A Developmental Mouse Brain Common Coordinate Framework For Cell Census Atlasing

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A Developmental Mouse Brain Common Coordinate Framework for Cell Census Atlasing

Author : Fae Kronman
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (144 download)

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Book Synopsis A Developmental Mouse Brain Common Coordinate Framework for Cell Census Atlasing by : Fae Kronman

Download or read book A Developmental Mouse Brain Common Coordinate Framework for Cell Census Atlasing written by Fae Kronman and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain reference atlases have transformed from images of gross anatomy to magnified histological slides to interactive digital 3D models. Today, 3D standard reference brains serve as key resources to understand the spatial organization of the brain and promote interoperability across different studies. Unlike the adult mouse brain, the absence of a standard 3D reference atlas for developing mouse brains has hindered advancement in understanding brain development. Here, we present a multimodal 3D developmental common coordinate framework (DevCCF) spanning mouse embryonic day (E) 11.5, E13.5, E15.5, E18.5, and postnatal day (P) 4, P14, and P56. The DevCCF features undistorted morphologically averaged atlas templates created from magnetic resonance imaging and co-registered high-resolution templates from light sheet fluorescence microscopy. The prosomeric model of mammalian brain development guides 3D anatomical segmentations at each age. To appreciate the developmental gap between P4 and P14, we supplement the DevCCF with the early postnatal developmental atlas (epDevAtlas), featuring morphologically averaged templates created from serial two-photon tomography at ages P4, P6, P8, P10, P12, and P14. Moreover, we integrated the P4 and P14 epDevAtlas and Allen Institute adult mouse brain common coordinate framework (CCFv3) into the undistorted P4, P14, and P56 DevCCF morphology, respectively. The DevCCF and epDevAtlas can be explored via an interactive 3D web visualizer. To demonstrate use cases, we employed the DevCCF to unveil the emergence of GABAergic neurons in embryonic brains and mapped spatial transcriptome cell-type data with the developmental ontology to visualize the gene expression changes through development. Further, we suggest atlas improvements and applications to further progress in basic and translational developmental neuroscience. In summary, this work describes the development of openly accessible 3D standard reference atlases that serve as resources for large-scale data integration to gain a comprehensive understanding of brain development.

The Mouse Brain in Stereotaxic Coordinates

Author : George Paxinos
Publisher : San Diego : Academic Press
ISBN 13 : 9780125476362
Total Pages : 264 pages
Book Rating : 4.4/5 (763 download)

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Book Synopsis The Mouse Brain in Stereotaxic Coordinates by : George Paxinos

Download or read book The Mouse Brain in Stereotaxic Coordinates written by George Paxinos and published by San Diego : Academic Press. This book was released on 2001 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mouse Brain in Stereotaxic Coordinates, Second Edition is the most comprehensive and accurate atlas of the mouse brain ever published. The first edition of this book has become the acknowledged reference in its field. In the second edition, the authors incorporated lower brainstem sections, an entire sagittal plane of section and revised all delineations, especially of the cortex. This guide is essential to those who study the brain of this species or any similar species, including hamsters. The large, spiral-bound format makes it easy to see the details in each illustration or photograph and compare them to animal models in the lab.

The Mouse Nervous System

Author : Charles Watson
Publisher : Academic Press
ISBN 13 : 0123694973
Total Pages : 815 pages
Book Rating : 4.1/5 (236 download)

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Book Synopsis The Mouse Nervous System by : Charles Watson

Download or read book The Mouse Nervous System written by Charles Watson and published by Academic Press. This book was released on 2011-11-28 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Neuronal Identity from Fate Specification to Function

Author : Nikolaos Konstantinides
Publisher : Frontiers Media SA
ISBN 13 : 2832513239
Total Pages : 159 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Neuronal Identity from Fate Specification to Function by : Nikolaos Konstantinides

Download or read book Neuronal Identity from Fate Specification to Function written by Nikolaos Konstantinides and published by Frontiers Media SA. This book was released on 2023-02-02 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurobehavioral Genetics

Author : Byron C. Jones
Publisher : CRC Press
ISBN 13 : 1420003569
Total Pages : 522 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neurobehavioral Genetics by : Byron C. Jones

Download or read book Neurobehavioral Genetics written by Byron C. Jones and published by CRC Press. This book was released on 2006-08-30 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: De

Brain Maps

Author : Larry W. Swanson
Publisher : Elsevier Science & Technology
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Brain Maps by : Larry W. Swanson

Download or read book Brain Maps written by Larry W. Swanson and published by Elsevier Science & Technology. This book was released on 1998 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This set can be used for producing and publishing rat brain illustrations.

The Claustrum

Author : John R. Smythies
Publisher : Academic Press
ISBN 13 : 012404722X
Total Pages : 408 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis The Claustrum by : John R. Smythies

Download or read book The Claustrum written by John R. Smythies and published by Academic Press. This book was released on 2013-11-11 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integrations—the hallmark of consciousness. The claustrum, previously in a humble position at the back of the stage, might in fact be the conductor of the brain's orchestra. The Claustrum brings together leading experts on the claustrum from the varied disciplines of neuroscience, providing a state-of-the-art presentation of what is currently known about the claustrum, promising lines of current research (including epigenetics), and projections of new lines of investigation on the horizon. - Develops a unifying hypothesis about the claustrum's role in consciousness, as well as the integration of sensory information and other higher brain functions - Discusses the involvement of the claustrum with autism, schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease - Coverage of all aspects of the claustrum, from its evolution and development to promising new lines of research, including epigenetics, provides a platform and point of reference for future investigative efforts

Systems Neuroscience

Author : Albert Cheung-Hoi Yu
Publisher : Springer
ISBN 13 : 3319945939
Total Pages : 313 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Systems Neuroscience by : Albert Cheung-Hoi Yu

Download or read book Systems Neuroscience written by Albert Cheung-Hoi Yu and published by Springer. This book was released on 2018-10-17 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of Advances in Neurobiology brings together experts in the emerging field of Systems Neuroscience to present an overview of this area of research. Topics covered include: how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements; how nerve cells behave when connected together to form neural networks; the relationship between molecular and cellular approaches to understanding brain structure and function; the study of high-level mental functions; and studying brain pathologies and diseases with Systems Neuroscience. A hierarchy of biological complexity arises from the genome, transcriptome, proteome, organelles, cells, synapses, circuits, brain regions, the whole brain, and behaviour. The best way to study the brain, the most complex organ in the body composed of 100 billion cells with trillions of interconnections, is with a Systems Biology approach. Systems biology is an inter-disciplinary field that focuses on complex interactions within biological systems to reveal 'emergent properties' - properties of cells and groups of cells functioning as a system whose actual and theoretical description is only possible using Systems Biology techniques.

Learning to Think Spatially

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309092086
Total Pages : 333 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Learning to Think Spatially by : National Research Council

Download or read book Learning to Think Spatially written by National Research Council and published by National Academies Press. This book was released on 2005-02-03 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learning to Think Spatially examines how spatial thinking might be incorporated into existing standards-based instruction across the school curriculum. Spatial thinking must be recognized as a fundamental part of Kâ€"12 education and as an integrator and a facilitator for problem solving across the curriculum. With advances in computing technologies and the increasing availability of geospatial data, spatial thinking will play a significant role in the information-based economy of the twenty-first century. Using appropriately designed support systems tailored to the Kâ€"12 context, spatial thinking can be taught formally to all students. A geographic information system (GIS) offers one example of a high-technology support system that can enable students and teachers to practice and apply spatial thinking in many areas of the curriculum.

Advances in Geroscience

Author : Felipe Sierra
Publisher : Springer
ISBN 13 : 3319232460
Total Pages : 637 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Advances in Geroscience by : Felipe Sierra

Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.

Human Monocytes

Author : Marek Zembala
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Monocytes by : Marek Zembala

Download or read book Human Monocytes written by Marek Zembala and published by . This book was released on 1989 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.

Fundamental Neuroscience

Author : Larry Squire
Publisher : Academic Press
ISBN 13 : 0080561020
Total Pages : 1277 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Fundamental Neuroscience by : Larry Squire

Download or read book Fundamental Neuroscience written by Larry Squire and published by Academic Press. This book was released on 2008-04-02 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing

Intelligence Revolution 1960

Author : Ingard Clausen
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (8 download)

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Book Synopsis Intelligence Revolution 1960 by : Ingard Clausen

Download or read book Intelligence Revolution 1960 written by Ingard Clausen and published by . This book was released on 2012 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overview: Provides a history of the Corona Satellite photo reconnaissance Program. It was a joint Central Intelligence Agency and United States Air Force program in the 1960s. It was then highly classified.

The Coding Manual for Qualitative Researchers

Author : Johnny Saldana
Publisher : SAGE
ISBN 13 : 1446200124
Total Pages : 282 pages
Book Rating : 4.4/5 (462 download)

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Book Synopsis The Coding Manual for Qualitative Researchers by : Johnny Saldana

Download or read book The Coding Manual for Qualitative Researchers written by Johnny Saldana and published by SAGE. This book was released on 2009-02-19 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Coding Manual for Qualitative Researchers is unique in providing, in one volume, an in-depth guide to each of the multiple approaches available for coding qualitative data. In total, 29 different approaches to coding are covered, ranging in complexity from beginner to advanced level and covering the full range of types of qualitative data from interview transcripts to field notes. For each approach profiled, Johnny Saldaña discusses the method’s origins in the professional literature, a description of the method, recommendations for practical applications, and a clearly illustrated example.

An Introduction to Community Development

Author : Rhonda Phillips
Publisher : Routledge
ISBN 13 : 1134482329
Total Pages : 682 pages
Book Rating : 4.1/5 (344 download)

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Book Synopsis An Introduction to Community Development by : Rhonda Phillips

Download or read book An Introduction to Community Development written by Rhonda Phillips and published by Routledge. This book was released on 2014-11-26 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with the foundations of community development, An Introduction to Community Development offers a comprehensive and practical approach to planning for communities. Road-tested in the authors’ own teaching, and through the training they provide for practicing planners, it enables students to begin making connections between academic study and practical know-how from both private and public sector contexts. An Introduction to Community Development shows how planners can utilize local economic interests and integrate finance and marketing considerations into their strategy. Most importantly, the book is strongly focused on outcomes, encouraging students to ask: what is best practice when it comes to planning for communities, and how do we accurately measure the results of planning practice? This newly revised and updated edition includes: increased coverage of sustainability issues, discussion of localism and its relation to community development, quality of life, community well-being and public health considerations, and content on local food systems. Each chapter provides a range of reading materials for the student, supplemented with text boxes, a chapter outline, keywords, and reference lists, and new skills based exercises at the end of each chapter to help students turn their learning into action, making this the most user-friendly text for community development now available.

Atlas of Early Zebrafish Brain Development

Author : Dr. Thomas Mueller
Publisher : Academic Press
ISBN 13 : 0124172865
Total Pages : 260 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Atlas of Early Zebrafish Brain Development by : Dr. Thomas Mueller

Download or read book Atlas of Early Zebrafish Brain Development written by Dr. Thomas Mueller and published by Academic Press. This book was released on 2015-11-18 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain. - Documentation on the distribution of neurons expressing GABA, dopamine and serotonin - Material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon - New theories about the early organization of the telencephalon and thalamus - Integration of a comparative perspective on the mid- and hindbrain

The Allen Reference Atlas, (Book + CD-ROM)

Author : Hong Wei Dong
Publisher : Wiley
ISBN 13 : 9780470054086
Total Pages : 0 pages
Book Rating : 4.0/5 (54 download)

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Book Synopsis The Allen Reference Atlas, (Book + CD-ROM) by : Hong Wei Dong

Download or read book The Allen Reference Atlas, (Book + CD-ROM) written by Hong Wei Dong and published by Wiley. This book was released on 2008-01-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: “… this atlas acts not only as a key companion to the Allen Reference Atlas but also as a harbinger of things to come.” –Genes, Brain and Behavior, 2010 The best resource available for brain research! The Allen Reference Atlas is available for the first time in this lavishly produced, full-color print edition. This exciting new resource provides users with a meticulously selected and compiled collection of key information from the highly successful web-based Allen Brain Atlas, the now-famous online mouse brain anatomical atlas and gene expression database (www.brain-map.org). Including both coronal and sagittal mouse brain sectional views, these finely detailed brain map images have been carefully chosen for maximum utility and information content, and are presented as full-color plates on pages with corresponding text labels and lists of selected genetic markers. Every brain structure annotated in the Atlas is assigned a distinct color based on its hierarchical position in the brain, which not only provides stunning visual effects to emphasize brain organization, but also facilitates unique definition and segmentation, which is critical to informatics processing and computer-generated 3D reconstruction in the online Allen Brain Atlas. In addition, more than eighty genes showing unique expression patterns in the brain were carefully selected and are presented with the brain map images as molecular markers, for substantially increasing the accuracy of brain structure delineations. The brain map images are the heart and soul of the Allen Reference Atlas, but also included are extremely useful text materials such as thoughtfully annotated nomenclature tables, comprehensive indices, lists of abbreviations, and a thorough and up-to-date bibliography. A free accompanying CD-ROM contains all of the Atlas images in a black-and-white format, perfect for quick reference and use in presentations. The Allen Reference Atlas is a valuable addition to the reference libraries of millions of neuro-scientists, molecular biologists, genomicists, genomics researchers, informaticians, informatics researchers, and many other scientists for whom beautifully developed and perfectly accurate brain reference images are an indispensable tool. The Allen Institute for Brain Science is an independent, 501(c)(3) non-profit medical research organization dedicated to performing innovative basic research on the brain and distributing its discoveries to researchers around the world. Through its efforts, the Institute aims to advance understanding of the brain in health and disease and have a positive, long-lasting impact on brain science. The Institute was established by philanthropist Paul G. Allen and Jody Allen Patton. Available in print format (with CD-ROM), as DVD edition, and as comprehensive reference set.