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Author : Phillip I. Good
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (31 download)
Download or read book Aging in Mammalian Cell Populations written by Phillip I. Good and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Rothenberg Kohn
Publisher : Prentice Hall
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (45 download)
Download or read book Principles of Mammalian Aging written by Robert Rothenberg Kohn and published by Prentice Hall. This book was released on 1978 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alvaro Macieira-Coelho
Publisher : Springer Science & Business Media
ISBN 13 : 3642189946
Total Pages : 198 pages
Book Rating : 4.6/5 (421 download)
Download or read book Biology of Aging written by Alvaro Macieira-Coelho and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.
Author : Kunio Ōta
Publisher : Springer
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (45 download)
Download or read book Aging Phenomena written by Kunio Ōta and published by Springer. This book was released on 1980-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been felt by some gerontologists that it was time for the various specialists to step back and take a generalist view of gerontology, to reconsider and reevaluate the fruits of their analytical pursuits at different levels within a broader context. Some others may think it still premature. It seemed, however, that the majority of those who gathered in Tokyo on the occasion of the XIth International Congress of Gerontology were of the opinion that there was much to be gained in looking for interrelationships among the facts and theories originated in the different levels of investigation in an attempt to observe and appreciate the biological drama of senescence as an entity. In spite of the unusual late summer heat and heavy schedules during the post-congress period, the Naito Symposium was attended by no less than 170 people from a variety of disciplines.
Author : Norman S. Wolf
Publisher : Springer Science & Business Media
ISBN 13 : 904813465X
Total Pages : 397 pages
Book Rating : 4.0/5 (481 download)
Download or read book Comparative Biology of Aging written by Norman S. Wolf and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].
Author : Gil Atzmon, PhD
Publisher : Springer
ISBN 13 : 1493924044
Total Pages : 199 pages
Book Rating : 4.4/5 (939 download)
Download or read book Longevity Genes written by Gil Atzmon, PhD and published by Springer. This book was released on 2015-04-27 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171431
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cells and Surveys written by National Research Council and published by National Academies Press. This book was released on 2001-01-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.
Author : Caleb Finch
Publisher : Van Nostrand Reinhold Company
ISBN 13 :
Total Pages : 1062 pages
Book Rating : 4.F/5 ( download)
Download or read book Handbook of the Biology of Aging written by Caleb Finch and published by Van Nostrand Reinhold Company. This book was released on 1985 with total page 1062 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alex Comfort
Publisher : CreateSpace
ISBN 13 : 9781456392420
Total Pages : 274 pages
Book Rating : 4.3/5 (924 download)
Download or read book The Biology of Senescence written by Alex Comfort and published by CreateSpace. This book was released on 2010-11-25 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology of Senescence
Author : Juan Carlos Gomez-Verjan
Publisher : Springer Nature
ISBN 13 : 3030409554
Total Pages : 274 pages
Book Rating : 4.0/5 (34 download)
Download or read book Clinical Genetics and Genomics of Aging written by Juan Carlos Gomez-Verjan and published by Springer Nature. This book was released on 2020-04-13 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.
Author : Alvaro Macieira-Coelho
Publisher : CRC Press
ISBN 13 : 1351359975
Total Pages : 577 pages
Book Rating : 4.3/5 (513 download)
Download or read book Molecular Basis of Aging written by Alvaro Macieira-Coelho and published by CRC Press. This book was released on 2017-11-22 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a new, integrative approach, Molecular Basis of Aging describes the aging phenomenon within mammalian organisms from the perspective of changes in information storage and coordination between hierarchical orders of structure. This unique approach provides the reader with a thorough insight into the evolution of molecular, cellular, tissue, and organ systems and processes in mammals. This informative volume contains up-to-date reviews of:
Author : Michael Breitenbach
Publisher : Springer Science & Business Media
ISBN 13 : 9400725612
Total Pages : 373 pages
Book Rating : 4.4/5 (7 download)
Download or read book Aging Research in Yeast written by Michael Breitenbach and published by Springer Science & Business Media. This book was released on 2011-11-19 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
Author :
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.:/5 (311 download)
Download or read book Cellular Ageing, Concepts, and Mechanisms written by and published by . This book was released on 1976 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
ISBN 13 : 1441906398
Total Pages : 462 pages
Book Rating : 4.4/5 (419 download)
Download or read book Epigenetics of Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Author :
Publisher :
ISBN 13 :
Total Pages : 588 pages
Book Rating : 4.3/5 (91 download)
Download or read book Frontiers in Aging Research written by and published by . This book was released on 1979 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Burnet MacFarlane
Publisher : Springer Science & Business Media
ISBN 13 : 9401166064
Total Pages : 245 pages
Book Rating : 4.4/5 (11 download)
Download or read book Intrinsic mutagenesis written by Burnet MacFarlane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.
Author : Warren W. Nichols
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.3/5 (91 download)
Download or read book Differentiated Cells in Aging Research written by Warren W. Nichols and published by . This book was released on 1979 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
