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X Ray Crystallographic Studies In Some Peptides And Proteins
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Book Synopsis Principles of Protein X-ray Crystallography by : Jan Drenth
Download or read book Principles of Protein X-ray Crystallography written by Jan Drenth and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.
Book Synopsis X-Ray Crystallographic Studies in Some Peptides and Proteins by : Pauline May Cowan
Download or read book X-Ray Crystallographic Studies in Some Peptides and Proteins written by Pauline May Cowan and published by . This book was released on 1952 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Crystallography in Drug Discovery by : Robert E. Babine
Download or read book Protein Crystallography in Drug Discovery written by Robert E. Babine and published by John Wiley & Sons. This book was released on 2008-07-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
Book Synopsis X-ray Crystallographic Studies of Oligomers Derived from Amyloidogenic Peptides and Proteins by : Ryan K. Spencer
Download or read book X-ray Crystallographic Studies of Oligomers Derived from Amyloidogenic Peptides and Proteins written by Ryan K. Spencer and published by . This book was released on 2015 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Crystals, X-rays and Proteins by : Dennis Sherwood
Download or read book Crystals, X-rays and Proteins written by Dennis Sherwood and published by OUP Oxford. This book was released on 2010-11-05 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete account of the theory of the diffraction of X-rays by crystals, with particular reference to the processes of determining the structures of protein molecules. This book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the field with a background in physical sciences or chemistry. It may be used at any post-school level, and develops from first principles all relevant mathematics, diffraction and wave theory, assuming no mathematical knowledge beyond integral calculus. The book covers a host of important topics in the area, including: - The practical aspects of sample preparation and X-ray data collection, using both laboratory and synchrotron sources - Data analysis at both theoretical and practical levels - The important role played by the Patterson function in structure analysis, by both molecular replacement and experimental phasing approaches - Methods for improving the resulting electron density map - The theoretical basis of methods used in refinement of protein crystal structures - In-depth explanation of the crucial task of defining the binding sites of ligands and drug molecules - The complementary roles of other diffraction methods: these reveal further detail of great functional importance in a crystal structure.
Book Synopsis Preparation and Analysis of Protein Crystals by : Alexander McPherson
Download or read book Preparation and Analysis of Protein Crystals written by Alexander McPherson and published by John Wiley & Sons. This book was released on 1982-05-04 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete guide to techniques and procedures for the preparation of proteins for crystallographic studies. Describes methods for protein crystallization; formation of isomorphous heavy atoms; x-ray diffraction and analysis; and photographic and computerbased data collection methods and instrumentation.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Studies Of Designed Peptides, Self Assembling Pseudopeptides And Molecular Modeling by :
Download or read book X-ray Crystallographic Studies Of Designed Peptides, Self Assembling Pseudopeptides And Molecular Modeling written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural studies of peptides has relevance for various applications, like, in de novo design of proteins, in designing better catalysts for organic synthesis, in structure based drug design, in the design and construction of synthetic protein mimics and in building novel materials via supramolecular self assembly. Crystal structure determination of peptides is expected to provide information about their static structure, mode of aggregation, solvation and hydrogen bond interactions of the sequences in the solid state. Comparison and analysis of the related structures from the database analysis could provide information about sequence dependent conformational features, which eventually would act as precursor for de novo protein design. Self assembling processes are common throughout nature and technology. Living cells self assemble, and understanding life will therefore require an understanding of self assembly. Supramolecular chemistry has become an area of intense research, partly inspired by biological ensembles in nature, such as collagen and enzymes or protein assemblies in general. Understanding, inducing, and directing such self assembling processes are key to unraveling the progressive emergence of complex matter. Most of the drugs available today have a broad spectrum of action in that they can act on more than one receptor and the mechanism of action of these drugs are poorly understood. Homology modeling of receptors and docking studies with drug molecules (both peptides and non-peptides) would result in a better understanding of the mechanism of drug-receptor binding thus resulting in the design of more specific and effective drugs. This thesis reports the results of X-ray crystallographic studies of ten molecules listed below (Ter: terephthalic acid) and the molecular model of cholecystokinin type 1 receptor (CCK1R). The abbreviations used for the sequences are given in parenthesis. Boc-Gly-Dpg-Gly-Leu-OMe (GDGL), C24H44N4O7 Boc-Val-Ala-Leu-Dpg-Val-Ala.
Book Synopsis X-ray Diffraction Studies of Amino Acids, Peptides and Proteins by : Linus Pauling
Download or read book X-ray Diffraction Studies of Amino Acids, Peptides and Proteins written by Linus Pauling and published by . This book was released on 1948 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protein Crystallography by : Eaton E. Lattman
Download or read book Protein Crystallography written by Eaton E. Lattman and published by JHU Press. This book was released on 2008-04-28 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.
Book Synopsis X-Ray Crystallography of Biomacromolecules by : Albrecht Messerschmidt
Download or read book X-Ray Crystallography of Biomacromolecules written by Albrecht Messerschmidt and published by Wiley-Blackwell. This book was released on 2007-01-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely clearly written book. Part A covers the theoretical basis and such experimental techniques as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS and MAD techniques, molecular replacement, and the difference Fourier technique.
Book Synopsis Protein Crystallization by : Terese M. Bergfors
Download or read book Protein Crystallization written by Terese M. Bergfors and published by Internat'l University Line. This book was released on 2009 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Methods for the Study of Native and Non-native Protein Structure by :
Download or read book X-ray Crystallographic Methods for the Study of Native and Non-native Protein Structure written by and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diverse functions that proteins carry out are intimately connected with the three-dimensional shapes that these molecules adopt in solution. Our understanding of the various biological roles that proteins play depends critically on our ability to probe their underlying structural parameters. Among the various experimental methods that have been used to interrogate protein structure, X-ray crystallography is unrivaled in its capacity to provide high-resolution structural information. In spite of its advantages as a tool for protein structural analysis, X-ray crystallography suffers a critical drawback in that it requires that a single crystal of the protein of interest be grown. The racemic crystallization method, which involves the combination of enantiomeric proteins in a crystallization experiment, has attracted significant interest because it is believed to facilitate crystal growth from proteins that are recalcitrant to conventional crystallization techniques. The majority of the work described in this dissertation centers on the application of racemic crystallization to the structural characterization of several different peptides and proteins. Through our studies, we have found that the racemic method can provide insights into how non-canonical amino acid subunits are accommodated within an otherwise native protein context; these findings are relevant to design efforts involving non-natural subunits. Additionally, we used the racemic method to explore interactions between enantiomeric (i.e., L- and D-) polypeptides. These studies provide a starting point for efforts to design protease-resistant D-peptide inhibitors of protein-protein interactions of therapeutic interest. Chapter Two of this dissertation describes our efforts to assess the impact of incorporating a highly fluorinated amino acid into the hydrophobic core of a model protein tertiary structure. Chapter Three details our structural analysis of the racemic form of a [beta]-sheet protein tertiary structure that had resisted previous attempts at conventional crystallization. Chapter Four of this dissertation describes the results of our efforts to crystallize the racemic form of a membrane-embedded peptide segment using two different crystallization media. These studies have provided structural insights into intimate packing interactions that occur between L- and D-polypeptides. Chapter Five details an ongoing study involving substitutions of backbone-modified amino acids into protein loops.
Book Synopsis X-Ray Crystallographic Studies Of Designed Peptides by :
Download or read book X-Ray Crystallographic Studies Of Designed Peptides written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics by : Xiaofei Jia
Download or read book X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics written by Xiaofei Jia and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-ray Crystallographic Studies of Some Antibiotic Peptides by : M. N. G. James
Download or read book X-ray Crystallographic Studies of Some Antibiotic Peptides written by M. N. G. James and published by . This book was released on 1966 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis X-Ray Crystallographic Studies Of Designed Peptides And Protected Omega Amino Acids by :
Download or read book X-Ray Crystallographic Studies Of Designed Peptides And Protected Omega Amino Acids written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
