Understanding and Assessment of a Two-component G-prior in Variable Selection

Download Understanding and Assessment of a Two-component G-prior in Variable Selection PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (114 download)

DOWNLOAD NOW!


Book Synopsis Understanding and Assessment of a Two-component G-prior in Variable Selection by : Farnaz Solatikia

Download or read book Understanding and Assessment of a Two-component G-prior in Variable Selection written by Farnaz Solatikia and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Then we present a Bayesian variable selection method based on an extension of the Zellner's g-prior in linear models. More specifically, we propose a two-component G-prior, wherein a tuning parameter, calibrated by use of pseudo variables, is introduced to adjust the distance between the two components. We Assess the impact of tuning parameter b, the distance between important and unimportant variables, on the selection of variables by controlling Bayesian false model selection rate with respect to unimportant variables based on creating pseudo variables. We show that implementing the proposed prior in variable selection is more efficient than using the Zellner's g-prior.

Assigning G in Zellner's G Prior for Bayesian Variable Selection

Download Assigning G in Zellner's G Prior for Bayesian Variable Selection PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 62 pages
Book Rating : 4.:/5 (929 download)

DOWNLOAD NOW!


Book Synopsis Assigning G in Zellner's G Prior for Bayesian Variable Selection by : Mengjie Wang

Download or read book Assigning G in Zellner's G Prior for Bayesian Variable Selection written by Mengjie Wang and published by . This book was released on 2015 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are numerous frequentist statistics variable selection methods such as Stepwise regression, AIC and BIC etc. In particular, the latter two criteria include a penalty term which discourages overfitting. In terms of the framework of Bayesian variable selection, a popular approach is using Bayes Factor (Kass & Raftery 1995), which also has a natural built-in penalty term (Berger & Pericchi 2001). Zellner's g prior (Zellner 1986) is a common prior for coefficients in the linear regression model due to its computational speed of analytic solutions for posterior. However, the choice of g is a problem which has attracted a lot of attention. (Zellner 1986) pointed out that if g is unknown, a prior can be introduced and g can be integrated out. One of the prior choices is Hyper-g Priors proposed by (Liang et al. 2008). Instead of proposing a prior for g, we will assign a fixed value for g based on controlling the Type I error for the test based on the Bayes factor. Since we are using Bayes factor to do model selection, the test statistic is Bayes factor. Every test comes with a Type I error, so it is reasonable to restrict this error under a critical value, which we will take as benchmark values, such as 0.1 or 0.05. This approach will automatically involve setting a value of g. Based on this idea, a fixed g can be selected, hence avoiding the need to find a prior for g.

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Download Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide PDF Online Free

Author :
Publisher : Government Printing Office
ISBN 13 : 1587634236
Total Pages : 236 pages
Book Rating : 4.5/5 (876 download)

DOWNLOAD NOW!


Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)

Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Handbook of Bayesian Variable Selection

Download Handbook of Bayesian Variable Selection PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1000510204
Total Pages : 491 pages
Book Rating : 4.0/5 (5 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Bayesian Variable Selection by : Mahlet G. Tadesse

Download or read book Handbook of Bayesian Variable Selection written by Mahlet G. Tadesse and published by CRC Press. This book was released on 2021-12-24 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian variable selection has experienced substantial developments over the past 30 years with the proliferation of large data sets. Identifying relevant variables to include in a model allows simpler interpretation, avoids overfitting and multicollinearity, and can provide insights into the mechanisms underlying an observed phenomenon. Variable selection is especially important when the number of potential predictors is substantially larger than the sample size and sparsity can reasonably be assumed. The Handbook of Bayesian Variable Selection provides a comprehensive review of theoretical, methodological and computational aspects of Bayesian methods for variable selection. The topics covered include spike-and-slab priors, continuous shrinkage priors, Bayes factors, Bayesian model averaging, partitioning methods, as well as variable selection in decision trees and edge selection in graphical models. The handbook targets graduate students and established researchers who seek to understand the latest developments in the field. It also provides a valuable reference for all interested in applying existing methods and/or pursuing methodological extensions. Features: Provides a comprehensive review of methods and applications of Bayesian variable selection. Divided into four parts: Spike-and-Slab Priors; Continuous Shrinkage Priors; Extensions to various Modeling; Other Approaches to Bayesian Variable Selection. Covers theoretical and methodological aspects, as well as worked out examples with R code provided in the online supplement. Includes contributions by experts in the field. Supported by a website with code, data, and other supplementary material

Bayesian Data Analysis, Third Edition

Download Bayesian Data Analysis, Third Edition PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1439840954
Total Pages : 677 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!


Book Synopsis Bayesian Data Analysis, Third Edition by : Andrew Gelman

Download or read book Bayesian Data Analysis, Third Edition written by Andrew Gelman and published by CRC Press. This book was released on 2013-11-01 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.

High-dimensional Variable Selection for Genomics Data, from Both Frequentist and Bayesian Perspectives

Download High-dimensional Variable Selection for Genomics Data, from Both Frequentist and Bayesian Perspectives PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)

DOWNLOAD NOW!


Book Synopsis High-dimensional Variable Selection for Genomics Data, from Both Frequentist and Bayesian Perspectives by : Jie Ren

Download or read book High-dimensional Variable Selection for Genomics Data, from Both Frequentist and Bayesian Perspectives written by Jie Ren and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Variable selection is one of the most popular tools for analyzing high-dimensional genomic data. It has been developed to accommodate complex data structures and lead to structured sparse identification of important genomics features. We focus on the network and interaction structure that commonly exist in genomic data, and develop novel variable selection methods from both frequentist and Bayesian perspectives. Network-based regularization has achieved success in variable selections for high-dimensional cancer genomic data, due to its ability to incorporate the correlations among genomic features. However, as survival time data usually follow skewed distributions, and are contaminated by outliers, network-constrained regularization that does not take the robustness into account leads to false identifications of network structure and biased estimation of patients' survival. In the first project, we develop a novel robust network-based variable selection method under the accelerated failure time (AFT) model. Extensive simulation studies show the advantage of the proposed method over the alternative methods. Promising findings are made in two case studies of lung cancer datasets with high dimensional gene expression measurements. Gene-environment (G×E) interactions are important for the elucidation of disease etiology beyond the main genetic and environmental effects. In the second project, a novel and powerful semi-parametric Bayesian variable selection model has been proposed to investigate linear and nonlinear G×E interactions simultaneously. It can further conduct structural identification by distinguishing nonlinear interactions from main-effects-only case within the Bayesian framework. The proposed method conducts Bayesian variable selection more efficiently and accurately than alternatives. Simulation shows that the proposed model outperforms competing alternatives in terms of both identification and prediction. In the case study, the proposed Bayesian method leads to the identification of effects with important implications in a high-throughput profiling study with high-dimensional SNP data. In the last project, a robust Bayesian variable selection method has been developed for G×E interaction studies. The proposed robust Bayesian method can effectively accommodate heavy-tailed errors and outliers in the response variable while conducting variable selection by accounting for structural sparsity. Spike and slab priors are incorporated on both individual and group levels to identify the sparse main and interaction effects. Extensive simulation studies and analysis of both the diabetes data with SNP measurements from the Nurses' Health Study and TCGA melanoma data with gene expression measurements demonstrate the superior performance of the proposed method over multiple competing alternatives. To facilitate reproducible research and fast computation, we have developed open source R packages for each project, which provide highly efficient C++ implementation for all the proposed and alternative approaches. The R packages regnet and spinBayes, associated with the first and second project correspondingly, are available on CRAN. For the third project, the R package robin is available from GitHub and will be submitted to CRAN soon.

Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology

Download Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889450422
Total Pages : 115 pages
Book Rating : 4.8/5 (894 download)

DOWNLOAD NOW!


Book Synopsis Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology by : David A. Rosenblueth,

Download or read book Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology written by David A. Rosenblueth, and published by Frontiers Media SA. This book was released on 2016-11-21 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research.

Doing Meta-Analysis with R

Download Doing Meta-Analysis with R PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1000435636
Total Pages : 500 pages
Book Rating : 4.0/5 (4 download)

DOWNLOAD NOW!


Book Synopsis Doing Meta-Analysis with R by : Mathias Harrer

Download or read book Doing Meta-Analysis with R written by Mathias Harrer and published by CRC Press. This book was released on 2021-09-15 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including calculation and pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced but highly relevant topics such as network meta-analysis, multi-three-level meta-analyses, Bayesian meta-analysis approaches and SEM meta-analysis are also covered. A companion R package, dmetar, is introduced at the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide. The programming and statistical background covered in the book are kept at a non-expert level, making the book widely accessible. Features • Contains two introductory chapters on how to set up an R environment and do basic imports/manipulations of meta-analysis data, including exercises • Describes statistical concepts clearly and concisely before applying them in R • Includes step-by-step guidance through the coding required to perform meta-analyses, and a companion R package for the book

Multivariable Model - Building

Download Multivariable Model - Building PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 9780470770788
Total Pages : 322 pages
Book Rating : 4.7/5 (77 download)

DOWNLOAD NOW!


Book Synopsis Multivariable Model - Building by : Patrick Royston

Download or read book Multivariable Model - Building written by Patrick Royston and published by John Wiley & Sons. This book was released on 2008-09-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multivariable regression models are of fundamental importance in all areas of science in which empirical data must be analyzed. This book proposes a systematic approach to building such models based on standard principles of statistical modeling. The main emphasis is on the fractional polynomial method for modeling the influence of continuous variables in a multivariable context, a topic for which there is no standard approach. Existing options range from very simple step functions to highly complex adaptive methods such as multivariate splines with many knots and penalisation. This new approach, developed in part by the authors over the last decade, is a compromise which promotes interpretable, comprehensible and transportable models.

Cochrane Handbook for Systematic Reviews of Interventions

Download Cochrane Handbook for Systematic Reviews of Interventions PDF Online Free

Author :
Publisher : Wiley
ISBN 13 : 9780470699515
Total Pages : 672 pages
Book Rating : 4.6/5 (995 download)

DOWNLOAD NOW!


Book Synopsis Cochrane Handbook for Systematic Reviews of Interventions by : Julian P. T. Higgins

Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Principal Component Analysis

Download Principal Component Analysis PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1475719043
Total Pages : 283 pages
Book Rating : 4.4/5 (757 download)

DOWNLOAD NOW!


Book Synopsis Principal Component Analysis by : I.T. Jolliffe

Download or read book Principal Component Analysis written by I.T. Jolliffe and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principal component analysis is probably the oldest and best known of the It was first introduced by Pearson (1901), techniques ofmultivariate analysis. and developed independently by Hotelling (1933). Like many multivariate methods, it was not widely used until the advent of electronic computers, but it is now weIl entrenched in virtually every statistical computer package. The central idea of principal component analysis is to reduce the dimen sionality of a data set in which there are a large number of interrelated variables, while retaining as much as possible of the variation present in the data set. This reduction is achieved by transforming to a new set of variables, the principal components, which are uncorrelated, and which are ordered so that the first few retain most of the variation present in all of the original variables. Computation of the principal components reduces to the solution of an eigenvalue-eigenvector problem for a positive-semidefinite symmetrie matrix. Thus, the definition and computation of principal components are straightforward but, as will be seen, this apparently simple technique has a wide variety of different applications, as weIl as a number of different deri vations. Any feelings that principal component analysis is a narrow subject should soon be dispelled by the present book; indeed some quite broad topics which are related to principal component analysis receive no more than a brief mention in the final two chapters.

Introduction to Probability

Download Introduction to Probability PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1466575573
Total Pages : 599 pages
Book Rating : 4.4/5 (665 download)

DOWNLOAD NOW!


Book Synopsis Introduction to Probability by : Joseph K. Blitzstein

Download or read book Introduction to Probability written by Joseph K. Blitzstein and published by CRC Press. This book was released on 2014-07-24 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed from celebrated Harvard statistics lectures, Introduction to Probability provides essential language and tools for understanding statistics, randomness, and uncertainty. The book explores a wide variety of applications and examples, ranging from coincidences and paradoxes to Google PageRank and Markov chain Monte Carlo (MCMC). Additional application areas explored include genetics, medicine, computer science, and information theory. The print book version includes a code that provides free access to an eBook version. The authors present the material in an accessible style and motivate concepts using real-world examples. Throughout, they use stories to uncover connections between the fundamental distributions in statistics and conditioning to reduce complicated problems to manageable pieces. The book includes many intuitive explanations, diagrams, and practice problems. Each chapter ends with a section showing how to perform relevant simulations and calculations in R, a free statistical software environment.

Generalized Linear Models for Insurance Rating

Download Generalized Linear Models for Insurance Rating PDF Online Free

Author :
Publisher :
ISBN 13 : 9780996889728
Total Pages : 106 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!


Book Synopsis Generalized Linear Models for Insurance Rating by : Mark Goldburd

Download or read book Generalized Linear Models for Insurance Rating written by Mark Goldburd and published by . This book was released on 2016-06-08 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Topics in Modal Analysis II, Volume 8

Download Topics in Modal Analysis II, Volume 8 PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319047744
Total Pages : 409 pages
Book Rating : 4.3/5 (19 download)

DOWNLOAD NOW!


Book Synopsis Topics in Modal Analysis II, Volume 8 by : Randall Allemang

Download or read book Topics in Modal Analysis II, Volume 8 written by Randall Allemang and published by Springer. This book was released on 2014-05-05 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eighth volume of eight from the IMAC - XXXII Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Structural Dynamics, including papers on: Linear Systems Substructure Modelling Adaptive Structures Experimental Techniques Analytical Methods Damage Detection Damping of Materials & Members Modal Parameter Identification Modal Testing Methods System Identification Active Control Modal Parameter Estimation Processing Modal Data

A First Course in Bayesian Statistical Methods

Download A First Course in Bayesian Statistical Methods PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387924078
Total Pages : 270 pages
Book Rating : 4.3/5 (879 download)

DOWNLOAD NOW!


Book Synopsis A First Course in Bayesian Statistical Methods by : Peter D. Hoff

Download or read book A First Course in Bayesian Statistical Methods written by Peter D. Hoff and published by Springer Science & Business Media. This book was released on 2009-06-02 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: A self-contained introduction to probability, exchangeability and Bayes’ rule provides a theoretical understanding of the applied material. Numerous examples with R-code that can be run "as-is" allow the reader to perform the data analyses themselves. The development of Monte Carlo and Markov chain Monte Carlo methods in the context of data analysis examples provides motivation for these computational methods.

Feature Selection for Data and Pattern Recognition

Download Feature Selection for Data and Pattern Recognition PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 9783662508459
Total Pages : 0 pages
Book Rating : 4.5/5 (84 download)

DOWNLOAD NOW!


Book Synopsis Feature Selection for Data and Pattern Recognition by : Urszula Stańczyk

Download or read book Feature Selection for Data and Pattern Recognition written by Urszula Stańczyk and published by Springer. This book was released on 2016-09-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research book provides the reader with a selection of high-quality texts dedicated to current progress, new developments and research trends in feature selection for data and pattern recognition. Even though it has been the subject of interest for some time, feature selection remains one of actively pursued avenues of investigations due to its importance and bearing upon other problems and tasks. This volume points to a number of advances topically subdivided into four parts: estimation of importance of characteristic features, their relevance, dependencies, weighting and ranking; rough set approach to attribute reduction with focus on relative reducts; construction of rules and their evaluation; and data- and domain-oriented methodologies.

Bayesian Ideas and Data Analysis

Download Bayesian Ideas and Data Analysis PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1439803552
Total Pages : 518 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!


Book Synopsis Bayesian Ideas and Data Analysis by : Ronald Christensen

Download or read book Bayesian Ideas and Data Analysis written by Ronald Christensen and published by CRC Press. This book was released on 2011-07-07 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing the use of WinBUGS and R to analyze real data, Bayesian Ideas and Data Analysis: An Introduction for Scientists and Statisticians presents statistical tools to address scientific questions. It highlights foundational issues in statistics, the importance of making accurate predictions, and the need for scientists and statisticians to collaborate in analyzing data. The WinBUGS code provided offers a convenient platform to model and analyze a wide range of data. The first five chapters of the book contain core material that spans basic Bayesian ideas, calculations, and inference, including modeling one and two sample data from traditional sampling models. The text then covers Monte Carlo methods, such as Markov chain Monte Carlo (MCMC) simulation. After discussing linear structures in regression, it presents binomial regression, normal regression, analysis of variance, and Poisson regression, before extending these methods to handle correlated data. The authors also examine survival analysis and binary diagnostic testing. A complementary chapter on diagnostic testing for continuous outcomes is available on the book’s website. The last chapter on nonparametric inference explores density estimation and flexible regression modeling of mean functions. The appropriate statistical analysis of data involves a collaborative effort between scientists and statisticians. Exemplifying this approach, Bayesian Ideas and Data Analysis focuses on the necessary tools and concepts for modeling and analyzing scientific data. Data sets and codes are provided on a supplemental website.