Author : Maryam Razaghi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (131 download)
Book Synopsis Vitamin D Status in Early Life and Body Composition by : Maryam Razaghi
Download or read book Vitamin D Status in Early Life and Body Composition written by Maryam Razaghi and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pregnancy cohort studies suggest that exposure to insufficient vitamin D status in utero associates with greater fat mass and lower lean mass in children. In Canada, 24-35 % of infants are born with insufficient vitamin D status. The role of maternal factors, such as adiposity, or vitamin D status, and postnatal vitamin D supplementation in relation to lean body mass is unknown. The objectives of this thesis research were: 1) to test the effects of vitamin D on body composition and growth-related hormones in weanling Sprague Dawley rats fed diets with varied vitamin D content (1, 2, or 4 IU/kg) from 4 to 12 weeks of age; 2) to explore the influential factors related to maternal and neonatal vitamin D status and the interrelationships among maternal and neonatal vitamin D status and body composition; and 3) to examine whether correction of insufficient vitamin D status with either 1000 IU/d or 400 IU/d of vitamin D supplementation is associated with body composition (lean and fat mass) across infancy from 1 to 12 months in a randomized controlled trial. Maternal adiposity and low maternal-fetal vitamin D transfer were associated with neonatal adiposity; infants of mothers with elevated BMI and insufficient vitamin D status had 28% higher fat mass versus those of mothers with elevated BMI, yet vitamin D sufficient (P=0.04). This reinforces the need for early strategies to enhance intake of vitamin D supplementation with high adherence for both mothers and infants. The trial in weanling rats indicated that moderate increases in dietary vitamin D attenuated the physiological decline in IGF-1 (P0.05) as a stimulus for lean mass accretion. The trials in human infants and rats, demonstrated that the achievement of higher vitamin D status (25(OH)D50 nmol/L) increases whole body lean mass (4.8-14.0% difference; P