Trichloroethylene Health Risks

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Assessing the Human Health Risks of Trichloroethylene

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309102839
Total Pages : 449 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Assessing the Human Health Risks of Trichloroethylene by : National Research Council

Download or read book Assessing the Human Health Risks of Trichloroethylene written by National Research Council and published by National Academies Press. This book was released on 2007-01-08 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.

WHO Guidelines for Indoor Air Quality

Author :
Publisher : World Health Organization
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis WHO Guidelines for Indoor Air Quality by :

Download or read book WHO Guidelines for Indoor Air Quality written by and published by World Health Organization. This book was released on 2010 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

Trichloroethylene: Toxicity and Health Risks

Author : Kathleen M. Gilbert
Publisher : Springer Science & Business Media
ISBN 13 : 1447163117
Total Pages : 249 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Trichloroethylene: Toxicity and Health Risks by : Kathleen M. Gilbert

Download or read book Trichloroethylene: Toxicity and Health Risks written by Kathleen M. Gilbert and published by Springer Science & Business Media. This book was released on 2014-02-18 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.

Environmental Medicine

Author : Committee on Curriculum Development in Environmental Medicine
Publisher : National Academies Press
ISBN 13 : 0309568722
Total Pages : 988 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Environmental Medicine by : Committee on Curriculum Development in Environmental Medicine

Download or read book Environmental Medicine written by Committee on Curriculum Development in Environmental Medicine and published by National Academies Press. This book was released on 1995-05-12 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: People are increasingly concerned about potential environmental health hazards and often ask their physicians questions such as: "Is the tap water safe to drink?" "Is it safe to live near power lines?" Unfortunately, physicians often lack the information and training related to environmental health risks needed to answer such questions. This book discusses six competency based learning objectives for all medical school students, discusses the relevance of environmental health to specific courses and clerkships, and demonstrates how to integrate environmental health into the curriculum through published case studies, some of which are included in one of the book's three appendices. Also included is a guide on where to obtain additional information for treatment, referral, and follow-up for diseases with possible environmental and/or occupational origins.

Contaminated Water Supplies at Camp Lejeune

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309136997
Total Pages : 338 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Contaminated Water Supplies at Camp Lejeune by : National Research Council

Download or read book Contaminated Water Supplies at Camp Lejeune written by National Research Council and published by National Academies Press. This book was released on 2009-09-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.

Toxicological Profile for Trichloroethylene

Author :
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Toxicological Profile for Trichloroethylene by :

Download or read book Toxicological Profile for Trichloroethylene written by and published by . This book was released on 1997 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Assessing the Human Health Risks of Trichloroethylene

Author : National Research Council (U.S.). Committee on Human Health Risks of Trichloroethylene
Publisher :
ISBN 13 : 9780309663632
Total Pages : 362 pages
Book Rating : 4.6/5 (636 download)

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Book Synopsis Assessing the Human Health Risks of Trichloroethylene by : National Research Council (U.S.). Committee on Human Health Risks of Trichloroethylene

Download or read book Assessing the Human Health Risks of Trichloroethylene written by National Research Council (U.S.). Committee on Human Health Risks of Trichloroethylene and published by . This book was released on 2006 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene Health Risks

Author : Cheryl Siegel Scott
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Trichloroethylene Health Risks by : Cheryl Siegel Scott

Download or read book Trichloroethylene Health Risks written by Cheryl Siegel Scott and published by . This book was released on 2000 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water

Author :
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water by :

Download or read book Health Risk Assessment of Trichloroethylene (TCE) in California Drinking Water written by and published by . This book was released on 1988 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Special Occupational Hazard Review of Trichloroethylene

Author : Norbert P. Page
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Special Occupational Hazard Review of Trichloroethylene by : Norbert P. Page

Download or read book Special Occupational Hazard Review of Trichloroethylene written by Norbert P. Page and published by . This book was released on 1978 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene (TCE) Evaluation of Human Health Hazards

Author : California. Hazard Evaluation System and Information Service
Publisher :
ISBN 13 :
Total Pages : 88 pages
Book Rating : 4.:/5 (311 download)

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Book Synopsis Trichloroethylene (TCE) Evaluation of Human Health Hazards by : California. Hazard Evaluation System and Information Service

Download or read book Trichloroethylene (TCE) Evaluation of Human Health Hazards written by California. Hazard Evaluation System and Information Service and published by . This book was released on 1982 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Occupational Exposure to Trichloroethylene

Author : National Institute for Occupational Safety and Health
Publisher :
ISBN 13 :
Total Pages : 122 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Occupational Exposure to Trichloroethylene by : National Institute for Occupational Safety and Health

Download or read book Occupational Exposure to Trichloroethylene written by National Institute for Occupational Safety and Health and published by . This book was released on 1973 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Profile for Trichloroethylene

Author :
Publisher :
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Trichloroethylene by :

Download or read book Toxicological Profile for Trichloroethylene written by and published by . This book was released on 1989 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene Health Risks, State of the Science

Author : Cheryl Siegel Scott
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (675 download)

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Book Synopsis Trichloroethylene Health Risks, State of the Science by : Cheryl Siegel Scott

Download or read book Trichloroethylene Health Risks, State of the Science written by Cheryl Siegel Scott and published by . This book was released on 2000 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Taking an Exposure History

Author : Arthur L. Frank
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Taking an Exposure History by : Arthur L. Frank

Download or read book Taking an Exposure History written by Arthur L. Frank and published by . This book was released on 2001 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trichloroethylene Health Risks

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (962 download)

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Book Synopsis Trichloroethylene Health Risks by :

Download or read book Trichloroethylene Health Risks written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Science and Decisions

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.