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A Cardioprotective Role For The Small Heat Shock Protein Alpha B Crystallin In Ischemia Reperfusion Injury
Download A Cardioprotective Role For The Small Heat Shock Protein Alpha B Crystallin In Ischemia Reperfusion Injury full books in PDF, epub, and Kindle. Read online A Cardioprotective Role For The Small Heat Shock Protein Alpha B Crystallin In Ischemia Reperfusion Injury ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis A Cardioprotective Role for the Small Heat Shock Protein, Alpha B-crystallin, in Ischemia-reperfusion Injury by : Lisa Eileen Morrison
Download or read book A Cardioprotective Role for the Small Heat Shock Protein, Alpha B-crystallin, in Ischemia-reperfusion Injury written by Lisa Eileen Morrison and published by . This book was released on 2003 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Small Heat Shock Proteins and Protection Against Cardiac Ischemic Damage by : Jody L. Martin
Download or read book Small Heat Shock Proteins and Protection Against Cardiac Ischemic Damage written by Jody L. Martin and published by . This book was released on 1997 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Roles for Alpha B-crystallin in Protecting the Myocardium from Ischemia/reperfusion Injury by : Ross J. Whittaker
Download or read book New Roles for Alpha B-crystallin in Protecting the Myocardium from Ischemia/reperfusion Injury written by Ross J. Whittaker and published by . This book was released on 2008 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expression of [alpha]BC in the heart has been implicated in providing protection from acute stresses, such as ischemia and reperfusion, by binding to specific target proteins. This dissertation explores two new mechanisms by which [alpha]BC can protect the heart from I/R. First, the role of [alpha]BC in maintaining mitochondrial integrity and function during I/R is examined. Previous work has demonstrated that [alpha]BC associates with and protects mitochondria during I/R. This work expands upon these studies by examining the kinetics of [alpha]BC translocation and phosphorylation of [alpha]BC, an event that is required for [alpha]BC to provide maximal protection against stress. This study shows that, in response to ischemia, [alpha]BC reaches maximal accumulation at the mitochondria following 20 minutes of ischemia. Furthermore, there is an accumulation of phospho-[alpha]BC-S59, the most protective form of [alpha]BC, at the mitochondria. This study goes further to demonstrate that the presence of a phospho-[alpha]BC-S59 mimic, at the mitochondria, provides protection against H2O2-induced cytochrome c release. Moreover, this study demonstrates that [alpha]BC physically interacts with VDAC, a possible mechanism by which [alpha]BC prevents cytochrome c release. The second study explores a role for [alpha]BC in regulating the ceullar redox environment. Hearts from mice harboring deletions of both [alpha]BC and HSPB2 were found to have significantly lower levels of glutathione compared to controls. Consistent with this finding, glutathione reductase (GR) activity was significantly impaired in the knockout mice. HeLa cells were used as a model to further examine a role for [alpha]BC in glutathione recycling since, like the knockout mice, they lack both [alpha]BC and HSPB2. Expression of [alpha]BC in HeLa cells was found to enhance glutathione levels during H2O2 treatment, enhance GR activity, and prevent apoptosis. Moreover, [alpha]BC was shown to directly interact with GR and enhance its activity. The third study of this dissertation examines the use of protein transduction domains to facilitate the delivery of [alpha]BC proteins across cell membranes. This study introduces a novel system that could be used as a research or a therapeutic platform for delivering proteins, nucleic acids or small molecules.
Book Synopsis New Roles for Alpha B-Crystallin in Protecting the Myocardium from Ischemia/reperfusion Injury by : Ross J. Whittaker
Download or read book New Roles for Alpha B-Crystallin in Protecting the Myocardium from Ischemia/reperfusion Injury written by Ross J. Whittaker and published by . This book was released on 2008 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Chaperone Action of Small Heat Shock Protein, Alpha-crystallin by : Arezou Ghahghaei
Download or read book The Chaperone Action of Small Heat Shock Protein, Alpha-crystallin written by Arezou Ghahghaei and published by . This book was released on 2010-09-14 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Big Book on Small Heat Shock Proteins by : Robert M. Tanguay
Download or read book The Big Book on Small Heat Shock Proteins written by Robert M. Tanguay and published by Springer. This book was released on 2015-06-15 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.
Book Synopsis Heat Shock Proteins in Inflammatory Diseases by : Alexzander A. A. Asea
Download or read book Heat Shock Proteins in Inflammatory Diseases written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2021-10-13 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Book Synopsis Hurst's the Heart, 13th Edition: Two Volume Set by : Valentin Fuster
Download or read book Hurst's the Heart, 13th Edition: Two Volume Set written by Valentin Fuster and published by McGraw Hill Professional. This book was released on 2010-12-27 with total page 2558 pages. Available in PDF, EPUB and Kindle. Book excerpt: The trusted landmark cardiology resource—thoroughly updated to reflect the latest clinical perspectives Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 5 STAR DOODY'S REVIEW! "This is an outstanding choice for those who strive for a firm foundation in cardiovascular medicine, as well as an up-to-date and user-friendly source that addresses every discipline in the field. The updates and enhancements to this edition have made the book easier to use."--Doody's Review Service Through thirteen editions, Hurst’s the Heart has always represented the cornerstone of current scholarship in the discipline. Cardiologists, cardiology fellows, and internists from across the globe have relied on its unmatched authority, breadth of coverage, and clinical relevance to help optimize patient outcomes. The thirteenth edition of Hurst’s the Heart continues this standard-setting tradition with 19 new chapters and 59 new authors, each of whom are internationally recognized as experts in their respective content areas. Featuring an enhanced, reader-friendly design, the new edition covers need-to-know clinical advances, as well as issues that are becoming increasingly vital to cardiologists worldwide. As in previous editions, you will find the most complete overview of cardiology topics available—plus a timely new focus on evidence-based medicine, health outcomes, and health quality. New Features 1548 full-color illustrations and 578 tables Companion DVD with image bank includes key figures and tables from the text The Cardiovascular Disease: Past, Present, and Future section includes a new chapter on assessing and improving quality of care in cardiovascular medicine The section on the scientific foundations of cardiovascular medicine has been thoroughly revised 2 new chapters in the section on the evaluation of the patient detail the process of effective diagnostic decision making based on technology, clinical trials, and practice guidelines A new chapter in the section on heart failure details cardiac transplantation The sections on primary heart disease include new chapters on topics such as preventive strategies for coronary artery disease and updated pharmacologic strategies for acute coronary syndromes The section on cardiopulmonary disease features new chapters on chronic cor pulmonale and sleep disorder breathing and its relationship to cardiovascular disease The section on valvular heart disease has four of the six chapter completely rewritten by new authors who are authorities in the field The final six sections feature new chapters on the environment and heart disease, surgical treatment of carotid and peripheral vascular disease and cost effective strategies in cardiology
Book Synopsis Targeting Cardiac Proteotoxicity by : Xuejun Wang
Download or read book Targeting Cardiac Proteotoxicity written by Xuejun Wang and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Mechanisms of Cardiac Hypertrophy and Failure by : Richard A. Walsh
Download or read book Molecular Mechanisms of Cardiac Hypertrophy and Failure written by Richard A. Walsh and published by CRC Press. This book was released on 2005-11-29 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.
Book Synopsis Regulation of Heat Shock Protein Responses by : Alexzander A A Asea
Download or read book Regulation of Heat Shock Protein Responses written by Alexzander A A Asea and published by Springer. This book was released on 2018-05-01 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.
Book Synopsis Recent advances on myocardium physiology, volume II by : Norio Fukuda
Download or read book Recent advances on myocardium physiology, volume II written by Norio Fukuda and published by Frontiers Media SA. This book was released on 2023-04-10 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Traditional Chinese Medicine (TCM): A multi target approach to complex cardiovascular disease - Volume I by : Jing-Yan Han
Download or read book Traditional Chinese Medicine (TCM): A multi target approach to complex cardiovascular disease - Volume I written by Jing-Yan Han and published by Frontiers Media SA. This book was released on 2021-07-29 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease by : Mariarosaria Santillo
Download or read book Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease written by Mariarosaria Santillo and published by Frontiers Media SA. This book was released on 2019-01-22 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two levels of investigation remain separate and not interlaced, failing in the attempt to provide a unified vision of the pathophysiologic mechanisms of cardiovascular diseases. The major aim of the Research Topic has been to collect original papers and review articles dealing with the issue from basic to translation research point of views. The topic includes contributions that highlight different interesting aspects of cardiovascular biology with an integrated approach useful for the development of new ideas and advancements in the field of redox signaling in the control of normal cardiovascular functions and their disruption in diseases.
Book Synopsis Understanding Molecular Mechanisms in Diabetic Cardiomyopathy (DCM) by : VijayaKumar Sukumaran
Download or read book Understanding Molecular Mechanisms in Diabetic Cardiomyopathy (DCM) written by VijayaKumar Sukumaran and published by Frontiers Media SA. This book was released on 2022-08-03 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Chaperonopathies by : Alberto J.L. Macario
Download or read book The Chaperonopathies written by Alberto J.L. Macario and published by Springer Science & Business Media. This book was released on 2013-04-10 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
