Value-based Learning Healthcare Systems

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Publisher :
ISBN 13 : 9781785613272
Total Pages : 377 pages
Book Rating : 4.6/5 (132 download)

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Book Synopsis Value-based Learning Healthcare Systems by : Bernard P. Zeigler

Download or read book Value-based Learning Healthcare Systems written by Bernard P. Zeigler and published by . This book was released on 2018 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an innovative, unique and holistic approach to modeling and simulation approaches in healthcare management from leaders in computer modeling and simulation.

Recent Trends and Advances in Model Based Systems Engineering

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Publisher : Springer Nature
ISBN 13 : 3030820831
Total Pages : 709 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Recent Trends and Advances in Model Based Systems Engineering by : Azad M. Madni

Download or read book Recent Trends and Advances in Model Based Systems Engineering written by Azad M. Madni and published by Springer Nature. This book was released on 2022-03-24 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises papers from the 18th Conference on Systems Engineering Research (CSER). The theme of this volume, “Recent Trends and Advances in Model-Based Systems Engineering,” reflects the fact that systems engineering is undergoing a transformation motivated by mission and system complexity and enabled by technological advances such as model-based systems engineering, digital engineering, and the convergence of systems engineering with other disciplines. This conference is focused on exploring recent trends and advances in model-based systems engineering (MBSE) and the synergy of MBSE with simulation technology and digital engineering. Contributors have submitted papers on MBSE methods, modeling approaches, integration of digital engineering with MBSE, standards, modeling languages, ontologies and metamodels, and economics analysis of MBSE to respond to the challenges posed by 21st century systems. What distinguishes this volume are the latest advances in MBSE research, the convergence of MBSE with digital engineering, and recent advances in applied research in MBSE, including growing convergence with systems science and decision science. This volume is appropriate as a reference text in graduate engineering courses in Model-Based Systems Engineering.

Body of Knowledge for Modeling and Simulation

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Publisher : Springer Nature
ISBN 13 : 3031110854
Total Pages : 549 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Body of Knowledge for Modeling and Simulation by : Tuncer Ören

Download or read book Body of Knowledge for Modeling and Simulation written by Tuncer Ören and published by Springer Nature. This book was released on 2023-01-27 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Commissioned by the Society for Modeling and Simulation International (SCS), this needed, useful new ‘Body of Knowledge’ (BoK) collects and organizes the common understanding of a wide collection of professionals and professional associations. Modeling and simulation (M&S) is a ubiquitous discipline that lays the computational foundation for real and virtual experimentation, clearly stating boundaries—and interactions—of systems, data, and representations. The field is well known, too, for its training support via simulations and simulators. Indeed, with computers increasingly influencing the activities of today’s world, M&S is the third pillar of scientific understanding, taking its place along with theory building and empirical observation. This valuable new handbook provides intellectual support for all disciplines in analysis, design and optimization. It contributes increasingly to the growing number of computational disciplines, addressing the broad variety of contributing as well as supported disciplines and application domains. Further, each of its sections provide numerous references for further information. Highly comprehensive, the BoK represents many viewpoints and facets, captured under such topics as: Mathematical and Systems Theory Foundations Simulation Formalisms and Paradigms Synergies with Systems Engineering and Artificial Intelligence Multidisciplinary Challenges Ethics and Philosophy Historical Perspectives Examining theoretical as well as practical challenges, this unique volume addresses the many facets of M&S for scholars, students, and practitioners. As such, it affords readers from all science, engineering, and arts disciplines a comprehensive and concise representation of concepts, terms, and activities needed to explain the M&S discipline. Tuncer Ören is Professor Emeritus at the University of Ottawa. Bernard Zeigler is Professor Emeritus at the University of Arizona. Andreas Tolk is Chief Scientist at The MITRE Corporation. All three editors are long-time members and Fellows of the Society for Modeling and Simulation International. Under the leadership of three SCS Fellows, Dr. Ören, University of Ottawa, Dr. Zeigler, The University of Arizona, and Dr. Tolk, The MITRE Corporation, more than 50 international scholars from 15 countries provided insights and experience to compile this initial M&S Body of Knowledge.

Complexity Challenges in Cyber Physical Systems

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Publisher : John Wiley & Sons
ISBN 13 : 1119552494
Total Pages : 373 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Complexity Challenges in Cyber Physical Systems by : Saurabh Mittal

Download or read book Complexity Challenges in Cyber Physical Systems written by Saurabh Mittal and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a one-stop reference on the application of advanced modeling and simulation (M&S) in cyber physical systems (CPS) engineering This book provides the state-of-the-art in methods and technologies that aim to elaborate on the modeling and simulation support to cyber physical systems (CPS) engineering across many sectors such as healthcare, smart grid, or smart home. It presents a compilation of simulation-based methods, technologies, and approaches that encourage the reader to incorporate simulation technologies in their CPS engineering endeavors, supporting management of complexity challenges in such endeavors. Complexity Challenges in Cyber Physical Systems: Using Modeling and Simulation (M&S) to Support Intelligence, Adaptation and Autonomy is laid out in four sections. The first section provides an overview of complexities associated with the application of M&S to CPS Engineering. It discusses M&S in the context of autonomous systems involvement within the North Atlantic Treaty Organization (NATO). The second section provides a more detailed description of the challenges in applying modeling to the operation, risk and design of holistic CPS. The third section delves in details of simulation support to CPS engineering followed by the engineering practices to incorporate the cyber element to build resilient CPS sociotechnical systems. Finally, the fourth section presents a research agenda for handling complexity in application of M&S for CPS engineering. In addition, this text: Introduces a unifying framework for hierarchical co-simulations of cyber physical systems (CPS) Provides understanding of the cycle of macro-level behavior dynamically arising from spaciotemporal interactions between parts at the micro-level Describes a simulation platform for characterizing resilience of CPS Complexity Challenges in Cyber Physical Systems has been written for researchers, practitioners, lecturers, and graduate students in computer engineering who want to learn all about M&S support to addressing complexity in CPS and its applications in today’s and tomorrow’s world.

Value-based Learning Healthcare Systems Integrative Modeling and Simulation

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Author :
Publisher : Institution of Engineering and Technology
ISBN 13 : 178561326X
Total Pages : 377 pages
Book Rating : 4.7/5 (856 download)

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Book Synopsis Value-based Learning Healthcare Systems Integrative Modeling and Simulation by : Bernard P. Zeigler

Download or read book Value-based Learning Healthcare Systems Integrative Modeling and Simulation written by Bernard P. Zeigler and published by Institution of Engineering and Technology. This book was released on 2019-01-19 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an innovative, unique and holistic approach to modeling and simulation approaches in healthcare management from leaders in computer modeling and simulation. From system architecture to modeling methodology, this book shows how to improve patient health and costs of care via the design and implementation of an efficient infrastructure. The framework, algorithms and methods are evaluated in real community environments. Researchers and professionals in health informatics, technology and policy will find this book invaluable.

Healthcare Simulation

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Publisher : John Wiley & Sons
ISBN 13 : 1118949439
Total Pages : 224 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Healthcare Simulation by : Laura T. Gantt

Download or read book Healthcare Simulation written by Laura T. Gantt and published by John Wiley & Sons. This book was released on 2015-11-05 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A focused guide for healthcare simulation operations in education and training With the growing use of simulation within the field of healthcare, Healthcare Simulation: A Guide for Operations Specialists provides a much needed resource for developing the roles and responsibilities of simulation operations specialists. The book illustrates the current state and evolution of the simulation professional workforce and discusses the topics necessary for the development of these pivotal roles. The book promotes the value of simulation-based education in healthcare and its associated outcomes while clarifying the operational requirements of successful simulations. Featuring numerous contributions from international experts, consultants, and specialists, Healthcare Simulation: A Guide for Operations Specialists presents advances in healthcare simulation techniques and also features: Coverage of the best practices and available technologies for healthcare simulation operations specialists within healthcare education, training, and assessment Interdisciplinary, practical examples throughout to help readers better understand the presented material An overview of the many facets of day-to-day operations within a healthcare simulation program Discussions regarding the concurrent need for understanding proper patient care that accompanies the human-to-machine interface in patient simulation Healthcare Simulation: A Guide for Operations Specialists is an excellent reference for healthcare simulation professionals including administrators, medical directors, managers, simulation technologists, faculty members, and educators in academic and healthcare settings. The book is also a useful supplementary textbook for graduate-level courses related to simulation and certificate programs in simulation education and simulation operations.

Innovative Healthcare Systems for the 21st Century

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Author :
Publisher : Springer
ISBN 13 : 3319557742
Total Pages : 341 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Innovative Healthcare Systems for the 21st Century by : Hassan Qudrat-Ullah

Download or read book Innovative Healthcare Systems for the 21st Century written by Hassan Qudrat-Ullah and published by Springer. This book was released on 2017-05-11 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest in decision-making tools, techniques, and solutions for policy makers to utilize in overcoming the challenges faced by healthcare systems. With contributions from experts world-wide, an array of healthcare management models, techniques, and integrative solutions are presented, drawing on econometric, system dynamics, and agent-based models as well as state-of-the-art empirical studies. As total healthcare spending (both total expenditures on health as a percentage of GDP and average spending on per capita) increases across most of the world’s economies, healthcare systems continue to face challenges in terms of cost, quality, and access, as a result of its fragmented nature. Consequently, healthcare managers and policy makers require innovative integrative approaches and solutions to better manage complex, dynamic healthcare systems. This volume offers researchers and policy makers an insightful and critical review of the state of the art in healthcare modeling, with a particular focus on system dynamics, agent-based models, and modern empirical studies. It will be of interest to those in the fields of health, business management, and information systems.

Guide to Modeling and Simulation of Systems of Systems

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Publisher : Springer Science & Business Media
ISBN 13 : 1447145704
Total Pages : 50 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Guide to Modeling and Simulation of Systems of Systems by : Bernard Zeigler

Download or read book Guide to Modeling and Simulation of Systems of Systems written by Bernard Zeigler and published by Springer Science & Business Media. This book was released on 2012-10-22 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user’s reference is a companion to the separate book also titled “Guide to Modelling and Simulation of Systems of Systems.” The principal book explicates integrated development environments to support virtual building and testing of systems of systems, covering in some depth the MS4 Modelling EnvironmentTM. This user’s reference provides a quick reference and exposition of the various concepts and functional features covered in that book. The topics in the user’s reference are grouped in alignment with the workflow displayed on the MS4 Modeling EnvironmentTM launch page, under the headings Atomic Models, System Entity Structure, Pruning SES, and Miscellaneous. For each feature, the reference discusses why we use it, when we should use it, and how to use it. Further comments and links to related features are also included.

The Learning Healthcare System

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Publisher : National Academies Press
ISBN 13 : 0309133939
Total Pages : 374 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Learning Healthcare System by : Institute of Medicine

Download or read book The Learning Healthcare System written by Institute of Medicine and published by National Academies Press. This book was released on 2007-06-01 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: As our nation enters a new era of medical science that offers the real prospect of personalized health care, we will be confronted by an increasingly complex array of health care options and decisions. The Learning Healthcare System considers how health care is structured to develop and to apply evidence-from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement-and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers. The Learning Healthcare System is the first in a series that will focus on issues important to improving the development and application of evidence in health care decision making. The Roundtable on Evidence-Based Medicine serves as a neutral venue for cooperative work among key stakeholders on several dimensions: to help transform the availability and use of the best evidence for the collaborative health care choices of each patient and provider; to drive the process of discovery as a natural outgrowth of patient care; and, ultimately, to ensure innovation, quality, safety, and value in health care.

Object-Oriented Simulation with Hierarchical, Modular Models

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Author :
Publisher : Academic Press
ISBN 13 : 1483264912
Total Pages : 414 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Object-Oriented Simulation with Hierarchical, Modular Models by : Bernard P. Zeigler

Download or read book Object-Oriented Simulation with Hierarchical, Modular Models written by Bernard P. Zeigler and published by Academic Press. This book was released on 2014-05-10 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Object-Oriented Simulation with Hierarchical, Modular Models: Intelligent Agents and Endomorphic Systems describes an approach to object-oriented discrete event simulation and the concepts of hierarchical, modular model construction, The implementation of the concepts of multifaceted modeling methodology in the DEVS-Scheme modeling and simulation environment is discussed. The use of the DEVS-Scheme environment in modeling artificial intelligent agents is also considered, along with the concept of endomorphism to characterize the application of self-embedded models, including models of self. Comprised of 15 chapters, this book begins with an overview of the dimensions of knowledge representation in simulation environments, followed by a discussion on object-oriented programming as well as the concepts of modular, hierarchical models and the system entity structure. Subsequent chapters focus on digraph-models and experimental frames; DEVS formalism and DEVS-Scheme simulation environment; a model base for simple multi-computer architectures; and rule-based specification of atomic models. Model bases in endomorphic systems and intelligent agents are also examined. This monograph will be of interest to simulation theorists as well as practitioners and researchers in the fields of artificial intelligence, systems engineering, computer science and engineering, and operations research.

Modeling and Simulation of Healthcare Systems

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Publisher :
ISBN 13 : 9781687006745
Total Pages : 338 pages
Book Rating : 4.0/5 (67 download)

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Book Synopsis Modeling and Simulation of Healthcare Systems by : Juan Martín García

Download or read book Modeling and Simulation of Healthcare Systems written by Juan Martín García and published by . This book was released on 2019-10-17 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: INDEX OF PAPERS Paper 1. Patient Flow and Hospital Staffing Requirements Paper 2. Forecasting Public Regional Health Needs Paper 3. Forecasting the Shortage of Neurosurgeons Paper 4. Simulating Childhood Obesity Paper 5. Modeling Vector Borne Disease Paper 6. Generic Model of Contagious Disease Paper 7. Increasing Patient's Safety Level Paper 8. Prevention of Rabies and Vaccination Coverage Paper 9. Deceased Donors for Organ Transplantation Paper 10. Antimicrobial and Antibiotic Resistance Paper 11. Cost Treatment of Hepatitis C Paper 12. Model for Suicide Prevention Paper 13. Modeling For Human Resources Planning Paper 14. Scenario Planning Workshop Paper 15. Stereotypes in Socio-Economic Systems Paper 16. The Bass Diffusion Model Paper 17. Evaluate Future Businesses Performance Paper 18. Group Model Building Paper 19. Infectious Disease Model Paper 20. Management of a large public hospital INDEX OF MODELS FOR BEGINNERS 1. Population Growth 2. A Catastrophe Study 3. The Young Ambitious Worker 4. Development of an Epidemic 5. The Golden Number 6. The Butterfly Effect 7. Building Games and Learning Labs 8. Sensitivity Analysis COLLECTION OF BOOKS Selected papers on System Dynamics 1.Agriculture and food production ISBN: 9781686984570 2.Business ISBN: 9781686997556 3.Ecology and the environment ISBN: 9781687000323 4.Economy: money and finances ISBN: 9781687003133 5.Energy ISBN: 9781687004932 6.Healthcare ISBN: 9781687006745 7.Housing and urban dynamics ISBN: 9781687008367 8.Supply chain and industrial dynamics ISBN: 9781687009975 9.Labor, human resources and social ISBN: 9781687015389 10.Sustainable development ISBN: 9781700341600 Detailed content in http://atc-innova.com/papers.htm ABOUT THE AUTHOR Juan Martin Garcia, expert in System Dynamics and System Thinking, Ph. D. Industrial Engineer UPC (Spain) and Postgraduate Diploma in Business Dynamics at the Sloan School of Management of the Massachusetts Institute of Technology (USA). He has been teacher of building simulation models during twenty years in several universities and now he teaches the online courses of Vensim in http://vensim.com/vensim-online-courses/

Systems Medicine

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Publisher : Academic Press
ISBN 13 : 0128160780
Total Pages : 1571 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Medicine by :

Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Modeling & Simulation-Based Data Engineering

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Author :
Publisher : Elsevier
ISBN 13 : 0080550541
Total Pages : 448 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Modeling & Simulation-Based Data Engineering by : Bernard P. Zeigler

Download or read book Modeling & Simulation-Based Data Engineering written by Bernard P. Zeigler and published by Elsevier. This book was released on 2007-08-07 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Engineering has become a necessary and critical activity for business, engineering, and scientific organizations as the move to service oriented architecture and web services moves into full swing. Notably, the US Department of Defense is mandating that all of its agencies and contractors assume a defining presence on the Net-centric Global Information Grid. This book provides the first practical approach to data engineering and modeling, which supports interoperabililty with consumers of the data in a service- oriented architectures (SOAs). Although XML (eXtensible Modeling Language) is the lingua franca for such interoperability, it is not sufficient on its own. The approach in this book addresses critical objectives such as creating a single representation for multiple applications, designing models capable of supporting dynamic processes, and harmonizing legacy data models for web-based co-existence. The approach is based on the System Entity Structure (SES) which is a well-defined structure, methodology, and practical tool with all of the functionality of UML (Unified Modeling Language) and few of the drawbacks. The SES originated in the formal representation of hierarchical simulation models. So it provides an axiomatic formalism that enables automating the development of XML dtds and schemas, composition and decomposition of large data models, and analysis of commonality among structures. Zeigler and Hammond include a range of features to benefit their readers. Natural language, graphical and XML forms of SES specification are employed to allow mapping of legacy meta-data. Real world examples and case studies provide insight into data engineering and test evaluation in various application domains. Comparative information is provided on concepts of ontologies, modeling and simulation, introductory linguistic background, and support options enable programmers to work with advanced tools in the area. The website of the Arizona Center for Integrative Modeling and Simulation, co-founded by Zeigler in 2001, provides links to downloadable software to accompany the book. The only practical guide to integrating XML and web services in data engineering Introduces linguistic levels of interoperability for effective information exchange Covers the interoperability standards mandated by national and international agencies Complements Zeigler's classic THEORY OF MODELING AND SIMULATION

An Integrative Paradigm for Mental Health Care

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Author :
Publisher : Springer
ISBN 13 : 3030152855
Total Pages : 264 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis An Integrative Paradigm for Mental Health Care by : James H. Lake

Download or read book An Integrative Paradigm for Mental Health Care written by James H. Lake and published by Springer. This book was released on 2019-05-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This crucial volume provides a concise overview of the conceptual foundations and clinical methods underlying the rapidly emerging subspecialty of integrative mental healthcare. It discusses methods for guiding practitioners to individualized integrative strategies that address unique symptoms and circumstances for each patient and includes practical clinical techniques for developing interventions addressed at wellness, prevention, and treatment. Included among the overview: Meeting the challenges of mental illness through integrative mental health care. Evolving paradigms and their impact on mental health care Models of consciousness: How they shape understandings of normal mental functioning and mental illness Foundations of methodology in integrative mental health care Treatment planning in integrative mental health care The future of mental health care A New Paradigm for Integrative Mental Healthcare is relevant and timely for the increasing numbers of patients seeking integrative and alternative care for depressed mood, anxiety, ADHD, bipolar disorder, schizophrenia, and other mental health problems such as fatigue and chronic pain. “Patients are crying out for a more integrative approach, and this exemplary book provides the template for achieving such a vision.” -Jerome Sarris, MHSc, PhD, ND “For most conventionally trained clinicians the challenge is not “does CAM work?” but “how do I integrate CAM into my clinical practice?” Lake’s comprehensive approach answers this central question, enabling the clinician to plan truly integrative and effective care for the mind and body.” -Leslie Korn, PhD, MPH

Big Data Analytics and Intelligence

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Author :
Publisher : Emerald Group Publishing
ISBN 13 : 1839091010
Total Pages : 252 pages
Book Rating : 4.8/5 (39 download)

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Book Synopsis Big Data Analytics and Intelligence by : Poonam Tanwar

Download or read book Big Data Analytics and Intelligence written by Poonam Tanwar and published by Emerald Group Publishing. This book was released on 2020-09-30 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data Analytics and Intelligence is essential reading for researchers and experts working in the fields of health care, data science, analytics, the internet of things, and information retrieval.

Theory of Modelling and Simulation

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Author :
Publisher :
ISBN 13 :
Total Pages : 478 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Theory of Modelling and Simulation by : Bernard P. Zeigler

Download or read book Theory of Modelling and Simulation written by Bernard P. Zeigler and published by . This book was released on 1984 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Complexity Challenges in Cyber Physical Systems

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119552397
Total Pages : 432 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Complexity Challenges in Cyber Physical Systems by : Saurabh Mittal

Download or read book Complexity Challenges in Cyber Physical Systems written by Saurabh Mittal and published by John Wiley & Sons. This book was released on 2019-12-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a one-stop reference on the application of advanced modeling and simulation (M&S) in cyber physical systems (CPS) engineering This book provides the state-of-the-art in methods and technologies that aim to elaborate on the modeling and simulation support to cyber physical systems (CPS) engineering across many sectors such as healthcare, smart grid, or smart home. It presents a compilation of simulation-based methods, technologies, and approaches that encourage the reader to incorporate simulation technologies in their CPS engineering endeavors, supporting management of complexity challenges in such endeavors. Complexity Challenges in Cyber Physical Systems: Using Modeling and Simulation (M&S) to Support Intelligence, Adaptation and Autonomy is laid out in four sections. The first section provides an overview of complexities associated with the application of M&S to CPS Engineering. It discusses M&S in the context of autonomous systems involvement within the North Atlantic Treaty Organization (NATO). The second section provides a more detailed description of the challenges in applying modeling to the operation, risk and design of holistic CPS. The third section delves in details of simulation support to CPS engineering followed by the engineering practices to incorporate the cyber element to build resilient CPS sociotechnical systems. Finally, the fourth section presents a research agenda for handling complexity in application of M&S for CPS engineering. In addition, this text: Introduces a unifying framework for hierarchical co-simulations of cyber physical systems (CPS) Provides understanding of the cycle of macro-level behavior dynamically arising from spaciotemporal interactions between parts at the micro-level Describes a simulation platform for characterizing resilience of CPS Complexity Challenges in Cyber Physical Systems has been written for researchers, practitioners, lecturers, and graduate students in computer engineering who want to learn all about M&S support to addressing complexity in CPS and its applications in today’s and tomorrow’s world.