Ageing The Biology Of Senescence

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The Biology of Senescence

Author : Bernard Swynghedauw
Publisher : Springer
ISBN 13 : 9783030151133
Total Pages : 0 pages
Book Rating : 4.1/5 (511 download)

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Book Synopsis The Biology of Senescence by : Bernard Swynghedauw

Download or read book The Biology of Senescence written by Bernard Swynghedauw and published by Springer. This book was released on 2020-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

The Biology of Senescence

Author : Alex 1920- Comfort
Publisher : Hassell Street Press
ISBN 13 : 9781014542403
Total Pages : 282 pages
Book Rating : 4.5/5 (424 download)

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Book Synopsis The Biology of Senescence by : Alex 1920- Comfort

Download or read book The Biology of Senescence written by Alex 1920- Comfort and published by Hassell Street Press. This book was released on 2021-09-09 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

Author : J. Robin Harris
Publisher : Springer
ISBN 13 : 9811328358
Total Pages : 526 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Biochemistry and Cell Biology of Ageing: Part I Biomedical Science by : J. Robin Harris

Download or read book Biochemistry and Cell Biology of Ageing: Part I Biomedical Science written by J. Robin Harris and published by Springer. This book was released on 2019-02-18 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Cellular Ageing and Replicative Senescence

Author : Suresh I.S. Rattan
Publisher : Springer
ISBN 13 : 3319262394
Total Pages : 364 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Cellular Ageing and Replicative Senescence by : Suresh I.S. Rattan

Download or read book Cellular Ageing and Replicative Senescence written by Suresh I.S. Rattan and published by Springer. This book was released on 2016-05-09 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

The Biology of Senescence

Author : Alex Comfort
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Biology of Senescence by : Alex Comfort

Download or read book The Biology of Senescence written by Alex Comfort and published by Elsevier Publishing Company. This book was released on 1979 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Times, Cells, and Aging

Author : Bernard Strihler
Publisher : Academic Press
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Times, Cells, and Aging by : Bernard Strihler

Download or read book Times, Cells, and Aging written by Bernard Strihler and published by Academic Press. This book was released on 1977-01-28 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

The Biology of Senescence

Author : Bernard Swynghedauw
Publisher :
ISBN 13 : 9783030151126
Total Pages : 121 pages
Book Rating : 4.1/5 (511 download)

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Book Synopsis The Biology of Senescence by : Bernard Swynghedauw

Download or read book The Biology of Senescence written by Bernard Swynghedauw and published by . This book was released on 2019 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

An Introduction to Gerontology

Author : Ian Stuart-Hamilton
Publisher : Cambridge University Press
ISBN 13 : 1139500171
Total Pages : 459 pages
Book Rating : 4.1/5 (395 download)

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Book Synopsis An Introduction to Gerontology by : Ian Stuart-Hamilton

Download or read book An Introduction to Gerontology written by Ian Stuart-Hamilton and published by Cambridge University Press. This book was released on 2011-03-31 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the world's population getting increasingly older, there has never been a more pressing need for the study of old age and ageing. An Introduction to Gerontology provides a wide-ranging introduction to this important topic. By assuming no prior expert knowledge and avoiding jargon, this book will guide students through all the main subjects in gerontology, covering both traditional areas, such as biological and social ageing, and more contemporary areas, such as technology, the arts and sexuality. An Introduction to Gerontology is written by a team of international authors with multidisciplinary backgrounds who draw evidence from a variety of different perspectives and traditions.

The Biology of Aging

Author : John A. Behnke
Publisher : Springer Science & Business Media
ISBN 13 : 1461339944
Total Pages : 388 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis The Biology of Aging by : John A. Behnke

Download or read book The Biology of Aging written by John A. Behnke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Egocentricity is characteristically human. It is natural for our prime in terest to be ourselves and for one of our major concerns to be what affects us personally. Aging and death - universal and inevitable have always been of compelling concern. Mystical explanations were invented when scientific answers were lacking. and gross physiologi As scientific knowledge developed, anatomy cal processes were explained, and the roles of the endocrine glands were revealed. Since the sex hormones obviously lose some of their potency with age, it was logical to assume that they played the major role in declining general well-being. The puzzle of aging would now be solved. The Ponce de Leon quest would soon be fulfilled. Pseudoscientists and quacks rushed in where most scientists feared to tread. By the time the glowing promises of perpetual youth through gland transplants and injections had proved illusory, serious study of the aging process had been set back for years. The field had lost "respect ability," and most capable scientists shunned it. Those who did con tinue to seek answers to its tough questions deserve special recognition.

The Evolution of Senescence in the Tree of Life

Author : Richard P. Shefferson
Publisher : Cambridge University Press
ISBN 13 : 1108138608
Total Pages : 445 pages
Book Rating : 4.1/5 (81 download)

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Book Synopsis The Evolution of Senescence in the Tree of Life by : Richard P. Shefferson

Download or read book The Evolution of Senescence in the Tree of Life written by Richard P. Shefferson and published by Cambridge University Press. This book was released on 2017-02-23 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The existing theories on the evolution of senescence assume that senescence is inevitable in all organisms. However, recent studies have shown that this is not necessarily true. A better understanding of senescence and its underlying mechanisms could have far-reaching consequences for conservation and eco-evolutionary research. This book is the first to offer interdisciplinary perspectives on the evolution of senescence in many species, setting the stage for further developments. It brings together new insights from a wide range of scientific fields and cutting-edge research done on a multitude of different animals (including humans), plants and microbes, giving the reader a complete overview of recent developments and of the controversies currently surrounding the topic. Written by specialists from a variety of disciplines, this book is a valuable source of information for students and researchers interested in ageing and life history traits and populations.

Handbook of the Biology of Aging

Author : Matt Kaeberlein
Publisher : Academic Press
ISBN 13 : 0124116205
Total Pages : 576 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Handbook of the Biology of Aging by : Matt Kaeberlein

Download or read book Handbook of the Biology of Aging written by Matt Kaeberlein and published by Academic Press. This book was released on 2015-08-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Oxford Textbook of Old Age Psychiatry

Author : Tom Dening
Publisher : Oxford University Press, USA
ISBN 13 : 0198807295
Total Pages : 961 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Old Age Psychiatry by : Tom Dening

Download or read book Oxford Textbook of Old Age Psychiatry written by Tom Dening and published by Oxford University Press, USA. This book was released on 2020-11-05 with total page 961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the authoritative Oxford Textbooks in Psychiatry series, Oxford Textbook of Old Age Psychiatry, Third Edition has been thoroughly updated to reflect the developments in old age psychiatry since publication of the Second Edition in 2013, and remains an essential reference for anyone interested in the mental health care of older people.

Senescence and Aging in Plants

Author : L.D. Nooden
Publisher : Elsevier
ISBN 13 : 0323145957
Total Pages : 564 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Senescence and Aging in Plants by : L.D. Nooden

Download or read book Senescence and Aging in Plants written by L.D. Nooden and published by Elsevier. This book was released on 2012-12-02 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Senescence and Aging in Plants reviews the state of knowledge in the processes involved in plant senescence and aging. The book begins by discussing the emergence of senescence as a concept; experimental analysis of senescence; and patterns of senescence. It then examines membrane deterioration during senescence; photosynthesis in relation to leaf senescence; senescence of detached plant organs; changing patterns of nucleic acid and protein synthesis during senescence; and degradative and associated assimilatory aspects of nitrogen removal. This is followed by chapters on aspects of ethylene that may impinge upon its role in promoting senescence of higher plants; the role of cytokinins in plant senescence; the promoters and retardants of senescence; and the role of calcium in plant senescence. The concept of whole plant senescence is discussed, which can be subdivided into patterns, correlative controls, cessation of vegetative growth, declining assimilatory processes, assimilate partitioning, and hormonal controls. The final chapters cover the deterioration of cellular membranes during the plant aging process and seed aging.

Epigenetics of Aging

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
ISBN 13 : 1441906398
Total Pages : 469 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Epigenetics of Aging by : Trygve O. Tollefsbol

Download or read book Epigenetics of Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Biology of Ageing

Author : Marion J. Lamb
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biology of Ageing by : Marion J. Lamb

Download or read book Biology of Ageing written by Marion J. Lamb and published by . This book was released on 1977 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Aging

Author : Calogero Caruso
Publisher : Academic Press
ISBN 13 : 0128227370
Total Pages : 382 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Human Aging by : Calogero Caruso

Download or read book Human Aging written by Calogero Caruso and published by Academic Press. This book was released on 2021-05-11 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Longevity, Senescence, and the Genome

Author : Caleb E. Finch
Publisher : University of Chicago Press
ISBN 13 : 9780226248899
Total Pages : 948 pages
Book Rating : 4.2/5 (488 download)

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Book Synopsis Longevity, Senescence, and the Genome by : Caleb E. Finch

Download or read book Longevity, Senescence, and the Genome written by Caleb E. Finch and published by University of Chicago Press. This book was released on 1994-05-16 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.