Pediatric Neuropsychiatry

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781751919
Total Pages : 780 pages
Book Rating : 4.7/5 (519 download)

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Book Synopsis Pediatric Neuropsychiatry by : C. Edward Coffey

Download or read book Pediatric Neuropsychiatry written by C. Edward Coffey and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Neuropsychiatry provides the most updated and clinically relevant information on psychiatric disorders in children and adolescents with disturbances of brain function. Bridging the fields of psychiatry and neurology, this landmark work emphasizes the link between developmental brain biology and behavior. Major sections focus on neuropsychiatric aspects of specific psychiatric and neurologic disorders, highlighting the influence of the developing nervous system on these disorders' pathophysiology, manifestations, clinical course, treatment, and prognosis. Other sections discuss all contemporary diagnostic and therapeutic modalities. Chapters include case histories, algorithms, tables, and appendices that explain the rudiments of testing.

Dementia, 4th Edition

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Author :
Publisher : CRC Press
ISBN 13 : 1444128744
Total Pages : 817 pages
Book Rating : 4.4/5 (441 download)

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Book Synopsis Dementia, 4th Edition by : David Ames

Download or read book Dementia, 4th Edition written by David Ames and published by CRC Press. This book was released on 2010-11-26 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.

Pitfalls in the Diagnosis of Neurological Disorders

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Author :
Publisher : Jaypee Brothers Medical Publishers
ISBN 13 : 9354656668
Total Pages : 744 pages
Book Rating : 4.3/5 (546 download)

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Book Synopsis Pitfalls in the Diagnosis of Neurological Disorders by : Ambar Chakravarty

Download or read book Pitfalls in the Diagnosis of Neurological Disorders written by Ambar Chakravarty and published by Jaypee Brothers Medical Publishers. This book was released on 2022-10-31 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate diagnosis of neurological disorders can often be difficult due to the complex nature of the nervous system. Whilst technological advances have greatly improved diagnostic and interpretation techniques, errors can still occur, which consequently result in mistakes in therapeutic care. This book is a guide to diagnostic strategies for a multitude of common and less common neurological disorders. Scenarios are set in both a clinical and an intensive care setting. Divided into 13 sections, the text begins with an overview of general neurology. Each of the following sections examines disorders in a different part of the nervous system. Diagnostic processes are evaluated and potential areas where a clinician may make a mistake, are examined and explained in depth. The final section presents 15 authentic cases covering diagnostic challenges in critical care units, all provided by leading experts from the University of Texas Southwestern Medical Centre, USA. With contributions from internationally recognised neurologists, this comprehensive text is highly illustrated with neurological images, and many chapters feature additional editorial notes and appendices. Access to a selection of clinical videos via a QR code is also provided with this book.

Neurological Disorders

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Author :
Publisher : World Health Organization
ISBN 13 : 9241563362
Total Pages : 233 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Neurological Disorders by : World Health Organization

Download or read book Neurological Disorders written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Disease Control Priorities, Third Edition (Volume 4)

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Author :
Publisher : World Bank Publications
ISBN 13 : 1464804281
Total Pages : 307 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 4) by : Vikram Patel

Download or read book Disease Control Priorities, Third Edition (Volume 4) written by Vikram Patel and published by World Bank Publications. This book was released on 2016-03-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.

Handbook of Assessment in Clinical Gerontology

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Publisher : Academic Press
ISBN 13 : 0080959725
Total Pages : 753 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Assessment in Clinical Gerontology by : Peter A. Lichtenberg

Download or read book Handbook of Assessment in Clinical Gerontology written by Peter A. Lichtenberg and published by Academic Press. This book was released on 2010-08-20 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: New trends in mental healthcare practice and a rapid increase in the aged population are causing an explosion in the fields of clinical gerontology and geropsychology today. This comprehensive second edition handbook offers clinicians and graduate students clear guidelines and reliable tools for assessing general mental health, cognitive functioning, functional age, psychosocial health, comorbidity, behavior deficits, and more. Psychopathology, behavioral disorders, changes in cognition, and changes in everyday functioning are addressed in full, and a wide range of conditions and disorders common to this patient population are covered. Each chapter provides an empirical review of assessment instruments, assessment scales in their totality, a review of how these instruments are used with and adapted for different cultural groups, illustration of assessments through case studies, and information on how to utilize ongoing assessment in treatment and/or treatment planning. This combination of elements will make the volume the definitive assessment source for clinicians working with elderly patients. The most comprehensive source of up-to-date data on gerontological assessment, with review articles covering: psychopathology, behavioral disorders, changes in cognition, and changes in everyday functioning Consolidates broadly distributed literature into single source, saving researchers and clinicians time in obtaining and translating information and improving the level of further research and care they can provide Chapters directly address the range of conditions and disorders most common for this patient population - i.e. driving ability, mental competency, sleep, nutrition, sexual functioning, demntias, elder abuse, depression, anxiety disorders, etc Fully informs readers regarding conditions most commonly encountered in real world treatment of an elderly patient population Each chapter cites case studies to illustrate assessment techniques Exposes reader to real-world application of each assessment discussed

Blindsight

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Publisher : BenBella Books
ISBN 13 : 1950665232
Total Pages : 243 pages
Book Rating : 4.9/5 (56 download)

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Book Synopsis Blindsight by : Matt Johnson

Download or read book Blindsight written by Matt Johnson and published by BenBella Books. This book was released on 2020-05-19 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever notice that all watch ads show 10:10 as the time? Or that all fast-food restaurants use red or yellow in their logos? Or that certain stores are always having a sale? You may not be aware of these details, yet they've been influencing you all along. Every time you purchase, swipe, or click, marketers are able to more accurately predict your behavior. These days, brands know more about you than you know about yourself. Blindsight is here to change that. With eye-opening science, engaging stories, and fascinating real-world examples, neuroscientist Matt Johnson and marketer Prince Ghuman dive deep into the surprising relationship between brains and brands. In Blindsight, they showcase how marketing taps every aspect of our mental lives, covering the neuroscience of pain and pleasure, emotion and logic, fear and safety, attention and addiction, and much more. We like to think of ourselves as independent actors in control of our decisions, but the truth is far more complicated. Blindsight will give you the ability to see the unseeable when it comes to marketing, so that you can consume on your own terms. On the surface, you will learn how the brain works and how brands design for it. But peel back a layer, and you'll find a sharper image of your psychology, reflected in your consumer behavior. This book will change the way you view not just branding, but yourself, too.

Art and Neurological Disorders

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Author :
Publisher : Springer Nature
ISBN 13 : 3031147243
Total Pages : 299 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Art and Neurological Disorders by : Alby Richard

Download or read book Art and Neurological Disorders written by Alby Richard and published by Springer Nature. This book was released on 2023-02-21 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is significant academic interest in the field of art and neurological disorders. Considering how artistic expression may be modified by alterations in neural circuits, as well as in our bodies and everyday lives, associated with a range of disorders and diseases is a rich territory from which to understand the workings of our brains, the unique blend of factors leading to human art making, and disease itself. This book will be an exposé of how different neurological disorders may influence and/or relate to the artistic process, with a particular focus on visual art and painting. The book will interrogate the question of different aspects of neurological disorders and associated brain changes that may impact artistic expression (and vice versa) and will include devoted chapters on Parkinson’s disease, Epilepsy, Mood Disorders, Autism, and Schizophrenia. Moreover, we will elaborate on the question from the perspective of the artist themselves, with chapters that highlight the artistic process in the context of lived experience (either directly or indirectly) with disease-mediated brain changes. Finally, engagement in creative acts has been linked to therapeutic benefits in multiple disease processes and neuroplasticity, which is another line of inquiry directly addressed in the book. As a whole, the volume focuses on themes and concepts at the boundary of creativity and neuroscience in such a way as to be relevant to both the medical and broader (artistic) community.

Handbook of Developmental Cognitive Neuroscience, second edition

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Author :
Publisher : MIT Press
ISBN 13 : 0262141043
Total Pages : 985 pages
Book Rating : 4.2/5 (621 download)

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Book Synopsis Handbook of Developmental Cognitive Neuroscience, second edition by : Charles A. Nelson

Download or read book Handbook of Developmental Cognitive Neuroscience, second edition written by Charles A. Nelson and published by MIT Press. This book was released on 2008-07-11 with total page 985 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of an essential resource to the evolving field of developmental cognitive neuroscience, completely revised, with expanded emphasis on social neuroscience, clinical disorders, and imaging genomics. The publication of the second edition of this handbook testifies to the rapid evolution of developmental cognitive neuroscience as a distinct field. Brain imaging and recording technologies, along with well-defined behavioral tasks—the essential methodological tools of cognitive neuroscience—are now being used to study development. Technological advances have yielded methods that can be safely used to study structure-function relations and their development in children's brains. These new techniques combined with more refined cognitive models account for the progress and heightened activity in developmental cognitive neuroscience research. The Handbook covers basic aspects of neural development, sensory and sensorimotor systems, language, cognition, emotion, and the implications of lifelong neural plasticity for brain and behavioral development. The second edition reflects the dramatic expansion of the field in the seven years since the publication of the first edition. This new Handbook has grown from forty-one chapters to fifty-four, all original to this edition. It places greater emphasis on affective and social neuroscience—an offshoot of cognitive neuroscience that is now influencing the developmental literature. The second edition also places a greater emphasis on clinical disorders, primarily because such research is inherently translational in nature. Finally, the book's new discussions of recent breakthroughs in imaging genomics include one entire chapter devoted to the subject. The intersection of brain, behavior, and genetics represents an exciting new area of inquiry, and the second edition of this essential reference work will be a valuable resource for researchers interested in the development of brain-behavior relations in the context of both typical and atypical development.

The Digitalization of Neurology

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832537685
Total Pages : 156 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Digitalization of Neurology by : Daniel B. Hier

Download or read book The Digitalization of Neurology written by Daniel B. Hier and published by Frontiers Media SA. This book was released on 2023-10-31 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 20 years Medicine in general, and Neurology in specific, has become increasingly digitized. Increasingly, Neurology has made a transition from qualitative to quantitative methods. The conversion of neurological data from free text to a computable format has made the application of digital tools to neurological diagnosis and prognosis a reality. This Research Topic in Frontiers in Digital Health will highlight how the digitization of data has revolutionized Neurology. Themes covered will include natural language processing, ontologies, phenotyping, big data, bio-banks, machine learning, graph theory, network analysis, computational models, electronic health records, telemetry, and teleneurology.

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

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Author :
Publisher : Elsevier
ISBN 13 : 0124105491
Total Pages : 1465 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by : Roger N. Rosenberg

Download or read book Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease written by Roger N. Rosenberg and published by Elsevier. This book was released on 2014-10-28 with total page 1465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Transactions of the American Neurological Association

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Author :
Publisher :
ISBN 13 :
Total Pages : 1076 pages
Book Rating : 4.A/5 ( download)

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Book Synopsis Transactions of the American Neurological Association by :

Download or read book Transactions of the American Neurological Association written by and published by . This book was released on 1904 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Psychiatric Care of the Medical Patient

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Publisher : Oxford University Press
ISBN 13 : 0190226293
Total Pages : 1813 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Psychiatric Care of the Medical Patient by : Barry S. Fogel

Download or read book Psychiatric Care of the Medical Patient written by Barry S. Fogel and published by Oxford University Press. This book was released on 2015-05-28 with total page 1813 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of Psychiatric Care of the Medical Patient brings a classic reference text into the twenty-first century. It combines critical scholarship with the voice of expert clinicians who work at the interface of psychiatry with medical specialties. It is meant to be read for pleasure as well as consulted as a reference. The editors have worked with the authors to bring a consistent perspective to the book - one that sees the medical psychiatrist as an agent for bringing a more comprehensive perspective to medical care. Even seasoned and knowledgeable practitioners will find much that is new to them in this book. The volume covers topics in depth that other books in the field may not cover at all, such as the use of herbal and nutritional therapies for medical-psychiatric symptoms and syndromes, and the choice of questionnaires to supplement history-taking. It looks at old topics in a new way: The chapter on the physical examination applies psychometric considerations to the Babinski sign, describes the method and application of quantitative bedside olfactory testing, and discusses smartphone apps to improve the sensitivity of the examination. Psychiatric Care of the Medical Patient, 3rd Edition provides concepts and information to facilitate the dialogue between psychiatrists and general medical specialists - minimizing psychiatric jargon and speaking in the common language of caring and curious physicians.

Application and Evaluation of Acupuncture in the Treatment of Neurological Diseases

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832521746
Total Pages : 333 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Application and Evaluation of Acupuncture in the Treatment of Neurological Diseases by : Liming Lu

Download or read book Application and Evaluation of Acupuncture in the Treatment of Neurological Diseases written by Liming Lu and published by Frontiers Media SA. This book was released on 2023-06-21 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological disorders, such as Alzheimer's disease and Parkinson's disease, are an important cause of disability and death worldwide and pose a serious burden on the global health system over the past 30 years. Acupuncture, as the most widely used traditional Chinese medicine therapy in the world, has been widely used in 183 countries and regions. Acupuncture can treat more than 300 kinds of diseases, especially for neurological diseases. Due to the unique advantages of acupuncture such as good therapeutic effect and low side effects, many researchers have conducted extensive clinical studies on the effectiveness and safety of acupuncture in the treatment of neurological diseases, laying a foundation for the practicability and scientific vigor of this complementary and alternative therapeutic approach. There are still many problems unanswered in the current clinical research on acupuncture for the treatment of neurological diseases: First of all, clinical research is lagging behind due to the lack of emphasis on modern advanced methods and analytical techniques (e.g., artificial intelligence, omics analysis, bioinformatics analysis, data mining) and multidisciplinary integration process. Secondly, the quality of reports on most clinical studies of acupuncture treatment for neurological diseases is extremely low. Most clinical studies have not adopted standardized methodological evaluations, authoritative disease diagnosis standards, and efficacy evaluation standards. The lack of compliance regulations and strict study design reduces the accuracy and authenticity of the research. Thirdly, there is a lack of integrated assessment of the distribution of evidence for acupuncture treatment of neurological diseases. Therefore, strictly designed clinical research and in depth and systematic analysis method are currently needed to provide high-quality evidence for acupuncture treatment of neurological diseases. In this Research Topic, we hope to further understand the role of acupuncture in the treatment of neurological diseases through clinical research and secondary research. The range of acupuncture includes manual acupuncture, electro-acupuncture, body needling, auricular acupuncture, scalp acupuncture, laser acupuncture and acupressure, etc. Neurological diseases include stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neurone disease, migraine, tense-type headaches, headaches from drug overuse, and others.

Stem Cell Therapy for Autoimmune Disease

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Publisher : CRC Press
ISBN 13 : 1000716856
Total Pages : 512 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Stem Cell Therapy for Autoimmune Disease by : Richard K. Burt

Download or read book Stem Cell Therapy for Autoimmune Disease written by Richard K. Burt and published by CRC Press. This book was released on 2019-11-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

The Practice of Emergency and Critical Care Neurology

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Author :
Publisher : Oxford University Press
ISBN 13 : 0197544975
Total Pages : 1081 pages
Book Rating : 4.1/5 (975 download)

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Book Synopsis The Practice of Emergency and Critical Care Neurology by : Eelco F. M. Wijdicks

Download or read book The Practice of Emergency and Critical Care Neurology written by Eelco F. M. Wijdicks and published by Oxford University Press. This book was released on 2024-08 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Practice of Emergency and Critical Care Neurology is the classic and comprehensive reference for physicians caring for patients with critical neurologic disorders, at risk of deterioation and in need of immediate attention. This third edition is richly illustrated and contains new chapters on the basics of neuroimaging, pharmacology issues in the intensive care setting, intoxications, critical care ultrasound, and more.

Cancer Neurology in Clinical Practice

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Author :
Publisher : Humana Press
ISBN 13 : 3319579010
Total Pages : 629 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Cancer Neurology in Clinical Practice by : David Schiff

Download or read book Cancer Neurology in Clinical Practice written by David Schiff and published by Humana Press. This book was released on 2017-09-16 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life. "This textbook is a valuable resource for medical oncologists and radiation oncologists, as well as neurologists and neuro-oncologists dealing with these patients. ... Overall, the chapters are well organized, clearly written, fairly balanced, and reasonably up to date. ... I would recommend it as a learning tool to physicians in training (medical students, residents, and fellows) and for more experienced physicians as both a review/ update and a way to gain more in-depth knowledge and insight into the neurologic problems of cancer patients." (John C. Flickinger, International Journal of Radiation Oncology Biology Physics, Vol. 73 (2), 2009) "The general organization of the book is logical and facilitates its practical and everyday use. ... Overall this textbook is very comprehensive and encompasses main neuro-oncological challenges. ... Schiff, Kesari and Wen have edited a very elegant and highly practical textbook, written by recognized authorities in their respective fields, which will be used by a wide range of medical and surgical specialists who are confronted on a daily basis with neurological manifestations of cancer in their practice." (I. Radovanovic and G. Zadeh, British Journal of Cancer, Vol. 100 (6), 2009)