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Author : Jun Wang
Publisher :
ISBN 13 :
Total Pages : 302 pages
Book Rating : 4.:/5 (223 download)
Download or read book Transcriptional Regulation of the Mouse and Human Interleukin-5 Genes in T-lymphocytes written by Jun Wang and published by . This book was released on 2001 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chiok Ling Tan
Publisher :
ISBN 13 :
Total Pages : 374 pages
Book Rating : 4.:/5 (222 download)
Download or read book Transcriptional Regulation of the Mouse Interleukin-5 Gene in T-Lymphocytes written by Chiok Ling Tan and published by . This book was released on 1998 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter Francis Bourke
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.:/5 (223 download)
Download or read book Transcriptional Regulation of the Mouse Interleukin-5 Gene in T Lymphocytes written by Peter Francis Bourke and published by . This book was released on 1993 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anish D. Singh
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (155 download)
Download or read book Studies on the Transcriptional Regulation of Human Interleukin 5 written by Anish D. Singh and published by . This book was released on 2000 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fiona Rolfe
Publisher :
ISBN 13 :
Total Pages : 458 pages
Book Rating : 4.:/5 (222 download)
Download or read book Transcriptional and Post-transcriptional Regulation of Human Interleukin 5 Gene Expression written by Fiona Rolfe and published by . This book was released on 1996 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cameron Stuart Osborne
Publisher :
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (222 download)
Download or read book Transcriptional Regulation of the GM-CSF Gene in T Lymphocytes written by Cameron Stuart Osborne and published by . This book was released on 1996 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the investigation as to whether the mouse granulocyte-macrophage colony-stimulating factor and interleukin-3 genes are regulated in a similar manner as those of the human, focussing on regulation through an enhancer.
Author : Marc Andrew Thomas
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.:/5 (222 download)
Download or read book Regulation Studies of the Interleukin-5 Gene in T-lymphocytes written by Marc Andrew Thomas and published by . This book was released on 1999 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiaojing Ma
Publisher : Springer
ISBN 13 : 9402409211
Total Pages : 228 pages
Book Rating : 4.4/5 (24 download)
Download or read book Regulation of Cytokine Gene Expression in Immunity and Diseases written by Xiaojing Ma and published by Springer. This book was released on 2016-10-12 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Author : Janet Valentine
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.:/5 (222 download)
Download or read book Regulation of Human Interleukin-5 Gene Expression written by Janet Valentine and published by . This book was released on 1995 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 135 pages
Book Rating : 4.:/5 (686 download)
Download or read book Interleukin-17 Gene Regulation in T Cells written by and published by . This book was released on 2005 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: IL-17 is the founding member of a novel family of cytokines and plays a central role in inflammation, rheumatoid arthritis and lung disease. However, little is known about how IL-17 expression is controlled. This study explores three aspects of the mechanism of IL-17 gene regulation: proximal cis -acting elements in the human IL-17 promoter that respond to T cell receptor (TCR) signaling, signals provided by antigen presenting cells that are necessary for optimal IL-17 production in mouse primary cells, and IL-17 gene regulation in a mouse cell model. To define cis -acting elements important for IL-17 gene regulation, we cloned 1 kb of a putative promoter, and found that it was active in Jurkat T cells. Studies using pharmacological inhibitors, over-expression systems and Jurkat sublines all indicated a role for the transcription factor nuclear factor of activated T cells (NFAT). We then showed that a region containing two NFAT sites was sufficient for TCR inducible promoter activity. Moreover, mutations of these sites dramatically reduced reporter gene activity. Chromatin immunoprecipitation assays showed occupancy of NFAT at this region in vivo . Together, these data show that NFAT is a crucial sensor of TCR signaling in the IL-17 promoter. IL-17 is primarily made by T cells, but relatively little is known about the requirements and mechanisms for IL-17 expression in mouse lymphocytes. Like many cytokines, we found that IL-17 was induced rapidly in primary lymphocytes after CD3 crosslinking. Although a panel of costimulatory signals failed to increase IL-I7 levels, we found that IL-23, produced by activated dendritic cells, increased IL-17 production both independently and in conjugation with TCR signals. To begin to characterize signaling pathways required for IL-17 production in mice, we identified an IL-17-producing EL4 T cell line. Next, we cloned a 3000 by putative promoter, and showed that it was transcriptionally active in EL4 cells. This cell line will be a useful tool for further work on the mouse IL-17 promoter study in vitro . Overall, these studies are the first report about the mechanism of IL-17 gene regulation, and they may offer new opportunities for therapeutic intervention for diseases involving this cytokine.
Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)
Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Author : James J. Lee
Publisher : Academic Press
ISBN 13 : 012394385X
Total Pages : 679 pages
Book Rating : 4.1/5 (239 download)
Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Author : Robert A. Stockley
Publisher : Springer Science & Business Media
ISBN 13 : 9783764359683
Total Pages : 220 pages
Book Rating : 4.3/5 (596 download)
Download or read book Molecular Biology of the Lung written by Robert A. Stockley and published by Springer Science & Business Media. This book was released on 1998 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this two-volume work is to provide an update on the use of this powerful technology. As such, the books provide an insight in to the techniques for the non-specialist. Scientists embarking upon st udies in chronic lung disease will find a review of the current status of research. At the same time, the books are useful to clinicians, bo th specialist and academic, and to scientists already involved in the basic aspects of the pathogenesis of lung disease. Both volumes deal w ith basic mechanisms of cell biology, receptors and cellactivation and provide an insight as to how the technology influences our concepts o f pathogenesis and viceversa.
Author : Robert Stockley
Publisher : Birkhäuser
ISBN 13 : 3034887841
Total Pages : 209 pages
Book Rating : 4.0/5 (348 download)
Download or read book Molecular Biology of the Lung written by Robert Stockley and published by Birkhäuser. This book was released on 2013-12-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author : Simon Fillatreau
Publisher : Springer
ISBN 13 : 366243492X
Total Pages : 244 pages
Book Rating : 4.6/5 (624 download)
Download or read book Interleukin-10 in Health and Disease written by Simon Fillatreau and published by Springer. This book was released on 2014-07-08 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Author : B. Kyewski
Publisher : Springer Science & Business Media
ISBN 13 : 3540277021
Total Pages : 331 pages
Book Rating : 4.5/5 (42 download)
Download or read book CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential written by B. Kyewski and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
