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Treatments For Localized Prostate Cancer
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Book Synopsis Technical Aspects of Focal Therapy in Localized Prostate Cancer by : Eric Barret
Download or read book Technical Aspects of Focal Therapy in Localized Prostate Cancer written by Eric Barret and published by Springer. This book was released on 2015-01-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.
Book Synopsis Treatment of Localized Prostate Cancer by :
Download or read book Treatment of Localized Prostate Cancer written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options by : Timothy Showalter
Download or read book Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options written by Timothy Showalter and published by Frontiers Media SA. This book was released on 2020-10-30 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis The Management of Clinically Localized Prostate Cancer by :
Download or read book The Management of Clinically Localized Prostate Cancer written by and published by . This book was released on 1986 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adenocarcinoma of the Prostate by : Andrew W. Bruce
Download or read book Adenocarcinoma of the Prostate written by Andrew W. Bruce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.
Book Synopsis Localized Prostate Cancer by : Fernand Labrie
Download or read book Localized Prostate Cancer written by Fernand Labrie and published by Blackwell Science Incorporated. This book was released on 1996-01-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Consensus Development Conference on the Management of Clinically Localized Prostate Cancer by :
Download or read book Consensus Development Conference on the Management of Clinically Localized Prostate Cancer written by and published by . This book was released on 1988 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Active Surveillance for Localized Prostate Cancer by : Laurence Klotz
Download or read book Active Surveillance for Localized Prostate Cancer written by Laurence Klotz and published by Springer Science & Business Media. This book was released on 2012-06-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.
Book Synopsis Understanding Treatment Choices for Prostate Cancer by :
Download or read book Understanding Treatment Choices for Prostate Cancer written by and published by . This book was released on 2000 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Active Surveillance for Localized Prostate Cancer by : Laurence Klotz
Download or read book Active Surveillance for Localized Prostate Cancer written by Laurence Klotz and published by Humana Press. This book was released on 2017-09-29 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
Book Synopsis Focal Therapy in Prostate Cancer by : Hashim Uddin Ahmed
Download or read book Focal Therapy in Prostate Cancer written by Hashim Uddin Ahmed and published by John Wiley & Sons. This book was released on 2011-12-27 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.
Book Synopsis Treatments for Localized Prostate Cancer by :
Download or read book Treatments for Localized Prostate Cancer written by and published by . This book was released on 2011 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Screening with prostate-specific antigen testing can detect prostate cancer in earlier, asymptomatic stages, when treatments might be more effective. However, treatments for prostate cancer are also associated with potential harms. PURPOSE: To systematically review benefits and harms associated with treatments for screen-detected or localized prostate cancer. DATA SOURCES: We searched the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (through the second quarter of 2011), and Ovid MEDLINE (2002 to July 2011) for relevant studies and systematic reviews published in English. Electronic database searches were supplemented by reviews of reference lists of relevant articles. STUDY SELECTION: We selected randomized trials and cohort studies that reported all-cause mortality, prostate cancer-specific mortality, or harms associated with prostatectomy, radiation therapy, hormonal therapy, cryotherapy, and high-intensity focused ultrasonography versus watchful waiting or active surveillance in men with localized prostate cancer. We also included large (n>1,000) uncontrolled observational studies that reported perioperative harms. If no randomized trials, cohort studies, or large uncontrolled studies were available, we included smaller uncontrolled studies. DATA EXTRACTION: One investigator abstracted data and a second investigator checked data abstraction for accuracy. Two investigators independently assessed study quality using methods developed by the U.S. Preventive Services Task Force. DATA SYNTHESIS (RESULTS): Two randomized trials and nine cohort studies on benefits of prostate cancer treatments and two randomized trials, 14 cohort studies, and 11 intervention series of harms were included in the review. One good-quality randomized trial found that prostatectomy for localized (primarily stage T2) prostate cancer was associated with decreased risk of prostate cancer-specific mortality compared with watchful waiting through 13 years of followup (relative risk, 0.62 [95% CI, 0.44-0.87]; absolute risk reduction, 6.1 percentage points); subgroup analyses suggested that benefits were limited to men younger than age 65 years. Cohort studies consistently found that prostatectomy and radiation therapy were associated with decreased risk of all-cause mortality and prostate cancer-specific mortality compared with watchful waiting, but estimates were susceptible to residual confounding. Based primarily on cohort studies, treating approximately three men with prostatectomy, seven men with radiation therapy, or two to three men with androgen deprivation therapy instead of watchful waiting would each result in one additional case of erectile dysfunction, and treating approximately five men with prostatectomy would result in one additional case of urinary incontinence. Prostatectomy was associated with perioperative (30-day) mortality (about 0.5%) and cardiovascular events (0.6% to 3%), radiation therapy with bowel dysfunction, and androgen deprivation therapy with gynecomastia and hot flashes. Evidence did not suggest adverse effects related to general health-related quality of life with either prostatectomy or radiation therapy compared with watchful waiting. Evidence on cryotherapy and high-intensity focused ultrasonography was too limited to reliably estimate benefits or harms. LIMITATIONS: Only English-language articles were included, few randomized trials met inclusion criteria, the lone randomized trial of treatment did not specifically enroll men with screen-detected prostate cancer, and few studies evaluated newer therapies and techniques. CONCLUSIONS: Additional research is needed to understand benefits of treatments for screen-detected, localized prostate cancer. Commonly selected therapies for localized prostate cancer are associated with an increased risk of important harms. More research is needed to understand whether newer therapies and techniques for treating localized prostate cancer are associated with fewer harms.
Author :U. S. Department of Health and Human Services Publisher :CreateSpace ISBN 13 :9781484077337 Total Pages :130 pages Book Rating :4.0/5 (773 download)
Book Synopsis Treatments for Localized Prostate Cancer by : U. S. Department of Health and Human Services
Download or read book Treatments for Localized Prostate Cancer written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-04-09 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most commonly diagnosed cancer in American men. Adenocarcinoma accounts for over 95% of all prostate cancer cases. Prostate cancer is typically staged according to the American Joint Committee on Cancer's tumor, node, metastasis (TNM) system, in which the tumor stage (T) is based on the extent of penetration or invasion beyond the prostatic capsule into adjacent structures. Localized prostate cancer is classified as stages T1 (non-palpable) and T2 (palpable) and is confined within the prostatic capsule. The likelihood of progression to invasive cancer is associated with the presence of more poorly differentiated cells and other histopathologic features. This review focuses on the benefits and harms of treatments for screen-detected prostate cancer. However, many studies do not report how prostate cancer was initially detected. Therefore, we also included studies of treatments for localized (stages T1 and T2) prostate cancer, which is far more frequently detected by screening than more advanced cancer. Among newly diagnosed patients in 2004–2005, 94% had clinically localized prostate cancer. Screening with prostate-specific antigen (PSA) testing can detect prostate cancer in earlier, asymptomatic stages, when treatments might be more effective. In 2008, based on an earlier systematic review that focused on studies of PSA-based screening versus no screening, the U.S. Preventive Services Task Force (USPSTF) found insufficient evidence to determine the balance of benefits and harms associated with prostate cancer screening in men younger than age 75 years (I statement), and recommended against screening in men ages 75 years or older (grade D recommendation). Once prostate cancer has been detected by screening, treatments are frequently initiated. Understanding the benefits and harms associated with such treatments is therefore critical for informing screening decisions. Evidence on benefits and harms of treatments for localized prostate cancer was last reviewed by the USPSTF in 2002. This report summarizes the evidence on benefits and harms of treatment for screen-detected or early-stage prostate cancer, with an emphasis on studies published since 2002.
Book Synopsis Salvage Therapy for Prostate Cancer by : Sanchia S. Goonewardene
Download or read book Salvage Therapy for Prostate Cancer written by Sanchia S. Goonewardene and published by Springer Nature. This book was released on 2020-11-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers application of salvage therapy in reccurrent prostate cancer. Chapters focus on specific issues associated with a range of surgical and oncological management techniques and strategies including hormone therapy, lymphnode dissection, robotic prostatectomy and salvage reirradiation after locoregional failure. Learning objectives, and definitions of keywords are provided to aid the reader develop a thorough understanding of the topic and reinforce the key points covered in each chapter. Salvage Therapy for Prostate Cancer provides a detailed practically applicable guide on how salvage therapy can be utilised in the treatment of prostate cancer. It represents a valuable resource for trainee and practicing urologists, oncologists, and specialist nurses.
Author :U. S. Department of Health and Human Services Publisher :Createspace Independent Pub ISBN 13 :9781484974209 Total Pages :108 pages Book Rating :4.9/5 (742 download)
Book Synopsis Future Research Needs for Comparative Effectiveness of Treatments of Localized Prostate Cancer by : U. S. Department of Health and Human Services
Download or read book Future Research Needs for Comparative Effectiveness of Treatments of Localized Prostate Cancer written by U. S. Department of Health and Human Services and published by Createspace Independent Pub. This book was released on 2013-05-14 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 1.8 million men living in the United States have a diagnosis of prostate cancer, with about 218,890 newly diagnosed men each year. Approximately 90 percent of men with prostate cancer have disease considered confined to the prostate gland (i.e., clinically localized disease). If left untreated, frequently men die with, rather than from, prostate cancer. Largely because of widespread prostate-specific antigen (PSA) testing, the lifetime risk of prostate cancer diagnosis in the United States has nearly doubled to 20 percent, while the risk of dying of prostate cancer has remained at approximately 3 percent. Therefore, considerable over detection and treatment may exist. Moreover, the treatment of localized prostate cancer is associated with substantial adverse effects. The primary goal of treatment is to target those men most likely to need intervention to prevent prostate cancer death and disability, while minimizing intervention-related complications. Common treatments include watchful waiting (active surveillance), surgery to remove the prostate gland (i.e., radical prostatectomy), radiotherapy (e.g., external-beam radiation or brachytherapy), freezing the prostate (i.e., cryotherapy), and androgen-deprivation therapy (ADT). All treatments for prostate cancer have risks of complications, although their frequency and severity may vary. Common adverse events include urinary, bowel, and sexual dysfunction. The vast majority of prostate cancers currently detected in the United States are asymptomatic, clinically localized, and found on routine PSA testing. PSA testing detects more tumors, at an earlier stage, with a smaller volume within each stage, and at an earlier period in a man's life than nonscreen-detected tumors. The clinical significance, natural history, and comparative effectiveness of treatments in PSA-detected cancers are not known but likely differ from those detected and treated in the pre-PSA era (before the late 1980s to early 1990s). The objective of this project is to pilot an approach for developing future research priorities and suggesting specific projects to address evidence gaps. From the results of this and comparable pilot projects conducted by other Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Centers (EPCs), AHRQ will identify generalizable strategies and lessons learned. The topic of this pilot project, the comparative effectiveness of treatments for localized prostate cancer, was selected because of its importance. The Minnesota EPC completed a comparative effectiveness review (CER) on this topic in 2008 for AHRQ. This pilot project amends the list of recommendations from that report and creates prioritized lists of research gaps and proposed research studies. Subsequently, management strategies for local prostate cancer were in the first quartile of the Institute of Medicine's 100 initial priority topics for comparative effectiveness research: Compare the effectiveness of management strategies for localized prostate cancer (e.g., active surveillance, radical prostatectomy [conventional, robotic, and laparoscopic], and radiotherapy [conformal, brachytherapy, proton beam, and intensity-modulated radiotherapy]) on survival, recurrence, side effects, quality of life, and costs.
Book Synopsis Urological Pathology by : Mahul B. Amin
Download or read book Urological Pathology written by Mahul B. Amin and published by Lippincott Williams & Wilkins. This book was released on 2013-11-14 with total page 2443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge in the field of urologic pathology is growing at an explosive pace. Today’s pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology!
Author :International Atomic Energy Agency Publisher :International Atomic Energy Agency ISBN 13 :9789201020147 Total Pages :48 pages Book Rating :4.0/5 (21 download)
Book Synopsis Strategies for the Management of Localized Prostate Cancer by : International Atomic Energy Agency
Download or read book Strategies for the Management of Localized Prostate Cancer written by International Atomic Energy Agency and published by International Atomic Energy Agency. This book was released on 2014 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical guidelines for the management of prostate cancer exist in the published literature. However, these guidelines have usually been developed in and for affluent health care environments where all modern diagnostic and treatment modalities are available. In limited resource environments, the radiation oncologist is faced with the question: what would be the minimum acceptable (evidence based) line of action with the limited resources available? Clinical guidelines focusing on low-middle income countries aim to provide a practical tool to these practitioners. This publication is aimed at the radiation oncologists working in centres with limited resources and treating a large number of patients with prostate cancer on a daily basis. The approach and techniques recommended are intended to be simple, feasible and resource sparing to the extent that is possible when dealing with a complex treatment modality.
