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Author : Rui Li
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (93 download)
Download or read book Ultrasound Modulated Optical Tomography in Optical Diffuse Medium Using Acoustic Radiation Force written by Rui Li and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen P. Morgan
Publisher : Taylor & Francis
ISBN 13 : 1439854963
Total Pages : 445 pages
Book Rating : 4.4/5 (398 download)
Download or read book Optical Techniques in Regenerative Medicine written by Stephen P. Morgan and published by Taylor & Francis. This book was released on 2016-04-19 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: In regenerative medicine, tissue engineers largely rely on destructive and time-consuming techniques that do not allow in situ and spatial monitoring of tissue growth. Furthermore, once the therapy is implanted in the patient, clinicians are often unable to monitor what is happening in the body. To tackle these barriers, optical techniques have bee
Author : Yuta Suzuki
Publisher :
ISBN 13 :
Total Pages : 82 pages
Book Rating : 4.:/5 (98 download)
Download or read book Ultrasound-mediated Optical Imaging and Focusing in Scattering Media written by Yuta Suzuki and published by . This book was released on 2014 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of its non-ionizing and molecular sensing nature, light has been an attractive tool in biomedicine. Scanning an optical focus allows not only high-resolution imaging but also manipulation and therapy. However, due to multiple photon scattering events, conventional optical focusing using an ordinary lens is limited to shallow depths of one transport mean free path (lt'), which corresponds to approximately 1 mm in human tissue. To overcome this limitation, ultrasonic modulation (or encoding) of diffuse light inside scattering media has enabled us to develop both deep-tissue optical imaging and focusing techniques, namely, ultrasound-modulated optical tomography (UOT) and time-reversed ultrasonically encoded (TRUE) optical focusing. While UOT measures the power of the encoded light to obtain an image, TRUE focusing generates a time-reversed (or phase-conjugated) copy of the encoded light, using a phase-conjugate mirror to focus light inside scattering media beyond 1 lt'. However, despite extensive progress in both UOT and TRUE focusing, the low signal-to-noise ratio in encoded-light detection remains a challenge to meeting both the speed and depth requirements for in vivo applications. This dissertation describes technological advancements of both UOT and TRUE focusing, in terms of their signal detection sensitivities, operational depths, and operational speeds. The first part of this dissertation describes sensitivity improvements of encoded-light detection in UOT, achieved by using a large area (~5 cm x 5 cm) photorefractive polymer. The photorefractive polymer allowed us to improve the detection etendue by more than 10 times that of previous detection schemes. It has enabled us to resolve absorbing objects embedded inside diffused media thicker than 80 lt', using moderate light power and short ultrasound pulses. The second part of this dissertation describes energy enhancement and fluorescent excitation using TRUE focusing in turbid media, using photorefractive materials as the phase-conjugate mirrors. By using a large-area photorefractive polymer as the phase-conjugate mirror, we boosted the focused optical energy by ~40 times over the output of a previously used photorefractive Bi12SiO20 crystal. Furthermore, using both a photorefractive polymer and a Bi12SiO20 crystal as the phase-conjugate mirrors, we show direct visualization and dynamic control of TRUE focus, and demonstrate fluorescence imaging in a thick turbid medium. The last part of this dissertation describes improvements in the scanning speed of a TRUE focus, using digital phase-conjugate mirrors in both transmission and reflection modes. By employing a multiplex recording of ultrasonically encoded wavefronts in transmission mode, we have accelerated the generation of multiple TRUE foci, using frequency sweeping of both ultrasound and light. With this technique, we obtained a 2-D image of a fluorescent target centered inside a turbid sample having a thickness of 2.4 lt'. Also, by gradually moving the focal position in reflection mode, we show that the TRUE focal intensity is improved, and can be continuously scanned to image fluorescent targets in a shorter time.
Author :
Publisher :
ISBN 13 :
Total Pages : 33 pages
Book Rating : 4.:/5 (457 download)
Download or read book El Tirano de Lombardia written by and published by . This book was released on 1790* with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lei Sui
Publisher :
ISBN 13 :
Total Pages : 394 pages
Book Rating : 4.:/5 (31 download)
Download or read book Acousto-optic Imaging in Diffuse Media Using Pulsed Ultrasound and the Photorefractive Effect written by Lei Sui and published by . This book was released on 2006 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Acousto-optic imaging (AOI) in optically diffuse media is a hybrid imaging modality in which a focused ultrasound beam is used to locally phase modulate light inside of turbid media. The modulated optical field carries with it information about the optical properties in the region where the light and sound interact. The motivation for the development of AOI systems is to measure optical properties at large depths within biological tissue with high spatial resolution.
Author : Wenjuan Qi
Publisher :
ISBN 13 : 9781303612725
Total Pages : 129 pages
Book Rating : 4.6/5 (127 download)
Download or read book Phase-resolved Acoustic Radiation Force Optical Coherence Elastography written by Wenjuan Qi and published by . This book was released on 2013 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a noninvasive, high resolution and high speed imaging modality that provides cross-sectional depth resolved microstructure information of biological tissues based on their tissue scattering properties. However, subtle scattering property changes in diseased tissue are difficult to visualize solely by OCT structural imaging at the early stages of disease. Elastography has opened new horizons for medical imaging by characterizing the mechanical properties of biological tissues. However, current elastography imaging modalities such as ultrasound (US) elastography and magnetic resonant elastography (MRE) can only image mechanical properties at the organ level due to their limitations in resolution. Although current optical coherence elastography (OCE) technologies can achieve microscale imaging of tissue mechanical properties, they are still facing challenges for real time in vivo imaging. My Ph.D. research focuses on the development of a novel phase-resolved acoustic radiation force optical coherence elastography technology (ARF-OCE). This technique combines the dynamic acoustic radiation force (ARF) excitation with phase-resolved OCT to achieve high resolution, high speed and high sensitivity for imaging and characterizing tissue biomechanical properties. The ARF-OCE technique uses a localized amplitude modulated (AM) acoustic wave to apply dynamic "pushes" on the sample and phase-resolved OCT to evaluate the ARF-induced displacement of the sample by determining the phase shift of OCT interference fringe. Three generations of ARF-OCE configurations have been developed as a consequence of system optimization. The first generation ARF-OCE system utilizes a focused ultrasonic transducer and stimulates the object in "transmission" mode. Aiming for in vivo imaging, the second generation ARF-OCE system features a confocal OCT and ARF arrangement and a "reflection" excitation mode. A dual-element ring transducer is used for the third generation ARF-OCE system that makes use of the "beat" phenomenon in order to achieve highly localized ARF excitation. Imaging results from both tissue phantoms and ex vivo real tissue specimens have demonstrated the feasibility of the phase-resolved ARF-OCE technique for tissue elasticity imaging with superior performance. Finally, a frequency-dependent resonant ARF-OCE method has also been developed to characterize tissue biomechanical properties using the resonant frequency without the knowledge of ARF parameters.
Author :
Publisher :
ISBN 13 :
Total Pages : 612 pages
Book Rating : 4.3/5 (91 download)
Download or read book Photons Plus Ultrasound written by and published by . This book was released on 2007 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David A. Boas
Publisher : CRC Press
ISBN 13 : 1420090372
Total Pages : 816 pages
Book Rating : 4.4/5 (2 download)
Download or read book Handbook of Biomedical Optics written by David A. Boas and published by CRC Press. This book was released on 2016-04-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Author : Xiao Xu
Publisher :
ISBN 13 :
Total Pages : 89 pages
Book Rating : 4.:/5 (76 download)
Download or read book Ultrasound-encoded Optical Tomography and Time-reversed Ultrasonically Encoded Optical Focusing written by Xiao Xu and published by . This book was released on 2011 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound modulated optical tomography is a developing hybrid imaging modality that combines high optical contrast and good ultrasonic resolution to image soft biological tissue. We developed a photorefractive crystal-based, time-resolved detection scheme with the use of a millisecond long ultrasound burst to image both the optical and mechanical properties of biological tissues, with improved detection efficiency of ultrasound-tagged photons. We also applied spectral-hole burning (SHB) aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB was improved by using a Tm3+: YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration. With the improved SHB-UOT system, we imaged absorbing, scattering, and phase contrast objects that were embedded in the middle plane of a 30-mm thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also imaged two absorbing objects embedded in the middle plane of a 32-mm thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to a practical optical imaging application in biological and clinical studies. Light focusing plays a central role in biomedical imaging, manipulation, and therapy. In optical scattering media such as biological tissue, light propagation is randomized by multiple scattering. Beyond one transport mean free path, where photon propagation is in the diffusive regime, direct light focusing becomes infeasible. Although various methods have been developed to overcome this optical diffusion limit, all are limited by the lack of a practical internal "guide star." Here we proposed and experimentally validated a novel concept, called Time-Reversed Ultrasonically Encoded (TRUE) optical focusing, to deliver light dynamically into any predefined location inside a scattering medium. First, diffused coherent light is encoded by an ultrasonic wave focused to a predefined location; then, the encoded component of the diffused light is time-reversed and consequently converges back to the ultrasonic focus. The ultrasonic encoding noninvasively provides a virtual internal "guide star" for the time reversal. The TRUE optical focus--dynamically defined by the ultrasonic focus--is unaffected by multiple scattering of light, which is especially desirable in biological tissue where ultrasonic scattering is ~1000 times weaker than optical scattering. Various fields, such as biomedical, colloidal, atmospheric, and ocean optics, can benefit from TRUE optical focusing. Further, the concept can be generalized for non-optical waves.
Author : Ali Vakili
Publisher :
ISBN 13 :
Total Pages : 108 pages
Book Rating : 4.:/5 (122 download)
Download or read book Light and Ultrasound written by Ali Vakili and published by . This book was released on 2018 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In optical imaging, the depth and resolution are limited due to scattering. Unlike light, scattering of an ultrasound waves in tissue is negligible. Hybrid imaging methods such as ultrasound modulated optical tomography (UOT) use the advantages of both modalities. UOT tags light by inducing phase change caused by modulating the local index of refraction of the medium. The challenge in UOT is detecting the weak signal. The displacement induced by the acoustic radiation force (ARF) is another ultrasound effect that can be utilized to tag the light. It induces greater phase change, resulting in a stronger signal. Moreover, the absorbed acoustic energy generates heat, resulting in a change in the index of refraction and a strong phase change. Since the speckle pattern is governed by the phase of the interfering scattered waves speckle pattern analysis can obtain information about local displacement and temperature changes in the tissue. We have presented a model to simulate the insonation processes. Simulation results based on fixed-particle Monte Carlo and experimental results show that the signal acquired by utilizing ARF is stronger compared to UOT. The introduced mean irradiance change (MIC) signal reveals both thermal and mechanical effects of the focused ultrasound wave in different timescales. Simulation results suggest that variation in the MIC signal can be used to generate a displacement image of the medium. In addition to the displacement correlated image, the MIC signal can provide images based on the morphology of the tissue. The MIC signal can provide for tumor detection in a healthy tissue"--Author's abstract.
Author : Huabei Jiang
Publisher : CRC Press
ISBN 13 : 1439847584
Total Pages : 366 pages
Book Rating : 4.4/5 (398 download)
Download or read book Diffuse Optical Tomography written by Huabei Jiang and published by CRC Press. This book was released on 2018-09-03 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging. This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including: Early-stage detection of breast tumors and prostate cancer "Real-time" functional brain imaging Joint imaging to treat progressive diseases such as arthritis Monitoring of tumor response New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.
Author : Baohong Yuan
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.:/5 (71 download)
Download or read book Diffuse Optical Tomography and Fluorescence Diffuse Optical Tomography written by Baohong Yuan and published by . This book was released on 2006 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chulhong Kim
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (48 download)
Download or read book Ultrasound-modulated Optical Tomography with Dark-field Illumination and Functional Photoacoustic Imaging written by Chulhong Kim and published by . This book was released on 2009 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gang Yao
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (485 download)
Download or read book Ultrasound written by Gang Yao and published by . This book was released on 2000 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pál Greguss
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.F/5 ( download)
Download or read book Ultrasonic Imaging written by Pál Greguss and published by . This book was released on 1980 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tuan Vo-Dinh
Publisher : CRC Press
ISBN 13 : 142008514X
Total Pages : 894 pages
Book Rating : 4.4/5 (2 download)
Download or read book Biomedical Photonics Handbook, Second Edition written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2014-07-29 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shaped by Quantum Theory, Technology, and the Genomics Revolution The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside. Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition contains new topics and chapters including: • Fiber Optic Probe Design • Laser and Optical Radiation Safety • Photothermal Detection • Multidimensional Fluorescence Imaging • Surface Plasmon Resonance Imaging • Molecular Contrast Optical Coherence Tomography • Multiscale Photoacoustics • Polarized Light for Medical Diagnostics • Quantitative Diffuse Reflectance Imaging • Interferometric Light Scattering • Nonlinear Interferometric Vibrational Imaging • Multimodality Theranostics Nanoplatforms • Nanoscintillator-Based Therapy • SERS Molecular Sentinel Nanoprobes • Plasmonic Coupling Interference Nanoprobes Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and lists of references for further reading.
Author : George Stroke
Publisher : Springer Science & Business Media
ISBN 13 : 146134493X
Total Pages : 647 pages
Book Rating : 4.4/5 (613 download)
Download or read book Ultrasonic Imaging and Holography written by George Stroke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image Processing in Bio-Medical Engineering.- Ultrasonic Holography: A Practical System.- New Dimensions for R&D Program Management.- Ultrasonic Tissue Visualization and Surgery in Brain.- A Project of Ultrasonic Tomography ("Sonoradiography").- Image Information Processing for Pulse Echo Scanning Methods.- Ultrasonic Imaging at Stanford Research Institute.- Optical Information Processing and Acousto-Optics.- Present Aspects of "Ultrasonotomography" for Medical Diagnostics.- New Forms of Ultrasonic and Radar Imaging.- Acoustic Microscopy.- Some Aspects of Optical Holography that Might be of In.
