Advances In Epithelial Mesenchymal Transitions

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Advances in Epithelial-mesenchymal Transitions

Author : Erik W. Thompson
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805582520
Total Pages : 0 pages
Book Rating : 4.5/5 (825 download)

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Book Synopsis Advances in Epithelial-mesenchymal Transitions by : Erik W. Thompson

Download or read book Advances in Epithelial-mesenchymal Transitions written by Erik W. Thompson and published by S. Karger AG (Switzerland). This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of epithelial-mesenchymal transitions (EMT) has brought valuable insights to the study of complex processes involved in early embryo development, wound healing, carcinoma progression or kidney fibrosis. Major advances are reported in identifying new model systems, transcriptional regulators (including chromatin structure and microRNA), specific signaling pathways, and effector molecules. In this special issue, recent developments in the EMT field are reviewed, including the first localizations of Snail proteins in human cancers. Snail signaling and targets are carefully explored in several systems. Another emerging signaling pathway discussed involves TGF-beta. Several new concepts are consolidated including partial EMT, resulting in a metastable phenotype in cancer systems, and reversed EMT, described during bladder cancer progression as a mesenchymal-epithelial transition. Some of the papers focus on the first therapeutic approaches and different microarray analysis approaches specifically targeting the EMT process. Basic and clinical reseachers, clinicians as well as graduate and PhD students in the fields of cell and developmental biology, oncology and nephrology will appreciate this multidisciplinary and up-to-date overview of the EMT process.

Epithelial-mesenchymal Transitions

Author :
Publisher :
ISBN 13 :
Total Pages : 133 pages
Book Rating : 4.:/5 (7 download)

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Book Synopsis Epithelial-mesenchymal Transitions by :

Download or read book Epithelial-mesenchymal Transitions written by and published by . This book was released on 2011 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Epithelial-mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer

Author : Erik W. Thompson
Publisher :
ISBN 13 : 9783805596213
Total Pages : 0 pages
Book Rating : 4.5/5 (962 download)

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Book Synopsis Epithelial-mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer by : Erik W. Thompson

Download or read book Epithelial-mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer written by Erik W. Thompson and published by . This book was released on 2010-12-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue represents a progression through signaling processes, development, fibrosis and cancer, illustrating common underlying mechanisms and highlighting the growing recognition of therapeutic possibilities. Novel molecular pathways are shown in the context of known regulators, and many articles offer specific insights into therapeutic targeting. Not surprisingly, several articles relate to the signaling pathways activated by the common anchor transforming growth factor (TGF)-beta in relation to epithelial-mesenchymal transition (EMT). A number of new mechanisms with therapeutic implications are described, specifically the interplay between the non-Smad PI3 kinase-Akt-mTOR axis and EMT-associated invasion in response to TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced EMT, the cooperativity between oncostatin M, hepatocyte growth factor and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and periostin in developmental EMT associated with gastrulation and palate fusion, respectively. Collectively, the issue presents the full spectrum of interest in EMT today.

The Epithelial-to-Mesenchymal Transition (EMT) in Cancer

Author : Joëlle Roche
Publisher : MDPI
ISBN 13 : 3038427934
Total Pages : 261 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis The Epithelial-to-Mesenchymal Transition (EMT) in Cancer by : Joëlle Roche

Download or read book The Epithelial-to-Mesenchymal Transition (EMT) in Cancer written by Joëlle Roche and published by MDPI. This book was released on 2018-04-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers

Epithelial-Mesenchymal Transitions

Author : D. F. Newgreen
Publisher :
ISBN 13 : 9783318059809
Total Pages : 0 pages
Book Rating : 4.0/5 (598 download)

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Book Synopsis Epithelial-Mesenchymal Transitions by : D. F. Newgreen

Download or read book Epithelial-Mesenchymal Transitions written by D. F. Newgreen and published by . This book was released on 2017-02-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special topic issue presents a selection of papers from the International EMT meeting held in Melbourne, October, 2015. The recent TEMTIA meetings have identified the emerging trends of big data and complex systems biology. A specific focus is on the positive impact that new methods of systems analysis can have on identifying novel regulators of EMT. There is also emphasis on the utility of mathematical models for assessing potential effects of EMT on the emergent behavior of tissues and in discriminating between stochastic and deterministic processes. Rather than the traditional bastions of EMT, such as development, cancer, fibrosis, wound healing, etc., the TEMTIA-VII session themes were based on concepts such as plasticity, stemness and self-renewal, signalling networks and transcription factors, and systems biology.

Recent Progress in Epithelial-Mesenchymal Transitions

Author : Donald F. Newgreen
Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805579278
Total Pages : 0 pages
Book Rating : 4.5/5 (792 download)

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Book Synopsis Recent Progress in Epithelial-Mesenchymal Transitions by : Donald F. Newgreen

Download or read book Recent Progress in Epithelial-Mesenchymal Transitions written by Donald F. Newgreen and published by S. Karger AG (Switzerland). This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of the epithelial-mesenchymal transition (EMT) provides a basis for understanding complex changes in gene expression, molecular function and cell behaviour. This field has undergone explosive growth in the last few years as the concept has spread from developmental biology to the pathologies of cancer and fibrosis. As scientists are on the verge of being able to control or mitigate the process of EMT in some pathological conditions, understanding of its fundamental mechanisms is of vital importance. This special issue brings together selected reviews and new data from the Boden Conference on Epithelial-Mesenchymal Transitions. The reviews highlight developmental, cancer and pathological EMTs, and are rich in detail at the cell and molecular levels. The publication is aimed at cancer biologists, pathologists and developmental biologists who are interested in why cells begin to move, and the genes and molecules involved in this process.

Epithelial-Mesenchymal Transitions

Author : Don Newgreen
Publisher : S Karger Ag
ISBN 13 : 9783805564359
Total Pages : 0 pages
Book Rating : 4.5/5 (643 download)

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Book Synopsis Epithelial-Mesenchymal Transitions by : Don Newgreen

Download or read book Epithelial-Mesenchymal Transitions written by Don Newgreen and published by S Karger Ag. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transitions between the epithelial and mesenchymal states are among the most basic of cellular events. They underpin major changes in animal development and in cancer progression. This publication is the second of two special issues of ACTA ANATOMICA presenting recent advances in understanding these transitions. The first volume gave an overview of epithelial-mesenchymal transitions, provided reviews of the molecular systems involved and presented two important developmental examples. The present volume continues and complements this, providing reviews from distinguished researchers exploring novel relationships of protease-like molecules to epithelial-mesenchymal transitions, and detailing such transitions in heart development, in trophoblast invasion, in cancer and in tissue culture model systems, as well as changes in the reverse direction in kidney development. This publication and its predecessor are required reading for cell and developmental biologists and oncologists.

Advances in Modelling of Epithelial to Mesenchymal Transition

Author : Tariq Abdulla
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (872 download)

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Book Synopsis Advances in Modelling of Epithelial to Mesenchymal Transition by : Tariq Abdulla

Download or read book Advances in Modelling of Epithelial to Mesenchymal Transition written by Tariq Abdulla and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Epithelial-to Mesenchymal Transition

Author : Kyra Campbell
Publisher :
ISBN 13 : 9781071607817
Total Pages : pages
Book Rating : 4.6/5 (78 download)

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Book Synopsis The Epithelial-to Mesenchymal Transition by : Kyra Campbell

Download or read book The Epithelial-to Mesenchymal Transition written by Kyra Campbell and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hyaluronan in Cancer Biology

Author : Robert Stern
Publisher : Academic Press
ISBN 13 : 0080921086
Total Pages : 467 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Hyaluronan in Cancer Biology by : Robert Stern

Download or read book Hyaluronan in Cancer Biology written by Robert Stern and published by Academic Press. This book was released on 2009-03-07 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Epithelial-Mesenchymal Plasticity in Cancer Metastasis

Author : Mohit Kumar Jolly
Publisher : MDPI
ISBN 13 : 3039367242
Total Pages : 512 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Epithelial-Mesenchymal Plasticity in Cancer Metastasis by : Mohit Kumar Jolly

Download or read book Epithelial-Mesenchymal Plasticity in Cancer Metastasis written by Mohit Kumar Jolly and published by MDPI. This book was released on 2020-12-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Author :
Publisher : Academic Press
ISBN 13 : 0128137541
Total Pages : 310 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Targeting Cell Survival Pathways to Enhance Response to Chemotherapy by :

Download or read book Targeting Cell Survival Pathways to Enhance Response to Chemotherapy written by and published by Academic Press. This book was released on 2018-03-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials

Cell & Molecular Biology of Prostate Cancer

Author : Heide Schatten
Publisher : Springer
ISBN 13 : 3319956930
Total Pages : 135 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Cell & Molecular Biology of Prostate Cancer by : Heide Schatten

Download or read book Cell & Molecular Biology of Prostate Cancer written by Heide Schatten and published by Springer. This book was released on 2018-09-18 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Drug Repurposing in Cancer Therapy

Author : Kenneth K.W. To
Publisher : Academic Press
ISBN 13 : 0128199032
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug Repurposing in Cancer Therapy by : Kenneth K.W. To

Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Rise and Fall of Epithelial Phenotype

Author : Pierre Savagner
Publisher : Springer Science & Business Media
ISBN 13 : 0387286713
Total Pages : 341 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Rise and Fall of Epithelial Phenotype by : Pierre Savagner

Download or read book Rise and Fall of Epithelial Phenotype written by Pierre Savagner and published by Springer Science & Business Media. This book was released on 2007-07-05 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

Epithelial-mesanchymal Interactions

Author : Raul Fleischmajer (ed)
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Epithelial-mesanchymal Interactions by : Raul Fleischmajer (ed)

Download or read book Epithelial-mesanchymal Interactions written by Raul Fleischmajer (ed) and published by . This book was released on 1968 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advanced Healthcare Materials

Author : Ashutosh Tiwari
Publisher : John Wiley & Sons
ISBN 13 : 1118773683
Total Pages : 421 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Advanced Healthcare Materials by : Ashutosh Tiwari

Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers