Transformer The Deep Chemistry Of Life And Death

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Transformer: The Deep Chemistry of Life and Death

Author : Nick Lane
Publisher : W. W. Norton & Company
ISBN 13 : 0393651495
Total Pages : 275 pages
Book Rating : 4.3/5 (936 download)

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Book Synopsis Transformer: The Deep Chemistry of Life and Death by : Nick Lane

Download or read book Transformer: The Deep Chemistry of Life and Death written by Nick Lane and published by W. W. Norton & Company. This book was released on 2022-07-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.

Oxygen

Author : Nick Lane
Publisher : Oxford University Press, USA
ISBN 13 : 0198607830
Total Pages : 385 pages
Book Rating : 4.1/5 (986 download)

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Book Synopsis Oxygen by : Nick Lane

Download or read book Oxygen written by Nick Lane and published by Oxford University Press, USA. This book was released on 2002 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. Damage to DNA caused by oxidative stress appears to explain aging and many of its diseases, hence the popularity in alternative health circles of antioxidants. But antioxidants alone fail to prevent aging. Lane suggests two different avenues of study: modulation of the immune system, which generates free radicals as part of its defense against infectious diseases; and ways of improving the health of our cellular mitochondria, on which many age-related ailments seem to depend. Provocative and complexly argued. Copyright ©Kirkus Reviews, used with permission.

Power, Sex, Suicide

Author : Nick Lane
Publisher : OUP Oxford
ISBN 13 : 9780191513015
Total Pages : 370 pages
Book Rating : 4.5/5 (13 download)

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Book Synopsis Power, Sex, Suicide by : Nick Lane

Download or read book Power, Sex, Suicide written by Nick Lane and published by OUP Oxford. This book was released on 2005-10-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford

Life Ascending

Author : Nick Lane
Publisher : Profile Books
ISBN 13 : 1847652220
Total Pages : 353 pages
Book Rating : 4.8/5 (476 download)

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Book Synopsis Life Ascending by : Nick Lane

Download or read book Life Ascending written by Nick Lane and published by Profile Books. This book was released on 2010-10-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the 2010 Royal Society Prize for science books Powerful new research methods are providing fresh and vivid insights into the makeup of life. Comparing gene sequences, examining the atomic structure of proteins and looking into the geochemistry of rocks have all helped to explain creation and evolution in more detail than ever before. Nick Lane uses the full extent of this new knowledge to describe the ten greatest inventions of life, based on their historical impact, role in living organisms today and relevance to current controversies. DNA, sex, sight and consciousnesses are just four examples. Lane also explains how these findings have come about, and the extent to which they can be relied upon. The result is a gripping and lucid account of the ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.

The Vital Question

Author : Nick Lane
Publisher :
ISBN 13 : 9781781250372
Total Pages : 0 pages
Book Rating : 4.2/5 (53 download)

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Book Synopsis The Vital Question by : Nick Lane

Download or read book The Vital Question written by Nick Lane and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.

Life's Ratchet

Author : Peter M. Hoffmann
Publisher :
ISBN 13 : 0465022537
Total Pages : 290 pages
Book Rating : 4.4/5 (65 download)

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Book Synopsis Life's Ratchet by : Peter M. Hoffmann

Download or read book Life's Ratchet written by Peter M. Hoffmann and published by . This book was released on 2012-10-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.

Fundamentals of Enzyme Kinetics

Author : Athel Cornish-Bowden
Publisher : Elsevier
ISBN 13 : 1483161196
Total Pages : 245 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Fundamentals of Enzyme Kinetics by : Athel Cornish-Bowden

Download or read book Fundamentals of Enzyme Kinetics written by Athel Cornish-Bowden and published by Elsevier. This book was released on 2014-05-20 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Enzyme Kinetics details the rate of reactions catalyzed by different enzymes and the effects of varying the conditions on them. The book includes the basic principles of chemical kinetics, especially the order of a reaction and its rate constraints. The text also gives an introduction to enzyme kinetics - the idea of an enzyme-substrate complex; the Michaelis-Menten equation; the steady state treatment; and the validity of its assumption. Practical considerations, the derivation of steady-state rate equations, inhibitors and activators, and two-substrate reactions are also explained. Problems after the end of each chapter have also been added, as well as their solutions at the end of the book, to test the readers' learning. The text is highly recommended for undergraduate students in biochemistry who wish to study about enzymes or focus completely on enzymology, as most of the mathematics used in this book, which have been explained in detail to remove most barriers of understanding, is elementary.

Life Evolving

Author : Christian de Duve
Publisher : Oxford University Press
ISBN 13 : 0199882614
Total Pages : 485 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis Life Evolving by : Christian de Duve

Download or read book Life Evolving written by Christian de Duve and published by Oxford University Press. This book was released on 2002-10-17 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: In just a half century, humanity has made an astounding leap in its understanding of life. Now, one of the giants of biological science, Christian de Duve, discusses what we've learned in this half century, ranging from the tiniest cells to the future of our species and of life itself. With wide-ranging erudition, De Duve takes us on a dazzling tour of the biological world, beginning with the invisible workings of the cell, the area in which he won his Nobel Prize. He describes how the first cells may have arisen and suggests that they may have been like the organisms that exist today near deep-sea hydrothermal vents. Contrary to many scientists, he argues that life was bound to arise and that it probably only took millennia--maybe tens of thousands of years--to move from rough building blocks to the first organisms possessing the basic properties of life. With equal authority, De Duve examines topics such as the evolution of humans, the origins of consciousness, the development of language, the birth of science, and the origin of emotion, morality, altruism, and love. He concludes with his conjectures on the future of humanity--for instance, we may evolve, perhaps via genetic engineering, into a new species--and he shares his personal thoughts about God and immortality. In Life Evolving, one of our most eminent scientists sums up what he has learned about the nature of life and our place in the universe. An extraordinarily wise and humane volume, it will fascinate readers curious about the world around them and about the impact of science on philosophy and religion.

Cost-Sensitive Machine Learning

Author : Balaji Krishnapuram
Publisher : CRC Press
ISBN 13 : 143983928X
Total Pages : 316 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Cost-Sensitive Machine Learning by : Balaji Krishnapuram

Download or read book Cost-Sensitive Machine Learning written by Balaji Krishnapuram and published by CRC Press. This book was released on 2011-12-19 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: In machine learning applications, practitioners must take into account the cost associated with the algorithm. These costs include: Cost of acquiring training dataCost of data annotation/labeling and cleaningComputational cost for model fitting, validation, and testingCost of collecting features/attributes for test dataCost of user feedback collect

The Life and Death Parade

Author : Eliza Wass
Publisher : Little, Brown Books for Young Readers
ISBN 13 : 1368002447
Total Pages : 234 pages
Book Rating : 4.3/5 (68 download)

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Book Synopsis The Life and Death Parade by : Eliza Wass

Download or read book The Life and Death Parade written by Eliza Wass and published by Little, Brown Books for Young Readers. This book was released on 2018-06-04 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: One year ago, Kitty's boyfriend Nikki Bramley visited a psychic who told him he had no future. Now, he's dead. With the Bramley family grieving in separate corners of their home, Kitty sets out to find the psychic who read Nikki his fate. Instead she finds Roan, an enigmatic boy posing as a medium who belongs to the Life and Death Parade -- a group of supposed charlatans that explore, and exploit, the thin veil between this world and the next. A group whose members include the psychic . . . and Kitty's late mother. Desperate to learn more about the group and their connection to Nikki, Kitty convinces Roan to return to the Bramley house with her and secures a position for him within the household. Roan quickly ingratiates himself with the Bramleys, and soon enough it seems like everyone is ready to move on. Kitty, however, increasingly suspects Roan knows more about Nikki than he's letting on. And when they finally locate the Life and Death Parade, and the psychic who made that fateful prophecy to Nikki, Kitty uncovers a secret about Roan that changes everything. From rising star Eliza Wass comes a sophisticated, mesmerizing meditation on the depths of grief and the magic of faith. After all, it only works if you believe it.

Ahead of the Curve

Author : Michael Levin
Publisher : Iph001
ISBN 13 : 9780750316750
Total Pages : 400 pages
Book Rating : 4.3/5 (167 download)

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Book Synopsis Ahead of the Curve by : Michael Levin

Download or read book Ahead of the Curve written by Michael Levin and published by Iph001. This book was released on 2019-01-31 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popular conception of science is of a steady, upward climb of progress. The reality is not that simple. Highly significant discoveries often stay unrecognized for decades, particularly if they conflict with the current paradigm or extend it in ways hard to imagine at the time. Ahead of the Curve: Hidden breakthroughs in the biosciences is a fascinating collection of lost research that the editors believe are important scientific contributions.

Alone Time

Author : Stephanie Rosenbloom
Publisher : Penguin
ISBN 13 : 039956232X
Total Pages : 290 pages
Book Rating : 4.3/5 (995 download)

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Book Synopsis Alone Time by : Stephanie Rosenbloom

Download or read book Alone Time written by Stephanie Rosenbloom and published by Penguin. This book was released on 2019-06-04 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wise, passionate account of the pleasures of traveling solo In our hectic, hyperconnected lives, many people are uncomfortable with the prospect of solitude. Yet a little time to ourselves can be an opportunity to slow down, savor, and try new things, especially when traveling. Through on-the-ground reporting, insights from social science, and recounting the experiences of artists, writers, and innovators who cherished solitude, Stephanie Rosenbloom considers how traveling alone deepens appreciation for everyday beauty, bringing into sharp relief the sights, sounds, and smells that one isn't necessarily attuned to in the presence of company. Walking through four cities--Paris, Florence, Istanbul, and New York--and four seasons, Alone Time gives us permission to pause, to relish the sensual details of the world rather than hurtling through museums and uploading photos to Instagram. In chapters about dining out, visiting museums, and pursuing knowledge, we begin to see how the moments we have to ourselves--on the road or at home--can be used to enrich our lives. Rosenbloom's engaging and elegant prose makes Alone Time as warmly intimate an account as the details of a trip shared by a beloved friend--and will have its many readers eager to set off on their own solo adventures.

First Life

Author : David Deamer
Publisher : Univ of California Press
ISBN 13 : 0520258320
Total Pages : 288 pages
Book Rating : 4.5/5 (22 download)

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Book Synopsis First Life by : David Deamer

Download or read book First Life written by David Deamer and published by Univ of California Press. This book was released on 2011-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: All life starts as stardust and all life requires packaging for molecules, proteins, DNA, and other crucial bits. Introducing astrobiology, this book presents a provocative hypothesis for the environmental conditions and raw materials needed for life to begin and evolve on earth.

Diving Into Darkness

Author : Phillip Finch
Publisher : Macmillan
ISBN 13 : 9780312383947
Total Pages : 340 pages
Book Rating : 4.3/5 (839 download)

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Book Synopsis Diving Into Darkness by : Phillip Finch

Download or read book Diving Into Darkness written by Phillip Finch and published by Macmillan. This book was released on 2008-09-30 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finch chronicles the harrowing true story of two friends who plunge 900 feet into the water in South Africa--and only one returns. What happened that day is the stuff of nightmarish drama, but it's also a compelling human story of friendship and of coming to terms with loss and tragedy. 8-page color photo insert.

On Life

Author : Franklin M. Harold
Publisher : Oxford University Press
ISBN 13 : 0197604544
Total Pages : 225 pages
Book Rating : 4.1/5 (976 download)

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Book Synopsis On Life by : Franklin M. Harold

Download or read book On Life written by Franklin M. Harold and published by Oxford University Press. This book was released on 2021-12-17 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Franklin M. Harold's On Life reveals what science can tell us about the living world. All creatures, from bacteria and redwoods to garden snails and humans, belong to a single biochemical family. We all operate by the same principles and are all made up of cells, either one or many. We flaunt capacities that far exceed those of inanimate matter, yet we stand squarely within the material world. So what is life, anyway? How do living things function, and how did they come into existence? Questions like these have baffled philosophers and scientists since antiquity, but over the past half-century answers have begun to emerge. Offering an inside look, Franklin M. Harold makes life accessible to readers interested in the biological big picture. The book traces how living things operate, focusing on the interplay of biology with physics and chemistry. He asserts that biology stands apart from the physical sciences because life revolves around organization-- that is, purposeful order. On Life aims to make life intelligible by giving readers an understanding of the biological landscape; it sketches the principles as biologists presently understand them and highlights major unresolved issues. What emerges is a biology bracketed by two stubborn mysteries: the nature of the mind and the origin of life. This portrait of biology is comprehensible but inescapably complex, internally consistent, and buttressed by a wealth of factual knowledge.

Eating the Sun

Author : Oliver Morton
Publisher : Harper Collins
ISBN 13 : 0007163657
Total Pages : 74 pages
Book Rating : 4.0/5 (71 download)

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Book Synopsis Eating the Sun by : Oliver Morton

Download or read book Eating the Sun written by Oliver Morton and published by Harper Collins. This book was released on 2009-11-17 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wherever there is greenery, photosynthesis is working to make oxygen, release energy, and create living matter from the raw material of sunlight, water, and carbon dioxide. Without photosynthesis, there would be an empty world, an empty sky, and a sun that does nothing more than warm the rocks and reflect off the sea. Eating the Sun is the story of a world in crisis; an appreciation of the importance of plants; a history of the earth and the feuds and fantasies of warring scientists; a celebration of how the smallest things, enzymes and pigments, influence the largest things, the oceans, the rainforests, and the fossil fuel economy. Oliver Morton offers a fascinating, lively, profound look at nature's greatest miracle and sounds a much-needed call to arms—illuminating a potential crisis of climatic chaos and explaining how we can change our situation, for better or for worse.

A New History of Life

Author : Peter Ward
Publisher : Bloomsbury Publishing USA
ISBN 13 : 1608199088
Total Pages : 401 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis A New History of Life by : Peter Ward

Download or read book A New History of Life written by Peter Ward and published by Bloomsbury Publishing USA. This book was released on 2015-04-07 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of life on Earth is, in some form or another, known to us all--or so we think. A New History of Life offers a provocative new account, based on the latest scientific research, of how life on our planet evolved--the first major new synthesis for general readers in two decades. Charles Darwin's theories, first published more than 150 years ago, form the backbone of how we understand the history of the Earth. In reality, the currently accepted history of life on Earth is so flawed, so out of date, that it's past time we need a 'New History of Life.' In their latest book, Joe Kirschvink and Peter Ward will show that many of our most cherished beliefs about the evolution of life are wrong. Gathering and analyzing years of discoveries and research not yet widely known to the public, A New History of Life proposes a different origin of species than the one Darwin proposed, one which includes eight-foot-long centipedes, a frozen “snowball Earth”, and the seeds for life originating on Mars. Drawing on their years of experience in paleontology, biology, chemistry, and astrobiology, experts Ward and Kirschvink paint a picture of the origins life on Earth that are at once too fabulous to imagine and too familiar to dismiss--and looking forward, A New History of Life brilliantly assembles insights from some of the latest scientific research to understand how life on Earth can and might evolve far into the future.