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Author : Ann Rawkins
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (535 download)
Download or read book Virulence and Pathogenic Mechanisms of Legionella Pneumophila written by Ann Rawkins and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hubert Hilbi
Publisher : Springer Science & Business Media
ISBN 13 : 3642405916
Total Pages : 297 pages
Book Rating : 4.6/5 (424 download)
Download or read book Molecular Mechanisms in Legionella Pathogenesis written by Hubert Hilbi and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Author : Hayley Newton
Publisher : Frontiers Media SA
ISBN 13 : 2889456617
Total Pages : 181 pages
Book Rating : 4.8/5 (894 download)
Download or read book Biology and Pathogenesis of Legionella written by Hayley Newton and published by Frontiers Media SA. This book was released on 2018-12-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030949382X
Total Pages : 291 pages
Book Rating : 4.3/5 (94 download)
Download or read book Management of Legionella in Water Systems written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-02-20 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionnaires' disease, a pneumonia caused by the Legionella bacterium, is the leading cause of reported waterborne disease outbreaks in the United States. Legionella occur naturally in water from many different environmental sources, but grow rapidly in the warm, stagnant conditions that can be found in engineered water systems such as cooling towers, building plumbing, and hot tubs. Humans are primarily exposed to Legionella through inhalation of contaminated aerosols into the respiratory system. Legionnaires' disease can be fatal, with between 3 and 33 percent of Legionella infections leading to death, and studies show the incidence of Legionnaires' disease in the United States increased five-fold from 2000 to 2017. Management of Legionella in Water Systems reviews the state of science on Legionella contamination of water systems, specifically the ecology and diagnosis. This report explores the process of transmission via water systems, quantification, prevention and control, and policy and training issues that affect the incidence of Legionnaires' disease. It also analyzes existing knowledge gaps and recommends research priorities moving forward.
Author : James W. Moulder
Publisher : CRC Press
ISBN 13 : 1000141667
Total Pages : 296 pages
Book Rating : 4.0/5 (1 download)
Download or read book Intracellular Parasitism written by James W. Moulder and published by CRC Press. This book was released on 2020-10-28 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.
Author : James M. Barbaree
Publisher : ASM Press
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.:/5 (319 download)
Download or read book Legionella written by James M. Barbaree and published by ASM Press. This book was released on 1993 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawn from ASM′s 1992 symposium on the subject, this book completely updates information on all aspects of Legionella and Legionnaires disease. Strategy sessions held at the symposium to address current issues involving preventive measures to minimize the presence of Legionella and occurence of Legionnaires disease, the evolution of chemotherapy and diagnostic tests, and prospects for vaccine development are summarized. Legionella is required reading for anyone working in this area of infectious disease. As the sole source of current knowledge and theory on Legionella, it is an extremely useful reference for clinical microbiologists, environmental microbiologists, epidemiologists, infectious disease and other clinical specialists, and environmental engineers.
Author : Mark Russell Liles
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (563 download)
Download or read book Type II Secretion of Virulence Factors and Iron Acquisition Mechanisms of Legionella Pneumophila written by Mark Russell Liles and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Survival and growth within the intracellular environment of an alveolar macrophage requires Legionella pneumophila to subvert the normal phagocytic pathway and acquire limiting nutrients, such as iron. Many pathogens excrete siderophores to chelate iron from host proteins. Biochemical investigations revealed that L. pneumophila supernatants contain multiple iron-binding molecules: the melanin homogentisic acid, the media component cysteine, and an unidentified low molecular weight molecule produced only in some strains of L. pneumophila. To identify iron uptake mechanisms by a genetic approach, transposon-generated mutants were screened for resistance to the iron-activated drug streptonigrin. While sequencing the L. pneumophila DNA downstream of the transposon in the mutant NU218, genes were discovered whose predicted proteins have strong homology to PilB, PilC, and PilD of Pseudomonas aeruginosa, proteins all required for type IV pilus biogenesis. Northern blot analysis demonstrated that the L. pneumophila pilBCD genes are expressed as an operon, and that pilBCD expression is greater at 30$\sp\circ$C than at 37$\sp\circ$C. This temperature-regulated pilBCD expression was correlated with an increase in piliation at 30$\sp\circ$C. Other investigators recently discovered the L. pneumophila type IV pilin subunit (PilE$\rm\sb{L}),$ and found that a $pilE\sb{L}$ mutant lacks type IV pili, but is fully competent for intracellular replication. Since PilD, the prepilin peptidase, is also required for type II protein secretion in other gram-negative bacteria, a pilD mutant was constructed to establish whether L. pneumophila exports proteins through a type II apparatus and whether this process contributes to pathogenesis. The pilD mutant exhibits a unique colony morphology, lacks type IV pili, and is impaired in replication within cultured human macrophages and amoebae. Additionally, the pilD mutant does not cause respiratory distress, high fever, weight loss, or death in guinea pigs, and is rapidly cleared from the lungs of infected animals. From these data it can be concluded that L. pneumophila has a type II secretion system, and that one or more proteins exported via this pathway are important for the virulence of L. pneumophila.
Author :
Publisher : Academic Press
ISBN 13 : 0124159761
Total Pages : 719 pages
Book Rating : 4.1/5 (241 download)
Download or read book Microbiology of Waterborne Diseases written by and published by Academic Press. This book was released on 2013-11-08 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
Author : Paul Hoffman
Publisher : Springer Science & Business Media
ISBN 13 : 0387708960
Total Pages : 217 pages
Book Rating : 4.3/5 (877 download)
Download or read book Legionella Pneumophila: Pathogenesis and Immunity written by Paul Hoffman and published by Springer Science & Business Media. This book was released on 2007-10-24 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume brings together all of the latest research on this pathogen, the interest in which is rapidly growing. Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been major new developments in this field, including the publication of three whole genome sequences and the discovery of a developmental cycle and novel cyst-like highly infectious form.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book Biology and Pathogenesis of Legionella written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires' disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative "omics", it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
Author :
Publisher : Academic Press
ISBN 13 : 0080860567
Total Pages : 643 pages
Book Rating : 4.0/5 (88 download)
Download or read book Bacterial Pathogenesis written by and published by Academic Press. This book was released on 1998-07-01 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Author : Barry I. Eisenstein
Publisher :
ISBN 13 :
Total Pages : 4 pages
Book Rating : 4.:/5 (793 download)
Download or read book Pathogenic Mechanisms of "Legionella Pneumophila" and "Escherichia Coli" written by Barry I. Eisenstein and published by . This book was released on 1987 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sadik Dincer
Publisher : BoD – Books on Demand
ISBN 13 : 1789858992
Total Pages : 362 pages
Book Rating : 4.7/5 (898 download)
Download or read book Bacterial Biofilms written by Sadik Dincer and published by BoD – Books on Demand. This book was released on 2020-10-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sahra Kırmusaoğlu
Publisher : BoD – Books on Demand
ISBN 13 : 1789859875
Total Pages : 248 pages
Book Rating : 4.7/5 (898 download)
Download or read book Pathogenic Bacteria written by Sahra Kırmusaoğlu and published by BoD – Books on Demand. This book was released on 2020-12-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria are the main problem in hospital- and community-acquired infections. As bacteria continue to develop more resistance to antibiotics, it is imperative to develop antibacterial treatment strategies. Written by experts from all over the world, this book examines pathogenic bacteria and their link to multidrug resistance. Over thirteen chapters, it presents examples of pathogenesis, virulence factors, and treatment strategies.
Author : Howard Goldfine
Publisher : Springer Science & Business Media
ISBN 13 : 038749376X
Total Pages : 292 pages
Book Rating : 4.3/5 (874 download)
Download or read book Listeria monocytogenes: Pathogenesis and Host Response written by Howard Goldfine and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.
Author : Silvia Bonetta
Publisher : MDPI
ISBN 13 : 3036506942
Total Pages : 298 pages
Book Rating : 4.0/5 (365 download)
Download or read book Legionella Contamination in Water Environment written by Silvia Bonetta and published by MDPI. This book was released on 2021-09-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Legionella spp. are ubiquitous microorganisms that are widely distributed in aquatic environments. Water systems of large buildings, such as hospitals, hotels, and rental units are often contaminated by legionellae and various parameters such as physical, chemical, and microbial building water system characteristics can influence Legionella occurrence. A range of physical and chemical disinfection methods have been proposed to control Legionella contamination; however, to date, the most effective procedures have not been defined. There is a need to survey legionellae in water systems to prevent legionellosis. Although the assessment of L. pneumophila in water is typically performed by culture isolation on selective media, it has several limits. For this reason, alternative tools for rapid, sensitive, and specific detection of Legionella in water samples have been proposed. In order to increase knowledge on different aspects of Legionella contamination in the water environment, this book gathers research studies related to the occurrence of Legionella in water systems of different environments; the role of different factors that can influence the Legionella contamination, as well as the advantages and disadvantages of different methodological approaches.
