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Viral Infection And Apoptosis
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Download or read book Viral Infection and Apoptosis written by and published by Mdpi AG. This book was released on 2018-01-11 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is a form of programmed cell death that enables the removal of damaged, infected, or otherwise unwanted cells in a controlled manner. Apoptosis can be initiated by multiple independent pathways that ultimately converge at a point where proteolytic enzymes belonging to the caspase family are activated, which dismantle the apoptotic cell. Multicellular organism have employed apoptotic mechanisms during host defence in response to viral infection to limit or prevent viral spread and replication. Consequently, viruses have evolved sophisticated molecular countermeasures to disarm host apoptotic defences, and this series of reviews and primary research articles in this Special Issue explores the intricate molecular interplay between viruses and their hosts when they battle for control of host apoptotic check-points.
Book Synopsis Viruses and Apoptosis by : Covadonga Alonso
Download or read book Viruses and Apoptosis written by Covadonga Alonso and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.
Book Synopsis Viral Infection and Apoptosis by : Marc Kvansakul (Ed.)
Download or read book Viral Infection and Apoptosis written by Marc Kvansakul (Ed.) and published by . This book was released on 2018 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is a form of programmed cell death that enables the removal of damaged, infected, or otherwise unwanted cells in a controlled manner. Apoptosis can be initiated by multiple independent pathways that ultimately converge at a point where proteolytic enzymes belonging to the caspase family are activated, which dismantle the apoptotic cell.Multicellular organism have employed apoptotic mechanisms during host defence in response to viral infection to limit or prevent viral spread and replication. Consequently, viruses have evolved sophisticated molecular countermeasures to disarm host apoptotic defences, and this series of reviews and primary research articles in this Special Issue explores the intricate molecular interplay between viruses and their hosts when they battle for control of host apoptotic check-points.
Book Synopsis Human Cytomegalovirus by : Thomas E. Shenk
Download or read book Human Cytomegalovirus written by Thomas E. Shenk and published by Springer Science & Business Media. This book was released on 2008-05-09 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Role of Apoptosis in Infection by : Diane E. Griffin
Download or read book Role of Apoptosis in Infection written by Diane E. Griffin and published by Springer Science & Business Media. This book was released on 2005-08-29 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: (will follow)
Book Synopsis Cell Activation and Apoptosis in HIV Infection by : Jean-Marie Andrieu
Download or read book Cell Activation and Apoptosis in HIV Infection written by Jean-Marie Andrieu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune cell-targeted therapeutic interventions.
Book Synopsis T Cell Activation and Apoptosis in Viral Infection by : Marisa Ann Galvan
Download or read book T Cell Activation and Apoptosis in Viral Infection written by Marisa Ann Galvan and published by . This book was released on 1996 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Cell Survival by Host and Viral Anti-apoptotic Bcl-2 Proteins by : Michaela Ohmer
Download or read book Regulation of Cell Survival by Host and Viral Anti-apoptotic Bcl-2 Proteins written by Michaela Ohmer and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Molecular Biology of Picornaviruses by : Bert L. Semler
Download or read book Molecular Biology of Picornaviruses written by Bert L. Semler and published by . This book was released on 2002 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: -- Up-to-date and in-depth analysis.
Book Synopsis Mechanisms of Virus-Induced Neural Cell Death by :
Download or read book Mechanisms of Virus-Induced Neural Cell Death written by and published by . This book was released on 2002 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually all known neurotropic viruses are capable of killing infected cells by inducing a specific pattern of cell death known as apoptosis, yet the mechanism by which this occurs and its relevance to human disease remain largely unknown. We have shown that apoptosis is an important feature of human CNS viral infections including herpes simplex virus and cytomegalovirus encephalitis, and PML.
Download or read book RNA Viruses written by Decheng Yang and published by World Scientific. This book was released on 2009 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection. Organized into 29 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host?virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.
Book Synopsis Alternate Programmed Cell Death Signaling in Antiviral Host Defense by : Edward S. Mocarski
Download or read book Alternate Programmed Cell Death Signaling in Antiviral Host Defense written by Edward S. Mocarski and published by Springer Nature. This book was released on 2023-12-16 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.
Book Synopsis Encyclopedia of Metalloproteins by : Robert H. Kretsinger
Download or read book Encyclopedia of Metalloproteins written by Robert H. Kretsinger and published by Springer. This book was released on 2013-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
Book Synopsis Cell Organelle Exploitation by Viruses During Infection by : Parikshit Bagchi
Download or read book Cell Organelle Exploitation by Viruses During Infection written by Parikshit Bagchi and published by Frontiers Media SA. This book was released on 2021-06-28 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Virus-Induced Immunosuppression by : Steven Specter
Download or read book Virus-Induced Immunosuppression written by Steven Specter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.
