Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Tumor Aneuploidy full books in PDF, epub, and Kindle. Read online Tumor Aneuploidy ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Thomas Büchner
Publisher : Springer Science & Business Media
ISBN 13 : 3642704581
Total Pages : 143 pages
Book Rating : 4.6/5 (427 download)
Download or read book Tumor Aneuploidy written by Thomas Büchner and published by Springer Science & Business Media. This book was released on 2013-12-18 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : David Rasnick
Publisher : CRC Press
ISBN 13 : 1466502495
Total Pages : 354 pages
Book Rating : 4.4/5 (665 download)
Download or read book The Chromosomal Imbalance Theory of Cancer written by David Rasnick and published by CRC Press. This book was released on 2016-04-19 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of ca
Author : Thomas Büchner
Publisher : Springer
ISBN 13 : 9783642704598
Total Pages : 141 pages
Book Rating : 4.7/5 (45 download)
Download or read book Tumor Aneuploidy written by Thomas Büchner and published by Springer. This book was released on 2014-10-03 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : B. Michael Ghadimi
Publisher : Springer
ISBN 13 : 331920291X
Total Pages : 228 pages
Book Rating : 4.3/5 (192 download)
Download or read book Chromosomal Instability in Cancer Cells written by B. Michael Ghadimi and published by Springer. This book was released on 2015-09-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Author : Theodor Boveri
Publisher :
ISBN 13 :
Total Pages : 119 pages
Book Rating : 4.:/5 (29 download)
Download or read book The Origin of Malignant Tumors written by Theodor Boveri and published by . This book was released on 1929 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The translation helped bring her husband's chromosome theory of cancer to the attention of a wider audience and rediscover his work.
Author : Harvey Bialy
Publisher : North Atlantic Books
ISBN 13 : 9781556435317
Total Pages : 332 pages
Book Rating : 4.4/5 (353 download)
Download or read book Oncogenes, Aneuploidy, and AIDS written by Harvey Bialy and published by North Atlantic Books. This book was released on 2004 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to author Harvey Bialy, the work of molecular biologist Peter Duesberg has been grossly distorted by the media and scientific establishments. Until recently, the scientific community--and most notably, those from the National Institute for Health--have been unwilling to look at his provocative theories of different causes for cancer and HIV/AIDS. Inspired by UC Berkeley's rare creation of an archive for Duesberg's papers, this book explores Duesberg's early groundbreaking work with viruses and oncogenes, his contentious fights with other scientists, and the profound influence of his life's work.
Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Author : Zuzana Storchova
Publisher : BoD – Books on Demand
ISBN 13 : 9535106082
Total Pages : 260 pages
Book Rating : 4.5/5 (351 download)
Download or read book Aneuploidy in Health and Disease written by Zuzana Storchova and published by BoD – Books on Demand. This book was released on 2012-05-16 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464904219
Total Pages : 64 pages
Book Rating : 4.4/5 (649 download)
Download or read book Aneuploidy: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aneuploidy: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Aneuploidy in a concise format. The editors have built Aneuploidy: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Aneuploidy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aneuploidy: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Randy Y.C. Poon
Publisher : Springer Science & Business Media
ISBN 13 : 1441961992
Total Pages : 157 pages
Book Rating : 4.4/5 (419 download)
Download or read book Polyploidization and Cancer written by Randy Y.C. Poon and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.
Author : John Michael Replogle
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)
Download or read book The Benefits and Detriments of Aneuploidy in Cancer written by John Michael Replogle and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aneuploidy, defined as having a chromosome number that is not a multiple of the organism's haploid number, is a hallmark of cancer. This creates an imbalanced karyotype, where the copy number of hundreds or thousands of genes is altered. About 90% of solid tumors and 70% of blood cancers are aneuploid. How does aneuploidy affect cancer cells? These copy number alterations affect expression at the RNA and protein level, which causes numerous problems for cells. Aneuploidy increases genomic instability, both through higher rates of DNA damage and causing more chromosome missegregation. The proteome is also significantly challenged; excess proteins aggregate or must be degraded and stress chaperones and the proteasome. These stresses culminate in slow proliferation, particularly through G1 of the cell cycle, relative to euploid cells. However, evidence is growing for the ways that aneuploidy benefits cancer cell fitness. Aneuploidy is associated with poor patient survival in cancer. In chapter 2, this dissertation describes another effect of aneuploidy: increased resistance to a wide variety of drugs. The slower proliferation of aneuploid cells is the predominant mechanism that protects them from some of the most common chemotherapeutics used today. When proliferation rate is equal between euploid and aneuploid cells, the chemotherapy resistance caused by aneuploidy mostly disappears; however, there is also some evidence for aneuploidy-induced-chemotherapeutic-resistance not explained by the cell cycle defects of aneuploidy. Beyond drug resistance, aneuploidy may benefit cancer cell fitness in other ways: there is growing, but still mixed, evidence that aneuploidy may promote immune-evasion of tumors and increase metastasis. This dissertation discusses the current evidence for how aneuploidy may provide advantages to a cancer cell. Outside of cancer, several chromosomal disorders exist, including Down syndrome, which may be better understood through aneuploidy. The appendix of this dissertation explores aneuploidy-tolerance and how trisomy 21 cells can relieve their proliferation deficit. A CRISPR screen for improved growth of trisomy 21 cells identified several genes of interest that may specifically contribute to proliferation of trisomy 21 cells. Ultimately, more work is needed to understand how these genes of interest interact with aneuploidy and trisomy 21 to affect proliferation.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464973423
Total Pages : 69 pages
Book Rating : 4.4/5 (649 download)
Download or read book Aneuploidy: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aneuploidy: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Aneuploidy in a concise format. The editors have built Aneuploidy: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Aneuploidy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aneuploidy: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Sverre Heim
Publisher : John Wiley & Sons
ISBN 13 : 1118795512
Total Pages : 645 pages
Book Rating : 4.1/5 (187 download)
Download or read book Cancer Cytogenetics written by Sverre Heim and published by John Wiley & Sons. This book was released on 2015-06-29 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481650599
Total Pages : 56 pages
Book Rating : 4.4/5 (816 download)
Download or read book Aneuploidy: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aneuploidy: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Additional Research in a compact format. The editors have built Aneuploidy: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aneuploidy: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Su Xian
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.:/5 (15 download)
Download or read book Elucidating the Mechanism by which Aneuploidy Interferes with Immune Response During Tumor Progression written by Su Xian and published by . This book was released on 2018 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)
Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
