Use of Branched-chain Alpha-ketoacid Dehydrogenase Complex as a Model for Protien Import Into Mitochondria

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Total Pages : pages
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Book Synopsis Use of Branched-chain Alpha-ketoacid Dehydrogenase Complex as a Model for Protien Import Into Mitochondria by : Tracy Lynne Sitler

Download or read book Use of Branched-chain Alpha-ketoacid Dehydrogenase Complex as a Model for Protien Import Into Mitochondria written by Tracy Lynne Sitler and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Alpha-Keto Acid Dehydrogenase Complexes

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Publisher : Birkhäuser
ISBN 13 : 303488981X
Total Pages : 321 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Alpha-Keto Acid Dehydrogenase Complexes by : M.S. Patel

Download or read book Alpha-Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Birkhäuser. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.

Use of Branched Chain Alpha Keto Acid Dehydrogenase Complex for Production of Fusel Alcohols in Escherichia Coli

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ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (671 download)

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Book Synopsis Use of Branched Chain Alpha Keto Acid Dehydrogenase Complex for Production of Fusel Alcohols in Escherichia Coli by : Matthew John Silverman

Download or read book Use of Branched Chain Alpha Keto Acid Dehydrogenase Complex for Production of Fusel Alcohols in Escherichia Coli written by Matthew John Silverman and published by . This book was released on 2010 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Effect of Branched-Chain Alpha-Keto Acid Dehydrogenase Depletion on Myotube Protein Metabolism

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Effect of Branched-Chain Alpha-Keto Acid Dehydrogenase Depletion on Myotube Protein Metabolism by : Glory Nkechukwu Madu

Download or read book Effect of Branched-Chain Alpha-Keto Acid Dehydrogenase Depletion on Myotube Protein Metabolism written by Glory Nkechukwu Madu and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branched-chain amino acids (BCAAs) are essential amino acids that are crucial for skeletal muscle anabolism. Compared to the effects of these amino acids on skeletal muscle, much less is known on how impairment in BCAA catabolism affects this tissue. BCAA catabolism starts with the reversible transamination by the mitochondrial enzyme branched-chain aminotransferase 2 (BCAT2). This is followed by the irreversible decarboxylation, catalyzed by branched-chain -keto acid dehydrogenase (BCKD) complex. Our lab has previously shown that BCAT2 and BCKD catabolic activities are essential for the differentiation of skeletal myoblasts into myotubes in vitro. Here, we investigate the effect of depletion of BCAT2 or BCKD in differentiated myotubes. We demonstrate that disrupting BCAT2 negatively affects myotube survival. Furthermore, we show that BCKD depletion augments myofibrillar protein content and increases mTORC1 signaling in myotubes. Conclusively, interventions that target BCKD abundance or functions may promote muscle protein anabolism in individuals with muscle wasting conditions.

Alpha-keto Acid Dehydrogenase Complexes

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ISBN 13 :
Total Pages : 474 pages
Book Rating : 4.:/5 (246 download)

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Book Synopsis Alpha-keto Acid Dehydrogenase Complexes by : Thomas E. Roche

Download or read book Alpha-keto Acid Dehydrogenase Complexes written by Thomas E. Roche and published by . This book was released on 1989 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Formation of the Human Branched Chain Α-ketoacid Dehydrogenase Complex and Characterization of the E1β Subunit

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Book Synopsis Formation of the Human Branched Chain Α-ketoacid Dehydrogenase Complex and Characterization of the E1β Subunit by : Beth Bowers McConnell

Download or read book Formation of the Human Branched Chain Α-ketoacid Dehydrogenase Complex and Characterization of the E1β Subunit written by Beth Bowers McConnell and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Formation of the Human Branched Chain [alpha]-ketoacid Dehydrogenase Complex and Characterization of the E1[beta] Subunit

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ISBN 13 :
Total Pages : pages
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Book Synopsis Formation of the Human Branched Chain [alpha]-ketoacid Dehydrogenase Complex and Characterization of the E1[beta] Subunit by : Beth Bowers McConnell

Download or read book Formation of the Human Branched Chain [alpha]-ketoacid Dehydrogenase Complex and Characterization of the E1[beta] Subunit written by Beth Bowers McConnell and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Branched Chain Amino and Keto Acids in Health and Disease

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Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 596 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Branched Chain Amino and Keto Acids in Health and Disease by : Siamak A. Adibi

Download or read book Branched Chain Amino and Keto Acids in Health and Disease written by Siamak A. Adibi and published by S. Karger AG (Switzerland). This book was released on 1984 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Branched Chain Α-ketoacid Dehydrogenase Knase and the Regulation of Mammalian Brancehed Chain Α-ketoacid Dehydrogenase Complex

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Book Synopsis Branched Chain Α-ketoacid Dehydrogenase Knase and the Regulation of Mammalian Brancehed Chain Α-ketoacid Dehydrogenase Complex by : Christopher Bradley Doering

Download or read book Branched Chain Α-ketoacid Dehydrogenase Knase and the Regulation of Mammalian Brancehed Chain Α-ketoacid Dehydrogenase Complex written by Christopher Bradley Doering and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Effects of Protein Starvation and Diabetes on the Activity and Content of the Hepatic Branched Chain Α-ketoacid Dehydrogenase Complex

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ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.:/5 (29 download)

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Book Synopsis The Effects of Protein Starvation and Diabetes on the Activity and Content of the Hepatic Branched Chain Α-ketoacid Dehydrogenase Complex by : Reid G. Gibson

Download or read book The Effects of Protein Starvation and Diabetes on the Activity and Content of the Hepatic Branched Chain Α-ketoacid Dehydrogenase Complex written by Reid G. Gibson and published by . This book was released on 1992 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Backbone Dynamics of Human Mitochondrial Lipoic Acid-bearing Domain of Branched-chain -ketoacid Dehydrogenase Complex Probed by NMR Relaxation Analysis

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Book Synopsis Backbone Dynamics of Human Mitochondrial Lipoic Acid-bearing Domain of Branched-chain -ketoacid Dehydrogenase Complex Probed by NMR Relaxation Analysis by : 周慧婷

Download or read book Backbone Dynamics of Human Mitochondrial Lipoic Acid-bearing Domain of Branched-chain -ketoacid Dehydrogenase Complex Probed by NMR Relaxation Analysis written by 周慧婷 and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Effect of Inhibitors of Branched-chain Keto Acid Dehydrogenase Complex on Growth and Branched-chain [alpha]-keto Acid Dehydrogenase Activity of Listeria Monocytogenes

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ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.:/5 (476 download)

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Book Synopsis Effect of Inhibitors of Branched-chain Keto Acid Dehydrogenase Complex on Growth and Branched-chain [alpha]-keto Acid Dehydrogenase Activity of Listeria Monocytogenes by : Tonia R. Wooldridge

Download or read book Effect of Inhibitors of Branched-chain Keto Acid Dehydrogenase Complex on Growth and Branched-chain [alpha]-keto Acid Dehydrogenase Activity of Listeria Monocytogenes written by Tonia R. Wooldridge and published by . This book was released on 2000 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Longer Term Regulation of the Branched Chain Ketoacid Dehydrogenase Complex

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (597 download)

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Book Synopsis Longer Term Regulation of the Branched Chain Ketoacid Dehydrogenase Complex by : Mark Beggs

Download or read book Longer Term Regulation of the Branched Chain Ketoacid Dehydrogenase Complex written by Mark Beggs and published by . This book was released on 1988 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Longer Term Regulation of the Branched Chain Ketoacid Dehydrogenase Complex

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ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (597 download)

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Book Synopsis Longer Term Regulation of the Branched Chain Ketoacid Dehydrogenase Complex by : Mark Beggs

Download or read book Longer Term Regulation of the Branched Chain Ketoacid Dehydrogenase Complex written by Mark Beggs and published by . This book was released on 1988 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Branched-Chain Keto Acid Dehydrogenase Kinase Depletion Affects Branched-Chain Alpha-Keto Acid Dehydrogenase Activity and Muscle Cell Differentiation

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Branched-Chain Keto Acid Dehydrogenase Kinase Depletion Affects Branched-Chain Alpha-Keto Acid Dehydrogenase Activity and Muscle Cell Differentiation by : Brendan Eamon Beatty

Download or read book Branched-Chain Keto Acid Dehydrogenase Kinase Depletion Affects Branched-Chain Alpha-Keto Acid Dehydrogenase Activity and Muscle Cell Differentiation written by Brendan Eamon Beatty and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branched-chain amino acids are indispensible amino acids that are known for having anabolic effects in skeletal muscle. These effects BCAAs elicit in existing skeletal muscle are well documented in literature. However, much less is known about how they affect the process of myogensis and muscle regeneration. Data generated in our lab have shown that the intact BCAA catabolic pathway is required for proper skeletal muscle cell differentiation. In the current study, the main enzymes involved in the catabolism of BCAAs were assessed, in addition to the activity of the rate-limiting enzyme (Branched-chain -ketoacid dehydrogenase - BCKD) in the pathway. Increasing the flux of BCAAs through this pathway via siRNA mediated knockdown of a negative regulator of the pathway augmented differentiation. It is evident that BCAA catabolism is intricately involved in the process of muscle cell differentiation. Further study into the regulation of BCAA catabolism during differentiation is warranted; to aid in the development of nutritional based interventions for populations suffering from muscle wasting condition.

Molecular Studies of the Mammalian Branched-chain A-keto Acid Dehydrogenase Complex

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ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (222 download)

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Book Synopsis Molecular Studies of the Mammalian Branched-chain A-keto Acid Dehydrogenase Complex by : Thomas Andrew Griffin

Download or read book Molecular Studies of the Mammalian Branched-chain A-keto Acid Dehydrogenase Complex written by Thomas Andrew Griffin and published by . This book was released on 1989 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:

"In Vitro" Reconstitution of the 24-meric E2 Inner Core of Bovine Mitochondrial Branched-chain A[lfa]-keto Acid Dehydrogenase Complex

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ISBN 13 :
Total Pages : 7 pages
Book Rating : 4.:/5 (793 download)

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Book Synopsis "In Vitro" Reconstitution of the 24-meric E2 Inner Core of Bovine Mitochondrial Branched-chain A[lfa]-keto Acid Dehydrogenase Complex by : R. Max Wynn

Download or read book "In Vitro" Reconstitution of the 24-meric E2 Inner Core of Bovine Mitochondrial Branched-chain A[lfa]-keto Acid Dehydrogenase Complex written by R. Max Wynn and published by . This book was released on 1994 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: