Training Workshop On Advances In Boron Neutron Capture Therapy

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Advances in Neutron Capture Therapy

Author : R.F. Barth
Publisher : Springer Science & Business Media
ISBN 13 : 1461529786
Total Pages : 776 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Advances in Neutron Capture Therapy by : R.F. Barth

Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.

Neutron Capture Therapy

Author : Wolfgang A.G. Sauerwein
Publisher : Springer Science & Business Media
ISBN 13 : 3642313345
Total Pages : 545 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Neutron Capture Therapy by : Wolfgang A.G. Sauerwein

Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment

Author : Narayan S Hosmane
Publisher : World Scientific
ISBN 13 : 9814462187
Total Pages : 271 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment by : Narayan S Hosmane

Download or read book Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment written by Narayan S Hosmane and published by World Scientific. This book was released on 2012-03-07 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.

Intense Neutron Sources

Author : U.S. Atomic Energy Commission
Publisher :
ISBN 13 :
Total Pages : 856 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Intense Neutron Sources by : U.S. Atomic Energy Commission

Download or read book Intense Neutron Sources written by U.S. Atomic Energy Commission and published by . This book was released on 1966 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Boron Neutron Capture Therapy

Author : United States. Congress. Senate. Committee on Energy and Natural Resources
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Boron Neutron Capture Therapy by : United States. Congress. Senate. Committee on Energy and Natural Resources

Download or read book Boron Neutron Capture Therapy written by United States. Congress. Senate. Committee on Energy and Natural Resources and published by . This book was released on 1994 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Neutron Optics

Author : Maria L. Calvo
Publisher : CRC Press
ISBN 13 : 1000727548
Total Pages : 308 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Advances in Neutron Optics by : Maria L. Calvo

Download or read book Advances in Neutron Optics written by Maria L. Calvo and published by CRC Press. This book was released on 2019-11-11 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron optics studies the interactions of a beam of slow neutrons with matter. This book updates various advances on neutron optics. There will be a focus on the very active topics of neutron imaging (NI) and neutron spin optics (NSO). The book will also present applications of neutron beams in biomedicine, such as Boron Neutron Capture Therapy (BNCT) and related techniques. Features: Discusses diffraction and interference of slow neutrons, including computational approaches Reviews neutron imaging (NI) and neutron spin optics (NSO) Treats two major sources of slow neutron beams: (1) fission reactions at nuclear reactors and (2) collisions in particle accelerators (small ones, spallation sources) of charged particle beams with targets of heavy atoms Selects subjects on fundamental quantum aspects of slow neutrons and on confined propagation and waveguiding thereof Updates slow neutron beams and BNCT

Progress in Neutron Capture Therapy for Cancer

Author : B.J. Allen
Publisher : Springer Science & Business Media
ISBN 13 : 1461533848
Total Pages : 641 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Progress in Neutron Capture Therapy for Cancer by : B.J. Allen

Download or read book Progress in Neutron Capture Therapy for Cancer written by B.J. Allen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the odds are not evenly distributed. Prognosis for some cancers is good, but for others, few patients will survive 12 months. This latter group of cancers is characterised by a proclivity to disseminate malignant cells in the host organ. The degree of surgery possible may be limited by the critical nature of the organ, and chemotherapy and radiotherapy are of palliative value only. In some cases systemic metastases occur, but in other cases, failure to achieve local control results in death. First among these cancers are the high grade brain tumours, astrocytoma 3,4 and glioblastoma multiforme. Local control of these tumours should lead to cure. Other cancers melanoma metastatic to the brain, for which a useful palliative therapy is not yet available, and pancreatic cancer for which localised control at an early stage could bring about improved prognosis. Patients with these cancers have little grounds for hope. Our primary objective is to reverse this situation with Neutron Capture Therapy (NCT). The purpose of this fourth symposium is to hasten the day whereby patients with these cancers can reasonably hope for substantial remissions. The first symposium on NCT was held in Boston in 1983, followed by Tokyo in 1985 and Bremen, Germany in 1988.

Proton Therapy Physics

Author : Harald Paganetti
Publisher : CRC Press
ISBN 13 : 1439836450
Total Pages : 691 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Proton Therapy Physics by : Harald Paganetti

Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

Advances in Neutron Capture Therapy

Author : Börje Larsson
Publisher :
ISBN 13 :
Total Pages : 640 pages
Book Rating : 4.4/5 (88 download)

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Book Synopsis Advances in Neutron Capture Therapy by : Börje Larsson

Download or read book Advances in Neutron Capture Therapy written by Börje Larsson and published by . This book was released on 1997 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Boron-Based Compounds

Author : Evamarie Hey-Hawkins
Publisher : John Wiley & Sons
ISBN 13 : 1119275555
Total Pages : 490 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Boron-Based Compounds by : Evamarie Hey-Hawkins

Download or read book Boron-Based Compounds written by Evamarie Hey-Hawkins and published by John Wiley & Sons. This book was released on 2018-07-23 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.

Neutron Generators for Analytical Purposes

Author : International Atomic Energy Agency
Publisher : IAEA Radiation Technology Repo
ISBN 13 : 9789201251107
Total Pages : 145 pages
Book Rating : 4.2/5 (511 download)

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Book Synopsis Neutron Generators for Analytical Purposes by : International Atomic Energy Agency

Download or read book Neutron Generators for Analytical Purposes written by International Atomic Energy Agency and published by IAEA Radiation Technology Repo. This book was released on 2012 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication addresses recent developments in neutron generator (NG) technology. It presents information on compact instruments with high neutron yield to be used for neutron activation analysis (NAA) and prompt gamma neutron activation analysis in combination with high count rate spectrometers. Traditional NGs have been shown to be effective for applications including borehole logging, homeland security, nuclear medicine and the on-line analysis of aluminium, coal and cement. Pulsed fast thermal neutron analysis, as well as tagged and timed neutron analysis, are additional techniques which can be applied using NG. Furthermore, NG can effectively be used for elemental analysis and is also effective for analysis of hidden materials by neutron radiography. Useful guidelines for developing NG based research laboratories are also provided in this publication.

Energy Research Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 438 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Energy Research Abstracts by :

Download or read book Energy Research Abstracts written by and published by . This book was released on 1994-05 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Boron Neutron Capture Therapy

Author : Detlef Gabel
Publisher : Springer Science & Business Media
ISBN 13 : 1461534089
Total Pages : 274 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Boron Neutron Capture Therapy by : Detlef Gabel

Download or read book Boron Neutron Capture Therapy written by Detlef Gabel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.

Frontiers in neutron capture therapy

Author : M. Frederick Hawthorne
Publisher : Springer Science & Business Media
ISBN 13 : 9780306464423
Total Pages : 742 pages
Book Rating : 4.4/5 (644 download)

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Book Synopsis Frontiers in neutron capture therapy by : M. Frederick Hawthorne

Download or read book Frontiers in neutron capture therapy written by M. Frederick Hawthorne and published by Springer Science & Business Media. This book was released on 2001 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 1380 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1977 with total page 1380 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index of Conference Proceedings

Author : British Library. Document Supply Centre
Publisher :
ISBN 13 :
Total Pages : 938 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Index of Conference Proceedings by : British Library. Document Supply Centre

Download or read book Index of Conference Proceedings written by British Library. Document Supply Centre and published by . This book was released on 1997 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Reviews Of Accelerator Science And Technology - Volume 4: Accelerator Applications In Industry And The Environment

Author : Alexander Wu Chao
Publisher : World Scientific
ISBN 13 : 9814452793
Total Pages : 300 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Reviews Of Accelerator Science And Technology - Volume 4: Accelerator Applications In Industry And The Environment by : Alexander Wu Chao

Download or read book Reviews Of Accelerator Science And Technology - Volume 4: Accelerator Applications In Industry And The Environment written by Alexander Wu Chao and published by World Scientific. This book was released on 2012-02-20 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their debut in the late 1920s, particle accelerators have evolved into a backbone for the development of science and technology in modern society. Of about 30,000 accelerators at work in the world today, a majority is for applications in industry (about 20,000 systems worldwide).There are two major categories of industrial applications: materials processing and treatment, and materials analysis. Materials processing and treatment includes ion implantation (semi-conductor materials, metals, ceramics, etc.) and electron beam irradiation (sterilization of medical devices, food pasteurization, treatment of carcasses and tires, cross-linking of polymers, cutting and welding, curing of composites, etc.). Materials analysis covers ion beam analysis (IBA), non-destructive detection using photons and neutrons, as well as accelerator mass spectrometry (AMS). All the products that are processed, treated and inspected using beams from particle accelerators are estimated to have a collective value of US$500 billion per annum worldwide. Accelerators are also applied for environment protection, such as purifying drinking water, treating waste water, disinfecting sewage sludge and removing pollutants from flue gases.Industrial accelerators continue to evolve, in terms of new applications, qualities and capabilities, and reduction of their costs. Breakthroughs are encountered whenever a new product is made, or an existing product becomes more cost effective. Their impact on our society continues to grow with the potential to address key issues in economics or the society of today.This volume contains fourteen articles, all authored by renowned scientists in their respective fields.