Aging Mechanisms

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Aging Mechanisms

Author : Nozomu Mori
Publisher : Springer
ISBN 13 : 9784431566885
Total Pages : 0 pages
Book Rating : 4.5/5 (668 download)

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Book Synopsis Aging Mechanisms by : Nozomu Mori

Download or read book Aging Mechanisms written by Nozomu Mori and published by Springer. This book was released on 2019-03-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.

Brain Aging

Author : David R. Riddle
Publisher : CRC Press
ISBN 13 : 9781420005523
Total Pages : 408 pages
Book Rating : 4.0/5 (55 download)

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Book Synopsis Brain Aging by : David R. Riddle

Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Molecular Mechanisms of Aging

Author : Konrad Beyreuther
Publisher : Springer Science & Business Media
ISBN 13 : 3642842240
Total Pages : 206 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Molecular Mechanisms of Aging by : Konrad Beyreuther

Download or read book Molecular Mechanisms of Aging written by Konrad Beyreuther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms Linking Aging, Diseases and Biological Age Estimation

Author : Sara C. Zapico
Publisher : CRC Press
ISBN 13 : 1315354209
Total Pages : 200 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Mechanisms Linking Aging, Diseases and Biological Age Estimation by : Sara C. Zapico

Download or read book Mechanisms Linking Aging, Diseases and Biological Age Estimation written by Sara C. Zapico and published by CRC Press. This book was released on 2017-03-27 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

Human Aging

Author : Calogero Caruso
Publisher : Academic Press
ISBN 13 : 0128227370
Total Pages : 382 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Human Aging by : Calogero Caruso

Download or read book Human Aging written by Calogero Caruso and published by Academic Press. This book was released on 2021-05-11 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Aging Mechanisms

Author : Nozomu Mori
Publisher : Springer
ISBN 13 : 4431557636
Total Pages : 439 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Aging Mechanisms by : Nozomu Mori

Download or read book Aging Mechanisms written by Nozomu Mori and published by Springer. This book was released on 2015-11-26 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.

Aging Mechanisms II

Author : Nozomu Mori
Publisher : Springer Nature
ISBN 13 : 9811679770
Total Pages : 429 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Aging Mechanisms II by : Nozomu Mori

Download or read book Aging Mechanisms II written by Nozomu Mori and published by Springer Nature. This book was released on 2022-04-28 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area. As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.

Molecular Genetic Mechanisms in Development and Aging

Author : Morris Rockstein
Publisher :
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Genetic Mechanisms in Development and Aging by : Morris Rockstein

Download or read book Molecular Genetic Mechanisms in Development and Aging written by Morris Rockstein and published by . This book was released on 1972 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Genetic Mechanisms in Development and Aging ...

Handbook of the Biology of Aging

Author : Matt Kaeberlein
Publisher : Academic Press
ISBN 13 : 0124116205
Total Pages : 576 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Handbook of the Biology of Aging by : Matt Kaeberlein

Download or read book Handbook of the Biology of Aging written by Matt Kaeberlein and published by Academic Press. This book was released on 2015-08-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Science and the Navy

Author : Harvey M. Sapolsky
Publisher : Princeton University Press
ISBN 13 : 140086092X
Total Pages : 159 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Science and the Navy by : Harvey M. Sapolsky

Download or read book Science and the Navy written by Harvey M. Sapolsky and published by Princeton University Press. This book was released on 2014-07-14 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing all those interested in the history of American science and concerned with its future, a leading scholar of public policy explains how and why the Office of Naval Research became the first federal agency to support a wide range of scientific work in universities. Harvey Sapolsky shows that the ONR functioned as a "surrogate national science foundation" between 1946 and 1950 and argues that its activities emerged not from any particularly enlightened position but largely from a bureaucratic accident. Once involved with basic research, however, the ONR challenged a Navy skeptical of the value of independent scientific advice and established a national security rationale that gave American science its Golden Age. Eventually, the ONR's autonomy was worn away in bureaucratic struggles, but Sapolsky demonstrates that its experience holds lessons for those who are committed to the effective management of science and interested in the ability of scientists to choose the directions for their research. As military support for basic research fades, scientists are discovering that they are unprotected from the vagaries of distributive politics. Originally published in 1990. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

The Cambridge Handbook of Cognitive Aging

Author : Ayanna K. Thomas
Publisher : Cambridge University Press
ISBN 13 : 1108690742
Total Pages : 1019 pages
Book Rating : 4.1/5 (86 download)

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Book Synopsis The Cambridge Handbook of Cognitive Aging by : Ayanna K. Thomas

Download or read book The Cambridge Handbook of Cognitive Aging written by Ayanna K. Thomas and published by Cambridge University Press. This book was released on 2020-05-28 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.

Times, Cells, and Aging

Author : Bernard Strihler
Publisher : Academic Press
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Times, Cells, and Aging by : Bernard Strihler

Download or read book Times, Cells, and Aging written by Bernard Strihler and published by Academic Press. This book was released on 1977-01-28 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Insect Aging

Author : Klaus-Günter Collatz
Publisher : Springer Science & Business Media
ISBN 13 : 3642708536
Total Pages : 249 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Insect Aging by : Klaus-Günter Collatz

Download or read book Insect Aging written by Klaus-Günter Collatz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Leben ist die schonste Erfindung der Natur und der Tod ist ihr Kunstgriff, viel Leben zu haben" . J. W. v. Goethe Life is the most beautiful invention of nature, and death is her device to exhibit most life. The eminent British biologist Sir Vincent B. Wigglesworth noted in 1939 that insects are an ideal medium in which to study all problems of physiology. Many fundamental discoveries in biology, particularly genetics and development, have been made on the basis of studies conducted in insects. Because of their ex treme adaptability and diversity, an appropriate insect model is available for the study of virtually any biological problems. The applicability to other groups, including mammals, of basic studies conducted on insects has helped in the gradual acceptance of the fundamental unity of biochemical principles as a dogma among biologists, as well as among enlightened medical scientists. With the recent upsurge of interest in the study of the aging process, in sects have been increasingly employed not only for the investigation of basic mechanisms of aging, but also to gain insight into the evolution of aging and senescence. If only one aging mechanism exists, it is foreseeable that some in sects, especially Drosophila, will help to unravel its molecular basis. Because of their diversity, existing studies in the gerontology of insects are widely scat tered in various specialized journals. This wealth of existing information has not, as yet, been brought together in a synthesized and comprehensive form.

Epigenetics of Aging and Longevity

Author : Alexey Moskalev
Publisher : Academic Press
ISBN 13 : 012811083X
Total Pages : 544 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Epigenetics of Aging and Longevity by : Alexey Moskalev

Download or read book Epigenetics of Aging and Longevity written by Alexey Moskalev and published by Academic Press. This book was released on 2017-11-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Neuroregulatory Mechanisms in Aging

Author : G. B. Stefano
Publisher : Pergamon
ISBN 13 : 1483287742
Total Pages : 223 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Neuroregulatory Mechanisms in Aging by : G. B. Stefano

Download or read book Neuroregulatory Mechanisms in Aging written by G. B. Stefano and published by Pergamon. This book was released on 1993-11-24 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroregulatory Mechanisms in Aging.

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Author : Hartmut Geiger
Publisher : Springer
ISBN 13 : 370911232X
Total Pages : 354 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Stem Cell Aging: Mechanisms, Consequences, Rejuvenation by : Hartmut Geiger

Download or read book Stem Cell Aging: Mechanisms, Consequences, Rejuvenation written by Hartmut Geiger and published by Springer. This book was released on 2015-07-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

The Future of Human Healthspan

Author : The National Academies
Publisher : National Academies Press
ISBN 13 : 0309178223
Total Pages : 140 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Future of Human Healthspan by : The National Academies

Download or read book The Future of Human Healthspan written by The National Academies and published by National Academies Press. This book was released on 2008-04-24 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: An individual's healthspan can be defined as the length of time an individual is able to maintain good health. In 2007, over one hundred experts and researchers from public and private institutions across the nation convened to find new ways of addressing the human healthspan and the elusive nature of aging. Experts in public health, bioengineering, neuroscience and gerontology discussed how stress and lifestyle influence the decline of health at older ages. Other discussions focused on the integration of technology in the quality of life, gerontology, regenerative medicine and life expectancy with regard to social and behavioral traits. Still, other groups explored topics such as the cellular and molecular mechanisms of biological aging, the effects of exercise on the human healthspan, and changes in social context to enhance functional status of the elderly. Most importantly, experts agreed that it was imperative to ensure that the elderly have access to medical services by establishing relationships with health care and insurance providers.