Transmethylations And The Central Nervous System

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Transmethylations and the Central Nervous System

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Author : V. M. Andreoli
Publisher : Springer Science & Business Media
ISBN 13 : 3642885160
Total Pages : 193 pages
Book Rating : 4.6/5 (428 download)

Book Synopsis Transmethylations and the Central Nervous System by : V. M. Andreoli

Download or read book Transmethylations and the Central Nervous System written by V. M. Andreoli and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: V M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu ronal transmission and, more broadly, of behavior. The first suggestion that transmethylation processes might be involved in the origina tion of certain mental diseases came from Harley-Mason (1952), who noticed that many of the hallucinogenic substances known at that time contained methyl radicals, and par ticularly that mescaline represented the product of O-methylation of dopamine in posi tions 3, 4, and 5. This hypothesis was put forward when the O-methylation of catechol amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla tion might follow a "deviant" metabolie pathway, and that the accumulation of abnor mal methylated metabolites endowed with hallucinogenic properties might be responsi ble for the implementation of some mental diseases, notably schizophrenia. He also called attention to a substance, 3,4-dimethoxyphenylethylamine (3,4-DMPEA) as a possible psychotogenic moleeule, on the strength of its capacity for producing cata tonia in experimental animals

Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System

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Author : Vincenzo Zappia
Publisher : Elsevier
ISBN 13 : 1483159876
Total Pages : 185 pages
Book Rating : 4.4/5 (831 download)

Book Synopsis Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System by : Vincenzo Zappia

Download or read book Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System written by Vincenzo Zappia and published by Elsevier. This book was released on 2013-10-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System contains the proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System held in Naples, Italy, on May 2, 1978. The papers explore the biochemical and pharmacological roles of S-adenosylmethionine (SAM), with particular emphasis on its functions in the central nervous system (CNS). This book consists of 13 chapters and opens with an introduction to some novel biochemical aspects of SAM and related sulfur compounds, paying particular attention to transmethylation reactions; polyamine biosynthesis and unusual biological roles of adenosylmethionine; metabolic pathways related to adenosine-sulfur compounds; and transport of adenosylmethionine. The following chapters discuss a number of chemical and biochemical properties of SAM as well as its pharmacological aspects within the CNS. The relation between folate and adenosylmethionine metabolism in the brain is examined, along with the effect of SAM administration on noradrenaline and serotonin metabolism in rat brain; cerebral utilization of adenosylmethionine and adenosylhomocysteine; and antidepressant effects of adenosylmethionine. Methylation in schizophrenia is also considered. This monograph will be a valuable source of information for biochemists and pharmacologists.

Central Nervous System

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Author : E. Genazzani
Publisher : Springer Science & Business Media
ISBN 13 : 3642657141
Total Pages : 410 pages
Book Rating : 4.6/5 (426 download)

Book Synopsis Central Nervous System by : E. Genazzani

Download or read book Central Nervous System written by E. Genazzani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the Symposium "Metabolic Regulation and Functional Activity in the Central Nervous System" which was held on September 16 and 17, 1972, at Saint Vincent (Aosta)/Italy, and was sponsored by the Accademia di Medicina di Torino with the scientific cooperation of the Istituto di Farmacologia, Universita di Torino, and the Pharmakologisches Institut der Freien Universitat Berlin. Its purpose was to give a greater number of scientists from different countries an opportunity to report their latest results under a heading concerning general relationships between metabolism and function. We quite deliberately refrained from pursuing the partly heterogenous subjects into details. Thus, the organizers hoped to be able to interest a greater circle of readers for the manifold subjects from various fields dealing with the investigation of metabolic processes in the central nervous system. The discussion remarks to the lectures could not be considered for printing. The Accademia di Medicina di Torino and all others concerned do not only thank Dr. R. Di Carlo and other members of the Istituto di Farmacologia, Universita di Torino, for the excellent work they performed in preparing this Symposium, but also the Amministrazione Regionale della Valle di Aosta and SIT A V di Saint-Vincent for their generous support and their kind hospitality which made the stay at Saint-Vincent most agreeable for all participants.

HIV/AIDS and the Nervous System

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Author : Peter Portegies
Publisher : Newnes
ISBN 13 : 070203536X
Total Pages : 385 pages
Book Rating : 4.7/5 (2 download)

Book Synopsis HIV/AIDS and the Nervous System by : Peter Portegies

Download or read book HIV/AIDS and the Nervous System written by Peter Portegies and published by Newnes. This book was released on 2007-07-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others. Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies. In addition, the socioeconomic and political constraints that hinder treatment and disease management in developing parts of the world are presented. * A comprehensive understanding of HIV/AIDS and neuro-AIDS, and the progression of the scientific community’s understanding of the disease* Detailed information on fields such as neuroepidemiology, neuropathology, neuropharmacology, and neuroimaging and their contributions to HIV/AIDS research* Subject specific chapters on conditions associated with HIV/AIDS, including opportunistic infections, central nervous system tumors, and myopathies, amongst others

Nervous System

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Author : Thomas C. Jones
Publisher : Springer Science & Business Media
ISBN 13 : 3642835163
Total Pages : 248 pages
Book Rating : 4.6/5 (428 download)

Book Synopsis Nervous System by : Thomas C. Jones

Download or read book Nervous System written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicological testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the nervous system, is the sixth volume of a set pre pared under the sponsorship of the International Life Sciences Insti tute (ILSI).

Nutrition, Epigenetic Mechanisms, and Human Disease

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Author : Nilanjana Maulik
Publisher : CRC Press
ISBN 13 : 1439804826
Total Pages : 446 pages
Book Rating : 4.4/5 (398 download)

Book Synopsis Nutrition, Epigenetic Mechanisms, and Human Disease by : Nilanjana Maulik

Download or read book Nutrition, Epigenetic Mechanisms, and Human Disease written by Nilanjana Maulik and published by CRC Press. This book was released on 2010-12-03 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as

Biological Methylation and Drug Design

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Author : Ronald T. Borchardt
Publisher : Springer Science & Business Media
ISBN 13 : 1461250129
Total Pages : 463 pages
Book Rating : 4.4/5 (612 download)

Book Synopsis Biological Methylation and Drug Design by : Ronald T. Borchardt

Download or read book Biological Methylation and Drug Design written by Ronald T. Borchardt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans methylation inhibitors (Section E).

Handbook of Complementary and Alternative Therapies in Mental Health

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Author : Scott Shannon
Publisher : Elsevier
ISBN 13 : 0080533418
Total Pages : 603 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis Handbook of Complementary and Alternative Therapies in Mental Health by : Scott Shannon

Download or read book Handbook of Complementary and Alternative Therapies in Mental Health written by Scott Shannon and published by Elsevier. This book was released on 2002-01-22 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scott Shannon is an MD, president elect of the American Holistic Medical Association, and considered a national expert on holistic psychiatry. In this book he brings together a comprehensive overview of CAM treatments, with information on their effectiveness and safety for specific patient populations and for use in treating specific disorders. Modalities covered include Acupuncture, Nutritional Medicine, Herbal Medicine, Meditation, Biofeedback, Aromatherapy and others. Coverage also includes chapters on the best CAM modalities for treatment of Anxiety and PTSD, Depression, ADD, and Addictions. Each chapter will be in a similar template, beginning with a description of the treatment, its safety, compatibility with conventional treatments and/or contrindications, scientific documentation of its efficacy, discussion of which disorders it is best used for, and references. Most comprehensive overview of rapidly expanding field Includes chapters by 24 leading psychiatric/psychological experts in these fields Documents and rates the research base in each area Offers practical clinical approaches for four common mental health concerns—depression, anxiety, ADHD, and addictions Areas not yet covered in professional training Practices commonly employed by the public (40-50% of the American public use complementary or alternative approaches) No previous book of this nature or scope

Subject Catalog

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Author : Library of Congress
Publisher :
ISBN 13 :
Total Pages : 1036 pages
Book Rating : 4.F/5 ( download)

Book Synopsis Subject Catalog by : Library of Congress

Download or read book Subject Catalog written by Library of Congress and published by . This book was released on 1979 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adenosinergic System and Central Nervous System Disorders

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Author : Francisney Pinto Nascimento
Publisher : Frontiers Media SA
ISBN 13 : 2889767787
Total Pages : 161 pages
Book Rating : 4.8/5 (897 download)

Book Synopsis Adenosinergic System and Central Nervous System Disorders by : Francisney Pinto Nascimento

Download or read book Adenosinergic System and Central Nervous System Disorders written by Francisney Pinto Nascimento and published by Frontiers Media SA. This book was released on 2022-08-17 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Library of Congress Catalogs

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Author : Library of Congress
Publisher :
ISBN 13 :
Total Pages : 1060 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Library of Congress Catalogs by : Library of Congress

Download or read book Library of Congress Catalogs written by Library of Congress and published by . This book was released on 1980 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Transmethylation

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Author : Earl Usdin
Publisher : North-Holland
ISBN 13 :
Total Pages : 664 pages
Book Rating : 4.F/5 ( download)

Book Synopsis Transmethylation by : Earl Usdin

Download or read book Transmethylation written by Earl Usdin and published by North-Holland. This book was released on 1979 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Awards Index

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Author :
Publisher :
ISBN 13 :
Total Pages : 1170 pages
Book Rating : 4.3/5 ( download)

Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1982 with total page 1170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acta Neurologica Scandinavica

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Author :
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (318 download)

Book Synopsis Acta Neurologica Scandinavica by :

Download or read book Acta Neurologica Scandinavica written by and published by . This book was released on 1994 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Library of Congress Name Headings with References

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Author : Library of Congress
Publisher :
ISBN 13 :
Total Pages : 1126 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Library of Congress Name Headings with References by : Library of Congress

Download or read book Library of Congress Name Headings with References written by Library of Congress and published by . This book was released on 1979 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lyme Neuroborreliosis

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Author : Klaus Hansen
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.:/5 (318 download)

Book Synopsis Lyme Neuroborreliosis by : Klaus Hansen

Download or read book Lyme Neuroborreliosis written by Klaus Hansen and published by . This book was released on 1994 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Grants Index

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Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 1212 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt: