Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Transcription Factors In Immunological Disease And Haematological Malignancies
Download Transcription Factors In Immunological Disease And Haematological Malignancies full books in PDF, epub, and Kindle. Read online Transcription Factors In Immunological Disease And Haematological Malignancies ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Transcription Factors in Immunological Disease and Haematological Malignancies by : Tomokatsu Ikawa
Download or read book Transcription Factors in Immunological Disease and Haematological Malignancies written by Tomokatsu Ikawa and published by Frontiers Media SA. This book was released on 2024-02-23 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are nuclear proteins that control the rate of gene expression, activating or repressing transcription in a context-dependent manner. These regulators lie at the heart of most cell fate decisions of immune cells, guiding the initiation and maintenance of lineage identity and controlling the cell-type-specific gene expression that underpins the unique functions of each immune cell lineage. As such transcription factors are of critical importance for a healthy immune system, with mutation of specific factors leading to immune dysregulation with immunodeficiency and autoimmunity. In addition, perturbation of transcription factors known to regulate immune cell function have been implicated in the genesis of haematological malignancies through chromosomal translocation, over-expression or genetic deletion.
Book Synopsis Transcription Factors by : Katya Ravid
Download or read book Transcription Factors written by Katya Ravid and published by John Wiley & Sons. This book was released on 2003-11-04 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Book Synopsis Regulation of Cancer Immune Checkpoints by : Jie Xu
Download or read book Regulation of Cancer Immune Checkpoints written by Jie Xu and published by Springer Nature. This book was released on 2020-03-17 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
Book Synopsis Cancer Cell Lines by : Bernhard Ø Palsson
Download or read book Cancer Cell Lines written by Bernhard Ø Palsson and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes all human leukemia-lymphoma cell lines that have been established and that grow continuously under standardised in vitro conditions. These lines are derived from cells belonging to all the major hematopoietic cell lineages, i.e. B- and T-lymphocytes, natural killer cells, granulocytic cells and megakaryocytic cells. The clinical data, the culture conditions and the major phenotypic features of the cell lines are described with citations. This book is the first book describing human leukemia-lymphoma cell lines and will be of interest to scientists involved in the areas of hematology, oncology, immunology, molecular biology and cytogenetics. Cancer Cell Lines, Volumes 1-3: These 3 volumes provide a comprehensive text on the culture of established cell lines from every type of human cancer. The volumes provide a basic manual and reference resource for every cancer research scientist using human cancer cells.
Book Synopsis Neoplastic Diseases of the Blood by : Peter H. Wiernik
Download or read book Neoplastic Diseases of the Blood written by Peter H. Wiernik and published by Springer. This book was released on 2018-03-15 with total page 1338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this textbook integrates the history, epidemiology, pathology, pathophysiology, therapeutics, and supportive care of modern neoplastic hematopathology. Now in its sixth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. The textbook is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia, including chronic leukemias and related disorders, acute leukemias, myeloma and related disorders, and lymphomas, and the fifth section covering a variety of topics in supportive care. Chapters are presented in an accessible and easy-to-read layout, providing updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. Neoplastic Diseases of the Blood, Sixth Edition is an authoritative and indispensable resource for students, trainees, and clinicians, sure to distinguish itself as the definitive reference on this subject.
Book Synopsis Neonatal Hematology by : Pedro A. de Alarcón
Download or read book Neonatal Hematology written by Pedro A. de Alarcón and published by Cambridge University Press. This book was released on 2021-02-18 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
Book Synopsis Reviews in hematologic malignancies by : Alejandro Gru
Download or read book Reviews in hematologic malignancies written by Alejandro Gru and published by Frontiers Media SA. This book was released on 2023-01-31 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Reviews in hematologic malignancies: 2023 by : Billy Jebaraj
Download or read book Reviews in hematologic malignancies: 2023 written by Billy Jebaraj and published by Frontiers Media SA. This book was released on 2024-05-10 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Immunology E-Book by : Robert R. Rich
Download or read book Clinical Immunology E-Book written by Robert R. Rich and published by Elsevier Health Sciences. This book was released on 2022-08-23 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume. Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine. Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma. Provides new genetics content focused on data applications. Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. Summarizes promising research and development anticipated over the next 5–10 years with "On the Horizon" boxes and discussions of translational research.
Book Synopsis Biomedical Index to PHS-supported Research by :
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1993 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by :
Download or read book Biomedical Index to PHS-supported Research: pt. A. Subject access A-H written by and published by . This book was released on 1992 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis DNA Methylation and Complex Human Disease by : Michel Neidhart
Download or read book DNA Methylation and Complex Human Disease written by Michel Neidhart and published by Academic Press. This book was released on 2015-08-11 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
Book Synopsis Essential Immunology for Surgeons by : Oleg Eremin
Download or read book Essential Immunology for Surgeons written by Oleg Eremin and published by OUP Oxford. This book was released on 2011-04-28 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a huge increase in the knowledge and understanding of the immunological processes involved in surgical practice in recent years. Anaesthesiologists and intensive care physicians are increasingly recognising the significant derangements of immune function in the critically ill patient and the possible therapeutic approaches to manage such patients (including new approaches in transplantation rejections, novel vaccination strategies in cancer treatment, as well as a better understanding of the beneficial effects of standard chemotherapy). Written by recognised experts in their field from both the UK and the US, and extensively referenced for further reading, Essential Immunology for Surgeons provides a concise, up-to-date, and readable account of immunology in general and its translation into key areas of clinical practice. It provides the necessary foundation for a critical understanding of this essential and rapidly expanding area of biological science that underpins and explains the modern concepts of a range of diseases and conditions, encompassing autoimmunity, infection, trauma, cancer, nutrition, organ transplantation, and various forms of therapy. Previously published as Immunological Basis for Surgical Science and Practice, this fully-updated textbook is aimed predominantly at the surgical trainee, but will also be of value to undergraduate and postgraduate clinicians of any discipline who wish to have a better understanding and knowledge of the subject, as well as to researchers studying the various core topics discussed in the book.
Book Synopsis Cecil Essentials of Medicine E-Book by : Edward J. Wing
Download or read book Cecil Essentials of Medicine E-Book written by Edward J. Wing and published by Elsevier Health Sciences. This book was released on 2021-03-17 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science. New focus on high-yield, core knowledge necessary for clerkships or residencies in medicine, with concise, complete coverage of the core principles of medicine and how they apply to patient care. Each section describes key physiology and biochemistry, followed by comprehensive accounts of the diseases of the organ system or field covered in the chapters. Full-color design enhances readability and retention of concepts, while numerous imaging videos cover cardiovascular disease, endoscopy, sphincterotomy, and more. Superb images and photographs vividly illustrate the appearance and clinical features of disease. New chapters cover Women’s Cancer and Transitions in Care from Children to Adults with Pulmonary Disease.
Book Synopsis Fetal & Neonatal Hematology, Oncology and Immunology by : MR Lokeshwar
Download or read book Fetal & Neonatal Hematology, Oncology and Immunology written by MR Lokeshwar and published by JP Medical Ltd. This book was released on 2017-07-17 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns. Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions. The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders. Each topic explains new advances, all current treatment protocols, new drugs, and management approaches. Chapters are further enhanced by clinical images and tables. Key points Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches Includes discussion on neonatal malignancies and blood transfusion Highly illustrated with clinical images and tables
Book Synopsis Innate Immune Cell Therapy of Cancer by : Asha B. Pillai
Download or read book Innate Immune Cell Therapy of Cancer written by Asha B. Pillai and published by Frontiers Media SA. This book was released on 2023-09-13 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.
Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
