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Download or read book Two-dimensional Capillary-based Electrophoretic Separation Coupled to Mass Spectrometry by a Mechanical Valve written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kevin Jooß
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (113 download)
Download or read book Development and Application of Two-dimensional Separation Systems Coupled to Mass Spectrometry Incorporating Capillary Electrophoresis written by Kevin Jooß and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Felix Jonas Kohl
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (1 download)
Download or read book Design and Development of a Heart-cut Two-dimensional Capillary Electrophoresis System with Mass Spectrometric Detection Using a Mechanical Valve as Interface written by Felix Jonas Kohl and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jennifer Römer
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (132 download)
Download or read book Development and Application of Two-dimensional Capillary Electrophoresis for Online Mass Spectrometry of CE(SDS)-separated Proteins written by Jennifer Römer and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rawi Ramautar
Publisher : John Wiley & Sons
ISBN 13 : 3527833102
Total Pages : 404 pages
Book Rating : 4.5/5 (278 download)
Download or read book Capillary Electrophoresis - Mass Spectrometry for Proteomics and Metabolomics written by Rawi Ramautar and published by John Wiley & Sons. This book was released on 2022-10-03 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics A powerful and essential resource for researchers with an interest in CE-MS In Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications, a team of distinguished researchers delivers a comprehensive overview of bioanalytical capillary electrophoresis coupled to mass spectrometry (CE-MS). The book explains foundational principles, technology as well the strategies and techniques used in data analysis for metabolic and proteomic studies. It also provides a global overview of recent developments and advances for improving CE-MS sensitivity and reproducibility. An essential handbook for everyone performing metabolomic and proteomic analysis, the information provided here will assist researchers in tapping into the full potential of this technique to answer biological and clinical questions. Readers will also find: A thorough introduction to the principles of capillary electrophoresis, including its fundamentals, CE separation modes, capillary coatings, and the fundamentals of mass spectrometry In-depth examinations of technological developments in capillary electrophoresis, including sample preparation, online preconcentration, detection sensitivity, and metabolic coverage Comprehensive discussions of metabolomic studies, including their biomedical and clinical applications Recent advances in proteomics, including top-down and bottom-up approaches Perfect for analytical and clinical chemists, Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications will also earn a place in the libraries of biochemists, molecular biologists, and other molecular life scientists.
Author : Rawi Ramautar
Publisher : Royal Society of Chemistry
ISBN 13 : 178801104X
Total Pages : 300 pages
Book Rating : 4.7/5 (88 download)
Download or read book Capillary Electrophoresis–Mass Spectrometry for Metabolomics written by Rawi Ramautar and published by Royal Society of Chemistry. This book was released on 2018-07-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis–mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In this book, the unique features of CE-MS for metabolomics studies are highlighted including CE separation modes, capillary coatings and practical aspects of CE-MS coupling alongside a comprehensive overview of recent technological developments and applications. CE-MS can be considered a relatively new technique in the field of metabolomics and it is therefore important to inform the scientific community about the possibilities of advanced CE-MS approaches for metabolomics studies. This book outlines the potential of this technique for researchers working in metabolomics, bioanalytics and biomarker analysis.
Author : Ying-Chih Wang
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (568 download)
Download or read book On-chip Multi-dimensional Biomolecule Separation Using Multi-layer Microfabricated Valves written by Ying-Chih Wang and published by . This book was released on 2004 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent proteomics researches require a sensitive, high-speed, and automatic protein separation tool that far exceeds the capability of traditional two dimensional (2D) protein gel electrophoresis. Methods are described to achieve multi-dimensional biomolecule separation in a microfluidic channel. The new methods couple isoelectric focusing (IEF) with high ionic strength capillary electrophoresis (CE) by active micro valve control in a microchip. Several experiments demonstrating independent 2D separation were performed, and critical parameters for better chip performance were identified; including channel passivation, electroosmosis control, IEF linearity control, and detection enhancement. The result can be used for the filtration of high-abundance proteins, which used to be done by affinity columns. Also, it can be used for much possible integration between different heterogeneous separation/analysis techniques such as IEF, polyacrylamide gel electrophoresis (PAGE), CE, reverse-phase chromatography, and mass spectrometry (MS).
Author : Daniel Sydes
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (986 download)
Download or read book Instrumental and Method Development for Multidimensional Electrophoretic Separations - Coupling of Capillary Isoelectric Focusing to Mass Spectrometry written by Daniel Sydes and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel Sydes
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (986 download)
Download or read book Instrumental and Method Development for Multidimensional Electrophoretic Separations - Coupling of Capillary Isoelectric Focusing to Mass Spectrometry written by Daniel Sydes and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christian Neusüß
Publisher : Springer Nature
ISBN 13 : 1071624938
Total Pages : 264 pages
Book Rating : 4.0/5 (716 download)
Download or read book Capillary Electrophoresis-Mass Spectrometry written by Christian Neusüß and published by Springer Nature. This book was released on 2022-08-08 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details aspects and applications of interfacing capillary electrophoresis (CE) with mass spectrometry (MS). Chapters guide readers through approaches based on different types of CE-MS interfaces such as (nano)sheath liquid, porous tip, and liquid junction, as well as various capillary coatings, and a broad range of applications including several top-down and bottom-up proteomic approaches. Additionally, a list of analyte targets was provided consisting of amphetamines, antibiotics, carbohydrates (including glycosaminoglycans and glycopeptides), enantiomers, extracellular matrix metabolites, monoclonal antibodies, and nanoparticles, and therefore covers numerous fields of applications such as pharmaceutical, biomedical, food, agrochemical, and environmental analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Capillary Electrophoresis-Mass Spectrometry: Methods and Protocols aims to provide highly valuable information for both beginners and experts in the field be it students, technical staff, and scientists.
Author : John D. Chin
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book Independent Parallel Capillary Array Separations for Rapid Second Dimension Sampling in On-Line Two-Dimensional Capillary Electrophoresis of Complex Biological Samples written by John D. Chin and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological samples remain challenging in proteomic separations due to their complexity and large concentration dynamic range. Improvements to separation power are needed to interrogate proteomes more deeply and facilitate the advancement of biomarker discovery for personalized medicine. Current online multidimensional separations require compromise; long analysis times if the second dimension (2nd-D) must be regenerated between injections, or reduced separation efficiency if the 2nd-D is operated rapidly. Using an array of capillaries as the 2nd-D, operated in parallel, allows fast sampling of the first dimension (1st-D). This relaxes the constraints on the 2nd-D separation, allowing it to operate at optimal separation conditions that would otherwise be sacrificed for speed. This configuration allows total separation times to approximately equal to the 1st-D separation time. We have developed a novel interface that enables continuous sampling of a 1st-D separation by a 2nd-D capillary array for rapid, high peak capacity two dimensional (2D) separations, based upon automated precision positioning of capillaries. Within a laminar flow regime, a capillary electrophoresis (CE) 1st-D separation was coupled to an array of eight independent CE 2nd-D separations. The instrument terminus provides laser induced fluorescence detection via a sheath flow cuvette. Effluent transfer efficiency, from the 1st-D to the 2nd-D, and detection was optimized using visible and fluorescent dye tracers. To that end, this dissertation will discuss characterization of interface and detector parameters, including: inter capillary transverse alignment accuracy, injection distance, injection time, hydrodynamic flow rate, density considerations, inter and intra capillary differences, signal crosstalk and laser intensity. Separation performance will further be demonstrated using model protein and serum digestates. Each dimension of the 2D instrument will be operated as a one dimensional (1D) instrument to compare against an optimized commercial 1D CE instrument. These results will be used to evaluate the quality of the separations operated in on-line 2D capillary electrophoresis-to-capillary array electrophoresis (CE×CAE) mode. A novel application of the CE×CAE design will be discussed in the spirit of resolving the long standing challenge of migration time reproducibility in CE separations.
Author : Peter Q. Tranchida
Publisher : Elsevier
ISBN 13 : 012809639X
Total Pages : 516 pages
Book Rating : 4.1/5 (28 download)
Download or read book Hyphenations of Capillary Chromatography with Mass Spectrometry written by Peter Q. Tranchida and published by Elsevier. This book was released on 2019-11-29 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyphenations of Capillary Chromatography with Mass Spectrometry provides comprehensive coverage of capillary chromatography with mass spectrometry—both single and multidimensional approaches. The book examines nearly all capillary chromatography approaches, combined with a variety of MS forms, giving readers a wide and detailed view on current-day analytical strategies and applications. Of particular focus are novel developments in the field of MS, such as the Orbitrap, HR ToF, ToF MS with variable electron-impact energy, fast MS-MS and APGC technology. Junior scientists conducting research on mono-dimensional chromatography-MS fundamental relationships and experienced analytical chemists working in conventional capillary chromatography and classical multidimensional chromatography will find this an ideal application-based reference on the hyphenations of these domains. Combines mass spectrometry with a range of chromatographic approaches Emphasizes the importance of both capillary chromatography and mass spectrometry methods, thus stimulating separation scientists to fully exploit both analytical dimensions Authored by two of the world’s leading analytical chemists who have a total of more than 40 years of experience in research and instruction
Author : Anthony V. Lemmo
Publisher :
ISBN 13 :
Total Pages : 606 pages
Book Rating : 4.:/5 (327 download)
Download or read book Instrumentation for Two Dimensional Liquid Chromatography-capillary Zone Electrophoresis for the Separation of Protein Mixtures written by Anthony V. Lemmo and published by . This book was released on 1994 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andrea Renata Laine
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (93 download)
Download or read book V2D written by Andrea Renata Laine and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christian Neusüß
Publisher : Wiley-VCH
ISBN 13 : 9783527320691
Total Pages : 350 pages
Book Rating : 4.3/5 (26 download)
Download or read book Capillary Electrophoresis written by Christian Neusüß and published by Wiley-VCH. This book was released on 2015-07-07 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book to deal with this modern and powerful tool in instrumental analytical chemistry focuses on practical issues, making it a useful guide for both beginners and experienced scientists. The first part describes the methodological background for the coupling of electromigrative separation techniques with mass spectrometry, discussing various separation techniques, interfacing options and MS detection systems. The second part focuses on method development, applications and aspects of quantification and validation. The whole is rounded off with a look at future developments.
Author : Margaretha Hendrika Lamoree
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (674 download)
Download or read book Capillary Electrophoretic Separation Techniques Coupled to Electrospray Ionization Mass Spectrometry written by Margaretha Hendrika Lamoree and published by . This book was released on 2000 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gregory J. Opiteck
Publisher :
ISBN 13 :
Total Pages : 532 pages
Book Rating : 4.:/5 (46 download)
Download or read book Two Dimensional Separations Coupled to Mass Spectrometry for the Micropreparative Isolation, Identification, and Characterization of Proteins written by Gregory J. Opiteck and published by . This book was released on 1998 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
