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Von Willebrand Factor And The Mechanisms Of Platelet Function
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Book Synopsis Von Willebrand Factor and the Mechanisms of Platelet Function by : Zaverio M. Ruggeri
Download or read book Von Willebrand Factor and the Mechanisms of Platelet Function written by Zaverio M. Ruggeri and published by Springer. This book was released on 1998-06-30 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemostasis is the mechanism that controls thrombosis and bleeding after tissue trauma. In spite of the fact that thrombotic vascular diseases are the most common cause of mortality in developed countries, the basic mechanisms of hemostasis and the causes of thrombosis are still poorly understood. Von Willebrand factor is a key adhesive protein with a crucial role in platelet function and may thus be a key factor in the development of thrombosis. This book provides a state-of-the-art account of the progress made in understanding the structure and function of this protein, providing at the same time an update of the current knowledge of hemostasis and thrombosis.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Von Willebrand Factor and the Mechanisms of Platelet Function by : Zaverio M. Ruggeri
Download or read book Von Willebrand Factor and the Mechanisms of Platelet Function written by Zaverio M. Ruggeri and published by R. G. Landes. This book was released on 1931-12-12 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Platelet Function and Thrombosis by : Pier Mannuccio Mannucci
Download or read book Platelet Function and Thrombosis written by Pier Mannuccio Mannucci and published by Springer. This book was released on 1972 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The special contribution of the present volume is that of gathering a large amount of up-to-date information on the formidable problem of the methods used for testing platelet function in thrombosis. The methods used for studying platelet behavior in hemorrhagic disorders due to abnormal platelet function are undoubtedly characterized by difficulties in interpretation and by poor reproducibility. However, all will agree that the problem of the significance and importance of platelet function tests in thrombosis and atherosclerosis is an absolute "morass," and recent and past papers on the measurement of platelet adhesiveness in myocardial infarction could well appear in a special issue of the new "Journal of Irreproducible Results". This volume includes both general papers on the role of platelets in thrombosis by G. V. R. Born, Duncan P. Thomas, and J. R.
Book Synopsis Endothelial Dysfunction by : Helena Lenasi
Download or read book Endothelial Dysfunction written by Helena Lenasi and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.
Book Synopsis Anesthetic Pharmacology by : Alex S. Evers
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
Book Synopsis Hemophilia and Von Willebrand Disease by : David Green
Download or read book Hemophilia and Von Willebrand Disease written by David Green and published by Academic Press. This book was released on 2018-06-14 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology Delves into unanswered questions and future directions of this important blood-clotting complex
Book Synopsis Transfusion Medicine and Hemostasis by : Beth H. Shaz
Download or read book Transfusion Medicine and Hemostasis written by Beth H. Shaz and published by Newnes. This book was released on 2013-05-13 with total page 1014 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities
Book Synopsis Congenital Bleeding Disorders by : Akbar Dorgalaleh
Download or read book Congenital Bleeding Disorders written by Akbar Dorgalaleh and published by Springer. This book was released on 2018-07-25 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes in detail the clinical presentation, diagnosis, and management of a wide range of congenital bleeding disorders. It will assist readers in overcoming the significant challenges involved in clinical and laboratory diagnosis and in providing effective clinical care that makes optimal use of new products, including recombinant factor concentrate. The coverage ranges from hemophilia A and B and von Willebrand disease to rare bleeding disorders such as congenital factor V, factor X, factor XI, and factor XIII deficiency and inherited platelet function disorders. The exceptional attention to rarer conditions is of particular importance given the considerable risk of overlooking them during diagnosis, with potential consequences for disease-related morbidity and mortality. The authors are acknowledged specialists in the field from across the world who have particular expertise in the disorder that they discuss. The book will be of value to hematologists, oncologists, pediatricians, laboratory specialists and technicians, general physicians, and trainees.
Book Synopsis The Non-Thrombotic Role of Platelets in Health and Disease by : Steve W. Kerrigan
Download or read book The Non-Thrombotic Role of Platelets in Health and Disease written by Steve W. Kerrigan and published by BoD – Books on Demand. This book was released on 2015-11-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.
Book Synopsis Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis by : Rolando E. Rumbaut
Download or read book Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis written by Rolando E. Rumbaut and published by Biota Publishing. This book was released on 2010-02-01 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.
Book Synopsis Dentist's Guide to Medical Conditions and Complications by : Kanchan Ganda
Download or read book Dentist's Guide to Medical Conditions and Complications written by Kanchan Ganda and published by John Wiley & Sons. This book was released on 2011-11-16 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dentist's Guide to Medical Conditions and Complications is a highly accessible reference to dental treatment of medically compromised patients. The ability to treat medically compromised patients is necessary for most dentists and dental professionals, and this book serves as a guide to effectively treat these patients. In a succinct, easy-to-use format, Dentist's Guide to Medical Conditions and Complications outlines protocols for treating patients with common conditions, presents essential drug interaction information, and guides the dental professional through the prevention and management of in-office medical emergencies.
Book Synopsis Trauma Induced Coagulopathy by : Hunter B. Moore
Download or read book Trauma Induced Coagulopathy written by Hunter B. Moore and published by Springer Nature. This book was released on 2020-10-12 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
Book Synopsis Cerebral Ischemia and Hemorheology by : Alexander Hartmann
Download or read book Cerebral Ischemia and Hemorheology written by Alexander Hartmann and published by Springer Verlag. This book was released on 2012-07-31 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes current knowledge on the interrelationship between hemorheology and cerebral ischemia. The most relevant experimental and clinical findings regarding the influence of hemorheological factors on cerebral ischemic disorders are presented. Contributions by experts from both the fields of cerebral circulation and rheology are included in order to broaden perspectives and encourage exchange between the two groups. The book will thus help establish new strategies for a better understanding of metabolic, circulatory and rheologic changes during cerebral ischemia.
Download or read book Platelets written by Alan D. Michelson and published by Gulf Professional Publishing. This book was released on 2002 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2002 Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American Publishers Platelets is a comprehensive new textbook of 61 chapters and 1,100 pages (approx.) written by over 100 world leaders in the field. Platelets is a single definitive source of state-of-the-art knowledge about platelets. There has been no textbook that specifically and fully covers the entire field of platelet biology and clinical medicine. Platelets now fills this need. Platelets encompasses: platelet biology; platelet function testing; the role of platelets in disease; inherited and acquired disorders of platelet number and function; pharmacology of antiplatelet agents; pharmacology of agents to increase platelet numbers and/or function; platelet transfusion medicine; and gene therapy. The intended audience for Platelets includes hematologists, cardiologists, stroke physicians, blood bankers, pathologists, and researchers in thrombosis and hemostasis as well as students and fellows in these fields. * A single comprehensive source of state-of-the-art knowledge about platelets * Over 100 contributing authors from 13 countries * The authors of each chapter are world leaders in their fields * The definitive resource with 61 chapters, 1,100 pages (approx.), 12,000 references (approx.), 70 full color figures, 140 black and white figures, and 95 tables
Book Synopsis Mechanisms of Stimulus—Response Coupling in Platelets by : J. Westwick
Download or read book Mechanisms of Stimulus—Response Coupling in Platelets written by J. Westwick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.
Book Synopsis Platelet Protocols by : Melanie McCabe White
Download or read book Platelet Protocols written by Melanie McCabe White and published by Elsevier. This book was released on 1999-04-21 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now. Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing. Includes: A basic introduction to platelet anatomy and physiology Testing procedures for new anti-platelet therapies Descriptions of platelet function abnormalities Therapeutic approaches to inhibition of platelet function Step-by-step methodologies with clear explanations Helpful appendixes of recipes, instructions, sources of reagents, and more
