A Nobel Fellow On Every Floor

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A Nobel Fellow on Every Floor

Author : John Finch
Publisher : Icon Books
ISBN 13 : 1848316704
Total Pages : 458 pages
Book Rating : 4.8/5 (483 download)

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Book Synopsis A Nobel Fellow on Every Floor by : John Finch

Download or read book A Nobel Fellow on Every Floor written by John Finch and published by Icon Books. This book was released on 2024-06-07 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Cambridge in the 1950s, several research groups funded by the Medical Research Council were producing exciting results. In the Biochemistry Department, Sanger determined the amino acid sequence of insulin, and was awarded a Nobel Prize for this in 1958. At the Cavendish Laboratory, in the MRC Unit for the Study of the Molecular Structure of Biological Systems, Watson and Crick solved the structure of DNA, and Perutz and Kendrew produced the first three-dimensional maps of protein structures – haemoglobin and myoglobin – for which all four were later awarded Nobel Prizes. This made it timely to create, in 1962, a new Laboratory of Molecular Biology in Cambridge by amalgamating these groups with other MRC-funded groups from London. The Laboratory has become one of the most successful in its field, and the number of Nobel Prizes awarded over the years to scientists at LMB has risen to thirteen. This book follows the development of LMB, through the people who moved into the new Laboratory and their research. It describes events and personalities that have given the Laboratory a friendly, family atmosphere, while continuing to be scientifically productive.

Fred Sanger - Double Nobel Laureate

Author : George G. Brownlee
Publisher : Cambridge University Press
ISBN 13 : 1316124053
Total Pages : 315 pages
Book Rating : 4.3/5 (161 download)

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Book Synopsis Fred Sanger - Double Nobel Laureate by : George G. Brownlee

Download or read book Fred Sanger - Double Nobel Laureate written by George G. Brownlee and published by Cambridge University Press. This book was released on 2020-04-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.

Nobel Prizes And Notable Discoveries

Author : Erling Norrby
Publisher : World Scientific
ISBN 13 : 9813144661
Total Pages : 580 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Nobel Prizes And Notable Discoveries by : Erling Norrby

Download or read book Nobel Prizes And Notable Discoveries written by Erling Norrby and published by World Scientific. This book was released on 2016-09-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book discusses the prizes in physiology or medicine 1963-65. The 1963 prize recognized milestone discoveries in the field of neurosciences, the way electrical impulses are generated and spread in nerves. The impressive developments of insights into tantalizing brain functions, like consciousness and memory, is discussed in the perspective of prizes both before and after the 1963 prize. The prize in 1964 marked the advanced biochemical venture that led to a full understanding of the synthesis of cholesterol, a central molecule for providing flexibility of the membranes of the trillions of cell in our body. The importance of this molecule for the appearance of cardiovascular diseases and the possibilities to prevent them is presented in the light of other prizes earlier and later in this field. The 1965 prize recognized three impressive French intellectuals, Lwoff, Monod and Jacob. Their contributions allowed the full maturation of the initial phase of the emerging field of molecular biology. The comprehension of the information flow from DNA via RNA to proteins was the source of a revolution of life sciences and of medicine.

Nobel Prizes and Nature's Surprises

Author : Erling Norrby
Publisher : World Scientific
ISBN 13 : 9814522007
Total Pages : 470 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Nobel Prizes and Nature's Surprises by : Erling Norrby

Download or read book Nobel Prizes and Nature's Surprises written by Erling Norrby and published by World Scientific. This book was released on 2013 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year the Nobel Prizes in the natural sciences reveal amazing discoveries. Nominations are kept secret for 50 years after the awards have been made. Covering the awards from 1960 to 1962, this book reveals discoveries relating to the control of infectious diseases and the advent of organ transplant organs, as well as advances in molecular biology.

Nobel Prizes: Genes, Viruses And Cellular Signaling

Author : Erling Norrby
Publisher : World Scientific
ISBN 13 : 9811261342
Total Pages : 459 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Nobel Prizes: Genes, Viruses And Cellular Signaling by : Erling Norrby

Download or read book Nobel Prizes: Genes, Viruses And Cellular Signaling written by Erling Norrby and published by World Scientific. This book was released on 2022-09-05 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products.The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events.The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as 'secondary messengers'. They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism.The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies.

Frederick Sanger

Author : Joe S. Jeffers
Publisher : Springer
ISBN 13 : 3319547097
Total Pages : 94 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Frederick Sanger by : Joe S. Jeffers

Download or read book Frederick Sanger written by Joe S. Jeffers and published by Springer. This book was released on 2017-03-14 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.

A Place in History

Author : Paul M. Wassarman
Publisher :
ISBN 13 : 0199732043
Total Pages : 369 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis A Place in History by : Paul M. Wassarman

Download or read book A Place in History written by Paul M. Wassarman and published by . This book was released on 2020 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Place in History: The Biography of John C. Kendrew is the story of the influential 20th century scientific pioneer and winner of the 1962 Nobel Prize in chemistry.

Architects of Structural Biology

Author : John Meurig Thomas
Publisher : Oxford University Press, USA
ISBN 13 : 0198854501
Total Pages : 321 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Architects of Structural Biology by : John Meurig Thomas

Download or read book Architects of Structural Biology written by John Meurig Thomas and published by Oxford University Press, USA. This book was released on 2020-02-28 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a history of the personalities and single-minded devotion of four Nobel laureates who played a pivotal role in the creation of a new and prevalent branch of biology. This led to major medical advances in one of the greatest centres of scientific research: the Laboratory of Molecular Biology in Cambridge, which they helped to establish.

The Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the Discovery of DNA's Double Helix

Author : Howard Markel
Publisher : W. W. Norton & Company
ISBN 13 : 1324002247
Total Pages : 526 pages
Book Rating : 4.3/5 (24 download)

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Book Synopsis The Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the Discovery of DNA's Double Helix by : Howard Markel

Download or read book The Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the Discovery of DNA's Double Helix written by Howard Markel and published by W. W. Norton & Company. This book was released on 2021-09-21 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: An NPR Best Book of the Year An authoritative history of the race to unravel DNA’s structure, by one of our most prominent medical historians. James Watson and Francis Crick’s 1953 discovery of the double helix structure of DNA is the foundation of virtually every advance in our modern understanding of genetics and molecular biology. But how did Watson and Crick do it—and why were they the ones who succeeded? In truth, the discovery of DNA’s structure is the story of five towering minds in pursuit of the advancement of science, and for almost all of them, the prospect of fame and immortality: Watson, Crick, Rosalind Franklin, Maurice Wilkins, and Linus Pauling. Each was fascinating and brilliant, with strong personalities that often clashed. Howard Markel skillfully re-creates the intense intellectual journey, and fraught personal relationships, that ultimately led to a spectacular breakthrough. But it is Rosalind Franklin—fiercely determined, relentless, and an outsider at Cambridge and the University of London in the 1950s, as the lone Jewish woman among young male scientists—who becomes a focal point for Markel. The Secret of Life is a story of genius and perseverance, but also a saga of cronyism, misogyny, anti-Semitism, and misconduct. Drawing on voluminous archival research, including interviews with James Watson and with Franklin’s sister, Jenifer Glynn, Markel provides a fascinating look at how science is done, how reputations are undone, and how history is written, and revised. A vibrant evocation of Cambridge in the 1950s, Markel also provides colorful depictions of Watson and Crick—their competitiveness, idiosyncrasies, and youthful immaturity—and compelling portraits of Wilkins, Pauling, and most cogently, Rosalind Franklin. The Secret of Life is a lively and sweeping narrative of this landmark discovery, one that finally gives the woman at the center of this drama her due.

Unravelling the Double Helix

Author : Gareth Williams
Publisher : Simon and Schuster
ISBN 13 : 1643132830
Total Pages : 607 pages
Book Rating : 4.6/5 (431 download)

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Book Synopsis Unravelling the Double Helix by : Gareth Williams

Download or read book Unravelling the Double Helix written by Gareth Williams and published by Simon and Schuster. This book was released on 2019-10-01 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unraveling the Double Helix covers the most colorful period in the history of DNA, from the discovery of "nuclein" in the late 1860s to the publication of James Watson's The Double Helix in 1968. These hundred years included the establishment of the Nobel Prize, antibiotics, x-ray crystallography, the atom bomb and two devastating world wars—events which are strung along the thread of DNA like beads on a necklace. The story of DNA is a saga packed with awful mistakes as well as brilliant science, with a wonderful cast of heroes and villains. Surprisingly, much of it is unfamiliar. The elucidation of the double helix was one of the most brilliant gems of twentieth century science, but some of the scientists who paved the way have been airbrushed out of history. James Watson and Francis Crick solved a magnificent mystery, but Gareth Williams shows that their contribution was the last few pieces of a gigantic jigsaw puzzle assembled over several decades.The book is comprehensive in scope, covering the first century of the history of DNA in its entirety, including the eight decades that have been neglected by other authors. It also explores the personalities of the main players, the impact of their entanglement with DNA, and what unique qualities make great scientists tick.

Writing about Lives in Science

Author : Paola Govoni
Publisher : V&R unipress GmbH
ISBN 13 : 384710263X
Total Pages : 290 pages
Book Rating : 4.8/5 (471 download)

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Book Synopsis Writing about Lives in Science by : Paola Govoni

Download or read book Writing about Lives in Science written by Paola Govoni and published by V&R unipress GmbH. This book was released on 2014 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following discussions on scientific biography carried out over the past few decades, this book proposes a kaleidoscopic survey of the uses of biography as a tool to understand science and its context. The authors belong to a variety of academic and professional fields, including the history of science, anthropology, literary studies, and science journalism. The period covered spans from 1732, when Laura Bassi was the first woman to get a tenured professorship of physics, to 2009, when Elizabeth H. Blackburn and Carol W. Greider were the first women's team to have won a Nobel Prize in science.

Focus On: 100 Most Popular Former Roman Catholics

Author : Wikipedia contributors
Publisher : e-artnow sro
ISBN 13 :
Total Pages : 1617 pages
Book Rating : 4./5 ( download)

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Book Synopsis Focus On: 100 Most Popular Former Roman Catholics by : Wikipedia contributors

Download or read book Focus On: 100 Most Popular Former Roman Catholics written by Wikipedia contributors and published by e-artnow sro. This book was released on with total page 1617 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Lock and Key of Medicine

Author : Lara V. Marks
Publisher : Yale University Press
ISBN 13 : 0300213522
Total Pages : 345 pages
Book Rating : 4.3/5 (2 download)

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Book Synopsis The Lock and Key of Medicine by : Lara V. Marks

Download or read book The Lock and Key of Medicine written by Lara V. Marks and published by Yale University Press. This book was released on 2015-06-28 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world’s top ten blockbuster drugs and make up a third of new introduced treatments. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.

Aaron Klug - A Long Way from Durban

Author : Kenneth C. Holmes
Publisher : Cambridge University Press
ISBN 13 : 1107147379
Total Pages : 381 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Aaron Klug - A Long Way from Durban by : Kenneth C. Holmes

Download or read book Aaron Klug - A Long Way from Durban written by Kenneth C. Holmes and published by Cambridge University Press. This book was released on 2017-02-09 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The life and work of Aaron Klug, Nobel prize winner and one of the pioneers of structural molecular biology.

Membranes to Molecular Machines

Author : Mathias Grote
Publisher : University of Chicago Press
ISBN 13 : 022662529X
Total Pages : 307 pages
Book Rating : 4.2/5 (266 download)

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Book Synopsis Membranes to Molecular Machines by : Mathias Grote

Download or read book Membranes to Molecular Machines written by Mathias Grote and published by University of Chicago Press. This book was released on 2019-07-19 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher. The research described in the book and its central actor, Dieter Oesterhelt, were honored with the 2021 Albert Lasker Basic Medical Research Award for his contribution to the development of optogenetics.

Opening Doors: Joan Steitz and Jennifer Doudna of the RNA World

Author : Laura L Mays Hoopes
Publisher : Lulu.com
ISBN 13 : 0359485200
Total Pages : 172 pages
Book Rating : 4.3/5 (594 download)

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Book Synopsis Opening Doors: Joan Steitz and Jennifer Doudna of the RNA World by : Laura L Mays Hoopes

Download or read book Opening Doors: Joan Steitz and Jennifer Doudna of the RNA World written by Laura L Mays Hoopes and published by Lulu.com. This book was released on 2019-03-08 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dual biography of Joan Steitz and Jennifer Doudna, two women who combined successful home lives with successful careers in science.

Heredity under the Microscope

Author : Soraya de Chadarevian
Publisher : University of Chicago Press
ISBN 13 : 022668525X
Total Pages : 318 pages
Book Rating : 4.2/5 (266 download)

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Book Synopsis Heredity under the Microscope by : Soraya de Chadarevian

Download or read book Heredity under the Microscope written by Soraya de Chadarevian and published by University of Chicago Press. This book was released on 2020-07-02 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on chromosomes, Heredity under the Microscope offers a new history of postwar human genetics. Today chromosomes are understood as macromolecular assemblies and are analyzed with a variety of molecular techniques. Yet for much of the twentieth century, researchers studied chromosomes by looking through a microscope. Unlike any other technique, chromosome analysis offered a direct glimpse of the complete human genome, opening up seemingly endless possibilities for observation and intervention. Critics, however, countered that visual evidence was not enough and pointed to the need to understand the molecular mechanisms. Telling this history in full for the first time, Soraya de Chadarevian argues that the often bewildering variety of observations made under the microscope were central to the study of human genetics. Making space for microscope-based practices alongside molecular approaches, de Chadarevian analyzes the close connections between genetics and an array of scientific, medical, ethical, legal, and policy concerns in the atomic age. By exploring the visual evidence provided by chromosome research in the context of postwar biology and medicine, Heredity under the Microscope sheds new light on the cultural history of the human genome.