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A Mechanistic Approach Towards The Discovery Of Catalytic Acylation Reactions
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Book Synopsis A Mechanistic Approach Towards the Discovery of Catalytic Acylation Reactions by : Wanying Zhang
Download or read book A Mechanistic Approach Towards the Discovery of Catalytic Acylation Reactions written by Wanying Zhang and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new, efficient methods for the formation of carbon-carbon bonds using transition metal catalysis has broad applications in the field of organic chemistry and is the key to efficient chemical synthesis. Many efforts had been made to develop efficient ways to make these linkages particularly with the aid of metals such as Rh, Pd, Ni, Ru and Cu. Our group is primarily focused on exploring how these transition metals can activate typically inert functional groups, paving way to new synthetic routes to construct more complex molecules. Chapter 1 describes attempts that were conducted to achieve hydroacylation between an aldehyde and a non-conjugated alkene via a metal hydride intermediate. The use of RuHCl(CO)(PPh3)3 proved to be the most efficient catalyst for this transformation thus far. Mechanistic investigations were conducted to explore different possibilities to enable this transformation. This chapter also identifies a new self-aldol domino reaction, which consists of a self-aldol condensation of an aldehyde, followed by oxidation and decarbonylation giving rise to a ketone product. Finally, the use of a simple and direct method to access deuterated aldehydes using RuHCl(CO)(PPh3)3 as a catalyst and D2O as a deuterium source is outlined. Chapter 2 describes a novel Suzuki-Miyaura system that couples esters and boronic esters to form the corresponding ketone product. It was found that an NHC-based Pd catalyst is crucial in the transformation wherein it activates the C(acyl)-O bond of the ester. It is notable that this transformation takes place with the absence of decarbonylation. Reactivity under water in the presence of surfactants was also discovered. Results in aqueous media were demonstrated to be milder than in organic conditions, while achieving similar yields. This system was also applied to coupling of esters and anilines.
Book Synopsis Mechanistic Approach Towards Discovery of Catalytic Acylation Reaction by : Wanying Zhang
Download or read book Mechanistic Approach Towards Discovery of Catalytic Acylation Reaction written by Wanying Zhang and published by . This book was released on 2017-07-25 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanistic Investigations and Search Directions for Catalyst Discovery by : Saurabh Bhandari (Ph.D.)
Download or read book Mechanistic Investigations and Search Directions for Catalyst Discovery written by Saurabh Bhandari (Ph.D.) and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transition towards a sustainable energy future hinges strongly on the effective deployment of renewable energy carriers. Wide-scale adoption of sustainable technologies requires major innovation in the development of storage materials that exhibit high energy density and of catalytic materials, that help facilitate the relevant chemical transformations to release the stored energy, in an efficient and cost-effective manner. Fundamental investigations aimed at elucidating detailed mechanistic understanding of such chemistries could greatly accelerate the discovery of favorable energy-storage and catalytic materials. In this dissertation, we utilize a combination of first-principles density functional theory (DFT) calculations, reaction kinetics experimentation, and coverage self-consistent mean-field microkinetic modeling to elucidate detailed atomistic-scale insights for the heterogeneously catalyzed chemistries. We emphasize on the importance of formulating computational models that closely-replicate the surface environment present on the catalyst under reaction conditions, an aspect which is oft-ignored in conventional investigations. Consideration of spectator induced coverage-effects were found to not only influence the energetics of the reaction network through lateral adsorbate-adsorbate repulsions, but more importantly alter the reaction pathway itself, by participating in the reaction mechanism. Our multi-faceted methodology yields an unbiased understanding of the reaction mechanism and enables us to develop a comprehensive picture of the in situ active site. In a broader context, our algorithmic approach provides a systematic framework for elucidating novel descriptions for the nature of the active site as well as reaction mechanisms, consequently providing a more rigorous basis for computational prediction of improved catalytic materials.
Book Synopsis A Catalytic Approach to Cyclopentenones: Unexpected Challenges in Synthesizing Pent-2,4-dienals by : Hunter Wade English
Download or read book A Catalytic Approach to Cyclopentenones: Unexpected Challenges in Synthesizing Pent-2,4-dienals written by Hunter Wade English and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition metal catalysis has long been utilized to facilitate a number of chemical reactions outside the scope of traditional organic chemistry. Because of this, there has been a growing interest in the community in utilizing C-H bonds over C-X bonds as synthetic alternatives with better thermodynamic conditions (lower temperatures, pressures, energies, etc.) and forming C-C bonds. For example, rhodium-catalyzed hydroacylation can be used in the conversion of 4-pentenals to cyclopentanones. The mechanistic foundation of this reaction was applied to the synthesis of chiral 3-substituted indanones, unlocking a whole series of transformations towards the construction of biologically active molecules. The Morehead group recently proposed an alternate synthesis of cyclopentenones via a rhodium-catalyzed intramolecular hydroacylation reaction of penta-2,4-dienals by the following reaction sequence: 1. Vilsmeier-Haack Formylation to form 3-bromo-2-enals, 2. Suzuki Cross-Coupling with vinylboronates, and 3. Hydroacylation. Indeed, all reaction steps were performed successfully starting from acetophenone and allylboronic acid pinacol ester, resulting in 4-methyl-3-phenyl-2-cyclopenten-1-one. However, some surprising results were obtained along the way. It was found that when 3-bromo-3-phenyl-2-propenal underwent Suzuki Cross-Coupling, an unexpected mixture of pent-2,4-dienal isomers was obtained. To investigate this matter, a number of reaction conditions were examined in hopes of finding one with optimal yields and little to no isomerized pent-2,4-dienal product. In addition, a variety of cyclopentenones were synthesized to explore the steric effect in influencing the isomerization process. Some potential mechanistic details of this strange isomerization phenomenon along with results obtained from the synthesis will be reported and discussed.
Book Synopsis Vanadium Catalysis by : Manas Sutradhar
Download or read book Vanadium Catalysis written by Manas Sutradhar and published by Royal Society of Chemistry. This book was released on 2020-11-05 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vanadium is one of the more abundant elements in the Earth’s crust and exhibits a wide range of oxidation states in its compounds making it potentially a more sustainable and more economical choice as a catalyst than the noble metals. A wide variety of reactions have been found to be catalysed by homogeneous, supported and heterogeneous vanadium complexes and the number of applications is growing fast. Bringing together the research on the catalytic uses of this element into one essential resource, including theoretical perspectives on proposed mechanisms for vanadium catalysis and an overview of its relevance in biological processes, this book is a useful reference for industrial and academic chemists alike.
Book Synopsis Organotransition Metal Chemistry A Mechanistic Approach by : Richard Heck
Download or read book Organotransition Metal Chemistry A Mechanistic Approach written by Richard Heck and published by Elsevier. This book was released on 2012-12-02 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organotransition Metal Chemistry: A Mechanistic Approach describes a mechanistic approach to the study of the chemistry of organotransition metals. Organotransition metals are discussed in relation to their reactions with specific functional groups or types of compounds rather than by metals. Topics covered include the formation of hydrogen and carbon bonds to transition metals; reactions of transition metal d- and p-bonded derivatives; and addition and elimination reactions of olefinic compounds. This book is comprised of 10 chapters and begins with a historical overview of organotransition metal chemistry, together with the unique chemistry of transition metals and mechanisms of ligand replacements. The following chapters discuss the methods of preparation of hydrido complexes and carbon-transition metal bonds; homogeneous hydrogenation reactions; isomerization, dimerization, oligomerization, and polymerization of olefins; and reactions of dienes, trienes, and tetraenes with transition metal compounds. Transition metal reactions with acetylenes and carbon monoxide as well as organic carbonyl compounds are also examined. This monograph should be of value to organic chemists as well as students and researchers of organic chemistry.
Book Synopsis Site-Selective Catalysis by : Takeo Kawabata
Download or read book Site-Selective Catalysis written by Takeo Kawabata and published by Springer. This book was released on 2016-02-23 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Review articles for the individual volumes are invited by the volume editors.Readership: research chemists at universities or in industry, graduate students
Book Synopsis Asymmetric Dearomatization Reactions by : Shu-Li You
Download or read book Asymmetric Dearomatization Reactions written by Shu-Li You and published by John Wiley & Sons. This book was released on 2016-09-13 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive account of the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods. It introduces the concept of dearomatization and describes recent progress in asymmetric reaction procedures with different catalyst systems, such as organocatalysts, transition metal catalysts, and enzymes. Chapters on dearomatizations of electron-deficient aromatic rings, dearomatization reactions via transition metal-catalyzed cross-couplings as well as dearomatization strategies in the synthesis of complex natural products are also included. Written by pioneers in the field, this is a highly valuable source of information not only for professional synthetic chemists in academia and industry but also for all those are interested in asymmetric methodologies and organic synthesis in general.
Book Synopsis Visible Light Photocatalysis in Organic Chemistry by : Corey R.J. Stephenson
Download or read book Visible Light Photocatalysis in Organic Chemistry written by Corey R.J. Stephenson and published by John Wiley & Sons. This book was released on 2018-05-29 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the need for a ready reference that reflects the vast developments in this field, this book presents everything from fundamentals, applications, various reaction types, and technical applications. Edited by rising stars in the scientific community, the text focuses solely on visible light photocatalysis in the context of organic chemistry. This primarily entails photoinduced electron transfer and energy transfer chemistry sensitized by polypyridyl complexes, yet also includes the use of organic dyes and heterogeneous catalysts. A valuable resource to the synthetic organic community, polymer and medicinal chemists, as well as industry professionals.
Book Synopsis Olefin Polymerization by : Walter Kaminsky
Download or read book Olefin Polymerization written by Walter Kaminsky and published by Wiley-VCH. This book was released on 2006-08-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an enormous velocity, olefin polymerization has expanded to one of the most significant fields in polymers since the first industrial use about 50 years ago. In 2005, 100 million tons of polyolefins were produced - the biggest part was catalyzed by metallorganic compounds. The Hamburg Macromolecular Symposium 2005 with the title "Olefin Polymerization" involved topics such as new catalysts and cocatalysts, kinetics, mechanism and polymer reaction engineering, synthesis of special polymers, and characterization of polyolefins. The conference combined scientists from different disciplines to discuss latest research results of polymers and to offer each other the possibility of cooperation. This is reflected in this volume, which contains invited lectures and selected posters presented at the symposium.
Book Synopsis Comprehensive Asymmetric Catalysis by : Eric N. Jacobsen
Download or read book Comprehensive Asymmetric Catalysis written by Eric N. Jacobsen and published by Springer Science & Business Media. This book was released on 2003-09-22 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first supplement to the three volume reference work "Comprehensive Asymmetric Catalysis" critically reviews new developments to the hottest topics in the field written by recognised experts. Eleven chapters which are already in the major reference work have been supplemented and additionally five new chapters have been included. Thus the state-of-the art in this area is now re-established. Together with the basic three volume book set this supplement is not only the principal reference source for synthetic organic chemists, but also for all scientific researchers who use chiral compounds in their work (for example, in biochemical investigations and molecular medicine) as well as for pharmaceutical chemists and other industrial researchers who prepare chiral compounds.
Book Synopsis Industrial Biocatalysis by : Peter Grunwald
Download or read book Industrial Biocatalysis written by Peter Grunwald and published by CRC Press. This book was released on 2014-12-11 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts-with
Book Synopsis Advances in Friedel-Crafts Acylation Reactions by : Giovanni Sartori
Download or read book Advances in Friedel-Crafts Acylation Reactions written by Giovanni Sartori and published by CRC Press. This book was released on 2009-12-04 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry. Nearly 40 years since the last major treatise on the topic and reflecting the growing emphasis on green technology, Advances in Friedel-Cr
Book Synopsis Lewis Base Catalysis in Organic Synthesis by : Edwin Vedejs
Download or read book Lewis Base Catalysis in Organic Synthesis written by Edwin Vedejs and published by John Wiley & Sons. This book was released on 2016-07-28 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Book Synopsis From Enzyme Models to Model Enzymes by : Anthony John Kirby
Download or read book From Enzyme Models to Model Enzymes written by Anthony John Kirby and published by Royal Society of Chemistry. This book was released on 2009 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is one of the great challenges facing science today. This introduction to the exciting area of artificial enzymes is suitable for both students and more senior researchers.
Book Synopsis Organic Chemistry by : Tadashi Okuyama
Download or read book Organic Chemistry written by Tadashi Okuyama and published by Oxford University Press. This book was released on 2013-11 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry: A mechanistic approach combines a focus on core topics and themes with a mechanistic approach to the explanation of the reactions it describes, making it ideal for those looking for a solid understanding of the central themes of organic chemistry.
Book Synopsis Comprehensive Organic Synthesis by :
Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
