Xenobiotic Metabolic Enzymes Bioactivation And Antioxidant Defense

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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

Author : Chang-Hwei Chen
Publisher : Springer Nature
ISBN 13 : 3030416798
Total Pages : 256 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense by : Chang-Hwei Chen

Download or read book Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense written by Chang-Hwei Chen and published by Springer Nature. This book was released on 2020-04-03 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.

Activation and Detoxification Enzymes

Author : Chang-Hwei Chen
Publisher : Springer Nature
ISBN 13 : 3031552873
Total Pages : 257 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Activation and Detoxification Enzymes by : Chang-Hwei Chen

Download or read book Activation and Detoxification Enzymes written by Chang-Hwei Chen and published by Springer Nature. This book was released on with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Public Health and Toxicology Issues in Drug Research, Volume 2

Author : Rakesh Kumar Tekade
Publisher : Elsevier
ISBN 13 : 0443158436
Total Pages : 854 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Public Health and Toxicology Issues in Drug Research, Volume 2 by : Rakesh Kumar Tekade

Download or read book Public Health and Toxicology Issues in Drug Research, Volume 2 written by Rakesh Kumar Tekade and published by Elsevier. This book was released on 2024-03-26 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health. Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments. - Discusses the impact of pharmaceuticals, food, and chemical toxicants on human health - Examines the toxic effects of medical treatments, clinical administrations, and materials - Explores public health issues around drug safety and toxicology

Deuterium Oxide and Deuteration in Biosciences

Author : Chang-Hwei Chen
Publisher : Springer Nature
ISBN 13 : 3031086058
Total Pages : 180 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Deuterium Oxide and Deuteration in Biosciences by : Chang-Hwei Chen

Download or read book Deuterium Oxide and Deuteration in Biosciences written by Chang-Hwei Chen and published by Springer Nature. This book was released on 2022-08-21 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book provides comprehensive coverage of the subjects of deuterium oxide and deuteration in biosciences, with an emphasis on the biochemical, biomedical, and pharmacological aspects. Deuterium oxide and deuteration effects also offer various implications for health-related issues, including diseases, vaccines and drugs. Organized in six sections, the chapter topics include the role of regular and heavy water in biosciences, and their implications to biomolecules, biochemical processes, health-related research, and pharmacology. Due to the broad scope, the book may be used as a supplemental text for upper-level undergraduate and graduate courses in the related fields of biochemistry, biology, biomedical sciences, biophysics, and pharmacology. Researchers and pharmaceutical industry professionals will also find the content useful in order to gain knowledge and better understand the implications of deuterium oxide and deuteration research.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Advances in Prodrugs

Author : Claudiu Trandafir Supuran
Publisher : Elsevier
ISBN 13 : 0443156344
Total Pages : 380 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Advances in Prodrugs by : Claudiu Trandafir Supuran

Download or read book Advances in Prodrugs written by Claudiu Trandafir Supuran and published by Elsevier. This book was released on 2024-10-01 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases. - Highlights chemistry and pharmacology-related aspects, offering a versatile tool for readers involved in prodrug development and study - Discusses in-depth treatment of several activation mechanisms and applications for disease treatments - Covers a range of topics from basic contents, design, and mechanisms of actions to current applications in drugs

Algae as a Natural Solution for Challenges in Water-Food-Energy Nexus

Author : Tonni Agustiono Kurniawan
Publisher : Springer Nature
ISBN 13 : 981972371X
Total Pages : 919 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Algae as a Natural Solution for Challenges in Water-Food-Energy Nexus by : Tonni Agustiono Kurniawan

Download or read book Algae as a Natural Solution for Challenges in Water-Food-Energy Nexus written by Tonni Agustiono Kurniawan and published by Springer Nature. This book was released on with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular and Biochemical Toxicology

Author : Robert C. Smart
Publisher : John Wiley & Sons
ISBN 13 : 1119042437
Total Pages : 1234 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Molecular and Biochemical Toxicology by : Robert C. Smart

Download or read book Molecular and Biochemical Toxicology written by Robert C. Smart and published by John Wiley & Sons. This book was released on 2017-11-06 with total page 1234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Cellular Antioxidant Defense Mechanisms

Author : Ching Kuang Chow
Publisher : CRC Press
ISBN 13 : 1000697312
Total Pages : 375 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Cellular Antioxidant Defense Mechanisms by : Ching Kuang Chow

Download or read book Cellular Antioxidant Defense Mechanisms written by Ching Kuang Chow and published by CRC Press. This book was released on 2019-07-17 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1988, this three-volume set offers a full insight into the immune systems and its response to antioxidants. Carefully compiled and filled with diagrams, references and information this set is recommended for students of immunology and other professionals in their respective fields.

Comprehensive Toxicology

Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Toxicology by :

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Drug Metabolism

Author : Mino R. Caira
Publisher : Springer Science & Business Media
ISBN 13 : 140204142X
Total Pages : 431 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Drug Metabolism by : Mino R. Caira

Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Fundamentals of Toxicologic Pathology

Author : Matthew A. Wallig
Publisher : Academic Press
ISBN 13 : 0080919324
Total Pages : 714 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Fundamentals of Toxicologic Pathology by : Matthew A. Wallig

Download or read book Fundamentals of Toxicologic Pathology written by Matthew A. Wallig and published by Academic Press. This book was released on 2009-11-23 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. - 25% brand new information, fully revised throughout - New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology - New color photomicrographs detailing specific toxicant-induced diseases in animals - Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Enzyme Systems that Metabolise Drugs and Other Xenobiotics

Author : Costas Ioannides
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Enzyme Systems that Metabolise Drugs and Other Xenobiotics by : Costas Ioannides

Download or read book Enzyme Systems that Metabolise Drugs and Other Xenobiotics written by Costas Ioannides and published by John Wiley & Sons. This book was released on 2002 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work focuses on the enzyme systems that participate in the metabolism of chemicals and other xenobiotics, with emphasis being placed on drug metabolism. Each chapter focuses on a specific enzyme system.

Oxidants in Biology

Author : Giuseppe Valacchi
Publisher : Springer Science & Business Media
ISBN 13 : 1402083998
Total Pages : 324 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Oxidants in Biology by : Giuseppe Valacchi

Download or read book Oxidants in Biology written by Giuseppe Valacchi and published by Springer Science & Business Media. This book was released on 2008-06-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Reaction Mechanisms in Environmental Engineering

Author : James G. Speight
Publisher : Butterworth-Heinemann
ISBN 13 : 0128006676
Total Pages : 458 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Reaction Mechanisms in Environmental Engineering by : James G. Speight

Download or read book Reaction Mechanisms in Environmental Engineering written by James G. Speight and published by Butterworth-Heinemann. This book was released on 2018-08-13 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reaction Mechanisms in Environmental Engineering: Analysis and Prediction describes the principles that govern chemical reactivity and demonstrates how these principles are used to yield more accurate predictions. The book will help users increase accuracy in analyzing and predicting the speed of pollutant conversion in engineered systems, such as water and wastewater treatment plants, or in natural systems, such as lakes and aquifers receiving industrial pollution. Using examples from air, water and soil, the book begins with a clear exposition of the properties of environmental and inorganic organic chemicals that is followed by partitioning and sorption processes and sorption and transformation processes. Kinetic principles are used to calculate or estimate the pollutants' half-lives, while physical-chemical properties of organic pollutants are used to estimate transformation mechanisms and rates. The book emphasizes how to develop an understanding of how physico-chemical and structural properties relate to transformations of organic pollutants. - Offers a one-stop source for analyzing and predicting the speed of organic and inorganic reaction mechanisms for air, water and soil - Provides the tools and methods for increased accuracy in analyzing and predicting the speed of pollutant conversion in engineered systems - Uses kinetic principles and the physical-chemical properties of organic pollutants to estimate transformation mechanisms and rates

Toxicological Profile for Polycyclic Aromatic Hydrocarbons

Author :
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Polycyclic Aromatic Hydrocarbons by :

Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxidative Stress and Antioxidant Defenses in Biology

Author : Sami Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 1461596890
Total Pages : 478 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Oxidative Stress and Antioxidant Defenses in Biology by : Sami Ahmad

Download or read book Oxidative Stress and Antioxidant Defenses in Biology written by Sami Ahmad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive treatment of the latest research on oxidative stress and antioxidant defenses in all types of aerobic organisms. This book investigates oxidative stress in prokaryotes, protists, plants, fungi, vertebrates, and invertebrates, stimulating cross-fertilization among diverse fields. In addition, it explains the basic science of oxygen activation and oxidative stress as a foundation for more advanced material, making this book useful as a resource for both specialists and non-specialists.