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Author : Francesca Ficara
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (14 download)
Download or read book Trasferimento di geni in cellule staminali-ematopoietiche con potenziale linfoide written by Francesca Ficara and published by . This book was released on 2003 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ygal Haupt
Publisher : Frontiers Media SA
ISBN 13 : 2889199614
Total Pages : 99 pages
Book Rating : 4.8/5 (891 download)
Download or read book Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins written by Ygal Haupt and published by Frontiers Media SA. This book was released on 2016-08-10 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.
Author : Aung Naing
Publisher : Springer Nature
ISBN 13 : 3030793087
Total Pages : 445 pages
Book Rating : 4.0/5 (37 download)
Download or read book Immunotherapy written by Aung Naing and published by Springer Nature. This book was released on 2022-01-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.
Author : Tongzhang Zheng
Publisher :
ISBN 13 : 9782953926804
Total Pages : 564 pages
Book Rating : 4.9/5 (268 download)
Download or read book Epidemiology and Biostatistics written by Tongzhang Zheng and published by . This book was released on 2011 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard G. Hovannisian
Publisher :
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.X/5 (1 download)
Download or read book Islam's Understanding of Itself written by Richard G. Hovannisian and published by . This book was released on 1983 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Habib Zaidi
Publisher : Springer
ISBN 13 : 1493908944
Total Pages : 762 pages
Book Rating : 4.4/5 (939 download)
Download or read book Molecular Imaging of Small Animals written by Habib Zaidi and published by Springer. This book was released on 2014-05-27 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Author : Carmel Shalev
Publisher :
ISBN 13 : 9780300051186
Total Pages : 201 pages
Book Rating : 4.0/5 (511 download)
Download or read book Birth Power written by Carmel Shalev and published by . This book was released on 1989-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the historical, legal, and social complications of surrogate motherhood, arguing in favor of this contractual arrangement
Author : MiKaela M. Olsen
Publisher :
ISBN 13 : 9781635930559
Total Pages : 0 pages
Book Rating : 4.9/5 (35 download)
Download or read book Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice written by MiKaela M. Olsen and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Oncology nursing is a unique specialty that requires continuous learning to stay up to date on cancer pathophysiology, cutting-edge drugs, and the evidence-based management of cancer and cancer treatment-related toxicities. The Oncology Nursing Society's (ONS's) second edition of Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice provides nurses with the tools to understand how medications are used in cancer treatment, the effect of medication-related toxicities, and evidence-based recommendations to manage and treat these toxicities. This edition features many new cancer therapies approved since the 2019 publication. Each drug is categorized as chemotherapy, hormone, targeted, or immunotherapy agents. Extensive drug tables in the book provide nurses with tips for managing patients receiving these drugs. The expansion of oral antineoplastic therapies, alone or in combination with infusion therapy, requires that nurses review a patient's complete cancer treatment plan and consider the side effects, toxicities, and adherence to oral drugs to ensure patient tolerance and efficacy. This second edition has seen content expanded on the topic of genomics as we move forward in the world of personalized oncology. Health equity is approached with information discussing financial distress, cultural disparities, and health literacy. The latest guidelines and recommendations for treatment, symptom management, and survivorship have been integrated into this new text. This edition features a QR code, provided with the purchase of this book, to download quarterly drug updates. You will see new evidence related to many aspects of cancer nursing care incorporated into this edition, such as hypersensitivity response, safe handling of hazardous drugs, and more. The editors want to thank all of the contributors to this edition who worked tirelessly, despite a pandemic, to make this new edition a reality. This work builds on the knowledge of many generations of oncology nurses and has been used nationally and internationally to guide oncology nursing practice. We are proud to continue to serve oncology nurses worldwide with an essential resource to guide their practice"--
Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0080553656
Total Pages : 655 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cancer Imaging written by M. A. Hayat and published by Academic Press. This book was released on 2007-10-25 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: With cancer-related deaths projected to rise to 10.3 million people by 2020, the need to prevent, diagnose, and cure cancer is greater than ever. Cancer Imaging presents readers with the most up-to-date imaging instrumentation, general and diagnostic applications for various cancers, with an emphasis on lung and breast carcinomas--the two major worldwide malignancy types. This book discusses the various imaging techniques used to locate and diagnose tumors, including ultrasound, X-ray, color Doppler sonography, PET, CT, PET/CT, MRI, SPECT, diffusion tensor imaging, dynamic infrared imaging, and magnetic resonance spectroscopy. It also details strategies for imaging cancer, emphasizing the importance of the use of this technology for clinical diagnosis. Imaging techniques that predict the malignant potential of cancers, response to chemotherapy and other treatments, recurrence, and prognosis are also detailed. - Concentrates on the application of imaging technology to the diagnosis and prognosis of lung and breast carcinomas, the two major worldwide malignancies - Addresses the relationship between radiation dose and image quality - Discusses the role of molecular imaging in identifying changes for the emergence and progression of cancer at the cellular and/or molecular levels
