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Tubulin Binding Agents
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Book Synopsis Microtubules, in vitro by : John J. Correia
Download or read book Microtubules, in vitro written by John J. Correia and published by Academic Press. This book was released on 2013-08-20 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This Second Edition brings together current research and protocols in the field of microtubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors. Chapters reflect experimental procedures and new developments in the field of microtubule in vitro research Combines classical approaches and modern technologies Presents easy-to-use protocols and thorough background information, compiled by leaders in the field
Book Synopsis Some Effects of Tubulin-Binding Agents on Behaviour by : G. Clingbine
Download or read book Some Effects of Tubulin-Binding Agents on Behaviour written by G. Clingbine and published by . This book was released on 1978 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tubulin-Binding Agents by : Teresa Carlomagno
Download or read book Tubulin-Binding Agents written by Teresa Carlomagno and published by Springer Science & Business Media. This book was released on 2009-06-26 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts.
Book Synopsis The Pursuit of Tubulin-binding Agents by : Vicki Chang
Download or read book The Pursuit of Tubulin-binding Agents written by Vicki Chang and published by . This book was released on 2012 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presented here are two bodies of work regarding the synthesis of molecules related to tubulin-binding agents. Described in Chapter 1 is the synthesis of a library of biosynthetically-inspired colchicine-related compounds and the data regarding their biological activity. This chapter discusses using a pair of oxidative coupling reagents to generate molecular diversity in hopes of creating highly bioactive molecules. Described in Chapter 2 is the progress towards the synthesis of fluorinated epothilone B sulfonamide analogs. This chapter delineates approaches taken during the pursuit of a pair of analogs desired for biological testing. As the title alludes, the original compounds of colchicine and the epothilones are tubulin-binding agents, and it is this quality that affords them their highly desired biological activity as anticancer agents.
Book Synopsis Chromosomal Instability in Cancer Cells by : B. Michael Ghadimi
Download or read book Chromosomal Instability in Cancer Cells written by B. Michael Ghadimi and published by Springer. This book was released on 2015-09-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Book Synopsis Discovery and Development of Anti-Breast Cancer Agents from Natural Products by : Goutam Brahmachari
Download or read book Discovery and Development of Anti-Breast Cancer Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2021-06-24 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines
Book Synopsis Design and Synthesis of Tubulin-binding Anticancer Agents by : Meiki Maggie Woo
Download or read book Design and Synthesis of Tubulin-binding Anticancer Agents written by Meiki Maggie Woo and published by . This book was released on 2001 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Evaluation of Tubulin Binding Agents Alone in Combination for the Treatment of Melanoma and Other Solid Cancers by : Ashraf Sa Ta Azzabi
Download or read book Evaluation of Tubulin Binding Agents Alone in Combination for the Treatment of Melanoma and Other Solid Cancers written by Ashraf Sa Ta Azzabi and published by . This book was released on 2007 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contemporary Aspects of Boron: Chemistry and Biological Applications by : Hijazi Abu Ali
Download or read book Contemporary Aspects of Boron: Chemistry and Biological Applications written by Hijazi Abu Ali and published by Elsevier. This book was released on 2005-09-07 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary Aspects of Boron: Chemistry and Biological Applications highlights the biological activity and applications of boron containing compounds. The authors’ specific approach surveys general features of the subject, while exploring new and novel strategies for preparing certain chemical and natural boron products that are of significant substance in medicinal chemistry. For example, cancer treatment is one of the most important issues related to such products. In addition to contributing to the development of new drugs by addressing biological applications in medicinal and industrial fields, the book provides a comprehensive review of the most relevant components that comprise the pharmaceutical, medicinal and environmental applications of boron containing compounds. * Timely and comprehensive * Provides new insights to active researchers in the field * Presents concepts and methods in simple scientific terms
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tau Biology written by Akihiko Takashima and published by Springer Nature. This book was released on 2020-02-24 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
Book Synopsis Microtubule Growth, Nucleation, and Novel Tubulin-binding Drugs by : Michal Wieczorek
Download or read book Microtubule Growth, Nucleation, and Novel Tubulin-binding Drugs written by Michal Wieczorek and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cellular morphology depends on a complex network of microtubules, which are long, hollow polymers made up of a/b-tubulin subunits. Microtubules are not fixed structures; rather, they are highly dynamic, constantly being built, taken apart, and changing in shape and location to suit the needs of the cell. This thesis aims to answer some of these questions. Microtubule growth is accelerated by enzymes such as XMAP215, but in vivo microtubule growth rates remain much higher than in vitro reconstitution assays using purified components. Recently, XMAP215 and EB1 have been shown to synergistically enhance microtubule growth to near physiological rates. The growth rates reported remain lower, however, than those observed in C. elegans embryos and the theoretical upper limit derived from mass-transfer models. We sought to determine the effects of macromolecular crowding agents on microtubule growth rates. We found that the apparent rate constant for tubulin addition increased up to 10-fold inviscous environments with large macromolecules. In contrast, increasing the viscosity with small solutes decreased growth rates in a manner consistent with tubulin binding to microtubule ends in a diffusion-limited reaction. Adding crowding agents with XMAP215 and EB1 resulted in growth rates that saturated at 45 um min−1 at 10 uM tubulin. To our knowledge, this represents the fastest in vitro microtubule growth rates measured to date and approaches the theoretical limit. Microtubules are born and reborn continuously, even during quiescence, but nucleation is arguably the least understood aspect of microtubule dynamics. Using single-molecule biophysics, we show that nucleation from g-TuRCs, axonemes, and seed microtubules requires tubulin concentrations that lie well above the critical concentration yet do not support spontaneous nucleation. We measured considerable time lags between the arrival of tubulin and the onset of steady-state elongation. Microtubule associated proteins (MAPs) alter these time-lags. Catastrophe factors (MCAK and EB1) inhibited nucleation, while a polymerase (XMAP215) and an anti-catastrophe factor, which we have characterized for the first time (TPX2), both promoted nucleation. We observed similar phenomena in cells: depleting soluble tubulin levels in cells with tubulin-sequestering drugs reduced centrosomal nucleation rates. We conclude that GTP hydrolysis inhibits microtubule nucleation by destabilizing the nascent plus ends required for persistent elongation. Given its importance for the survival of cells, it is not surprising that tubulin is an important pharmacological target. Several drugs used to treat cancer patients directly target microtubules. Some drugs stabilize microtubules, preventing disassembly, while others destabilize microtubules, but the resulting mechanism of action is generally the same: a block in M phase progression and subsequent cell death. The use of effective dosages of these drugs is often limited, however, by severely toxic side effects on non-cancerous cells. Diazonamide A (DZA) is a potent anti-tumor agent that disrupts mitotic spindle assembly but displays significantly reduced off-target toxicities. The literature is conflicted as to whether or not DZA directly targets microtubules, and therefore its mechanism of action is not known. We have discovered that DZA inhibits the growth of individual microtubules by directly binding to the vinca binding site of tubulin. This study describes how DZA acts on microtubules using a combination of in vitro reconstitutions, measurements of microtubule growth in cells, X-ray crystallography, and clinically relevant tumor models. The crystal structure of the DZA-tubulin complex revealed that DZA straightens the tubulin interdimer angle relative to the vinblastine-tubulin structure. Though they share a common binding site, vinca alkaloids are simultaneously less potent and more toxic than DZA." --
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Cardio-Oncology by : Roberta A. Gottlieb
Download or read book Cardio-Oncology written by Roberta A. Gottlieb and published by Academic Press. This book was released on 2016-11-26 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardio-Oncology: Principles, Prevention and Management is a clinical volume that focuses on the basic science of cardio-oncology, addresses cardiotoxicity as a consequence of cancer therapy, and discusses prevention, diagnosis and management of cardiovascular disease in patients with cancer. This comprehensive volume presents unique perspectives ranging from basic science to clinical medicine in the field of cardio-oncology. It would be a valuable resource for cardiologists, oncologists, internists, and pediatricians caring for patients with cancer who have cardiovascular risk factors, as well as for cardio-oncology researchers. Covers basic science of cardio-oncology to provide readers with the necessary background Addresses cardiotoxicity related to current cancer therapeutic modalities Discusses diagnostic and management approaches of patients with underlying cardiac risk factors as well as otherwise healthy cancer patients
Book Synopsis Role of Nutraceuticals in Cancer Chemosensitization by :
Download or read book Role of Nutraceuticals in Cancer Chemosensitization written by and published by Academic Press. This book was released on 2017-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations
Book Synopsis Microtubule Dynamics by : Anne Straube
Download or read book Microtubule Dynamics written by Anne Straube and published by Humana Press. This book was released on 2017-04-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtubule interactions in vitro, techniques to investigate the ultrastructure of microtubules and associated proteins, assays to study microtubule nucleation, turnover, and force production in cells, as well as approaches to isolate novel microtubule-associated proteins and their interacting proteins. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Definitive and practical, Microtubule Dynamics: Methods and Protocols provides the key protocols needed by novices and experts on how to perform a broad range of well-established and newly-emerging techniques in this vital field.
Book Synopsis Design and Synthesis of Tubulin-binding Agents, and Their Incorporation Into Novel Dual-acting Hybrid Molecules Targeting the Tumour Vasculature by : Adrian Coogan
Download or read book Design and Synthesis of Tubulin-binding Agents, and Their Incorporation Into Novel Dual-acting Hybrid Molecules Targeting the Tumour Vasculature written by Adrian Coogan and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
