What Is Kuru A Deadly First Human Prion Misfolded Proteinsdisease

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What is Kuru? A Deadly First Human Prion (misfolded proteins)Disease.

Author : Dr. Hakim. K. Saboowala
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 54 pages
Book Rating : 4./5 ( download)

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Book Synopsis What is Kuru? A Deadly First Human Prion (misfolded proteins)Disease. by : Dr. Hakim. K. Saboowala

Download or read book What is Kuru? A Deadly First Human Prion (misfolded proteins)Disease. written by Dr. Hakim. K. Saboowala and published by Dr.Hakim Saboowala. This book was released on 2021-04-28 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is Kuru? A Deadly First Human Prion (misfolded proteins)Disease. Kuru is an incurable and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea. Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). The discovery of kuru opened new vistas of human medicine and was pivotal in the subsequent transmission of Creutzfeldt–Jakob disease, as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century. An attempt is made here to summarize the history of this seminal discovery, epidemiology, clinical picture, neuropathology, investigations, management, complications, prognosis and the descriptions of electron microscopy and confocal microscopy of kuru amyloid plaques along with several illustrations for better understanding of a quaint but interesting entity. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London).

Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 512 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Fatal Flaws

Author : Jay Ingram
Publisher : Yale University Press
ISBN 13 : 0300189893
Total Pages : 294 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Fatal Flaws by : Jay Ingram

Download or read book Fatal Flaws written by Jay Ingram and published by Yale University Press. This book was released on 2013-03-19 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: DIVThe story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases/div

Neuropathology of Neurodegenerative Diseases

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1316337650
Total Pages : 320 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

The Prion Protein

Author : Jorg Tatzelt
Publisher :
ISBN 13 : 9780954333522
Total Pages : 80 pages
Book Rating : 4.3/5 (335 download)

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Book Synopsis The Prion Protein by : Jorg Tatzelt

Download or read book The Prion Protein written by Jorg Tatzelt and published by . This book was released on 2010 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Neurogenetics

Author :
Publisher : Elsevier
ISBN 13 : 0444640770
Total Pages : 480 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurogenetics by :

Download or read book Neurogenetics written by and published by Elsevier. This book was released on 2018-01-09 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. Contains comprehensive coverage of neurogenetics Details the latest science and its impact on our understanding of neurological, psychiatric disorders Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

Advancing Prion Science

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309168597
Total Pages : 125 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advancing Prion Science by : Institute of Medicine

Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-03-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

The Family That Couldn't Sleep

Author : D. T. Max
Publisher : Random House
ISBN 13 : 1588365581
Total Pages : 333 pages
Book Rating : 4.5/5 (883 download)

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Book Synopsis The Family That Couldn't Sleep by : D. T. Max

Download or read book The Family That Couldn't Sleep written by D. T. Max and published by Random House. This book was released on 2006-09-05 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass. What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world. In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study. With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.

Kuru Sorcery

Author : Shirley Lindenbaum
Publisher : Routledge
ISBN 13 : 131726472X
Total Pages : 240 pages
Book Rating : 4.3/5 (172 download)

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Book Synopsis Kuru Sorcery by : Shirley Lindenbaum

Download or read book Kuru Sorcery written by Shirley Lindenbaum and published by Routledge. This book was released on 2015-12-03 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perhaps the best-documented epidemic in the history of medicine, kuru has been studied for more than fifty years by international investigators from medicine and the human sciences. This significantly revised edition of the landmark anthropological classic Kuru Sorcery brings up to date the anthropological contribution to understanding disease, the medical research that resulted in two medical Nobel Prizes, and the views of the Fore people who endured the epidemic and who still believe that sorcerers, rather than cannibalism, caused kuru. The kuru epidemic serves as a prism through which to see how Fore notions of disease causation bring into single focus their views about the body, the world of social and spiritual relations, and changes in economic and political conditions-aspects of thought and behaviour that Western medicine keeps separate.

Slow, Latent, and Temperate Virus Infections

Author : Daniel Carleton Gajdusek
Publisher :
ISBN 13 :
Total Pages : 526 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Slow, Latent, and Temperate Virus Infections by : Daniel Carleton Gajdusek

Download or read book Slow, Latent, and Temperate Virus Infections written by Daniel Carleton Gajdusek and published by . This book was released on 1965 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:

PrPSc Prions: State of the Art

Author : Joaquín Castilla
Publisher : MDPI
ISBN 13 : 3038973084
Total Pages : 211 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis PrPSc Prions: State of the Art by : Joaquín Castilla

Download or read book PrPSc Prions: State of the Art written by Joaquín Castilla and published by MDPI. This book was released on 2018-11-07 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "PrP^Sc prions: state of the art" that was published in Pathogens

Human Biochemistry

Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 032391053X
Total Pages : 883 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Biochemistry by : Gerald Litwack

Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

Prions

Author : Ivo Nikolaev Sirakov
Publisher : BoD – Books on Demand
ISBN 13 : 1789850177
Total Pages : 84 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Prions by : Ivo Nikolaev Sirakov

Download or read book Prions written by Ivo Nikolaev Sirakov and published by BoD – Books on Demand. This book was released on 2019-01-30 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Handbook of Veterinary Neurology - E-Book

Author : Michael D. Lorenz
Publisher : Elsevier Health Sciences
ISBN 13 : 1437706525
Total Pages : 560 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Handbook of Veterinary Neurology - E-Book by : Michael D. Lorenz

Download or read book Handbook of Veterinary Neurology - E-Book written by Michael D. Lorenz and published by Elsevier Health Sciences. This book was released on 2010-12-14 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Veterinary Neurology provides quick access to vital information on neurologic conditions in a wide range of species, including canine, feline, bovine, caprine, equine, ovine, and porcine. A problem-oriented approach makes it easy to diagnose and treat neurologic problems in small and large animals. The coverage of disorders by problem, not by established disease diagnosis, emulates how animals present to the veterinary hospital and simplifies the formulation of a correct diagnosis. Within each chapter, discussions of neurologic disease include a review of the localization criteria and the diseases that can cause that problem, plus treatment and surgical techniques. Lead author Michael D. Lorenz brings decades of experience to neurologic assessment, using a diagnostic approach that requires minimal knowledge of neuroanatomy. A problem-based approach is organized by presenting sign rather than by condition, guiding you to logical conclusions regarding diagnosis and treatment. Algorithms diagram the logic necessary to localize lesions and to formulate diagnostic plans. Coverage of current diagnostic techniques includes the use of diagnostic tools, such as radiology, spinal fluid analysis, electrodiagnosis, and MR imaging. Case histories in each chapter present a problem and the results of the neurologic examination, then ask you to solve the problem by localizing the lesion, listing probable causes, and making a diagnostic plan. Answers are provided at the back of the book. A consistent format for each case history includes signalment, history, physical examination findings, and neurologic examination. A comprehensive appendix describes species and breeds that have a congenital predisposition for particular neurologic diseases. Extensive references make it easy to pursue in-depth research of more advanced topics. A companion website includes 20 narrated video clips with accompanying PowerPoint slides that correlate to the case histories in the book, covering neurologic assessment and clinical problems such as paresis of one limb, tetraparesis, stupor, seizures, ataxia of the head and limbs, and cranial nerve disorders. Two new co-authors, Jean Coates and Marc Kent, board-certified in neurology, enhance the credibility of this edition. A full-color design and numerous illustrations include enhanced images of neuroanatomy and pathology.

Madness and Memory

Author : Stanley B. Prusiner
Publisher : Yale University Press
ISBN 13 : 0300191146
Total Pages : 344 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Madness and Memory by : Stanley B. Prusiner

Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.

How the Cows Turned Mad

Author : Maxime Schwartz
Publisher : Univ of California Press
ISBN 13 : 0520243374
Total Pages : 264 pages
Book Rating : 4.5/5 (22 download)

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Book Synopsis How the Cows Turned Mad by : Maxime Schwartz

Download or read book How the Cows Turned Mad written by Maxime Schwartz and published by Univ of California Press. This book was released on 2004-09-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: "How the Cows Turned Mad tells the story of a disease that continues to elude on many levels. Yet science has come far in understanding its origins, incubation, and transmission. This book is a case history that illuminates the remarkable progression of science."--BOOK JACKET.

Neurobiology of Brain Disorders

Author : Michael J. Zigmond
Publisher : Elsevier
ISBN 13 : 0123982804
Total Pages : 823 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Neurobiology of Brain Disorders by : Michael J. Zigmond

Download or read book Neurobiology of Brain Disorders written by Michael J. Zigmond and published by Elsevier. This book was released on 2014-12-03 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material