X Ray Crystallography Of Biomacromolecules

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X-Ray Crystallography of Biomacromolecules

Author : Albrecht Messerschmidt
Publisher : John Wiley & Sons
ISBN 13 : 3527609679
Total Pages : 318 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis X-Ray Crystallography of Biomacromolecules by : Albrecht Messerschmidt

Download or read book X-Ray Crystallography of Biomacromolecules written by Albrecht Messerschmidt and published by John Wiley & Sons. This book was released on 2007-02-27 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely clearly written book. Part A covers the theoretical basis and such experimental techniques as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS and MAD techniques, molecular replacement, and the difference Fourier technique.

Macromolecular Crystallography

Author : Maria Armenia Carrondo
Publisher : Springer
ISBN 13 : 9400725302
Total Pages : 213 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Macromolecular Crystallography by : Maria Armenia Carrondo

Download or read book Macromolecular Crystallography written by Maria Armenia Carrondo and published by Springer. This book was released on 2011-12-01 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.

Crystallization of Biological Macromolecules

Author : Alexander McPherson
Publisher :
ISBN 13 :
Total Pages : 608 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Crystallization of Biological Macromolecules by : Alexander McPherson

Download or read book Crystallization of Biological Macromolecules written by Alexander McPherson and published by . This book was released on 1999 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively illustrated book by Alexander McPherson, a master practitioner, accomplishes several important goals: it presents the underlying physical and chemical principles of crystallization in an approachable way; it provides the reader with a biochemical context in which to understand and pursue successful crystal growth; it instructs the reader in practical aspects of the technologies required; and it lays out effective strategies for success that investigators can readily apply to their own experimental questions. This readable volume has been created for every investigator in biomedicine whose studies may require a shift in focus from gene to protein product, as well as chemists and physicists interested in the functions of biologically active macromolecules.

Principles of Protein X-ray Crystallography

Author : Jan Drenth
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Principles of Protein X-ray Crystallography by : Jan Drenth

Download or read book Principles of Protein X-ray Crystallography written by Jan Drenth and published by . This book was released on 1994 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals so set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface Macromolecules are the principal nonaqueous components of living cells. Among the macromolecules (proteins, nucleic acids, and carbohydrates), proteins are the largest group.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Fundamentals of Molecular Structural Biology

Author : Subrata Pal
Publisher : Academic Press
ISBN 13 : 0128148551
Total Pages : 518 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Fundamentals of Molecular Structural Biology by : Subrata Pal

Download or read book Fundamentals of Molecular Structural Biology written by Subrata Pal and published by Academic Press. This book was released on 2019-09-02 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Biomacromolecules

Author : C. Stan Tsai
Publisher : John Wiley & Sons
ISBN 13 : 0470080116
Total Pages : 770 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Biomacromolecules by : C. Stan Tsai

Download or read book Biomacromolecules written by C. Stan Tsai and published by John Wiley & Sons. This book was released on 2007-01-16 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an integrated treatment of the structure and function of nucleic acids, proteins, and glycans, including thorough coverage of relevant computational biochemistry. The text begins with an introduction to the biomacromolecules, followed by discussion of methods of isolation and purification, physiochemical and biochemical properties, and structural characteristics. The next section of the book deals with sequence analysis, analysis of conformation using spectroscopy, chemical synthesis, and computational approaches. The following chapters discuss biomolecular interactions, enzyme action, gene transmission, signal transduction, and biomacromolecular informatics. The author concludes with presenting the latest findings in genomics, proteomics, glycomics, and biomacromolecular evolution. This text is an invaluable resource for research professionals wishing to move into genomics, proteomics, and glycomics research. It is also useful for students in biochemistry, molecular biology, bioengineering, biotechnology, and bioinformatics.

Understanding Single-Crystal X-Ray Crystallography

Author : Dennis W. Bennett
Publisher : John Wiley & Sons
ISBN 13 : 3527326774
Total Pages : 826 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Understanding Single-Crystal X-Ray Crystallography by : Dennis W. Bennett

Download or read book Understanding Single-Crystal X-Ray Crystallography written by Dennis W. Bennett and published by John Wiley & Sons. This book was released on 2010-03-08 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first textbook for teaching this method to users with little mathematical background logically presents the theory and fundamentals in an easily comprehensible, self-contained way. The result is a must-have for advanced undergraduate students, as well as masters and graduate students and other users of single-crystal X-ray crystallography from many various disciplines.

Crystals, X-rays and Proteins

Author : Dennis Sherwood
Publisher : Oxford University Press
ISBN 13 : 019955904X
Total Pages : 640 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Crystals, X-rays and Proteins by : Dennis Sherwood

Download or read book Crystals, X-rays and Proteins written by Dennis Sherwood and published by Oxford University Press. This book was released on 2011 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.

Structure Determination by X-Ray Crystallography

Author : R.A. Palmer
Publisher : Springer Science & Business Media
ISBN 13 : 1461579392
Total Pages : 518 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Structure Determination by X-Ray Crystallography by : R.A. Palmer

Download or read book Structure Determination by X-Ray Crystallography written by R.A. Palmer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray crystallography provides us with the most accurate picture we can get of atomic and molecular structures in crystals. It provides a hard bedrock of structural results in chemistry and in mineralogy. In biology, where the structures are not fully crystalline, it can still provide valuable results and, indeed, the impact here has been revolutionary. It is still an immense field for young workers, and no doubt will provide yet more striking develop ments of a major character. It does, however, require a wide range of intellectual application, and a considerable ability in many fields. This book will provide much help. It is a very straightforward and thorough guide to every aspect of the subject. The authors are experienced both as research workers themselves and as teachers of standing, and this is shown in their clarity of exposition. There are plenty of iliustrations and worked examples to aid the student to obtain a real grasp of the subject.

Polymer Morphology

Author : Qipeng Guo
Publisher : John Wiley & Sons
ISBN 13 : 1118452151
Total Pages : 472 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Polymer Morphology by : Qipeng Guo

Download or read book Polymer Morphology written by Qipeng Guo and published by John Wiley & Sons. This book was released on 2016-05-16 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a focus on structure-property relationships, this book describes how polymer morphology affects properties and how scientists can modify them. The book covers structure development, theory, simulation, and processing; and discusses a broad range of techniques and methods. • Provides an up-to-date, comprehensive introduction to the principles and practices of polymer morphology • Illustrates major structure types, such as semicrystalline morphology, surface-induced polymer crystallization, phase separation, self-assembly, deformation, and surface topography • Covers a variety of polymers, such as homopolymers, block copolymers, polymer thin films, polymer blends, and polymer nanocomposites • Discusses a broad range of advanced and novel techniques and methods, like x-ray diffraction, thermal analysis, and electron microscopy and their applications in the morphology of polymer materials

NMR and Crystal Structures of Biomacromolecules

Author : Richard Lee Fahrner
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis NMR and Crystal Structures of Biomacromolecules by : Richard Lee Fahrner

Download or read book NMR and Crystal Structures of Biomacromolecules written by Richard Lee Fahrner and published by . This book was released on 2000 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Protein Molecular and Structural Biology Methods

Author : Timir Tripathi
Publisher : Academic Press
ISBN 13 : 0323902650
Total Pages : 716 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advances in Protein Molecular and Structural Biology Methods by : Timir Tripathi

Download or read book Advances in Protein Molecular and Structural Biology Methods written by Timir Tripathi and published by Academic Press. This book was released on 2022-01-14 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. Presents a thorough overview of the latest and emerging methods and technologies for protein study Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy Includes computational and machine learning methods Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins

Advanced X-ray Crystallography

Author : Kari Rissanen
Publisher : Springer Science & Business Media
ISBN 13 : 3642274072
Total Pages : 190 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Advanced X-ray Crystallography by : Kari Rissanen

Download or read book Advanced X-ray Crystallography written by Kari Rissanen and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Studies of Crystal Structure and Bonding, by Angelo Gavezzotti Cryo-Crystallography: Diffraction at Low Temperature and More, by Piero Macchi High-Pressure Crystallography, by Malcolm I. McMahon Chemical X-Ray Photodiffraction: Principles, Examples, and Perspectives, by Panče Naumov Powder Diffraction Crystallography of Molecular Solids, by Kenneth D. M. Harris

Macromolecular Crystallography

Author : Charles W. Carter
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121827779
Total Pages : 756 pages
Book Rating : 4.8/5 (277 download)

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Book Synopsis Macromolecular Crystallography by : Charles W. Carter

Download or read book Macromolecular Crystallography written by Charles W. Carter and published by Gulf Professional Publishing. This book was released on 1997 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software.

Innovative Screening Conditions for the Crystallization of Macromolecules

Author : Fabrice Gorrec
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (952 download)

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Book Synopsis Innovative Screening Conditions for the Crystallization of Macromolecules by : Fabrice Gorrec

Download or read book Innovative Screening Conditions for the Crystallization of Macromolecules written by Fabrice Gorrec and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray crystallography enables the structure determination of biological macromolecules, their complexes and assemblies to high-resolution. Nevertheless, protein crystallisation is a stochastic process and the yield of crystals is typically very poor. In addition, crystal properties are often deceiving. Herein, we introduce the basic principles of protein structure determination process and we will discuss two innovative developments of screen formulation (called Pi and MORPHEUS).

Macromolecular Crystallization and Crystal Perfection

Author : Naomi E Chayen
Publisher : Oxford University Press (UK)
ISBN 13 : 0199213259
Total Pages : 234 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Macromolecular Crystallization and Crystal Perfection by : Naomi E Chayen

Download or read book Macromolecular Crystallization and Crystal Perfection written by Naomi E Chayen and published by Oxford University Press (UK). This book was released on 2010-03-25 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural biology is key to our understanding of the mechanisms of biological processes. This book describes current methods and future frontiers in crystal growth and use of X-ray and Neutron crystallography, in the context of the very successful current automation of crystallization and generation of synchrotron X-ray and neutron beams.