Author : Sean Artello
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Book Synopsis Transanalysis of Human Serum Albumin Function Based On Evolutionarily and Experimentally Unique Amino Acids by : Sean Artello
Download or read book Transanalysis of Human Serum Albumin Function Based On Evolutionarily and Experimentally Unique Amino Acids written by Sean Artello and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Human serum albumin (HSA) is a predominant blood protein with binding affinity to many endogenous and exogenous compounds. Following an overview of this protein, the additional capacity for heme binding is analyzed as both an evolutionarily retained and experimentally inducible function. An inclusive analysis of HSA has examined all facets of HSAs current structure, potential variations of this structure that may be induced experimentally, and the potential for evolutionary selection regarding beneficial variance. Initial background information was analyzed including structure and function, the role of HSA within the body, and medical applications, including a proposal for protein modification to facilitate the new application of heme binding and oxygen carrying ability. Once these variations were reviewed, 10 different species (mammalian, reptilian, and avian) were examined for conserved or new heme binding functionality within five relevant heme binding regions. Analysis at these regions, positions 138, 142, 146, 161, and 190 showed relative conservation, but the potential for heme binding as an accommodation for oxidative stress appears negligible within these species. Following this evaluation, procedure and methodology was outlined for the generation of mutant HSA plasmid and possible routes of generating mutant HSA protein with heme binding capability.
