A Potential Therapeutic Role Of J Series Prostaglandins In Ppar Gamma Mediated Treatment Of Breast Cancer

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A Potential Therapeutic Role of J Series Prostaglandins in PPAR-gamma Mediated Treatment of Breast Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis A Potential Therapeutic Role of J Series Prostaglandins in PPAR-gamma Mediated Treatment of Breast Cancer by :

Download or read book A Potential Therapeutic Role of J Series Prostaglandins in PPAR-gamma Mediated Treatment of Breast Cancer written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Naturally occurring derivatives of arachidonic acid metabolism are potent and effective activators of PPAR-gamma. The most potent of these derivatives is 15deoxy-delta(12,14)PGJ2 (15dPGJ2), the dehydration and isomerization product of prostaglandin D2 (PGD2). 15dPGJ2 induces PPAR-gamma mediated transcriptional activation leading to the synthesis of critical gene products involved in cell cycle arrest and apoptosis. of these gene products, expression of the cyclin dependent kinase inhibitors, p21 and p27, is associated with marked cell cycle arrest with subsequent apoptosis involving caspase-3. However, apoptosis induced by 15dPGJ2 is unlikely to be PPAR-gamma mediated as demonstrated by studies with dominant negative forms of this receptor. To further elucidate how AA derivatives such as 15dPGJ2 induce apoptosis in breast cancer cells investigations into AA metabolic pathways were undertaken. We demonstrate that intracellular accumulation of AA induces apoptosis in cancer cells by activating the AP-1 family of nuclear transcription factors. Given the anti-cancer efficacy of therapies which alter AA metabolism, such as NSAIDs, further investigation into 15dPGJ2 and other facets of the AA metabolic pathway are warranted.

A Potential Therapeutic Role of J Series Prostaglandins in PPARy Mediated Treatment of Breast Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis A Potential Therapeutic Role of J Series Prostaglandins in PPARy Mediated Treatment of Breast Cancer by :

Download or read book A Potential Therapeutic Role of J Series Prostaglandins in PPARy Mediated Treatment of Breast Cancer written by and published by . This book was released on 2002 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peroxisome proliferator activated receptor gamma (PPAR gamma), is a potential therapeutic target for the treatment of breast cancer but the endogenous ligand for PPAR gamma is not yet known. Recent data suggest that the endogenous ligand of PPAR gamma may be a bioactive metabolite of arachidonic acid that is synthesized in normal breast tissue. Activation of PPAR gamma with different agonists (e.g. l5deoxy delta l2,l4PGJ2, troglitazone) elicits different physiological responses in breast cancer cells (i.e. differentiation or apoptosis) raising questions of the role PPARy plays in normal breast cell physiology. Results from our initial experiments show that prostaglandin metabolites of arachidonic acid inhibit cell cycle progression of MDA-MB-231 breast cancer cells. This cell cycle block induces apoptosis of breast cancer cells and inhibits tumor formation in nude mice. We hypothesize that human breast cancer cell lines (and human breast cancer tumors) have aberrant PPAR gamma mediated signal transduction pathways or contain disrupted pathways for the metabolism of fatty acid derivatives that act as PPAR gamma agonists. Understanding the metabolism of fatty acids in breast cancer cells, and elucidating the molecular and signal transduction events that are mediated by PPARy agonists may lead to novel strategies for the prevention and treatment of breast cancer.

Apoptosis in Carcinogenesis and Chemotherapy

Author : George G. Chen
Publisher : Springer Science & Business Media
ISBN 13 : 140209597X
Total Pages : 396 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Apoptosis in Carcinogenesis and Chemotherapy by : George G. Chen

Download or read book Apoptosis in Carcinogenesis and Chemotherapy written by George G. Chen and published by Springer Science & Business Media. This book was released on 2009-02-22 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

Inflammation and Cancer

Author : Bharat B. Aggarwal
Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal

Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1848 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1848 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxidative Stress in Cancer Biology and Therapy

Author : Douglas R. Spitz
Publisher : Springer Science & Business Media
ISBN 13 : 1617793973
Total Pages : 465 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Oxidative Stress in Cancer Biology and Therapy by : Douglas R. Spitz

Download or read book Oxidative Stress in Cancer Biology and Therapy written by Douglas R. Spitz and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

COX-2 Blockade in Cancer Prevention and Therapy

Author : Randall E. Harris
Publisher : Springer Science & Business Media
ISBN 13 : 159259302X
Total Pages : 641 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis COX-2 Blockade in Cancer Prevention and Therapy by : Randall E. Harris

Download or read book COX-2 Blockade in Cancer Prevention and Therapy written by Randall E. Harris and published by Springer Science & Business Media. This book was released on 2002-10-03 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis.

Healthful Lipids

Author : Casimir C. Akoh
Publisher : CRC Press
ISBN 13 : 143982228X
Total Pages : 762 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Healthful Lipids by : Casimir C. Akoh

Download or read book Healthful Lipids written by Casimir C. Akoh and published by CRC Press. This book was released on 2019-05-08 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthful Lipids addresses critical and current regulatory issues and emerging technologies, as well as the efforts made toward the production of healthier lipids. This book examines the latest technological advancements and the emerging technologies in processing and analysis, health-related concerns, and strategies used in the production and appl

Modification of Radiation Response

Author : Carsten Nieder
Publisher : Springer Science & Business Media
ISBN 13 : 3642556132
Total Pages : 308 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Modification of Radiation Response by : Carsten Nieder

Download or read book Modification of Radiation Response written by Carsten Nieder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects.

Breast Cancer

Author : Phuc Van Pham
Publisher : BoD – Books on Demand
ISBN 13 : 9535129996
Total Pages : 570 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Breast Cancer by : Phuc Van Pham

Download or read book Breast Cancer written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

Cardiovascular Disease

Author : BNF (British Nutrition Foundation)
Publisher : John Wiley & Sons
ISBN 13 : 1118829913
Total Pages : 552 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Cardiovascular Disease by : BNF (British Nutrition Foundation)

Download or read book Cardiovascular Disease written by BNF (British Nutrition Foundation) and published by John Wiley & Sons. This book was released on 2019-05-06 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, accessible summary of the latest research in heart disease risk factors Cardiovascular Disease (CVD) is a major cause of early death and disability across the world. The major markers of risk—including high blood cholesterol, smoking, and obesity—are well known, but studies show that such markers do not account for all cardiovascular risk. Written by a team of renowned experts in the field, this comprehensive and accessible book examines the evidence for emerging and novel risk factors, and their relationship with diet and nutrition. Fully updated throughout, Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition covers everything from the epidemiology of cardiovascular disease, to genetic factors, to inflammation and much more – offering invaluable advice on reducing risk factors and preventing CVD. This new edition: Authoritatively reports on the link between emerging aspects of diet, lifestyle and cardiovascular disease risk Focuses on novel risk factors of CVD, including the human gut microbiome and fetal and childhood origins, and how it can be prevented Features recommendations for interventions and future research Includes references, commonly asked questions that summarise the take-home messages, and an online glossary Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition is an important book for researchers and postgraduate students in nutrition, dietetics, food science, and medicine, as well as for cardiologists and cardiovascular specialists.

The Resolution of Inflammation

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis The Resolution of Inflammation by : Adriano Rossi

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Obesity and Lipotoxicity

Author : Ayse Basak Engin
Publisher : Springer
ISBN 13 : 331948382X
Total Pages : 618 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Obesity and Lipotoxicity by : Ayse Basak Engin

Download or read book Obesity and Lipotoxicity written by Ayse Basak Engin and published by Springer. This book was released on 2017-06-05 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Lipid Mediators

Author : Fiona M. Cunningham
Publisher :
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Lipid Mediators by : Fiona M. Cunningham

Download or read book Lipid Mediators written by Fiona M. Cunningham and published by . This book was released on 1994 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of lipid mediators from synthesis to inhibition. It addresses the immune system and its diseases from a pharmacological viewpoint and combines clinical aspects with basic science.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 2520 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Marine Nutraceuticals

Author : Se-Kwon Kim
Publisher : CRC Press
ISBN 13 : 1466513519
Total Pages : 467 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Marine Nutraceuticals by : Se-Kwon Kim

Download or read book Marine Nutraceuticals written by Se-Kwon Kim and published by CRC Press. This book was released on 2013-03-25 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a great deal of consumer interest in natural bioactive substances due to their health benefits. Offering the potential to provide valuable nutraceuticals and functional food ingredients, marine-derived compounds are an abundant source of nutritionally and pharmacologically active agents, with both chemical diversity and complexity. Functional ingredients derived from marine algae, invertebrates, vertebrates, and microorganisms can help fill the need for novel bioactives to treat chronic conditions such as cancer, microbial infections, and inflammatory processes. With contributions from an international group of experts, Marine Nutraceuticals: Prospects and Perspectives provides a comprehensive account of marine-derived nutraceuticals and their potential health benefits. These include antioxidant, anticancer, antiviral, anticoagulant, antidiabetic, antiallergic, anti-inflammatory, antihypertensive, antibacterial, and radioprotective properties. The book focuses on various types of marine-derived compounds—such as secondary metabolites like phlorotannins and fucoxanthin, carotenoid pigments, chito-oligosaccharide derivatives from chitin and chitosan, bioactive peptides, and polysaccharides—presenting an overview of their nutraceutical activities. Chapters address neuroprotecive properties of seaweeds, bioactive compounds in abalone, marine products and autoimmune disease, chitosan for weight management, anticancer actions of omega-3 fatty acids, chitosan in dentistry, and much more. The book discusses the sources, isolation and purification, chemistry, functional interactions, applications, and industrial perspectives of marine-derived nutraceuticals. The inaugural book in the new CRC Press series, Nutraceuticals: Basic Research/Clinical Applications, it provides a state-of-the-art reference for all readers interested in this growing field—a rich source for new compounds with promising uses in the nutraceutical, medicinal, and functional food industries.

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor

Author : Terry Lichtor
Publisher : BoD – Books on Demand
ISBN 13 : 953512031X
Total Pages : 436 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor by : Terry Lichtor

Download or read book Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor written by Terry Lichtor and published by BoD – Books on Demand. This book was released on 2015-03-25 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.