, Prevention and Therapeutics of Neurodegenerative Disease written by Sarika Singh and published by Springer. This book was released on 2018-09-24 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases
Author : Mark Polizzi
Publisher :
ISBN 13 : 9781629484945
Total Pages : 86 pages
Book Rating : 4.4/5 (849 download)
Download or read book Alpha-Synuclein written by Mark Polizzi and published by . This book was released on 2013 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: Book Description: Alpha-synuclein is a synuclein protein of unknown function primarily found in neural tissue, making up as much as 1% of all proteins in the cytosol. It is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum. In this book, the authors discuss the functional mechanisms, structure and role in Parkinson's disease of alpha-synuclein. Topics include -synuclein accumulation in Parkinson's disease and multiple system atrophy; -synuclein metabolism and aggregation in the pathogenesis of Parkinson's disease; and the potential role of -synuclein dysregulation in Parkinson's disease pathology.
Author : Pingyi Xu
Publisher : Frontiers Media SA
ISBN 13 : 2889741435
Total Pages : 367 pages
Book Rating : 4.8/5 (897 download)
Download or read book Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease written by Pingyi Xu and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Howard C. Kanowitz
Publisher : Nova Science Pub Incorporated
ISBN 13 : 9781629484938
Total Pages : 61 pages
Book Rating : 4.4/5 (849 download)
Download or read book Alpha-synuclein written by Howard C. Kanowitz and published by Nova Science Pub Incorporated. This book was released on 2013-01-01 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alpha-synuclein is a synuclein protein of unknown function primarily found in neural tissue, making up as much as 1% of all proteins in the cytosol. It is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum. In this book, the authors discuss the functional mechanisms, structure and role in Parkinson's disease of alpha-synuclein. Topics include α-synuclein accumulation in Parkinsons disease and multiple system atrophy; α-synuclein metabolism and aggregation in the pathogenesis of Parkinsons disease; and the potential role of α-synuclein dysregulation in Parkinsons disease pathology.
Author : Neurosciences Institute (New York, N.Y.)
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 808 pages
Book Rating : 4.3/5 (91 download)
Download or read book Synaptic Function written by Neurosciences Institute (New York, N.Y.) and published by Wiley-Interscience. This book was released on 1987 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important relationship of transmitter diversity and synaptic types to the behavior of actual cellular networks. All of the studies described in these sections point to the necessity of considering interactions between anatomy, chemistry, physiology and pharmacology if synaptic function is to be understood at any one of these levels of analysis.
Author : Tim Bartels
Publisher : Humana Press
ISBN 13 : 9781493991235
Total Pages : 289 pages
Book Rating : 4.9/5 (912 download)
Download or read book Alpha-Synuclein written by Tim Bartels and published by Humana Press. This book was released on 2019-02-18 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the reader with detailed protocols that describe a variety of in vitro and in vivo techniques that study reductionist systems and human samples. The methods covered in this book explore a broad selection of topics such as functional aspects of alpha-synuclein biology, its lipid-interactions and misfolding, and functional deficits in cells and mice. Chapters also cover topics such as kinetic measurements of endocytosis and exocytosis in cultured neurons; electrochemiluminescence-based detection; yeast-based screens to target alpha-synuclein toxicity; mass-spectrometry of alpha-synuclein in rat cortical neurons; and expression and purification of untagged a-synuclein. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Alpha-Synuclein: Methods and Protocols is a valuable reference guide that aids researchers working on topics related to alpha-synuclein and its various aspects.
Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author : Michael J. Zigmond
Publisher : Elsevier
ISBN 13 : 0123982804
Total Pages : 823 pages
Book Rating : 4.1/5 (239 download)
Download or read book Neurobiology of Brain Disorders written by Michael J. Zigmond and published by Elsevier. This book was released on 2014-12-03 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material
Author :
Publisher : Elsevier
ISBN 13 : 0080522513
Total Pages : 713 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Zebrafish: Genetics, Genomics and Informatics written by and published by Elsevier. This book was released on 2004-12-30 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 1999. This second volume covers advances in forward and reverse genetic techniques, provides an update on the zebrafish genome and gene/mutant mapping technologies, examines the new systems for efficient transgenesis in the zebrafish, provides an in-depth view of informatics and the emerging field of comparative genomics, and considers the extensive infrastructure now available to the zebrafish community. * Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls * Illustrates many techiques in full-color * Summarizes the Zebrafish Genome Project
Author : William E. Schiesser
Publisher : Academic Press
ISBN 13 : 0128148020
Total Pages : 230 pages
Book Rating : 4.1/5 (281 download)
Download or read book ODE/PDE a-synuclein Models for Parkinson’s Disease written by William E. Schiesser and published by Academic Press. This book was released on 2018-02-13 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: ODE/PDE Alpha-Synuclein Models for Parkinson’s Disease discusses a mechanism for the evolution of Parkinson’s Disease (PD) based on the dynamics of the protein a-synuclein, a monomer that has been implicated in this disease. Specifically, a-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the a-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms Includes PDE routines based on the method of lines (MOL) for computer-based implementation of ODE/PDE models Offers transportable computer source codes for readers, with line-by-line code descriptions relating to the mathematical model and algorithms Authored by a leading researcher and educator in ODE/PDE models
Author : James M. Gruschus
Publisher : Academic Press
ISBN 13 : 0323899684
Total Pages : 314 pages
Book Rating : 4.3/5 (238 download)
Download or read book Synuclein and the Coelacanth written by James M. Gruschus and published by Academic Press. This book was released on 2021-01-31 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease. Proposes a new hypothesis on the origins of Parkinson’s disease Examines genetic risk factors, environmental toxins, and neuroanatomy of PD Highlights new therapeutic treatment options in development for patients
Author : Peter Riederer
Publisher : Springer Science & Business Media
ISBN 13 : 3211452958
Total Pages : 484 pages
Book Rating : 4.2/5 (114 download)
Download or read book Parkinson's Disease and Related Disorders written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2006-11-23 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.
Author : Uddin, Md. Sahab
Publisher : IGI Global
ISBN 13 : 1799813185
Total Pages : 515 pages
Book Rating : 4.7/5 (998 download)
Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2020-02-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
