Translational Medicine What Why And How An International Perspective

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Clinical and Translational Science

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Author : David Robertson
Publisher : Academic Press
ISBN 13 : 012802111X
Total Pages : 812 pages
Book Rating : 4.1/5 (28 download)

Book Synopsis Clinical and Translational Science by : David Robertson

Download or read book Clinical and Translational Science written by David Robertson and published by Academic Press. This book was released on 2016-11-25 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Translational Medicine - What, Why and How: An International Perspective

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Author : B. Alving
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318022853
Total Pages : 136 pages
Book Rating : 4.3/5 (18 download)

Book Synopsis Translational Medicine - What, Why and How: An International Perspective by : B. Alving

Download or read book Translational Medicine - What, Why and How: An International Perspective written by B. Alving and published by Karger Medical and Scientific Publishers. This book was released on 2012-12-21 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide an aerial view, as well as detailed information, on ‘how’ activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high-value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

Translational Medicine - What, Why and How

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Author : Barbara Alving
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318022845
Total Pages : 136 pages
Book Rating : 4.3/5 (18 download)

Book Synopsis Translational Medicine - What, Why and How by : Barbara Alving

Download or read book Translational Medicine - What, Why and How written by Barbara Alving and published by Karger Medical and Scientific Publishers. This book was released on 2012-12-01 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide an aerial view, as well as detailed information, on 'how' activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high- value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

From Auto- to Allotransplantation

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Author : F.-C. Wei
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 331805867X
Total Pages : 190 pages
Book Rating : 4.3/5 (18 download)

Book Synopsis From Auto- to Allotransplantation by : F.-C. Wei

Download or read book From Auto- to Allotransplantation written by F.-C. Wei and published by Karger Medical and Scientific Publishers. This book was released on 2016-06-28 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important lessons from the successful Chang Gung Vascularized Composite Allotransplantation Center. From Auto- to Allotransplantation is indeed the only up-to-date and complete reference available on the topic. Scholars and research fellows interested in transplantation will benefit greatly from this work. It is also an invaluable resource for plastic, orthopedic, hand, ENT, oromaxillofacial, and general surgeons as well as for residents.

Biomaterials in Translational Medicine

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Author : Lei Yang
Publisher : Academic Press
ISBN 13 : 012813478X
Total Pages : 364 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Biomaterials in Translational Medicine by : Lei Yang

Download or read book Biomaterials in Translational Medicine written by Lei Yang and published by Academic Press. This book was released on 2018-11-30 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. - Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine - Includes the translational or commercialization status of these new biomaterials - Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine - Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

New Mentalities of Government in China

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Author : David Bray
Publisher : Routledge
ISBN 13 : 131742235X
Total Pages : 299 pages
Book Rating : 4.3/5 (174 download)

Book Synopsis New Mentalities of Government in China by : David Bray

Download or read book New Mentalities of Government in China written by David Bray and published by Routledge. This book was released on 2016-01-13 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: China continues to transform apace, flowing from the forces of deregulation, privatization and globalization unleashed by economic reforms which began in late 1978. The dramatic scope of economic change in China is often counterposed to the apparent lack of political change as demonstrated by continued Chinese Communist Party (CCP) rule. However, the ongoing dominance of the CCP belies the fact that much has also changed in relation to practices of government, including how authorities and citizens interact in the management of daily life. New Mentalities of Government in China examines how the privatization and professionalization of ‘public’ service provision is transforming the nature of government and everyday life in the People’s Republic of China (PRC). The book addresses key theoretical questions on the nature of government in China and documents the emergence of a range of ‘new mentalities of government’ in China. Its chapters focus on areas such as clinical trials, conceptualizing government, consumer activity, elite philanthropy, lifestyle and beauty advice, public health, social work, volunteering; and urban and rural planning. Offering a topical examination of shifting modes of governance in contemporary China, this book will appeal to scholars in the fields of anthropology, history, politics and sociology.

International Perspectives on Primary Care Research

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Author : Felicity Goodyear-Smith
Publisher : CRC Press
ISBN 13 : 1351855484
Total Pages : 278 pages
Book Rating : 4.3/5 (518 download)

Book Synopsis International Perspectives on Primary Care Research by : Felicity Goodyear-Smith

Download or read book International Perspectives on Primary Care Research written by Felicity Goodyear-Smith and published by CRC Press. This book was released on 2017-04-28 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Perspectives on Primary Care Research examines how the evidence base from primary care research can strengthen health care services and delivery, tackle the growing burden of disease, improve quality and safety, and increase a person-centred focus to health care. Demonstrating the inter-professional nature of the discipline, the book also features a section on cross-nation organisations and primary care networks supporting research. National perspectives are offered from researchers in 20 countries that form part of the World Organization of Family Doctors, providing case histories from research-rich to resource-poor nations that illustrate the range of research development and capacity building. This book argues the importance of primary care research, especially to policy makers, decision makers and funders in informing best practice, training primary health care providers and achieving equitable distribution of care.

Making Medical Knowledge

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Author : Miriam Solomon
Publisher :
ISBN 13 : 0198732619
Total Pages : 289 pages
Book Rating : 4.1/5 (987 download)

Book Synopsis Making Medical Knowledge by : Miriam Solomon

Download or read book Making Medical Knowledge written by Miriam Solomon and published by . This book was released on 2015 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is medical knowledge made? New methods for research and clinical care have reshaped the practices of medical knowledge production over the last forty years. Consensus conferences, evidence-based medicine, translational medicine, and narrative medicine are among the most prominent new methods. Making Medical Knowledge explores their origins and aims, their epistemic strengths, and their epistemic weaknesses. Miriam Solomon argues that the familiar dichotomy between the art and the science of medicine is not adequate for understanding this plurality of methods. The book begins by tracing the development of medical consensus conferences, from their beginning at the United States' National Institutes of Health in 1977, to their widespread adoption in national and international contexts. It discusses consensus conferences as social epistemic institutions designed to embody democracy and achieve objectivity. Evidence-based medicine, which developed next, ranks expert consensus at the bottom of the evidence hierarchy, thus challenging the authority of consensus conferences. Evidence-based medicine has transformed both medical research and clinical medicine in many positive ways, but it has also been accused of creating an intellectual hegemony that has marginalized crucial stages of scientific research, particularly scientific discovery. Translational medicine is understood as a response to the shortfalls of both consensus conferences and evidence-based medicine. Narrative medicine is the most prominent recent development in the medical humanities. Its central claim is that attention to narrative is essential for patient care. Solomon argues that the differences between narrative medicine and the other methods have been exaggerated, and offers a pluralistic account of how the all the methods interact and sometimes conflict. The result is both practical and theoretical suggestions for how to improve medical knowledge and understand medical controversies.

U.S. Health in International Perspective

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Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309264146
Total Pages : 421 pages
Book Rating : 4.3/5 (92 download)

Book Synopsis U.S. Health in International Perspective by : National Research Council

Download or read book U.S. Health in International Perspective written by National Research Council and published by National Academies Press. This book was released on 2013-04-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States is among the wealthiest nations in the world, but it is far from the healthiest. Although life expectancy and survival rates in the United States have improved dramatically over the past century, Americans live shorter lives and experience more injuries and illnesses than people in other high-income countries. The U.S. health disadvantage cannot be attributed solely to the adverse health status of racial or ethnic minorities or poor people: even highly advantaged Americans are in worse health than their counterparts in other, "peer" countries. In light of the new and growing evidence about the U.S. health disadvantage, the National Institutes of Health asked the National Research Council (NRC) and the Institute of Medicine (IOM) to convene a panel of experts to study the issue. The Panel on Understanding Cross-National Health Differences Among High-Income Countries examined whether the U.S. health disadvantage exists across the life span, considered potential explanations, and assessed the larger implications of the findings. U.S. Health in International Perspective presents detailed evidence on the issue, explores the possible explanations for the shorter and less healthy lives of Americans than those of people in comparable countries, and recommends actions by both government and nongovernment agencies and organizations to address the U.S. health disadvantage.

The Engaged Health Sciences Library Liaison

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Author : Lindsay Alcock
Publisher : Rowman & Littlefield
ISBN 13 : 1538126761
Total Pages : 195 pages
Book Rating : 4.5/5 (381 download)

Book Synopsis The Engaged Health Sciences Library Liaison by : Lindsay Alcock

Download or read book The Engaged Health Sciences Library Liaison written by Lindsay Alcock and published by Rowman & Littlefield. This book was released on 2020-05-15 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liaison roles are generally commonplace in medical and health sciences libraries as librarians strive to develop and enhance relationships and collaborations with clinicians and faculty. While the liaison of the past acted primarily as the main contact between respective departments and the library providing a facilitative function (e.g. arranging for instruction sessions, inviting feedback on the collection, providing updates on new programs and services, etc.), today’s liaison activities are more proactive and robust. The Engaged Health Sciences Library Liaison features ten program descriptions that illustrate how the reach and scope of librarians in the medical/healthcare arena has changed dramatically since the inception of liaison services. The program outcomes described: illustrate a direct impact on curriculum development, address new information types with new access and preservation technologies, expand stakeholder groups, create research and teaching collaborations, and enhance functional roles. This authoritative book copublished by the Medical Library Association demonstrates thatcollaboration and communication, the basic tenets of a liaison program, breed innovative programs and services that are relevant, current, and valuable.

Shockwave Medicine

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Author : C.-J. Wang
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318063134
Total Pages : 174 pages
Book Rating : 4.3/5 (18 download)

Book Synopsis Shockwave Medicine by : C.-J. Wang

Download or read book Shockwave Medicine written by C.-J. Wang and published by Karger Medical and Scientific Publishers. This book was released on 2018-04-05 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work provides a detailed overview of shockwave therapy, a relatively new clinical specialty in modern medicine. It follows the evolution of Extracorporeal Shockwave Therapy (ESWT) from its initial stage as the gold standard for the disintegration of kidney stones to its regenerative effects in biological tissues. Starting with the basic principles of shockwave treatment, the book goes on to review its application in musculoskeletal disorders, including osteonecrosis of the hip, tendinopathy, fracture treatment, and treatment of sports related injuries. The application of ESWT in cardiovascular diseases is discussed. This includes preclinical and clinical applications for ischemic cardiovascular disease and effects on angiogenesis and anti-inflammation-molecular-cellular signaling pathways. The treatment of urinary diseases and erectile dysfunction by ESWT is elaborated. The book concludes with a discussion of future prospects of the shockwave therapy. Scholars and research fellows interested in shockwave medicine will benefit greatly from this work. It is also a useful clinical resource for nephrologists, urologists, cardiologists, and orthopedists.

The Bloomsbury Companion to Contemporary Philosophy of Medicine

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Author : James A. Marcum
Publisher : Bloomsbury Publishing
ISBN 13 : 1474233015
Total Pages : 425 pages
Book Rating : 4.4/5 (742 download)

Book Synopsis The Bloomsbury Companion to Contemporary Philosophy of Medicine by : James A. Marcum

Download or read book The Bloomsbury Companion to Contemporary Philosophy of Medicine written by James A. Marcum and published by Bloomsbury Publishing. This book was released on 2016-12-15 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive and authoritative guide to a vibrant and growing discipline in current philosophy, The Bloomsbury Companion to Contemporary Philosophy of Medicine presents an overview of the issues facing contemporary philosophy of medicine, the research methods required to understand them and a trajectory for the discipline's future. Written by world leaders in the discipline, this companion addresses the ontological, epistemic, and methodological challenges facing philosophers of medicine today, from the debate between evidence-based and person-centered medicine, medical humanism, and gender medicine, to traditional issues such as disease, health, and clinical reasoning and decision-making. Practical and forward-looking, it also includes a detailed guide to research sources, a glossary of key terms, and an annotated bibliography, as well as an introductory survey of research methods and discussion of new research directions emerging in response to the rapid changes in modern medicine. “Philosophy needs medicine', Hillel Braude argues, 'to become more relevant'. By showing how modern medicine provides philosophers with a rich source of material for investigating issues facing contemporary society, The Bloomsbury Companion to Contemporary Philosophy of Medicine introduces the opportunities medicine offers philosophers together with the resources and skills required to contribute to contemporary debates and discussions.

Translational Regenerative Medicine

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Author : Anthony Atala
Publisher : Academic Press
ISBN 13 : 0124104576
Total Pages : 607 pages
Book Rating : 4.1/5 (241 download)

Book Synopsis Translational Regenerative Medicine by : Anthony Atala

Download or read book Translational Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2014-12-01 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. - Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications - Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system - Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

The Ethical Challenges of Emerging Medical Technologies

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Author : Arthur L. Caplan
Publisher : Routledge
ISBN 13 : 1000151999
Total Pages : 672 pages
Book Rating : 4.0/5 (1 download)

Book Synopsis The Ethical Challenges of Emerging Medical Technologies by : Arthur L. Caplan

Download or read book The Ethical Challenges of Emerging Medical Technologies written by Arthur L. Caplan and published by Routledge. This book was released on 2020-09-10 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays emphasizes society’s increasingly responsible engagement with ethical challenges in emerging medical technology. Expansion of technological capacity and attention to patient safety have long been integral to improving healthcare delivery but only relatively recently have concepts like respect, distributive justice, privacy, and autonomy gained some power to shape the development, use, and refinement of medical tools and techniques. Medical ethics goes beyond making better medicine to thinking about how to make the field of medicine better. These essays showcase several ways in which modern ethical thinking is improving safety, efficacy and efficiency of medical technology, increasing access to medical care, and empowering patients to choose care that comports with their desires and beliefs. Included are complimentary ethical approaches as well as compelling counter-arguments. Together, the articles demonstrate how improving the quality of medical technology relies on every stakeholder -- not just medical researchers and scientists -- to assess each given technology’s strengths and pitfalls. This collection also portends one of the next major issues in the ethics of medical technology: developing the requisite moral framework to accompany shifts toward patient-centred personalized healthcare.

Translational Pain Research

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Author : Lawrence Kruger
Publisher : CRC Press
ISBN 13 : 1439812101
Total Pages : 458 pages
Book Rating : 4.4/5 (398 download)

Book Synopsis Translational Pain Research by : Lawrence Kruger

Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical

Translational Medicine

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Author : Joy A. Cavagnaro
Publisher : CRC Press
ISBN 13 : 1000471853
Total Pages : 952 pages
Book Rating : 4.0/5 (4 download)

Book Synopsis Translational Medicine by : Joy A. Cavagnaro

Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Science, Technology and Innovation Ecosystem: An Indian and Global Perspective

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Author : Kashmir Singh
Publisher : Springer Nature
ISBN 13 : 9819728150
Total Pages : 441 pages
Book Rating : 4.8/5 (197 download)

Book Synopsis Science, Technology and Innovation Ecosystem: An Indian and Global Perspective by : Kashmir Singh

Download or read book Science, Technology and Innovation Ecosystem: An Indian and Global Perspective written by Kashmir Singh and published by Springer Nature. This book was released on with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: