Uprising New Strategies For The Treatment Of Acute Myeloid Leukemia

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Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Author : Richard K. Burt
Publisher : Springer Science & Business Media
ISBN 13 : 9780792377146
Total Pages : 440 pages
Book Rating : 4.3/5 (771 download)

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Book Synopsis Advances in Allogeneic Hematopoietic Stem Cell Transplantation by : Richard K. Burt

Download or read book Advances in Allogeneic Hematopoietic Stem Cell Transplantation written by Richard K. Burt and published by Springer Science & Business Media. This book was released on 2000-02-29 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Cancer Genomics for the Clinician

Author : Ramaswamy Govindan, MD
Publisher : Springer Publishing Company
ISBN 13 : 082616868X
Total Pages : 185 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Cancer Genomics for the Clinician by : Ramaswamy Govindan, MD

Download or read book Cancer Genomics for the Clinician written by Ramaswamy Govindan, MD and published by Springer Publishing Company. This book was released on 2019-01-28 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook

Advanced Computational Techniques for Sustainable Computing

Author : Megha Rathi
Publisher : CRC Press
ISBN 13 : 1000454312
Total Pages : 339 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Advanced Computational Techniques for Sustainable Computing by : Megha Rathi

Download or read book Advanced Computational Techniques for Sustainable Computing written by Megha Rathi and published by CRC Press. This book was released on 2022-07-25 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Computational Techniques for Sustainable Computing is considered multi-disciplinary field encompassing advanced computational techniques across several domain, including, Computer Science, Statistical Computation and Electronics Engineering. The core idea of sustainable computing is to deploy algorithms, models, policies and protocols to improve energy efficiency and management of resources, enhancing ecological balance, biological sustenance and other services on societal contexts. The book offers a comprehensive coverage of some of the most essential topics: It provides an insight on building smart sustainable solutions. Includes details of applying mining, learning, IOT and sensor-based techniques for sustainable computing. Entails data extraction from various sources followed with pre-processing of data, and how to make effective use of extracted data for application-based research. Involves practical usage of data analytic language, including R, Python, etc. for improving sustainable services offered by multi-disciplinary domains. Encompasses comparison and analysis of recent technologies and trends. Includes development of smart models for information gain and effective decision making with visualization. The readers would get acquainted with the utilization of massive data sets for intelligent mining and processing. It includes the integration of data mining techniques for effective decision-making in the social, economic, and global environmental domains to achieve sustainability. The implementation of computational frameworks can be accomplished using open-source software for the building of resource-efficient models. The content of the book demonstrates the usage of data science and the internet of things for the advent of smart and realistic solutions for attaining sustainability.

Childhood Cancer and Functional Impacts Across the Care Continuum

Author : National Academies of Sciences Engineering and Medicine
Publisher :
ISBN 13 : 9780309683494
Total Pages : pages
Book Rating : 4.6/5 (834 download)

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Book Synopsis Childhood Cancer and Functional Impacts Across the Care Continuum by : National Academies of Sciences Engineering and Medicine

Download or read book Childhood Cancer and Functional Impacts Across the Care Continuum written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2021-09-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Relaxation Revolution

Author : Herbert Benson
Publisher : Simon and Schuster
ISBN 13 : 143914866X
Total Pages : 288 pages
Book Rating : 4.4/5 (391 download)

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Book Synopsis Relaxation Revolution by : Herbert Benson

Download or read book Relaxation Revolution written by Herbert Benson and published by Simon and Schuster. This book was released on 2011-06-21 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In Relaxation Revolution, Dr. Herbert Benson and William Proctor present the latest scientific endings, revealing that we have the ability to self-heal diseases, prevent life-threatening conditions, and supplement established drug and surgical procedures with mind body techniques. In a special "treatment" section, Benson and Proctor describe how these mind body techniques can be applied - and are being applied - to treat a wide variety of conditions..."--Publisher.

Precision Medicine in Oncology

Author : Angela Re
Publisher : Frontiers Media SA
ISBN 13 : 2889457052
Total Pages : 163 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Precision Medicine in Oncology by : Angela Re

Download or read book Precision Medicine in Oncology written by Angela Re and published by Frontiers Media SA. This book was released on 2019-01-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration.

The Cancer Treatment Revolution

Author : David G. Nathan, M.D.
Publisher : Turner Publishing Company
ISBN 13 : 0470491965
Total Pages : 315 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis The Cancer Treatment Revolution by : David G. Nathan, M.D.

Download or read book The Cancer Treatment Revolution written by David G. Nathan, M.D. and published by Turner Publishing Company. This book was released on 2009-05-18 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for The Cancer Treatment Revolution "A wonderful journey through modern medical science, told with warmth and insight, brought to life through the stories of people confronting cancer. This book will inspire and educate both laymen and caregivers." —Jerome Groopman, M.D., author of The Measure of Our Days and The Anatomy of Hope and Recanati, Professor, Harvard Medical School "This is probably the best book on cancer that exists--beautifully written and unfailingly interesting, conveying a clear sense of hope for cancer patients and survivors. Cancer treatment has come a long way but not without intense struggles and passions, which David Nathan narrates from the inside as one of the leading players. He explains cancer more clearly than anyone else, and his portraits of great cancer doctors are sharp and unforgettable, a contribution to history." —Richard Preston, author of The Hot Zone and The Demon in the Freezer "No one is better positioned to tell the tale of the cancer treatment revolution of the last half century than David Nathan. A brilliant physician-scientist, he has been present at the cusps of history in this life-and-death field. The story he tells here is fascinating, and his book is captivating." —Atul Gawande, M.D., author of Complications: A Surgeon's Notes on an Imperfect Science and Better: A Surgeon's Notes on Performance and Assistant Professor of Surgery, Harvard Medical School "David Nathan is a true storyteller. In The Cancer Treatment Revolution, he tells stories that bridge cancer patients and cancer research as few others could. These gripping tales will be appreciated by those who live with cancer and those who strive to create new therapies." —Thomas Cech, Ph.D., recipient of the 1989 Nobel Prize in Chemistry and President of the Howard Hughes Medical Institute "David Nathan, one of the nation's preeminent clinician-scientists, tells the stories of three cancer patients, revealing compelling human facets--the dedication of the remarkable teams that care for these patients and, even more, the bravery and fortitude of the patients and their families." —Harold Varmus, M.D., recipient of the 1989 Nobel Prize in Medicine, President of the Memorial Sloan-Kettering Cancer Center, and former director of the National Institutes of Health "Engaged by the compelling triumphs and tragedies of patients whose normal lives are inevitably altered by a life-threatening cancer, the reader of The Cancer Treatment Revolution will easily appreciate the impact of the new cancer diagnostics and therapies compared to even relatively recent cancer treatments." —Karen Antman, M.D., Dean, Boston University School of Medicine "This personal, highly readable account by one of the leaders of the cancer treatment revolution explains how the revolution has come about and how it will change the future." —Sir Paul Nurse, Ph.D., President of Rockefeller University and recipient of the 2001 Nobel Prize in Medicine

Surgical Pathophysiology

Author : A. Aasen
Publisher : CRC Press
ISBN 13 : 9783718650385
Total Pages : 480 pages
Book Rating : 4.6/5 (53 download)

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Book Synopsis Surgical Pathophysiology by : A. Aasen

Download or read book Surgical Pathophysiology written by A. Aasen and published by CRC Press. This book was released on 1991-05-13 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proceedings in Print

Author :
Publisher :
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Proceedings in Print by :

Download or read book Proceedings in Print written by and published by . This book was released on 1997 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell Surface Proteases

Author :
Publisher : Elsevier
ISBN 13 : 0080490883
Total Pages : 475 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Cell Surface Proteases by :

Download or read book Cell Surface Proteases written by and published by Elsevier. This book was released on 2003-05-03 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource.* Provides an overview of the entire field of cell surface proteases in a single volume* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage

The Fourth Industrial Revolution

Author : Klaus Schwab
Publisher : Crown Currency
ISBN 13 : 1524758876
Total Pages : 194 pages
Book Rating : 4.5/5 (247 download)

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Book Synopsis The Fourth Industrial Revolution by : Klaus Schwab

Download or read book The Fourth Industrial Revolution written by Klaus Schwab and published by Crown Currency. This book was released on 2017-01-03 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: World-renowned economist Klaus Schwab, Founder and Executive Chairman of the World Economic Forum, explains that we have an opportunity to shape the fourth industrial revolution, which will fundamentally alter how we live and work. Schwab argues that this revolution is different in scale, scope and complexity from any that have come before. Characterized by a range of new technologies that are fusing the physical, digital and biological worlds, the developments are affecting all disciplines, economies, industries and governments, and even challenging ideas about what it means to be human. Artificial intelligence is already all around us, from supercomputers, drones and virtual assistants to 3D printing, DNA sequencing, smart thermostats, wearable sensors and microchips smaller than a grain of sand. But this is just the beginning: nanomaterials 200 times stronger than steel and a million times thinner than a strand of hair and the first transplant of a 3D printed liver are already in development. Imagine “smart factories” in which global systems of manufacturing are coordinated virtually, or implantable mobile phones made of biosynthetic materials. The fourth industrial revolution, says Schwab, is more significant, and its ramifications more profound, than in any prior period of human history. He outlines the key technologies driving this revolution and discusses the major impacts expected on government, business, civil society and individuals. Schwab also offers bold ideas on how to harness these changes and shape a better future—one in which technology empowers people rather than replaces them; progress serves society rather than disrupts it; and in which innovators respect moral and ethical boundaries rather than cross them. We all have the opportunity to contribute to developing new frameworks that advance progress.

Modulation of Human Immune Parameters by Anticancer Therapies

Author : Ulrich Sack
Publisher : Frontiers Media SA
ISBN 13 : 288966399X
Total Pages : 169 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Modulation of Human Immune Parameters by Anticancer Therapies by : Ulrich Sack

Download or read book Modulation of Human Immune Parameters by Anticancer Therapies written by Ulrich Sack and published by Frontiers Media SA. This book was released on 2021-01-18 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Flow Cytometry

Author : Alice Longobardi Givan
Publisher : John Wiley & Sons
ISBN 13 : 1118688392
Total Pages : 309 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Flow Cytometry by : Alice Longobardi Givan

Download or read book Flow Cytometry written by Alice Longobardi Givan and published by John Wiley & Sons. This book was released on 2013-04-10 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow cytometry continually amazes scientists with its ever-expanding utility. Advances in flow cytometry have opened new directions in theoretical science, clinical diagnosis, and medical practice. The new edition of Flow Cytometry: First Principles provides a thorough update of this now classic text, reflecting innovations in the field while outlining the fundamental elements of instrumentation, sample preparation, and data analysis. Flow Cytometry: First Principles, Second Edition explains the basic principles of flow cytometry, surveying its primary scientific and clinical applications and highlighting state-of-the-art techniques at the frontiers of research. This edition contains extensive revisions of all chapters, including new discussions on fluorochrome and laser options for multicolor analysis, an additionalsection on apoptosis in the chapter on DNA, and new chapters onintracellular protein staining and cell sorting, including high-speed sorting and alternative sorting methods, as well as traditional technology. This essential resource: Assumes no prior knowledge of flow cytometry Progresses with an informal, engaging lecture style from simpleto more complex concepts Offers a clear introduction to new vocabulary, principles of instrumentation, and strategies for data analysis Emphasizes the theory relevant to all flow cytometry, with examples from a variety of clinical and scientific fields Flow Cytometry: First Principles, Second Edition provides scientists, clinicians, technologists, and students with the knowledge necessary for beginning the practice of flow cytometry and for understanding related literature.

Nanoparticles in Cancer Therapy

Author : Neelam Thakur
Publisher : CRC Press
ISBN 13 : 1040144152
Total Pages : 345 pages
Book Rating : 4.0/5 (41 download)

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Book Synopsis Nanoparticles in Cancer Therapy by : Neelam Thakur

Download or read book Nanoparticles in Cancer Therapy written by Neelam Thakur and published by CRC Press. This book was released on 2024-11-08 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance. Additionally, it explores nanotechnology in radiation therapy, phototherapy modalities and bioengineered virus-like nanoparticles for diagnostics and therapeutics. The last section reviews the clinical applications and prospects, examining theranostic nanoparticles, the clinical translation of nanomedicine and the current limitations of cancer nanotherapy. It also addresses future directions in nanoparticle application, and examines the genotoxicity, immunotoxicity, cytotoxicity assessments, safety profiles, targeted drug delivery, and their role in viral oncogenesis. This book is a useful resource for researchers, clinicians and students in the fields of oncology and nanotechnology.

Highlights of Progress in Research on Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Highlights of Progress in Research on Cancer by :

Download or read book Highlights of Progress in Research on Cancer written by and published by . This book was released on 1957 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Allogeneic Stem Cell Transplantation

Author : Hillard M. Lazarus
Publisher : Springer Science & Business Media
ISBN 13 : 1597454788
Total Pages : 885 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Allogeneic Stem Cell Transplantation by : Hillard M. Lazarus

Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.