Viral Polymerases

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Author :
Publisher : Academic Press
ISBN 13 : 0128154233
Total Pages : 496 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Viral Polymerases by : Satya Prakash Gupta

Download or read book Viral Polymerases written by Satya Prakash Gupta and published by Academic Press. This book was released on 2018-10-29 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition Analyzes the structure-activity relationships of inhibitors of each viral polymerase Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets

Viral Molecular Machines

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461409802
Total Pages : 687 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Viral Molecular Machines by : Michael G. Rossmann

Download or read book Viral Molecular Machines written by Michael G. Rossmann and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.

Viral Polymerases and Related Proteins

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Author :
Publisher : Elsevier
ISBN 13 : 9780121821760
Total Pages : 698 pages
Book Rating : 4.8/5 (217 download)

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Book Synopsis Viral Polymerases and Related Proteins by : Lawrence C. Kuo

Download or read book Viral Polymerases and Related Proteins written by Lawrence C. Kuo and published by Elsevier. This book was released on 1996 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features* Expression, purification, and characterization* Activity assays* Kinetic and screening* Design and analysis of substrates and inhibitors* Molecular and structural characterizations.

RNA Tumor Viruses: Supplements and appendixes

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Publisher :
ISBN 13 :
Total Pages : 1254 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis RNA Tumor Viruses: Supplements and appendixes by :

Download or read book RNA Tumor Viruses: Supplements and appendixes written by and published by . This book was released on 1984 with total page 1254 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nucleic Acid Polymerases

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Publisher : Springer Science & Business Media
ISBN 13 : 3642397964
Total Pages : 342 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Nucleic Acid Polymerases by : Katsuhiko S. Murakami

Download or read book Nucleic Acid Polymerases written by Katsuhiko S. Murakami and published by Springer Science & Business Media. This book was released on 2013-10-22 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans. Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.

Human Herpesviruses

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Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

DNA Polymerases

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Publisher : World Scientific
ISBN 13 : 9814299170
Total Pages : 338 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis DNA Polymerases by : Ulrich Hübscher

Download or read book DNA Polymerases written by Ulrich Hübscher and published by World Scientific. This book was released on 2010 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.

Virus Protein and Nucleoprotein Complexes

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Author :
Publisher : Springer
ISBN 13 : 9811084564
Total Pages : 442 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Virus Protein and Nucleoprotein Complexes by : J. Robin Harris

Download or read book Virus Protein and Nucleoprotein Complexes written by J. Robin Harris and published by Springer. This book was released on 2018-06-13 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”. This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.

The Baculoviruses

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Publisher : Springer Science & Business Media
ISBN 13 : 1489918345
Total Pages : 459 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis The Baculoviruses by : Lois K. Miller

Download or read book The Baculoviruses written by Lois K. Miller and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has witnessed an explosion of information on the molecular biology of insect viruses and a frenzy of activity in applying this information to medicine and agriculture. Genetically engineered baculoviruses are presently being tested for commercial use as pesticides, and the study of such viruses is also revealing remarkable insights into basic cellular processes such as apoptosis. This comprehensive volume provides readers with knowledge of basic and applied baculovirology so that current literature in the field can be appreciated.

Inhibitors of DNA and RNA Polymerases

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Publisher : Pergamon
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Inhibitors of DNA and RNA Polymerases by : Prem S. Sarin

Download or read book Inhibitors of DNA and RNA Polymerases written by Prem S. Sarin and published by Pergamon. This book was released on 1980 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Virology

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Publisher : Springer
ISBN 13 : 9783642207174
Total Pages : 0 pages
Book Rating : 4.2/5 (71 download)

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Book Synopsis Molecular Virology by : Susanne Modrow

Download or read book Molecular Virology written by Susanne Modrow and published by Springer. This book was released on 2013-09-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.

Multiplication of RNA Plant Viruses

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Publisher : Springer Science & Business Media
ISBN 13 : 1402047258
Total Pages : 353 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Multiplication of RNA Plant Viruses by : Chundi L. Mandahar

Download or read book Multiplication of RNA Plant Viruses written by Chundi L. Mandahar and published by Springer Science & Business Media. This book was released on 2006-09-05 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical studies on plant virus RNA replication have advanced considerably since 2000, primarily because of new genetic, molecular, biochemical, and enzymatic studies. This book generates understanding of multiplication of plus-sense RNA plant viruses, especially at molecular level. Certain virus-encoded essential proteins, nucleotide sequence motifs, and RNA secondary structures are central to virus RNA replication, which has a number of stages. Each is a complex phenomenon requiring specific factors and conditions.

DNA Polymerases

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Publisher : World Scientific
ISBN 13 : 9814465453
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis DNA Polymerases by :

Download or read book DNA Polymerases written by and published by World Scientific. This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diagnosis of Human Viruses by Polymerase Chain Reaction Technology

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Publisher : Springer Science & Business Media
ISBN 13 : 3642847668
Total Pages : 428 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Diagnosis of Human Viruses by Polymerase Chain Reaction Technology by : Yechiel Becker

Download or read book Diagnosis of Human Viruses by Polymerase Chain Reaction Technology written by Yechiel Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basis for the effective treatment and cure of a patient is the rapid diagnosis of the disease and its causative agent, which is based on the analysis of the clinical symptoms coupled with laboratory tests. Although rapid advance ments have been made in the laboratory diagnosis of virus diseases, the neces sary isolation of the causative virus from the clinical specimens is a relatively long procedure. Viruses which integrate into the cellular DNA (such as human immunodeficiency virus, HIV -1, or hepatitis B virus) are difficult to identify by molecular techniques, while viruses which exist in the clinical material in low concentrations are even more formidable to identify. Recently, the application of the polymerase chain reaction (peR) technique developed by K. D. Mullis and detailed in the study by Saiki et al. (1985) led to a revolution in virus diagnosis. The peR technique was rapidly applied to the diagnosis of viruses in clinical material. Volume 1 of Frontiers of Virology provides new information on the advan tages of the use of the peR for the diagnosis of many human disease-causing viruses, as well as on some problems with its use.

Antiviral Strategies in the Treatment of Human and Animal Viral Infections

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 180356783X
Total Pages : 156 pages
Book Rating : 4.8/5 (35 download)

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Book Synopsis Antiviral Strategies in the Treatment of Human and Animal Viral Infections by :

Download or read book Antiviral Strategies in the Treatment of Human and Animal Viral Infections written by and published by BoD – Books on Demand. This book was released on 2023-12-20 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antiviral Strategies in the Treatment of Human and Animal Viral Infections provides a comprehensive overview of the most recent discoveries in the field of antiviral research. It covers topics like viral replication, immunological reactions, medication discovery, vaccine development, and clinical applications. It also provides a summary of the difficulties and possibilities in battling viral infections that affect both humans and animals. Antiviral Strategies in the Treatment of Human and Animal Viral Infections is a useful resource for researchers, doctors, veterinarians, and students who are interested in the prevention and treatment of viral infections

Viruses

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Publisher : Academic Press
ISBN 13 : 0128111941
Total Pages : 392 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Viruses by : Paula Tennant

Download or read book Viruses written by Paula Tennant and published by Academic Press. This book was released on 2018-03-12 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived ‘interactomics’ as defined by the molecules and the processes by which virus gene products interact with themselves and their host’s cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses Provides key insights into recent technological advances, including high-throughput sequencing Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions

Cell Biology by the Numbers

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Publisher : Garland Science
ISBN 13 : 1317230698
Total Pages : 400 pages
Book Rating : 4.3/5 (172 download)

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Book Synopsis Cell Biology by the Numbers by : Ron Milo

Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid