Twentieth Century Mouse Genetics

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Twentieth Century Mouse Genetics

Author : Robert P. Erickson
Publisher : Academic Press
ISBN 13 : 9780128240168
Total Pages : 248 pages
Book Rating : 4.2/5 (41 download)

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Book Synopsis Twentieth Century Mouse Genetics by : Robert P. Erickson

Download or read book Twentieth Century Mouse Genetics written by Robert P. Erickson and published by Academic Press. This book was released on 2021-09-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetic models throughout the twentieth century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and modern case studies connecting historic research to ongoing advances. Past studies discussed include the discovery of the T-locus, t-haplotypes in the wild and reproductive isolation, cytogenetics studies, population genetics and mutation studies, immunogenetics studies, reproductive genetics studies, cloning, X-inactivation and epigenetics research, sex determination studies, and pharmacogenetics studies. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models, and to translate those findings to clinical practice. Offers a comprehensive examination of key advances in mouse genetic models throughout the twentieth century Features modern case studies connecting historic research to ongoing advances Authored by a thought-leader in the field

Twentieth Century Mouse Genetics

Author : Robert P. Erickson
Publisher : Academic Press
ISBN 13 : 0128240172
Total Pages : 346 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Twentieth Century Mouse Genetics by : Robert P. Erickson

Download or read book Twentieth Century Mouse Genetics written by Robert P. Erickson and published by Academic Press. This book was released on 2021-08-26 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice. Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century Includes updates connecting historic research to ongoing advances Authored by a thought-leader in the field

Mouse Genetics

Author : Professor of Molecular Biology Lee M Silver, Professor Dr
Publisher : Oxford University Press on Demand
ISBN 13 : 9780195075540
Total Pages : 362 pages
Book Rating : 4.0/5 (755 download)

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Book Synopsis Mouse Genetics by : Professor of Molecular Biology Lee M Silver, Professor Dr

Download or read book Mouse Genetics written by Professor of Molecular Biology Lee M Silver, Professor Dr and published by Oxford University Press on Demand. This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

The Mouse in Animal Genetics and Breeding Research

Author : Eugene J. Eisen
Publisher : World Scientific
ISBN 13 : 1860945651
Total Pages : 378 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis The Mouse in Animal Genetics and Breeding Research by : Eugene J. Eisen

Download or read book The Mouse in Animal Genetics and Breeding Research written by Eugene J. Eisen and published by World Scientific. This book was released on 2005 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB)

Genetics of the Mouse

Author : Jean Louis Guénet
Publisher : Springer
ISBN 13 : 3662442876
Total Pages : 417 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Genetics of the Mouse by : Jean Louis Guénet

Download or read book Genetics of the Mouse written by Jean Louis Guénet and published by Springer. This book was released on 2014-11-29 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Mouse Genetics

Author : Lee M. Silver
Publisher :
ISBN 13 : 9783854484066
Total Pages : 362 pages
Book Rating : 4.4/5 (84 download)

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Book Synopsis Mouse Genetics by : Lee M. Silver

Download or read book Mouse Genetics written by Lee M. Silver and published by . This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Of Flies, Mice, and Men

Author : François Jacob
Publisher : Harvard University Press
ISBN 13 : 9780674631113
Total Pages : 178 pages
Book Rating : 4.6/5 (311 download)

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Book Synopsis Of Flies, Mice, and Men by : François Jacob

Download or read book Of Flies, Mice, and Men written by François Jacob and published by Harvard University Press. This book was released on 1998 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Tells the story of how the marvelous discoveries of molecular and developmental biology are transforming our understanding of who we are and where we came from. Jacob scrutinizes the place of the scientist in society". -- Jacket.

Science in the Twentieth Century

Author : John Krige
Publisher : Routledge
ISBN 13 : 1134406932
Total Pages : 986 pages
Book Rating : 4.1/5 (344 download)

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Book Synopsis Science in the Twentieth Century by : John Krige

Download or read book Science in the Twentieth Century written by John Krige and published by Routledge. This book was released on 2013-11-19 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe, and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.

Companion to Science in the Twentieth Century

Author : John Krige
Publisher : Taylor & Francis
ISBN 13 : 9780415286060
Total Pages : 988 pages
Book Rating : 4.2/5 (86 download)

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Book Synopsis Companion to Science in the Twentieth Century by : John Krige

Download or read book Companion to Science in the Twentieth Century written by John Krige and published by Taylor & Francis. This book was released on 2003 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work on science in the 20th century represents work in America, Europe and Asia. It includes such topics as the countries that have made the most significant contributions, the relationship between science and industry and the importance of instrumentation.

Companion Encyclopedia of Science in the Twentieth Century

Author : John Krige
Publisher : Routledge
ISBN 13 : 113648339X
Total Pages : 988 pages
Book Rating : 4.1/5 (364 download)

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Book Synopsis Companion Encyclopedia of Science in the Twentieth Century by : John Krige

Download or read book Companion Encyclopedia of Science in the Twentieth Century written by John Krige and published by Routledge. This book was released on 2013-11-05 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.

Making Mice

Author : Karen Rader
Publisher : Princeton University Press
ISBN 13 : 9780691016368
Total Pages : 326 pages
Book Rating : 4.0/5 (163 download)

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Book Synopsis Making Mice by : Karen Rader

Download or read book Making Mice written by Karen Rader and published by Princeton University Press. This book was released on 2004-03-21 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.

Mouse Genetics

Author : Shree Ram Singh
Publisher :
ISBN 13 : 9781071610084
Total Pages : 217 pages
Book Rating : 4.6/5 (1 download)

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Book Synopsis Mouse Genetics by : Shree Ram Singh

Download or read book Mouse Genetics written by Shree Ram Singh and published by . This book was released on 2021 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.

Contributions to Behavior-genetic Analysis

Author : Gardner Lindzey
Publisher : Ardent Media
ISBN 13 : 9780390562753
Total Pages : 362 pages
Book Rating : 4.5/5 (627 download)

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Book Synopsis Contributions to Behavior-genetic Analysis by : Gardner Lindzey

Download or read book Contributions to Behavior-genetic Analysis written by Gardner Lindzey and published by Ardent Media. This book was released on 1970 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mouse Genetics and Transgenics

Author : Ian J. Jackson
Publisher : Oxford University Press, USA
ISBN 13 : 9780199637096
Total Pages : 299 pages
Book Rating : 4.6/5 (37 download)

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Book Synopsis Mouse Genetics and Transgenics by : Ian J. Jackson

Download or read book Mouse Genetics and Transgenics written by Ian J. Jackson and published by Oxford University Press, USA. This book was released on 2000 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book integrates knowledge from a wide range of expertise, specifically applied to the mouse and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: A Practical Approach covers all aspects of using the mouse as a genetic model organism: care and husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; gene targeting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.

The Laboratory Mouse

Author : Hans Hedrich
Publisher : Academic Press
ISBN 13 : 0123820081
Total Pages : 869 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis The Laboratory Mouse by : Hans Hedrich

Download or read book The Laboratory Mouse written by Hans Hedrich and published by Academic Press. This book was released on 2012-07-16 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse"--Provided by publisher.

Mutagenesis of the Mouse Genome

Author : Monica Justice
Publisher : Springer Science & Business Media
ISBN 13 : 1402050577
Total Pages : 98 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Mutagenesis of the Mouse Genome by : Monica Justice

Download or read book Mutagenesis of the Mouse Genome written by Monica Justice and published by Springer Science & Business Media. This book was released on 2007-11-12 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

Brenner's Encyclopedia of Genetics

Author : Stanley Maloy
Publisher : Academic Press
ISBN 13 : 0080961568
Total Pages : 4360 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Brenner's Encyclopedia of Genetics by : Stanley Maloy

Download or read book Brenner's Encyclopedia of Genetics written by Stanley Maloy and published by Academic Press. This book was released on 2013-03-03 with total page 4360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics