Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231

Download Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231 full books in PDF, epub, and Kindle. Read online Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231 ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

VEGF-A Modulates Lymphangiogenic Mechanisms in an Orthotopic Model of Human Breast Carcinoma MDA-MB-231

Author : Brandt D. Whitehurst
Publisher :
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.:/5 (144 download)

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Book Synopsis VEGF-A Modulates Lymphangiogenic Mechanisms in an Orthotopic Model of Human Breast Carcinoma MDA-MB-231 by : Brandt D. Whitehurst

Download or read book VEGF-A Modulates Lymphangiogenic Mechanisms in an Orthotopic Model of Human Breast Carcinoma MDA-MB-231 written by Brandt D. Whitehurst and published by . This book was released on 2006 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis significantly contributes to cancer mortality and is facilitated by lymphangiogenesis. Recent reports indicate that VEGF-A can modulate this process. We therefore evaluated VEGF-A neutralization as a potential anti-lymphangiogenic treatment in an orthotopic model of human breast cancer MDA-MB-231. Anti-VEGF-A therapy caused an 80% reduction in lymphatic vessel density and inhibited metastasis. VEGF-A neutralization decreased expression of VEGF-C by 28% in cultured MDA-MB 231 cells but not affect global VEGF-C expression in vivo. Immunofluorescent staining of lymphatic vessels demonstrated robust expression of VEGFR-3 on LYVE-1-positive vessels in control tumors. However, decreased and aberrant expression of VEGFR-3 was detected on lymphatic vessels in VEGF-A depleted tumors. RT-PCR analysis revealed three-fold decreased expression of Ang-2 in treated tumors which correlated with decreased VEGFR-3 transcript. The study demonstrates VEGF-A neutralization is a potential target for anti-metastatic therapy and identifies a novel mechanism for VEGF-A dependent modulation of lymphangiogenesis.

Angiogenesis Assays

Author : Carolyn A. Staton
Publisher : John Wiley & Sons
ISBN 13 : 047002934X
Total Pages : 410 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Angiogenesis Assays by : Carolyn A. Staton

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

The Potential Effect and Mechanism of Chinese Traditional Medicine on Vascular Homeostasis and Remodeling

Author : Yuliang Wang
Publisher : Frontiers Media SA
ISBN 13 : 288966435X
Total Pages : 134 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis The Potential Effect and Mechanism of Chinese Traditional Medicine on Vascular Homeostasis and Remodeling by : Yuliang Wang

Download or read book The Potential Effect and Mechanism of Chinese Traditional Medicine on Vascular Homeostasis and Remodeling written by Yuliang Wang and published by Frontiers Media SA. This book was released on 2021-02-02 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemoprevention of Cancer

Author : Daniel W. Nixon
Publisher : CRC Press
ISBN 13 : 9780849368509
Total Pages : 160 pages
Book Rating : 4.3/5 (685 download)

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Book Synopsis Chemoprevention of Cancer by : Daniel W. Nixon

Download or read book Chemoprevention of Cancer written by Daniel W. Nixon and published by CRC Press. This book was released on 1994-11-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Pathology of Hepatocellular Carcinoma

Author : Masamichi Kojiro
Publisher : John Wiley & Sons
ISBN 13 : 1405172967
Total Pages : 184 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Pathology of Hepatocellular Carcinoma by : Masamichi Kojiro

Download or read book Pathology of Hepatocellular Carcinoma written by Masamichi Kojiro and published by John Wiley & Sons. This book was released on 2009-02-12 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the huge advances made in clinical diagnosisenabling earlier detection, while addressing the recent progressmade in treatment of hepatocellular carcinoma (HCC) to enablesuccessful therapy. It draws on the expertise of an internationally recognizedauthor famed for his understanding, knowledge and efforts indefining terms and diagnosis in this area. The text reviews the full range of pathological information ofHCC based on the study of surgical cases and biopsy materials,along with images, to help compare findings that may be encounteredby pathologists. It also makes special reference to developments inearly stage HCC detection and premalignant lesions which canincrease effective treatment.

Metastatic Cancer: Clinical and Biological Perspectives

Author : Rahul Jandial
Publisher : CRC Press
ISBN 13 : 9781587066597
Total Pages : 312 pages
Book Rating : 4.0/5 (665 download)

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Book Synopsis Metastatic Cancer: Clinical and Biological Perspectives by : Rahul Jandial

Download or read book Metastatic Cancer: Clinical and Biological Perspectives written by Rahul Jandial and published by CRC Press. This book was released on 2013-08-08 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Computational Modeling in Tissue Engineering

Author : Liesbet Geris
Publisher : Springer Science & Business Media
ISBN 13 : 3642325637
Total Pages : 438 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Computational Modeling in Tissue Engineering by : Liesbet Geris

Download or read book Computational Modeling in Tissue Engineering written by Liesbet Geris and published by Springer Science & Business Media. This book was released on 2012-10-30 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

Breast Cancer Metastasis and Drug Resistance

Author : Aamir Ahmad
Publisher : Springer Nature
ISBN 13 : 3030203018
Total Pages : 427 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Breast Cancer Metastasis and Drug Resistance by : Aamir Ahmad

Download or read book Breast Cancer Metastasis and Drug Resistance written by Aamir Ahmad and published by Springer Nature. This book was released on 2019-08-27 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Tumor Angiogenesis Assays

Author : Domenico Ribatti
Publisher : Springer Nature
ISBN 13 : 1071627031
Total Pages : 216 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Tumor Angiogenesis Assays by : Domenico Ribatti

Download or read book Tumor Angiogenesis Assays written by Domenico Ribatti and published by Springer Nature. This book was released on 2022-09-26 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated methods and protocols for studying tumor angiogenesis in vitro and in vivo. Chapters detail morphological aspects of tumor angiogenesis, aortic ring, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Tumor Angiogenesis Assays: Methods and Protocols, Second Edition is a valuable resource for all researchers interested in learning more about this important and developing field.

Handbook of Anticancer Drugs from Marine Origin

Author : Se-Kwon Kim
Publisher : Springer
ISBN 13 : 3319071459
Total Pages : 801 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Handbook of Anticancer Drugs from Marine Origin by : Se-Kwon Kim

Download or read book Handbook of Anticancer Drugs from Marine Origin written by Se-Kwon Kim and published by Springer. This book was released on 2014-11-27 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

Inflammation and Metastasis

Author : Yoshiro Maru
Publisher : Springer
ISBN 13 : 4431560246
Total Pages : 515 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Inflammation and Metastasis by : Yoshiro Maru

Download or read book Inflammation and Metastasis written by Yoshiro Maru and published by Springer. This book was released on 2016-07-25 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.

Tumor Microenvironment

Author : Alexander Birbrair
Publisher : Springer Nature
ISBN 13 : 3030371840
Total Pages : 136 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Tumor Microenvironment by : Alexander Birbrair

Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

Natural Products for Cancer Prevention and Therapy

Author : Anupam Bishayee
Publisher : MDPI
ISBN 13 : 3038973106
Total Pages : 285 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Natural Products for Cancer Prevention and Therapy by : Anupam Bishayee

Download or read book Natural Products for Cancer Prevention and Therapy written by Anupam Bishayee and published by MDPI. This book was released on 2018-11-07 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Oxford Textbook of Clinical Hepatology

Author :
Publisher :
ISBN 13 :
Total Pages : 1631 pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis Oxford Textbook of Clinical Hepatology by :

Download or read book Oxford Textbook of Clinical Hepatology written by and published by . This book was released on 1991 with total page 1631 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Targeted Drug Delivery : Concepts and Design

Author : Padma V. Devarajan
Publisher : Springer
ISBN 13 : 3319113550
Total Pages : 788 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan

Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Tumor Vascularization

Author : Domenico Ribatti
Publisher : Academic Press
ISBN 13 : 0128194944
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Tumor Vascularization by : Domenico Ribatti

Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Textbook of Onco-Anesthesiology

Author : Rakesh Garg
Publisher : Springer Nature
ISBN 13 : 9811600066
Total Pages : 539 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Textbook of Onco-Anesthesiology by : Rakesh Garg

Download or read book Textbook of Onco-Anesthesiology written by Rakesh Garg and published by Springer Nature. This book was released on 2021-05-09 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all essential evidence on perioperative care and anesthetic concerns for cancer surgeries, including the evaluation and assessment of patients’ schedule for cancer surgeries, perioperative anesthetic management of various cancers, perioperative analgesia for cancer surgeries, and issues related to inoperable cancers. It reviews anesthetic considerations of all cancer types as there is a wide variation in anesthetic requirements in this subset of patients. Cancer surgeries are on the rise worldwide and healthcare facilities with cancer as a core specialty are emerging quickly around the globe. As cancer is on rise and efficient surgical management is available, more and more patients are being treated surgically. However, cancer surgeries are complicated, have varied concerns and these are not covered sufficiently in presently available textbooks of anesthesiology. This book fulfills the growing need for complete and comprehensive textbook of onco-anesthesia and fills the gap in the current texts that do not exclusively cover anesthesia for cancer surgeries. This textbook serves as a comprehensive but quick guide for trainee residents/fellows and practicing anesthesiologists, clinicians and surgeons.