Translational Research and Discovery in Gastroenterology

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Publisher : John Wiley & Sons
ISBN 13 : 1118492870
Total Pages : 378 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Translational Research and Discovery in Gastroenterology by : Deborah L. Gumucio

Download or read book Translational Research and Discovery in Gastroenterology written by Deborah L. Gumucio and published by John Wiley & Sons. This book was released on 2014-08-11 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract

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Publisher : Academic Press
ISBN 13 : 9780123812803
Total Pages : 292 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract by :

Download or read book Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract written by and published by Academic Press. This book was released on 2010-12-16 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how digestive organs develop, their physiology and structure is important for determining new therapies to combat diseases of the digestive organs. Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract reviews the latest research and developments in this field. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Includes reference guide for researchers involved in molecular biology and related fields

Peptide Drug Discovery and Development

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Publisher : John Wiley & Sons
ISBN 13 : 3527636749
Total Pages : 547 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Peptide Drug Discovery and Development by : Miguel Castanho

Download or read book Peptide Drug Discovery and Development written by Miguel Castanho and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Translational Systems Medicine and Oral Disease

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Publisher : Academic Press
ISBN 13 : 0128137630
Total Pages : 458 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Translational Systems Medicine and Oral Disease by : Stephen Sonis

Download or read book Translational Systems Medicine and Oral Disease written by Stephen Sonis and published by Academic Press. This book was released on 2019-09-14 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Oxford Textbook of Global Public Health

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Publisher : Oxford University Press
ISBN 13 : 019881013X
Total Pages : 1717 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Global Public Health by : Roger Detels

Download or read book Oxford Textbook of Global Public Health written by Roger Detels and published by Oxford University Press. This book was released on 2017 with total page 1717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline

Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318021830
Total Pages : 259 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract by : Ludmila P. Filaretova

Download or read book Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract written by Ludmila P. Filaretova and published by Karger Medical and Scientific Publishers. This book was released on 2012 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.

Biomarkers for Endometriosis

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Publisher : Springer
ISBN 13 : 3319598562
Total Pages : 267 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Biomarkers for Endometriosis by : Thomas D'Hooghe

Download or read book Biomarkers for Endometriosis written by Thomas D'Hooghe and published by Springer. This book was released on 2017-09-22 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.

Translational Medicine

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Publisher : CRC Press
ISBN 13 : 1000471853
Total Pages : 952 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Translational Medicine by : Joy A. Cavagnaro

Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Clinical and Translational Science

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Publisher : Academic Press
ISBN 13 : 0080920195
Total Pages : 600 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Clinical and Translational Science by : David Robertson

Download or read book Clinical and Translational Science written by David Robertson and published by Academic Press. This book was released on 2009-03-02 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Principles of Translational Science in Medicine

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Publisher : Academic Press
ISBN 13 : 032399962X
Total Pages : 495 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Principles of Translational Science in Medicine by : Martin Wehling

Download or read book Principles of Translational Science in Medicine written by Martin Wehling and published by Academic Press. This book was released on 2021-07-15 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Directory of Research Grants 2008

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Publisher : AuthorHouse
ISBN 13 : 1434384489
Total Pages : 594 pages
Book Rating : 4.4/5 (343 download)

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Book Synopsis Directory of Research Grants 2008 by : Schoolhouse Partners Llc

Download or read book Directory of Research Grants 2008 written by Schoolhouse Partners Llc and published by AuthorHouse. This book was released on 2008-05 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was the 50s and life was simple, until September 25, 1954. That was the night that would be etched in the memory of the citizens of Stanfield, Massachusetts. The Chief of Police described the brutal savagery of the double homicide as "the most atrocious crime in the history of the city." A fourteen-year-old girl, and the four-year-old boy in her care were murdered at the hands of a deranged, depraved killer. A Thread of Evidence places the reader at the scene of the crime, an eye witness to the senseless stabbing of two innocent children. With a piece of crochet thread as their only clue, the entire police department, lead by detectives Steven Logan and Raymond Gage, scour the city in search of a maniacal savage. When all tips and leads have been exhausted, they review all evidence. They come back to the thread. The only real evidence. With tenacity and perseverance of Logan and Gage the killer is apprehended. The reader experiences the twists and turns of the investigation, and ultimately occupies a reserved seat in the Superior Court as the trial proceedings commence. A Thread of Evidence has been written as fiction, but inspired by an actual event. Fifty years later, it remains etched in the minds of all who had lived in the area. The author has researched court records, newspapers, interviewed neighbors, police and has drawn on personal recollections of the crime. The story has been recounted over and over and to this day, it continues to be discussed. A Thread of Evidence is a compelling account of superb detective work, and unprecedented dedication of an entire police department.

Gastric Cancer

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Publisher : BoD – Books on Demand
ISBN 13 : 9535135279
Total Pages : 299 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Gastric Cancer by : Gyula Mozsik

Download or read book Gastric Cancer written by Gyula Mozsik and published by BoD – Books on Demand. This book was released on 2017-09-20 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastric cancer remains an important issue in the world of oncology. In 2013, it ranked fifth by global incidence and second by mortality. Really, it is true that the death rates have decreased significantly in the USA and in Europe over the 100-year period; meanwhile, gastric cancer can be characterized by poor prognosis and high mortality, with the exception of early diagnosed patients. Oncological (basic and clinical) research increased extremely in the last decades (including gastric cancer). The authors participating in this book are internationally well-known experts from 11 countries of the world, working in different fields of gastric cancer research, and they summarize the results obtained in the last years. The conclusions of these abovementioned observations fall between the findings of classical prospective, randomized, multiclinical, multinational (and meta-analyzed) generally accepted studies (in accordance with the presently applied and internationally accepted protocols) and the scientifically-based (however individual) molecular targeting organ therapies. The book gathers experts in basic science, molecular pharmacologists, biochemical pharmacologists, basic and clinical oncologists, internists, surgeons, gastroenterologists, tumor pharmacologists as well as experts working in the field of oncology.

Canine and Feline Gastroenterology - E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 143770302X
Total Pages : 1024 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Canine and Feline Gastroenterology - E-Book by : Robert J. Washabau

Download or read book Canine and Feline Gastroenterology - E-Book written by Robert J. Washabau and published by Elsevier Health Sciences. This book was released on 2012-09-02 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference standard for the discipline, Canine and Feline Gastroenterology covers the biology, pathobiology, and diagnosis and treatment of diseases of the gastrointestinal, pancreatic, and hepatobiliary systems. An international team of experts, including 85 authors from 17 different countries, led by Robert Washabau and Michael Day, covers everything from minor problems such as adverse food reactions to debilitating inflammatory, infectious, metabolic, and neoplastic diseases of the digestive system. This authoritative text utilizes an evidence-based approach to reflect the latest science and research, complemented by principles of problem solving, algorithms to improve clinical diagnoses, and extensive full-color illustrations. For generalists and specialists alike, this gastroenterology reference should be part of every serious practitioner's professional library. A comprehensive, 928-page reference standard covers the discipline of canine and feline gastroenterology. An international focus is provided by 85 authors from 17 different countries, including renowned experts in veterinary gastroenterology, internal medicine, pathology, clinical pathology, radiology, and infectious disease. Coverage of the entire breadth and depth of gastroenterology ranges from biology to pathobiology, as well as diagnosis and treatment of diseases of the gastrointestinal, pancreatic, and hepatobiliary systems. Current information on GI microflora, immunology, cellular growth, and systems integration provides a foundation for treating clinical problems. Coverage of diseases in dogs and cats includes the oral cavity, esophagus, stomach, small intestine, large intestine, colon, anorectum, liver and biliary tract, exocrine pancreas, peritoneum, and associated vasculature. A focus on patient management examines the full range of procedures and techniques essential to diagnosis and treatment from clinical signs and diagnosis to nutritional support and pharmacologic management of disease. Clear explanations of current diagnostic modalities include laboratory tests, molecular methods, diagnostic imaging, endoscopy, and histopathology, also showing how to interpret and utilize results. A strong clinical approach emphasizes need-to-know information for managing the common and not-so-common G.I. clinical problems of everyday practice. Full-color photographs and illustrations depict concepts, conditions, and procedures. An evidence-based medicine perspective reflects the latest research as well as the modern practice of veterinary medicine. Logical, coherent, and consistent internal organization makes this a reader-friendly edition. Problem-based algorithms help in diagnosing every G.I. clinical problem from A to Z. A stand-alone section on the pharmacologic approach to G.I. disease offers quick and easy drug reference.

The use of large animal models to improve pre-clinical translational research

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832519326
Total Pages : 161 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The use of large animal models to improve pre-clinical translational research by : Mark Gray

Download or read book The use of large animal models to improve pre-clinical translational research written by Mark Gray and published by Frontiers Media SA. This book was released on 2023-03-30 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Gastroenterology

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Publisher : Academic Press
ISBN 13 : 012818728X
Total Pages : 3420 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Gastroenterology by :

Download or read book Encyclopedia of Gastroenterology written by and published by Academic Press. This book was released on 2019-11-06 with total page 3420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Gastroenterology, Second Edition provides a comprehensive and concise reference on all aspects of gastroenterology and hepatology, including the organs in the gastrointestinal system, their functions in health and disease, and strategies or procedures to resolve or prevent problems and disease. This concise, up-to-date information includes comprehensive sections on the impact of nutrition, gastrointestinal microbiota, lifestyle, commonly used drugs, and surgical procedures on health and disease. Since the first edition, attention to the roles of nutrition and gastrointestinal microorganisms (microbiota, formerly Microbiota) in health and disease has skyrocketed. In addition, an entirely new section on obesity and diabetes is included. Presents comprehensive coverage of every topic within gastroenterology Offers researchers a one-stop, fully-referenced resource to explore questions Includes teaching tools, multimedia and interactive elements Provides readers with multi-layered content and a media-rich learning resource for both instructors and students Covers hot new topics in GI health and disease, including new sections on stem cells, intestinal bacteria, obesity and intestinal microbiota

Physiology of the Gastrointestinal Tract, Two Volume Set

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Author :
Publisher : Academic Press
ISBN 13 : 0123820278
Total Pages : 2250 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Physiology of the Gastrointestinal Tract, Two Volume Set by : Hamid M. Said

Download or read book Physiology of the Gastrointestinal Tract, Two Volume Set written by Hamid M. Said and published by Academic Press. This book was released on 2012-07-04 with total page 2250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn’s disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. 2013 Highly Commended BMA Medical Book Award for Internal Medicine Discusses the multiple processes governing gastrointestinal function Each section edited by preeminent scientist in the field Updated, four-color illustrations

Journal of the National Cancer Institute

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Author :
Publisher :
ISBN 13 :
Total Pages : 514 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2006 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: